LOCUS       NM_031844               6867 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens heterogeneous nuclear ribonucleoprotein U (HNRNPU),
            transcript variant 1, mRNA.
ACCESSION   NM_031844
VERSION     NM_031844.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6867)
  AUTHORS   Lee,F.F.Y., Harris,C. and Alper,S.
  TITLE     RNA Binding Proteins that Mediate LPS-induced Alternative Splicing
            of the MyD88 Innate Immune Regulator
  JOURNAL   J Mol Biol 436 (8), 168497 (2024)
   PUBMED   38369277
  REMARK    GeneRIF: RNA Binding Proteins that Mediate LPS-induced Alternative
            Splicing of the MyD88 Innate Immune Regulator.
REFERENCE   2  (bases 1 to 6867)
  AUTHORS   Wu,X., Cao,C., Li,Z., Xie,Y., Zhang,S., Sun,W. and Guo,J.
  TITLE     Circular RNA CircSLC22A23 Promotes Gastric Cancer Progression by
            Activating HNRNPU Expression
  JOURNAL   Dig Dis Sci 69 (4), 1200-1213 (2024)
   PUBMED   38400886
  REMARK    GeneRIF: Circular RNA CircSLC22A23 Promotes Gastric Cancer
            Progression by Activating HNRNPU Expression.
REFERENCE   3  (bases 1 to 6867)
  AUTHORS   Wang,X., Xu,J., Li,Q., Zhang,Y., Lin,Z., Zhai,X., Wang,F.,
            Huang,J., Gao,Q., Wen,J., Li,L., Feng,Y., Luo,H., Li,Q., Liu,X.,
            Li,J., Zhao,F., Zhang,L., Niu,T., Sun,C. and Zheng,Y.
  TITLE     RNA-binding protein hnRNPU regulates multiple myeloma resistance to
            selinexor
  JOURNAL   Cancer Lett 580, 216486 (2024)
   PUBMED   37984724
  REMARK    GeneRIF: RNA-binding protein hnRNPU regulates multiple myeloma
            resistance to selinexor.
REFERENCE   4  (bases 1 to 6867)
  AUTHORS   Liu,W., Fang,S., Yang,Z., Ma,J., Tan,Y., Chen,Y., Zhang,K., Liu,K.
            and Gu,W.
  TITLE     ITGA9-AS1 up-regulates ITGA9 by targeting miR-4765 and recruiting
            HNRNPU to affect the proliferation and apoptosis of non-small cell
            lung cancer cells
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (14), 22-28 (2023)
   PUBMED   38279497
  REMARK    GeneRIF: ITGA9-AS1 up-regulates ITGA9 by targeting miR-4765 and
            recruiting HNRNPU to affect the proliferation and apoptosis of
            non-small cell lung cancer cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6867)
  AUTHORS   Li,H., Jiao,W., Song,J., Wang,J., Chen,G., Li,D., Wang,X., Bao,B.,
            Du,X., Cheng,Y., Yang,C., Tong,Q. and Zheng,L.
  TITLE     circ-hnRNPU inhibits NONO-mediated c-Myc transactivation and mRNA
            stabilization essential for glycosylation and cancer progression
  JOURNAL   J Exp Clin Cancer Res 42 (1), 313 (2023)
   PUBMED   37993881
  REMARK    GeneRIF: circ-hnRNPU inhibits NONO-mediated c-Myc transactivation
            and mRNA stabilization essential for glycosylation and cancer
            progression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6867)
  AUTHORS   Barel,M., Balbo,M., Gauffre,A. and Frade,R.
  TITLE     Binding sites of the Epstein-Barr virus and C3d receptor (CR2,
            CD21) for its three intracellular ligands, the p53
            anti-oncoprotein, the p68 calcium binding protein and the nuclear
            p120 ribonucleoprotein
  JOURNAL   Mol Immunol 32 (6), 389-397 (1995)
   PUBMED   7753047
REFERENCE   7  (bases 1 to 6867)
  AUTHORS   Sidorenko,S.P., Law,C.L., Chandran,K.A. and Clark,E.A.
