LOCUS       NM_001079559            5214 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens heterogeneous nuclear ribonucleoprotein U like 2
            (HNRNPUL2), mRNA.
ACCESSION   NM_001079559 XM_001128651 XM_495877
VERSION     NM_001079559.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5214)
  AUTHORS   Jiang,H., Wang,Y., Ai,M., Wang,H., Duan,Z., Wang,H., Zhao,L.,
            Yu,J., Ding,Y. and Wang,S.
  TITLE     Long noncoding RNA CRNDE stabilized by hnRNPUL2 accelerates cell
            proliferation and migration in colorectal carcinoma via activating
            Ras/MAPK signaling pathways
  JOURNAL   Cell Death Dis 8 (6), e2862 (2017)
   PUBMED   28594403
  REMARK    GeneRIF: it was demonstrated that CRNDE could form a functional
            complex with heterogeneous nuclear ribonucleoprotein U-like 2
            protein (hnRNPUL2) and direct the transport of hnRNPUL2 between the
            nucleus and cytoplasm.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5214)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 5214)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 5214)
  AUTHORS   Polo,S.E., Blackford,A.N., Chapman,J.R., Baskcomb,L., Gravel,S.,
            Rusch,A., Thomas,A., Blundred,R., Smith,P., Kzhyshkowska,J.,
            Dobner,T., Taylor,A.M., Turnell,A.S., Stewart,G.S., Grand,R.J. and
            Jackson,S.P.
  TITLE     Regulation of DNA-end resection by hnRNPU-like proteins promotes
            DNA double-strand break signaling and repair
  JOURNAL   Mol Cell 45 (4), 505-516 (2012)
   PUBMED   22365830
  REMARK    GeneRIF: hnRNPUL1 and -2 function downstream of MRN and
            CtBP-interacting protein (CtIP) to promote recruitment of the BLM
            helicase to DNA breaks.
REFERENCE   5  (bases 1 to 5214)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 5214)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   7  (bases 1 to 5214)
  AUTHORS   Fackelmayer,F.O. and Richter,A.
  TITLE     Purification of two isoforms of hnRNP-U and characterization of
            their nucleic acid binding activity
  JOURNAL   Biochemistry 33 (34), 10416-10422 (1994)
   PUBMED   8068679
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001160.4, BC029105.1, DQ470474.1 and AP001458.6.
            
            On May 17, 2019 this sequence version replaced NM_001079559.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ470474.1, SRR3476690.72252.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301785.7/ ENSP00000301785.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AP001160.4         4687-4758           c
            73-108              BC029105.1         88-123
            109-3096            DQ470474.1         1-2988
            3097-5214           AP001458.6         119897-122014       c
FEATURES             Location/Qualifiers
     source          1..5214
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..5214
                     /gene="HNRNPUL2"
                     /gene_synonym="HNRPUL2; SAF-A2"
                     /note="heterogeneous nuclear ribonucleoprotein U like 2"
                     /db_xref="GeneID:221092"
                     /db_xref="HGNC:HGNC:25451"
     exon            1..839
                     /gene="HNRNPUL2"
                     /gene_synonym="HNRPUL2; SAF-A2"
                     /inference="alignment:Splign:2.1.0"
     CDS             302..2545
                     /gene="HNRNPUL2"
                     /gene_synonym="HNRPUL2; SAF-A2"
                     /note="scaffold-attachment factor A2"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein U-like
