LOCUS       NM_007040               3925 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens heterogeneous nuclear ribonucleoprotein U like 1
            (HNRNPUL1), transcript variant 1, mRNA.
ACCESSION   NM_007040
VERSION     NM_007040.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3925)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3925)
  AUTHORS   Cichocka,M., Karlik,A., Plewka,P., Gawade,K., Stepien,A.,
            Swiergiel,P., Gadgil,A. and Raczynska,K.D.
  TITLE     The Novel Role of hnRNP UL1 in Human Cell Nucleoli
  JOURNAL   Int J Biol Sci 18 (13), 4809-4823 (2022)
   PUBMED   35982897
  REMARK    GeneRIF: The Novel Role of hnRNP UL1 in Human Cell Nucleoli.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3925)
  AUTHORS   Ma,Z., Zhou,Y., Wang,Y., Xu,Y., Liu,Y., Liu,Y., Jiang,M., Zhang,X.
            and Cao,X.
  TITLE     RNA-binding protein hnRNP UL1 binds kappaB sites to attenuate
            NF-kappaB-mediated inflammation
  JOURNAL   J Autoimmun 129, 102828 (2022)
   PUBMED   35429914
  REMARK    GeneRIF: RNA-binding protein hnRNP UL1 binds kappaB sites to
            attenuate NF-kappaB-mediated inflammation.
REFERENCE   4  (bases 1 to 3925)
  AUTHORS   Li,J., Sang,M., Zheng,Y., Meng,L., Gu,L., Li,Z., Liu,F., Wu,Y.,
            Li,W. and Shan,B.
  TITLE     HNRNPUL1 inhibits cisplatin sensitivity of esophageal squamous cell
            carcinoma through regulating the formation of circMAN1A2
  JOURNAL   Exp Cell Res 409 (1), 112891 (2021)
   PUBMED   34688610
  REMARK    GeneRIF: HNRNPUL1 inhibits cisplatin sensitivity of esophageal
            squamous cell carcinoma through regulating the formation of
            circMAN1A2.
REFERENCE   5  (bases 1 to 3925)
  AUTHORS   Barral,P.M., Rusch,A., Turnell,A.S., Gallimore,P.H., Byrd,P.J.,
            Dobner,T. and Grand,R.J.
  TITLE     The interaction of the hnRNP family member E1B-AP5 with p53
  JOURNAL   FEBS Lett 579 (13), 2752-2758 (2005)
   PUBMED   15907477
REFERENCE   6  (bases 1 to 3925)
  AUTHORS   Zhou,Z., Licklider,L.J., Gygi,S.P. and Reed,R.
  TITLE     Comprehensive proteomic analysis of the human spliceosome
  JOURNAL   Nature 419 (6903), 182-185 (2002)
   PUBMED   12226669
REFERENCE   7  (bases 1 to 3925)
  AUTHORS   Kzhyshkowska,J., Schutt,H., Liss,M., Kremmer,E., Stauber,R.,
            Wolf,H. and Dobner,T.
  TITLE     Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in
            its Arg-Gly-Gly (RGG) box and interacts with human arginine
            methyltransferase HRMT1L1
  JOURNAL   Biochem J 358 (Pt 2), 305-314 (2001)
   PUBMED   11513728
REFERENCE   8  (bases 1 to 3925)
  AUTHORS   Herold,A., Suyama,M., Rodrigues,J.P., Braun,I.C., Kutay,U.,
            Carmo-Fonseca,M., Bork,P. and Izaurralde,E.
  TITLE     TAP (NXF1) belongs to a multigene family of putative RNA export
            factors with a conserved modular architecture
  JOURNAL   Mol Cell Biol 20 (23), 8996-9008 (2000)
   PUBMED   11073998
REFERENCE   9  (bases 1 to 3925)
  AUTHORS   Bachi,A., Braun,I.C., Rodrigues,J.P., Pante,N., Ribbeck,K., von
            Kobbe,C., Kutay,U., Wilm,M., Gorlich,D., Carmo-Fonseca,M. and
            Izaurralde,E.