  TITLE     Human spleen tyrosine kinase p72Syk associates with the Src-family
            kinase p53/56Lyn and a 120-kDa phosphoprotein
  JOURNAL   Proc Natl Acad Sci U S A 92 (2), 359-363 (1995)
   PUBMED   7831290
REFERENCE   8  (bases 1 to 6867)
  AUTHORS   Fackelmayer,F.O. and Richter,A.
  TITLE     hnRNP-U/SAF-A is encoded by two differentially polyadenylated mRNAs
            in human cells
  JOURNAL   Biochim Biophys Acta 1217 (2), 232-234 (1994)
   PUBMED   7509195
REFERENCE   9  (bases 1 to 6867)
  AUTHORS   Balasubramanian,M.
  TITLE     HNRNPU-Related Neurodevelopmental Disorder
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   35274911
REFERENCE   10 (bases 1 to 6867)
  AUTHORS   Kiledjian,M. and Dreyfuss,G.
  TITLE     Primary structure and binding activity of the hnRNP U protein:
            binding RNA through RGG box
  JOURNAL   EMBO J 11 (7), 2655-2664 (1992)
   PUBMED   1628625
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX323046.3, AF068846.1,
            BC024767.1, BC015782.1 and AK095525.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_031844.2.
            
            Summary: This gene encodes a member of a family of proteins that
            bind nucleic acids and function in the formation of
            ribonucleoprotein complexes in the nucleus with heterogeneous
            nuclear RNA (hnRNA). The encoded protein has affinity for both RNA
            and DNA, and binds scaffold-attached region (SAR) DNA. Mutations in
            this gene have been associated with epileptic encephalopathy, early
            infantile, 54. A pseudogene of this gene has been identified on
            chromosome 14. [provided by RefSeq, Jun 2017].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.3396444.1,
                                           SRR14038197.1276289.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000640218.2/ ENSP00000491215.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BX323046.3         65827-65844         c
            19-211              AF068846.1         1-193
            212-541             BC024767.1         127-456
            542-3775            BC015782.1         1-3234
            3776-5992           AK095525.1         284-2500
            5993-6864           BX323046.3         51601-52472         c
            6865-6867           BX323046.3         51598-51600         c
FEATURES             Location/Qualifiers
     source          1..6867
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     gene            1..6867
                     /gene="HNRNPU"
                     /gene_synonym="DEE54; EIEE54; GRIP120; hnRNP U;
                     HNRNPU-AS1; HNRPU; pp120; SAF-A; SAFA; U21.1"
                     /note="heterogeneous nuclear ribonucleoprotein U"
                     /db_xref="GeneID:3192"
                     /db_xref="HGNC:HGNC:5048"
                     /db_xref="MIM:602869"
     exon            1..927
                     /gene="HNRNPU"
                     /gene_synonym="DEE54; EIEE54; GRIP120; hnRNP U;
                     HNRNPU-AS1; HNRPU; pp120; SAF-A; SAFA; U21.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..2714
                     /gene="HNRNPU"
                     /gene_synonym="DEE54; EIEE54; GRIP120; hnRNP U;
                     HNRNPU-AS1; HNRPU; pp120; SAF-A; SAFA; U21.1"