                     protein 2"
                     /protein_id="NP_001073027.1"
                     /db_xref="CCDS:CCDS41659.1"
                     /db_xref="GeneID:221092"
                     /db_xref="HGNC:HGNC:25451"
                     /translation="MEVKRLKVTELRSELQRRGLDSRGLKVDLAQRLQEALDAEMLED
                     EAGGGGAGPGGACKAEPRPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQA
                     LGQAAQPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEER
                     SGDETPGSEVPGDKAAEEQGDDQDSEKSKPAGSDGERRGVKRQRDEKDEHGRAYYEFR
                     EEAYHSRSKSPLPPEEEAKDEEEDQTLVNLDTYTSDLHFQVSKDRYGGQPLFSEKFPT
                     LWSGARSTYGVTKGKVCFEAKVTQNLPMKEGCTEVSLLRVGWSVDFSRPQLGEDEFSY
                     GFDGRGLKAENGQFEEFGQTFGENDVIGCFANFETEEVELSFSKNGEDLGVAFWISKD
                     SLADRALLPHVLCKNCVVELNFGQKEEPFFPPPEEFVFIHAVPVEERVRTAVPPKTIE
                     ECEVILMVGLPGSGKTQWALKYAKENPEKRYNVLGAETVLNQMRMKGLEEPEMDPKSR
                     DLLVQQASQCLSKLVQIASRTKRNFILDQCNVYNSGQRRKLLLFKTFSRKVVVVVPNE
                     EDWKKRLELRKEVEGDDVPESIMLEMKANFSLPEKCDYMDEVTYGELEKEEAQPIVTK
                     YKEEARKLLPPSEKRTNRRNNRNKRNRQNRSRGQGYVGGQRRGYDNRAYGQQYWGQPG
                     NRGGYRNFYDRYRGDYDRFYGRDYEYNRYRDYYRQYNRDWQSYYYHHPQDRDRYYRNY
                     YGYQGYR"
     exon            840..975
                     /gene="HNRNPUL2"
                     /gene_synonym="HNRPUL2; SAF-A2"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1052
                     /gene="HNRNPUL2"
                     /gene_synonym="HNRPUL2; SAF-A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1192
                     /gene="HNRNPUL2"
                     /gene_synonym="HNRPUL2; SAF-A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1283
                     /gene="HNRNPUL2"
                     /gene_synonym="HNRPUL2; SAF-A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1396
                     /gene="HNRNPUL2"
                     /gene_synonym="HNRPUL2; SAF-A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1660
                     /gene="HNRNPUL2"
                     /gene_synonym="HNRPUL2; SAF-A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1783
                     /gene="HNRNPUL2"
                     /gene_synonym="HNRPUL2; SAF-A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1912
                     /gene="HNRNPUL2"
                     /gene_synonym="HNRPUL2; SAF-A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2081
                     /gene="HNRNPUL2"
                     /gene_synonym="HNRPUL2; SAF-A2"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2282
                     /gene="HNRNPUL2"
                     /gene_synonym="HNRPUL2; SAF-A2"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2356
                     /gene="HNRNPUL2"
                     /gene_synonym="HNRPUL2; SAF-A2"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2464
                     /gene="HNRNPUL2"
                     /gene_synonym="HNRPUL2; SAF-A2"
                     /inference="alignment:Splign:2.1.0"
     exon            2465..5214
                     /gene="HNRNPUL2"
                     /gene_synonym="HNRPUL2; SAF-A2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2778..2783
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPUL2"
                     /gene_synonym="HNRPUL2; SAF-A2"
                     /note="hexamer: TATAAA"
     polyA_site      2797
                     /gene="HNRNPUL2"
                     /gene_synonym="HNRPUL2; SAF-A2"
     regulatory      3057..3062