  TITLE     The C-terminal domain of TAP interacts with the nuclear pore
            complex and promotes export of specific CTE-bearing RNA substrates
  JOURNAL   RNA 6 (1), 136-158 (2000)
   PUBMED   10668806
REFERENCE   10 (bases 1 to 3925)
  AUTHORS   Gabler,S., Schutt,H., Groitl,P., Wolf,H., Shenk,T. and Dobner,T.
  TITLE     E1B 55-kilodalton-associated protein: a cellular protein with
            RNA-binding activity implicated in nucleocytoplasmic transport of
            adenovirus and cellular mRNAs
  JOURNAL   J Virol 72 (10), 7960-7971 (1998)
   PUBMED   9733834
  REMARK    GeneRIF: Human E1B-AP5 binds to adenovirus E1B-55kDa protein.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011510.7 and AC011462.4.
            
            On May 17, 2019 this sequence version replaced NM_007040.5.
            
            Summary: This gene encodes a nuclear RNA-binding protein of the
            heterogeneous nuclear ribonucleoprotein (hnRNP) family. This
            protein binds specifically to adenovirus early-1B-55kDa
            oncoprotein. It may play an important role in nucleocytoplasmic RNA
            transport, and its function is modulated by early-1B-55kDa in
            adenovirus-infected cells. [provided by RefSeq, Mar 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK022863.1, AK291762.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392006.8/ ENSP00000375863.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-427               AC011510.7         92923-93349
            428-550             AC011510.7         96774-96896
            551-704             AC011510.7         100633-100786
            705-778             AC011510.7         102533-102606
            779-918             AC011510.7         104710-104849
            919-1018            AC011510.7         107628-107727
            1019-1131           AC011510.7         109714-109826
            1132-1398           AC011510.7         120796-121062
            1399-1521           AC011510.7         122889-123011
            1522-1650           AC011510.7         123109-123237
            1651-1819           AC011462.4         129258-129426       c
            1820-2104           AC011462.4         128013-128297       c
            2105-2394           AC011462.4         126701-126990       c
            2395-2586           AC011462.4         125095-125286       c
            2587-3925           AC011462.4         123175-124513       c
FEATURES             Location/Qualifiers
     source          1..3925
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..3925
                     /gene="HNRNPUL1"
                     /gene_synonym="E1B-AP5; E1BAP5; HNRPUL1"
                     /note="heterogeneous nuclear ribonucleoprotein U like 1"
                     /db_xref="GeneID:11100"
                     /db_xref="HGNC:HGNC:17011"
                     /db_xref="MIM:605800"
     exon            1..427
                     /gene="HNRNPUL1"
                     /gene_synonym="E1B-AP5; E1BAP5; HNRPUL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..2703
                     /gene="HNRNPUL1"
                     /gene_synonym="E1B-AP5; E1BAP5; HNRPUL1"
                     /note="isoform a is encoded by transcript variant 1;
                     heterogeneous nuclear ribonucleoprotein U-like protein 1;
                     adenovirus early region 1B-associated protein 5; E1B 55kDa