                     /note="isoform a is encoded by transcript variant 1; p120
                     nuclear protein; heterogeneous nuclear ribonucleoprotein U
                     (scaffold attachment factor A); nuclear p120
                     ribonucleoprotein; HNRNPU antisense RNA 1"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein U
                     isoform a"
                     /protein_id="NP_114032.2"
                     /db_xref="CCDS:CCDS41479.1"
                     /db_xref="GeneID:3192"
                     /db_xref="HGNC:HGNC:5048"
                     /db_xref="MIM:602869"
                     /translation="MSSSPVNVKKLKVSELKEELKKRRLSDKGLKAELMERLQAALDD
                     EEAGGRPAMEPGNGSLDLGGDSAGRSGAGLEQEAAAGGDEEEEEEEEEEEGISALDGD
                     QMELGEENGAAGAADSGPMEEEEAASEDENGDDQGFQEGEDELGDEEEGAGDENGHGE
                     QQPQPPATQQQQPQQQRGAAKEAAGKSSGPTSLFAVTVAPPGARQGQQQAGGKKKAEG
                     GGGGGRPGAPAAGDGKTEQKGGDKKRGVKRPREDHGRGYFEYIEENKYSRAKSPQPPV
                     EEEDEHFDDTVVCLDTYNCDLHFKISRDRLSASSLTMESFAFLWAGGRASYGVSKGKV
                     CFEMKVTEKIPVRHLYTKDIDIHEVRIGWSLTTSGMLLGEEEFSYGYSLKGIKTCNCE
                     TEDYGEKFDENDVITCFANFESDEVELSYAKNGQDLGVAFKISKEVLAGRPLFPHVLC
                     HNCAVEFNFGQKEKPYFPIPEEYTFIQNVPLEDRVRGPKGPEEKKDCEVVMMIGLPGA
                     GKTTWVTKHAAENPGKYNILGTNTIMDKMMVAGFKKQMADTGKLNTLLQRAPQCLGKF
                     IEIAARKKRNFILDQTNVSAAAQRRKMCLFAGFQRKAVVVCPKDEDYKQRTQKKAEVE
                     GKDLPEHAVLKMKGNFTLPEVAECFDEITYVELQKEEAQKLLEQYKEESKKALPPEKK
                     QNTGSKKSNKNKSGKNQFNRGGGHRGRGGFNMRGGNFRGGAPGNRGGYNRRGNMPQRG
                     GGGGGSGGIGYPYPRAPVFPGRGSYSNRGNYNRGGMPNRGNYNQNFRGRGNNRGYKNQ
                     SQGYNQWQQGQFWGQKPWSQHYHQGYY"
     exon            928..1039
                     /gene="HNRNPU"
                     /gene_synonym="DEE54; EIEE54; GRIP120; hnRNP U;
                     HNRNPU-AS1; HNRPU; pp120; SAF-A; SAFA; U21.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1113
                     /gene="HNRNPU"
                     /gene_synonym="DEE54; EIEE54; GRIP120; hnRNP U;
                     HNRNPU-AS1; HNRPU; pp120; SAF-A; SAFA; U21.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1253
                     /gene="HNRNPU"
                     /gene_synonym="DEE54; EIEE54; GRIP120; hnRNP U;
                     HNRNPU-AS1; HNRPU; pp120; SAF-A; SAFA; U21.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1353
                     /gene="HNRNPU"
                     /gene_synonym="DEE54; EIEE54; GRIP120; hnRNP U;
                     HNRNPU-AS1; HNRPU; pp120; SAF-A; SAFA; U21.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1466
                     /gene="HNRNPU"
                     /gene_synonym="DEE54; EIEE54; GRIP120; hnRNP U;
                     HNRNPU-AS1; HNRPU; pp120; SAF-A; SAFA; U21.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1730
                     /gene="HNRNPU"
                     /gene_synonym="DEE54; EIEE54; GRIP120; hnRNP U;
                     HNRNPU-AS1; HNRPU; pp120; SAF-A; SAFA; U21.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1850
                     /gene="HNRNPU"
                     /gene_synonym="DEE54; EIEE54; GRIP120; hnRNP U;
                     HNRNPU-AS1; HNRPU; pp120; SAF-A; SAFA; U21.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1979
