LOCUS       NM_001100388             733 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens HOATZ cilia and flagella associated protein (HOATZ),
            transcript variant 2, mRNA.
ACCESSION   NM_001100388
VERSION     NM_001100388.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 733)
  AUTHORS   Narita,K., Nagatomo,H., Kozuka-Hata,H., Oyama,M. and Takeda,S.
  TITLE     Discovery of a Vertebrate-Specific Factor that Processes Flagellar
            Glycolytic Enolase during Motile Ciliogenesis
  JOURNAL   iScience 23 (4), 100992 (2020)
   PUBMED   32248064
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP002008.5.
            
            On Oct 11, 2020 this sequence version replaced NM_001100388.1.
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            central region, compared to variant 1. The resulting isoform (2)
            lacks an internal segment, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039505.2, CD704138.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375618.9/ ENSP00000364768.4
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-233               AP002008.5         126022-126254
            234-275             AP002008.5         126755-126796
            276-346             AP002008.5         127284-127354
            347-406             AP002008.5         144990-145049
            407-459             AP002008.5         145656-145708
            460-733             AP002008.5         148014-148287
FEATURES             Location/Qualifiers
     source          1..733
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.1"
     gene            1..733
                     /gene="HOATZ"
                     /gene_synonym="C11orf88"
                     /note="HOATZ cilia and flagella associated protein"
                     /db_xref="GeneID:399949"
                     /db_xref="HGNC:HGNC:25061"
     exon            1..233
                     /gene="HOATZ"
                     /gene_synonym="C11orf88"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..517
                     /gene="HOATZ"
                     /gene_synonym="C11orf88"
                     /note="isoform 2 is encoded by transcript variant 2;
                     UPF0722 protein C11orf88; hypothetical gene supported by
                     BC039505; protein Hoatz; cilia- and flagella-associated
                     protein HOATZ"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein HOATZ
                     isoform 2"
                     /protein_id="NP_001093858.1"
                     /db_xref="CCDS:CCDS41713.1"
                     /db_xref="GeneID:399949"
                     /db_xref="HGNC:HGNC:25061"
                     /translation="METGPSEEPSGRKESQEMCPPGLLVFAGSSEQDANLAKQFWISA
                     SMYPPSESQLVLRRDSSQRLPVARPRRSRGSENSHSSQSFHLASNKNRDIFAEALKIQ
                     ESEEKVKYLQKAKTREEILQLLRKQREERISKELISLPYKPKAKEHKAKKVVSESDKE
                     DQEEVKTLD"
     exon            234..275
                     /gene="HOATZ"
                     /gene_synonym="C11orf88"
                     /inference="alignment:Splign:2.1.0"
     exon            276..346
                     /gene="HOATZ"
                     /gene_synonym="C11orf88"
                     /inference="alignment:Splign:2.1.0"
     exon            347..406
                     /gene="HOATZ"
                     /gene_synonym="C11orf88"
                     /inference="alignment:Splign:2.1.0"
     exon            407..459
                     /gene="HOATZ"
                     /gene_synonym="C11orf88"
                     /inference="alignment:Splign:2.1.0"
     exon            460..733
                     /gene="HOATZ"
                     /gene_synonym="C11orf88"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      688
                     /gene="HOATZ"
                     /gene_synonym="C11orf88"
                     /note="major polyA site"
     regulatory      695..700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HOATZ"
                     /gene_synonym="C11orf88"
                     /note="hexamer: AATAAA"
     polyA_site      725
                     /gene="HOATZ"
                     /gene_synonym="C11orf88"
ORIGIN      
        1 agttgccatg gaaacgggac ccagcgaaga acctagcggc cgaaaagagt cccaggaaat
       61 gtgccccccg ggattactgg tatttgctgg ctcctcggaa caagatgcca acttggctaa
      121 gcagttctgg atctcggcgt cgatgtatcc ccctagcgaa tctcagctgg tgctgcgcag
      181 agacagcagt cagcgtctgc cggtggcgcg gcccaggagg agcagagggt ctgaaaacag
      241 ccactcctcg cagtcttttc accttgcgag taacaaaaat agagacatct ttgccgaagc
      301 cctaaagata caggaatctg aggagaaagt aaagtatctc caaaaggcta aaacaagaga
      361 agagattctc caactcttaa gaaaacaaag agaagaaagg atctcgaaag aactgatttc
      421 ccttccgtat aaaccaaaag ccaaagaaca caaagcaaag aaagtggtat cagagtcaga
      481 taaagaggac caagaagaag tcaaaacttt ggactaattt gcttgacaca tggcagagga
      541 tggctcactt ataccttcac tttggaaaca accttctctt agatcaggat cattgagatc
      601 actggcaaca ttatagtaga caaagaaata caagttaaat acgcagactt ccaggaattt
      661 taccagttag tgagtacttg tgttaaaata aagaaataaa ggttaaatat gcaggcttct
      721 atgaattcta cca
//