                     associated protein 5; E1B-55 kDa-associated protein 5"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein U-like
                     protein 1 isoform a"
                     /protein_id="NP_008971.2"
                     /db_xref="CCDS:CCDS12576.1"
                     /db_xref="GeneID:11100"
                     /db_xref="HGNC:HGNC:17011"
                     /db_xref="MIM:605800"
                     /translation="MDVRRLKVNELREELQRRGLDTRGLKAELAERLQAALEAEEPDD
                     ERELDADDEPGRPGHINEEVETEGGSELEGTAQPPPPGLQPHAEPGGYSGPDGHYAMD
                     NITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQ
                     LKPDRQQFQSRKRPYEENRGRGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNC
                     DLHFKVARDRSSGYPLTIEGFAYLWSGARASYGVRRGRVCFEMKINEEISVKHLPSTE
                     PDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFAD
                     FECGNDVELSFTKNGKWMGIAFRIQKEALGGQALYPHVLVKNCAVEFNFGQRAEPYCS
                     VLPGFTFIQHLPLSERIRGTVGPKSKAECEILMMVGLPAAGKTTWAIKHAASNPSKKY
                     NILGTNAIMDKMRVMGLRRQRNYAGRWDVLIQQATQCLNRLIQIAARKKRNYILDQTN
                     VYGSAQRRKMRPFEGFQRKAIVICPTDEDLKDRTIKRTDEEGKDVPDHAVLEMKANFT
                     LPDVGDFLDEVLFIELQREEADKLVRQYNEEGRKAGPPPEKRFDNRGGGGFRGRGGGG
                     GFQRYENRGPPGGNRGGFQNRGGGSGGGGNYRGGFNRSGGGGYSQNRWGNNNRDNNNS
                     NNRGSYNRAPQQQPPPQQPPPPQPPPQQPPPPPSYSPARNPPGASTYNKNSNIPGSSA
                     NTSTPTVSSYSPPQPSYSQPPYNQGGYSQGYTAPPPPPPPPPAYNYGSYGGYNPAPYT
                     PPPPPTAQTYPQPSYNQYQQYAQQWNQYYQNQGQWPPYYGNYDYGSYSGNTQGGTSTQ
                     "
     exon            428..550
                     /gene="HNRNPUL1"
                     /gene_synonym="E1B-AP5; E1BAP5; HNRPUL1"
                     /inference="alignment:Splign:2.1.0"
     exon            551..704
                     /gene="HNRNPUL1"
                     /gene_synonym="E1B-AP5; E1BAP5; HNRPUL1"
                     /inference="alignment:Splign:2.1.0"
     exon            705..778
                     /gene="HNRNPUL1"
                     /gene_synonym="E1B-AP5; E1BAP5; HNRPUL1"
                     /inference="alignment:Splign:2.1.0"
     exon            779..918
                     /gene="HNRNPUL1"
                     /gene_synonym="E1B-AP5; E1BAP5; HNRPUL1"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1018
                     /gene="HNRNPUL1"
                     /gene_synonym="E1B-AP5; E1BAP5; HNRPUL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1131
                     /gene="HNRNPUL1"
                     /gene_synonym="E1B-AP5; E1BAP5; HNRPUL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1398
                     /gene="HNRNPUL1"
                     /gene_synonym="E1B-AP5; E1BAP5; HNRPUL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1521
                     /gene="HNRNPUL1"
                     /gene_synonym="E1B-AP5; E1BAP5; HNRPUL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1650
                     /gene="HNRNPUL1"
                     /gene_synonym="E1B-AP5; E1BAP5; HNRPUL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1819
                     /gene="HNRNPUL1"
                     /gene_synonym="E1B-AP5; E1BAP5; HNRPUL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..2104
                     /gene="HNRNPUL1"
                     /gene_synonym="E1B-AP5; E1BAP5; HNRPUL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2394