                     /gene="HNRNPU"
                     /gene_synonym="DEE54; EIEE54; GRIP120; hnRNP U;
                     HNRNPU-AS1; HNRPU; pp120; SAF-A; SAFA; U21.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2148
                     /gene="HNRNPU"
                     /gene_synonym="DEE54; EIEE54; GRIP120; hnRNP U;
                     HNRNPU-AS1; HNRPU; pp120; SAF-A; SAFA; U21.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2403
                     /gene="HNRNPU"
                     /gene_synonym="DEE54; EIEE54; GRIP120; hnRNP U;
                     HNRNPU-AS1; HNRPU; pp120; SAF-A; SAFA; U21.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..2588
                     /gene="HNRNPU"
                     /gene_synonym="DEE54; EIEE54; GRIP120; hnRNP U;
                     HNRNPU-AS1; HNRPU; pp120; SAF-A; SAFA; U21.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2589..2660
                     /gene="HNRNPU"
                     /gene_synonym="DEE54; EIEE54; GRIP120; hnRNP U;
                     HNRNPU-AS1; HNRPU; pp120; SAF-A; SAFA; U21.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2661..6867
                     /gene="HNRNPU"
                     /gene_synonym="DEE54; EIEE54; GRIP120; hnRNP U;
                     HNRNPU-AS1; HNRPU; pp120; SAF-A; SAFA; U21.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2722..2727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPU"
                     /gene_synonym="DEE54; EIEE54; GRIP120; hnRNP U;
                     HNRNPU-AS1; HNRPU; pp120; SAF-A; SAFA; U21.1"
                     /note="hexamer: AATAAA"
     polyA_site      2753
                     /gene="HNRNPU"
                     /gene_synonym="DEE54; EIEE54; GRIP120; hnRNP U;
                     HNRNPU-AS1; HNRPU; pp120; SAF-A; SAFA; U21.1"
                     /note="major polyA site"
     regulatory      3013..3018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPU"
                     /gene_synonym="DEE54; EIEE54; GRIP120; hnRNP U;
                     HNRNPU-AS1; HNRPU; pp120; SAF-A; SAFA; U21.1"
                     /note="hexamer: AGTAAA"
     polyA_site      3031
                     /gene="HNRNPU"
                     /gene_synonym="DEE54; EIEE54; GRIP120; hnRNP U;
                     HNRNPU-AS1; HNRPU; pp120; SAF-A; SAFA; U21.1"
                     /note="major polyA site"
     regulatory      3486..3491
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPU"
                     /gene_synonym="DEE54; EIEE54; GRIP120; hnRNP U;
                     HNRNPU-AS1; HNRPU; pp120; SAF-A; SAFA; U21.1"
                     /note="hexamer: ATTAAA"
     polyA_site      3506
                     /gene="HNRNPU"
                     /gene_synonym="DEE54; EIEE54; GRIP120; hnRNP U;
                     HNRNPU-AS1; HNRPU; pp120; SAF-A; SAFA; U21.1"
                     /note="major polyA site"
     regulatory      3757..3762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPU"
                     /gene_synonym="DEE54; EIEE54; GRIP120; hnRNP U;
                     HNRNPU-AS1; HNRPU; pp120; SAF-A; SAFA; U21.1"
                     /note="hexamer: AATAAA"
     polyA_site      3776
                     /gene="HNRNPU"
                     /gene_synonym="DEE54; EIEE54; GRIP120; hnRNP U;
                     HNRNPU-AS1; HNRPU; pp120; SAF-A; SAFA; U21.1"