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPUL2"
                     /gene_synonym="HNRPUL2; SAF-A2"
                     /note="hexamer: AATAAA"
     polyA_site      3096
                     /gene="HNRNPUL2"
                     /gene_synonym="HNRPUL2; SAF-A2"
                     /note="major polyA site"
     regulatory      5188..5193
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPUL2"
                     /gene_synonym="HNRPUL2; SAF-A2"
                     /note="hexamer: AATAAA"
     polyA_site      5214
                     /gene="HNRNPUL2"
                     /gene_synonym="HNRPUL2; SAF-A2"
ORIGIN      
        1 gtcgtcctcc gcgcgcgcct gcccgcggct ggggaaccaa gggcctggag gggaaacagc
       61 tccctgctgc gttgttttgg gctccgtgag ccgaaagggg gaggggagac gaaggagaag
      121 caaacactgc gcagcgggac cgtgcgcggc ctccgctcct gcgtgcgtgc gctcgctcgc
      181 gcgggctcag tgctggcgcg tgaggcggag gcgggcggcg gcggcggcgc ctgcgcggtc
      241 ggactcggtc gacggttcgc aggggaggag gcggcgggag gcggaggagg cggcggcggc
      301 gatggaggtg aagcggctga aagtgaccga gctgcggtcg gagctgcagc ggcggggcct
      361 ggactcgcgc ggcctcaagg tggatctggc gcagcggctg caggaggcgc tggacgccga
      421 gatgctcgag gacgaggccg gcggcggcgg ggccgggccc ggcggggcct gcaaggcgga
      481 gcctcggcct gtggccgcgt cgggcggcgg cccgggcggg gacgaggagg aggacgaaga
      541 ggaggaggag gaggacgagg aggcgctgct tgaggacgag gacgaggagc caccccctgc
      601 tcaagccttg ggtcaggccg cgcagccgcc gccggagccc ccggaggcgg cagccatgga
      661 ggccgcggcc gagccagatg cttccgagaa gccggcggag gccacggccg ggtcaggcgg
      721 ggtaaatggt ggcgaagagc agggcctcgg caagagggag gaagacgaac ccgaggagcg
      781 gagcggggac gagacgccgg gatccgaggt gccgggtgac aaggccgccg aggaacaggg
      841 agatgaccag gatagtgaaa agtcaaaacc agcaggctca gatggtgagc ggcggggggt
      901 aaagagacag cgggatgaga aggatgaaca tggccgagct tactatgaat tccgagagga
      961 ggcttaccac agccgctcaa agtctccact gcctcctgaa gaagaggcaa aagatgagga
     1021 ggaggatcaa actcttgtga acctggacac gtatacctcg gatctgcatt ttcaagtgag
     1081 caaagaccgc tatggagggc agccactttt ctcagagaag ttccccaccc tttggtctgg
     1141 ggcaaggagt acttacggag tgacaaaggg aaaagtctgc tttgaggcaa aggtaaccca
     1201 gaatctccca atgaaagaag gctgcacaga ggtctctctc cttcgagttg ggtggtctgt
     1261 tgatttttcc cgtccacagc ttggtgaaga tgaattctct tacggtttcg atggacgagg
     1321 actcaaggca gaaaatggac aatttgagga atttggccag acttttgggg agaatgatgt
     1381 tattggctgc tttgctaatt ttgagactga agaagtagaa ctttccttct ccaagaatgg
     1441 agaagaccta ggtgtggcat tctggatcag caaggattcc ctggcagacc gggcccttct
     1501 accccatgtc ctctgcaaaa attgtgttgt agaattaaac ttcggtcaga aggaggagcc
     1561 cttcttccca ccaccagaag agtttgtgtt cattcatgct gtgcctgttg aggagcgtgt
     1621 acgcactgca gtccctccca agaccataga ggaatgtgag gtgattctga tggtgggact
     1681 acccggatct ggaaagaccc agtgggcact gaaatatgca aaagaaaacc ctgagaaaag
     1741 atacaatgtc ctgggagctg agactgtgct caatcaaatg aggatgaagg gtctcgagga
     1801 gccagagatg gaccccaaaa gccgagacct tttagttcag caagcctccc agtgccttag
     1861 taagctggtc cagattgctt cccggacaaa gaggaacttt attcttgatc agtgtaatgt
     1921 gtacaattct ggccaacggc ggaagctatt gctgttcaag accttctctc ggaaagtggt
     1981 ggtggttgtc cctaatgagg aagattggaa gaagaggctg gagttgagga aggaagtaga
     2041 gggagatgat gtgcctgaat ctataatgct ggagatgaaa gccaacttct ctttgcctga
     2101 aaaatgcgac tatatggatg aggtgacata tggggagctg gagaaggagg aagctcagcc
     2161 cattgtcact aagtacaagg aggaggcaag gaagcttctg cccccctccg agaagcggac
     2221 aaatcgccga aacaaccgaa acaagcgtaa ccggcagaac cgaagccggg gccaaggcta
     2281 tgtgggcggg cagcgccgag gctacgacaa ccgggcctac gggcagcagt actgggggca