                     /gene="HNRNPUL1"
                     /gene_synonym="E1B-AP5; E1BAP5; HNRPUL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2586
                     /gene="HNRNPUL1"
                     /gene_synonym="E1B-AP5; E1BAP5; HNRPUL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2587..3925
                     /gene="HNRNPUL1"
                     /gene_synonym="E1B-AP5; E1BAP5; HNRPUL1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3515
                     /gene="HNRNPUL1"
                     /gene_synonym="E1B-AP5; E1BAP5; HNRPUL1"
                     /note="major polyA site"
     polyA_site      3731
                     /gene="HNRNPUL1"
                     /gene_synonym="E1B-AP5; E1BAP5; HNRPUL1"
                     /note="major polyA site"
     regulatory      3738..3743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPUL1"
                     /gene_synonym="E1B-AP5; E1BAP5; HNRPUL1"
                     /note="hexamer: AAGAAA"
     polyA_site      3743
                     /gene="HNRNPUL1"
                     /gene_synonym="E1B-AP5; E1BAP5; HNRPUL1"
                     /note="major polyA site"
     regulatory      3786..3791
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPUL1"
                     /gene_synonym="E1B-AP5; E1BAP5; HNRPUL1"
                     /note="hexamer: AATAAA"
     polyA_site      3815
                     /gene="HNRNPUL1"
                     /gene_synonym="E1B-AP5; E1BAP5; HNRPUL1"
     polyA_site      3838
                     /gene="HNRNPUL1"
                     /gene_synonym="E1B-AP5; E1BAP5; HNRPUL1"
     regulatory      3904..3909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPUL1"
                     /gene_synonym="E1B-AP5; E1BAP5; HNRPUL1"
                     /note="hexamer: ATTAAA"
     polyA_site      3925
                     /gene="HNRNPUL1"
                     /gene_synonym="E1B-AP5; E1BAP5; HNRPUL1"
ORIGIN      
        1 attttgagcc gctgccgcca ttggagtggg ccccccccct ttcccccttc gcctcctgac
       61 aggaaaggtt taagggggac agagccctgg gaggccgggc cgggctcggg ggccaccccg
      121 ggggcccggg ccatggatgt gcgccgtctg aaggtgaacg aacttcgcga ggagctgcag
      181 cgccgcggcc tggacactcg aggcctcaag gccgagcttg ctgagcggct gcaggcggcg
      241 ttggaggccg aggagcctga cgacgagcgg gagctcgacg ccgacgacga accggggcga
      301 cccgggcaca tcaacgagga ggtcgagacc gaggggggct ccgagctgga ggggaccgcg
      361 cagccaccgc cgcccgggct gcagccgcac gcggagcccg gcggctactc ggggccggac
      421 ggacattatg ccatggacaa tattaccagg cagaaccaat tctacgatac ccaagtcatc
      481 aaacaagaaa acgagtcagg ctacgagagg agaccactgg aaatggagca gcagcaggcc
      541 tatcgtccag aaatgaagac agagatgaag caaggagcac ccaccagctt cctcccgcct
      601 gaagcttctc aactcaagcc agacaggcag caattccaga gtcgaaagag gccttatgaa
      661 gaaaaccggg gacgggggta ctttgagcac cgagaggata ggaggggccg ctctcctcag
      721 cctcctgctg aagaggatga agatgacttt gatgataccc ttgttgctat tgacacctat
      781 aactgcgacc tccacttcaa ggtggcccga gatcggagta gtggctatcc gctcacaatt
      841 gagggctttg catacctgtg gtcaggagcc cgtgccagct atggggtcag aaggggccgt
      901 gtatgcttcg agatgaagat caatgaggaa atctccgtga agcaccttcc gtctacagag
      961 cctgaccccc acgtggtccg tatcggctgg tccctggact cctgcagcac ccagctaggc
     1021 gaagagcctt tctcctatgg ctatggaggc actgggaaga agtccaccaa tagccggttt
     1081 gaaaactacg gagacaagtt tgcagagaac gatgtgattg gctgctttgc ggattttgaa
     1141 tgtggaaatg acgtggaact gtcttttacc aagaatggaa agtggatggg cattgctttc