     regulatory      5914..5919
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPU"
                     /gene_synonym="DEE54; EIEE54; GRIP120; hnRNP U;
                     HNRNPU-AS1; HNRPU; pp120; SAF-A; SAFA; U21.1"
                     /note="hexamer: AATAAA"
     polyA_site      5937
                     /gene="HNRNPU"
                     /gene_synonym="DEE54; EIEE54; GRIP120; hnRNP U;
                     HNRNPU-AS1; HNRPU; pp120; SAF-A; SAFA; U21.1"
     regulatory      5975..5980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPU"
                     /gene_synonym="DEE54; EIEE54; GRIP120; hnRNP U;
                     HNRNPU-AS1; HNRPU; pp120; SAF-A; SAFA; U21.1"
                     /note="hexamer: AATAAA"
     polyA_site      5995
                     /gene="HNRNPU"
                     /gene_synonym="DEE54; EIEE54; GRIP120; hnRNP U;
                     HNRNPU-AS1; HNRPU; pp120; SAF-A; SAFA; U21.1"
     regulatory      6844..6849
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPU"
                     /gene_synonym="DEE54; EIEE54; GRIP120; hnRNP U;
                     HNRNPU-AS1; HNRPU; pp120; SAF-A; SAFA; U21.1"
                     /note="hexamer: ATTAAA"
     polyA_site      6867
                     /gene="HNRNPU"
                     /gene_synonym="DEE54; EIEE54; GRIP120; hnRNP U;
                     HNRNPU-AS1; HNRPU; pp120; SAF-A; SAFA; U21.1"
ORIGIN      
        1 gaggacgttg cgtgctcgct cgcgccaggc gagtctccgc gtctccctcg cgaactcggt
       61 gaaaggaatt ggcgccgttc gacaccaggc ggatccgctc tgcagcacga acccatctcc
      121 agccgcagcc gcagccgccg cccgggccga ggagcagccg cagcagccgc caccagtggc
      181 cgagtgagcg gagccgagtt tgaggcagcg cctagcggtg aatcggggcc ctcaccatga
      241 gttcctcgcc tgttaatgta aaaaagctga aggtgtcgga gctgaaagag gagctcaaga
      301 agcgacgcct ttctgacaag ggtctcaagg ccgagctcat ggagcgactc caggctgcgc
      361 tggacgacga ggaggccggg ggccgccccg ccatggagcc cgggaacggc agcctagacc
      421 tgggcgggga ttccgctggg cgctcgggag caggcctcga gcaggaggcc gcggccggcg
      481 gcgatgaaga ggaggaggaa gaggaagagg aggaggaagg aatctccgct ctggacggcg
      541 accagatgga gctaggagag gagaacgggg ccgcgggggc ggccgactcg ggcccgatgg
      601 aggaggagga ggccgcctcg gaagacgaga acggcgacga tcagggtttc caggaagggg
      661 aagatgagct cggggacgaa gaggaaggcg cgggcgacga gaacgggcac ggggagcagc
      721 agcctcaacc gccggcgacg cagcagcaac agccccaaca gcagcgcggg gccgccaagg
      781 aggccgcggg gaagagcagc ggccccacct cgctgttcgc ggtgacggtg gcgccgcccg
      841 gggcgaggca gggccagcag caggcgggag gtaagaagaa ggcggaaggc ggcggaggcg
      901 gcggtcgccc cggggctccg gcggcggggg acggcaaaac agaacagaaa ggcggagata
      961 aaaagagggg tgttaaaaga ccacgagaag atcatggccg tggatatttt gagtacattg
     1021 aagagaacaa gtatagcaga gccaaatctc ctcagccacc tgttgaagaa gaagatgaac
     1081 acttcgatga cacagtggtt tgtcttgata cttataattg tgatctacat tttaaaatat
     1141 caagagatcg tctcagtgct tcttccctta caatggagag ttttgctttt ctttgggctg
     1201 gaggaagagc atcctatggt gtgtcaaaag gcaaagtgtg ttttgagatg aaggttacag
     1261 agaagatccc agtaaggcat ttatatacaa aagatattga catacatgaa gttcgtattg
     1321 gctggtcact aactacaagt ggaatgttac ttggtgaaga agaattttct tatgggtatt
     1381 ctctaaaagg aataaaaaca tgcaactgtg agactgaaga ttatggagaa aagtttgatg
     1441 aaaatgatgt gattacatgt tttgctaact ttgaaagtga tgaagtagaa ctctcgtatg
     1501 ctaagaatgg acaagatctt ggcgttgcct tcaaaatcag taaggaagtt cttgctggac