     2341 gcctggaaac agagggggtt accgtaattt ctatgatcga tacaggggag actatgatcg
     2401 attttacggg cgagattatg agtacaacag atacagagac tattacagac aatacaatcg
     2461 ggattggcag agttactact accaccaccc ccaggacaga gaccgatact acaggaatta
     2521 ctacgggtac caagggtatc ggtgaagccc ctgccatggt cacctgtcag ccatgaagct
     2581 gaatctctgg gggtgccagg cacccccgca aaacacaacc aaggaaaaca ggggctgtcg
     2641 gggtggggct gagctgccgg ggaggggtgg tgggggggga gggtgctcaa gcaggggtgg
     2701 gggagggggg aggtggaaac aaacaacaaa actgtacatt ttttttaaag tttgttgaaa
     2761 agaatattgt cttattctat aaaacatttc aaacctagtt agagatttgt aatcaaaaaa
     2821 catttgcgca gaaagcagca cttagggctg cctgttctat accctacagt cagacaggaa
     2881 aagaactgaa aatggcaccc ttctgacatt ctgaggcagc tggactggca gccaagtaaa
     2941 ggagagtgat gaggtggtgt ggggagggtg gggaggcagc gcgagggtgc tctccacagc
     3001 aggtaggagc aggcaggagt ggggacagag ggagagcttg tgactgggac agtgaaaata
     3061 aacgattggc tcttatcaat cacttgcacc aactaaccgt ttgtattttc tttaccgacc
     3121 tttccctttt gggatatgtg gtctggtggg ctgggaggct tacagtgtcc caactctcca
     3181 ttttcctgtg cctttgtgct gtttggctga ggcatggaga ctgccagtgg gtggttctat
     3241 tttacaggat tcccaggcca agaaagcctg gggactgtcc ttgatggcag agcagaatag
     3301 cctgcccctt ctatagaccc attgattaat tcctgtaaaa tcttggggag aatgggattg
     3361 cagccctcag cctaaagatt gtgatttgcc agtctctagt ctctgtcttc caaggttgag
     3421 agaggtggga ggtctctgaa atcatccctg ttagagtgtc tgtcctctta cagtgcgaga
     3481 gaaggaacgt ttctcagggt ttcagctcac acgaaaacac agcaggattc ttttcactgc
     3541 agcgggatat gtatataggt gaatcctgtg gtgtgggctc acaggcccag gtgctgagaa
     3601 tagcaactag caactatttt ctacagtgtg gagggctcgt gccctgctgg tttttttgat
     3661 acacaggtag agaatgaata gaagagggga gggtggtggg ggggggtggg aggcagctca
     3721 gtggggctgc tgaaccttgg gaagagtgtg agtgtgaacg tgtgtaaatg tgcgtgtgaa
     3781 agggagcacc ccttcccgac ttctagaaac aaaattcctt ttggggcgct ttccctgtgt
     3841 gtccccagag aggcctctag ccaggagcct tcagttggga tagtttcatt tgtgacttta
     3901 ccaataccct cccagttctt gatagacagc tgtaggttgc tgggttcaag aatatgggtg
     3961 ggatatggaa tgctctttca atgtctagct tcagttttca ttcatcctcc tgctcagcac
     4021 tgtcagccaa gagcttactc agcagacacc acatactgca gcagttccta gtgagaaaat
     4081 ctgtgccact agaaaatgct tcacttccat ttcctcacct gggcagttct ctgtttaaaa
     4141 ttgtgggctg atttggtctt cctctcctcc tcccactgtt actgccctgc agcccttgtt
     4201 caggtgtaca gacccttatt ctggcctcta gtgtccttgt ctgtcatgac acacccttcc
     4261 gcccaaatac ctctgacccc aaggctggaa tggggctggt aggagataag tttgcttact
     4321 catagtcatg tcctttctct tggcacctgc ttccctgcgg tgtcctcaaa tggatttctg
     4381 tgtggcagtg gagtgattgc atgaattttt ctgtaacaca ttaactttgt attattatta
     4441 agggagtttg agaaagcttt gcttataatg tcaaggcaag gaggtaaaaa ctggagccca
     4501 aagaaattcc cttagggcaa gattatgtta taatagaaaa ttgaatttcc tgaggcagtg
     4561 gctgccaccc cttttcagat gtttagtcct gcaaatagca tctttcttgt agtctgtgac
     4621 atggatgggg atgctagggc ccttaggggc aaggggacta aactaaatca agttgagttt
     4681 ttttccagca ggggttaggg gaggtactcg ctgttgatat ttgacactag aaagtaatct
     4741 tttttacaaa actgtttttc taggtgggtg gaaagtgaaa ctgccacatc cttgttggtt
     4801 tagtccaaga gatcatttgc aacaacagta gatgtccggg ttttgtttct gtctttttat
     4861 tatgaaaaac tatgttaagg gggaaaatgt ggattatggt aaccagagga atccctagcc
     4921 ttgttttcct tagaagactt gtttagtgtt ttatcagacg tctgttgtag ttgtagacag
     4981 gaaagcttgt gagaaaaaca ccacatggag cctgtaaatg tttttgcaca acctgtaaag
     5041 cattcttgga agtggccagt aaaaaggggt tttaccattt aaaaaaaaaa tgtaactgtg
     5101 tcattgttta catctgtaac tttttcctcc cctgttctca ttacaccatt ctggcgaaaa
     5161 tgtaggcaaa gtagcttcca gttttagaat aaataaccat ttggattgaa ttca
//