     1201 cgaatccaga aggaagcctt ggggggtcag gccctctatc ctcatgtcct ggtgaagaat
     1261 tgcgcagtgg agttcaactt cggacagaga gcagagccct actgttctgt cctcccgggg
     1321 tttaccttca tccagcacct tccccttagt gagcgtatcc ggggcaccgt tggaccaaag
     1381 agcaaggcag aatgtgagat tctgatgatg gtgggcctgc ctgctgctgg caagaccaca
     1441 tgggccatca aacatgcagc ctccaaccct tccaagaagt acaacatcct gggtaccaat
     1501 gccatcatgg ataagatgcg ggtgatgggc ctacgccggc agcggaacta tgctggccgc
     1561 tgggatgtcc tgatccagca ggccacccag tgcctcaacc gcctcatcca gattgctgcc
     1621 cgcaagaaac gcaactatat cctagatcag acaaatgttt atgggtcagc ccagagacga
     1681 aaaatgagac catttgaagg cttccagcgc aaagctattg taatttgtcc cactgacgag
     1741 gacctaaaag accgaacaat aaagcgaacc gacgaggaag ggaaggatgt cccagatcat
     1801 gcggtcttag aaatgaaagc caacttcacg ttgccagatg ttggggactt cctggatgag
     1861 gttctgttca ttgagctgca gcgggaggaa gcggacaagc tagtgaggca gtacaacgag
     1921 gaaggccgca aggctgggcc accccctgaa aagcgctttg acaaccgagg tggtggtggc
     1981 ttccggggcc gcgggggtgg tggtggcttc cagcgctatg aaaaccgagg accccctgga
     2041 ggcaaccgtg gcggcttcca gaaccgaggg ggaggcagcg gtggaggagg caactaccga
     2101 ggaggtttca accgcagcgg aggtggtggc tatagccaga accgctgggg taacaacaac
     2161 cgggataaca acaactccaa caacagaggc agctacaacc gggctcccca gcaacagccg
     2221 ccaccacagc agcctccgcc accacagcca ccaccccagc agccaccgcc accacccagc
     2281 tacagccctg ctcggaaccc cccaggggcc agcacctaca ataagaacag caacatccct
     2341 ggctcaagcg ccaataccag cacccccacc gtcagcagct acagccctcc acagccgagt
     2401 tacagccagc caccctacaa ccagggaggt tacagccagg gctacacagc cccaccgcct
     2461 ccacctccac caccacctgc ctacaactat gggagctacg gcggttacaa cccggccccc
     2521 tataccccac cgccaccccc cactgcacag acctaccctc agcccagcta taaccagtat
     2581 cagcagtatg cccagcagtg gaaccagtac tatcagaacc agggccagtg gccgccatac
     2641 tacgggaact acgactacgg gagctactcc gggaacacac agggtggcac aagtacacag
     2701 tagccagtgt gacccagagg ctcccggagg cccctgccgg cttcctccac cagcgcctgc
     2761 ctcggcccct cctctgcccc cgccagatcc cgtggtgctg gggatggggt catcccaggg
     2821 ctgcctccct ccagcccact gcctcccctc tgaggggctt ccttcccctc catagggcca
     2881 ggcatttttt tctggattca aacaggcaac aatgaccttt tattttctgt ttgtccccac
     2941 ctccccagcc ttccacctcc tgttcttcct accttcttcc tttttgacta aataatcccc
     3001 acctcccttg atcatacagt gaggctacag tgactgaggg gagaatcccc tcctgttcac
     3061 tctcccaacc ctgctccagc ccctcagctt cccagaccct catgcagttg gttgtaaatt
     3121 ctcccaggag ctgttttact gtctactttt caggattaaa aaaaaaatca aaacttaaaa
     3181 aaaaaaaagt ttaaaaagca aaatggggag ggggaggaag cagtgacttt tttttggtaa
     3241 ttatgcgctt ttttttaatt tttagaattt gtctttttac tgtgggtggg ctgttgatat
     3301 ttcatcaaga taagcatttc tttcctgagt tcaggtgact gaggaagagc cacaaaacaa
     3361 aacacaacaa aaccaaacca cagaatcatc tttaacccaa ctttttatac gatgccccag
     3421 ttccccataa ctttgcacac aagcttctgt gttcagttga attgtaactg ctttttgtat
     3481 ttggagagag tgactattga acttgaaacc ttttattccg ggcgtcttgg tagtttctgg
     3541 tgggattcag tgggtgagag ggaagaaggg gaggttgggg ggctccttcc cttcagaact
     3601 tgaagtttct cccactgcct cctctccagt ggtctcccag gtgccagacc caaaagcttt
     3661 tcctacagtg atacccttta tttttacttc cccttgactc atatgtttta acatgatttt
     3721 aacaaactgc acttattaag aaatgtgttt gccctgtttt gtttggtttc gttttgtttt
     3781 ctttgaataa atgacatggc acctcctagc aggaaggaag cagggttgaa accctgaagt
     3841 gttactgcag ttggccgtta attggggtgg gggcctcttt aaagggaaat tatttactca
     3901 ttcattaaac aacttaactg aggga
//