     1561 ggccactgtt cccgcatgtt ctctgccaca actgtgcagt tgaatttaat tttggtcaga
     1621 aggaaaagcc atattttcca atacctgaag agtatacttt catccagaac gtccccttag
     1681 aggatcgagt tagaggacca aaggggcctg aagagaagaa agattgtgaa gttgtgatga
     1741 tgattggctt gccaggagct ggaaaaacta cctgggttac taaacatgca gcagaaaatc
     1801 cagggaaata taacattctt ggcacaaata ctattatgga taagatgatg gtggcaggtt
     1861 ttaagaagca aatggcagat actggaaaac tgaacacact gttgcagaga gccccccagt
     1921 gtcttgggaa atttattgag attgctgccc gaaagaagcg aaattttatt ctggatcaga
     1981 caaatgtgtc tgctgctgcc cagaggagaa aaatgtgcct gtttgcaggc ttccagcgaa
     2041 aagctgttgt agtttgccca aaagatgaag actataagca aagaacacag aagaaagcag
     2101 aagtagaggg gaaagaccta ccagaacatg cggtcctcaa aatgaaagga aactttaccc
     2161 tcccagaggt agctgagtgc tttgatgaaa taacctatgt tgaacttcag aaggaagaag
     2221 cccaaaaact cttggagcaa tataaggaag aaagcaaaaa ggctcttcca ccagaaaaga
     2281 aacagaacac tggctcaaag aaaagcaata aaaataagag tggcaagaac cagtttaaca
     2341 gaggtggtgg ccatagagga cgtggaggat tcaatatgcg tggtggaaat ttcagaggag
     2401 gagcccctgg gaatcgtggc ggatataata ggaggggcaa catgccacag agaggtggtg
     2461 gcggtggagg aagtggtgga atcggctatc cataccctcg tgcccctgtt tttcctggcc
     2521 gtggtagtta ctcaaacaga gggaactaca acagaggtgg aatgcccaac agagggaact
     2581 acaaccagaa cttcagagga cgaggaaaca atcgtggcta caaaaatcaa tctcagggct
     2641 acaaccagtg gcagcagggt caattctggg gtcagaagcc atggagtcag cattatcacc
     2701 aaggatatta ttgaataccc aaataaaacg aactgataca tatttctcca aaaccttcac
     2761 aagaagtcga ctgttttctt tagtaggcta actttttaaa cattccacaa gaggaagtgc
     2821 ctgcgggttc cttttttaga agctttgtgg gttgattttt tttcttttct tttttgtaca
     2881 tttttaattg cagtttaaaa gtgaatcgta agagaacctc agcattgtgc acgataagag
     2941 aatgtgtcag tatttcaggg ttctacattt tatctgtaaa atgtgacttt tttttttttt
     3001 tatcacaaca gaagtaaaat gttgctttgt acctggtgtc ttttattaag aatttactcc
     3061 ccccatttct cacagagaat aacagtcggg agtcattgtc acaatataat agaaatgtta
     3121 gcaaccagat tcatgtaagg actaagtggt cctcatgaat tgcattaaga ctctgtactg
     3181 ctcatattac actccatcct ctctgtagtt tgctgggtag tggagggggt aagctaaatc
     3241 atagtttctg acaataactg ggaaggtttt ttcttaaaat aacaatggaa ttggtataat
     3301 tgggattgaa aactaaaact tggaactaag atagagaaga tggagtgtat gtagaagggc
     3361 tgttaaaaat gtaaaacttg gttgcattat ttgtggaggc tcaaacttgt gaaggttaat
     3421 accataattt ttccatttgt tctgcatttt gattctgaaa agaaagctgg ctttgcccat
     3481 ttcttattaa aaaaacttgt tgtaaatcca gttgtctaat gggatctata tgaagttagc
     3541 catgtctgta tgcccttctc ccacaaaata ctgtataact agtgtgcttg tagtagttaa
     3601 ctccaccatc tttgtaagct aatgaaattg tgagtcaccc atttatatct taatttttaa
     3661 tcatgtcagt tcttgaatgg gtatctcctt agcctgctga tttctttttc tttctaaaga
     3721 aagtgggtgg agaaattaat ttagacgttt gtttgcaata aaaagaattc attttactct
     3781 tgttttggga ttctcgccat caaggttcaa aatcccttta tataactccc aagaggagaa
     3841 atttattaag tgtgtgcttt ctggacagct tattctttac tctgcataga acatttaggt
     3901 tttaaaaact taaatgtata ctgacaattg atacataatt atgaagtaaa gttgaattct
     3961 tcccttcccc tcccccccag acaactttta acatatttaa tgaggggaaa aggtactggc
     4021 tgggagaagt taacactgag tttatcatct ttacagaatg ctaatgctgt cctcaactga
     4081 ttattttata tacatatata tgatacatga aactctggga tcagatgctt ttagaagcca
     4141 tcatgcaagc cagtcattga tgtcactgct acacaacact gctaacttga ctgtagctat
     4201 gtaataacat tagatcccct aattgtaatt atattgggtt tgcacagaac actttaatct
     4261 tcccctcacc aatgtgaagt gaggaatcag gagtcaaact gtagaactaa aatttgactt
     4321 cagtctagcg tttccttggt gtttttaggt tgctttggta agtttaggtt tgctatattt
     4381 ctgattgctt agaattttgt tttagccctt taaaatcaga tcataaatat gaattcatac
     4441 ttctaaggaa ttttcttgct ataagctgga gtttaggtga tgtataggtt cagttgagac
     4501 atttttggaa caggcaaatc cttagttaac ataagatatt taacagttga agatagtgtc
     4561 atggattttt atctttttta gcaagtaatg ctaagaacca ctggcctgag ctactactct
     4621 tcagtataca ttattaggat tgcatagact tactagagga acagtttcag gttttgatgc
     4681 taatcagtgt tgtgtcctaa agttgtcctt tgtgccttta aaaagttttg gatatatctt
     4741 ctagtttaaa attgcttatt aaggaattca ttttataatt gcagtgggaa agtaatggtc
     4801 aagtaacact aggtagacta tcatgcctgt ttagcccaga gaatttgggg ggagagagaa
     4861 tagataaaaa tggcacccag aaaaatgtta aaatctttag tcaagactag aattaataca
     4921 attgtctaca cttgtatggc agaaataacc ttataaagtg tttaaggaat tcagagaagg
     4981 gaatgtacca aataagcaac agggagaaaa ttaggtaaga agtaagatac gaacgagaaa
     5041 cctgatttat tgctcatcct tcccttgcct ccctaatggc aagcaaaact ctgaacatct
     5101 gaaaaggatg tagttctgga caaatcctga ctacccagag gaaactcact gtgagattgc
     5161 tgttgatttg aagggtgctt tcactaaggt tatattttaa agtagaataa cacatgctga
     5221 gtgtaaactg gctttggatt ggtcagctgc agtagtacaa aaacagcata gaatttgaga
     5281 aaactaaaac tgctatgaga tagctatgag aaaactaaaa ctgctatgag atagaaatga
     5341 tgtaaaatta tgtggaaagt tttccctcat atactcacat acagcctttg aagggctctg
     5401 gctctgaccg gttgatggcc ttgagcgaga tgaaatcatg aaattgagtc aaatcaattt
     5461 gacattgaaa tgacaagagg aaactcttaa atacataaaa acaagctctc atttgcctag
     5521 gatagatact gtcttaaaaa taaagactga acctagatgt tctgagcact agcaacaagg
     5581 tattttaaca agtttaaagg aattctctga aaaagttata aaattattct aggaaacata
     5641 accataatag tgttttaagg gactttcacc tggggatttt atattcatga acagagtgta
     5701 ttctgtattt aaaatgtctc atttgtggga attggatgac atgttttttg ataaatttat
     5761 tcacaatata aattgacttt ttattctagg accatgtgaa taatgggttc cattgcacaa
     5821 atacaaatat tttaatagct tcttaggcag tggtgtagac atcttggata taaataattg
     5881 tagatcttgt atatttgatt tttaaaaaac tagaataaac agagaggcat aaacatatct
     5941 tagagtccaa gtggtagtgt ttagcattgg atataataaa tggatgtttt acaaagtgtt
     6001 tccataattc tcttcctata cataaatgtc ttgttttcaa aagtggatgg aacttggctg
     6061 ggtgtggtgg ctcacgcctg taatcctagc actttgggag gccaaggcgg gaggatcact
     6121 tgagctcagg agtttgagac catcctgggc aacatagtga gacctggtct cttgaaaaaa
     6181 aaaaagtgga tggaacttgt agcagagaat tttatctact tctcaacctg cttcagaata
     6241 cccatttgag atgttcccct ggaaagatga acacaatact gcatctgaag ccatttcttc
     6301 ccacctaaca ttcttaaaat gattagagtc taaactttgt cattcattcc taattctgga
     6361 gctctgaggt tgaggtgttc agagtttggt gaataattgg gtttaagttt taacatttta
     6421 gtaataataa aagcaaacac atacatgtta aggcctgaca ataggttgca atacccatgc
     6481 attgggactc atacccagca taaatggtga gggactgaac attagtgctt tgagcaagaa
     6541 ttggttaact acctgagatc tctaaaacag taatttgaat tactaataca taaaccacaa
     6601 gtctcttcga attgttaatt gcctaaattt accctaaaac ttagttaacg ctgcagtgcc
     6661 tttattaaag cttttttttg ggggggggtg tgggcacagc tactccataa ctttaaattt
     6721 taaagcatga aggtgatcta gctagtgtta gtgcttgagt tggtagttac ataggctgct
     6781 cttgaatcgt cctgttttct ttgcctagta ttagcaccac aggtacatat ttgtaaaata
     6841 agcattaaaa gtactttgtc cagctaa
//
