LOCUS       NM_005826               7751 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens heterogeneous nuclear ribonucleoprotein R (HNRNPR),
            transcript variant 2, mRNA.
ACCESSION   NM_005826
VERSION     NM_005826.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7751)
  AUTHORS   Hu,T., Zeng,C., Song,Z., Liu,Q., Chen,S., Huang,W., Ma,Q. and Li,H.
  TITLE     HNRNPA2B1 and HNRNPR stabilize ASCL1 in an m6A-dependent manner to
            promote neuroblastoma progression
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (3), 167050 (2024)
   PUBMED   38331110
  REMARK    GeneRIF: HNRNPA2B1 and HNRNPR stabilize ASCL1 in an m6A-dependent
            manner to promote neuroblastoma progression.
REFERENCE   2  (bases 1 to 7751)
  AUTHORS   Yang,Y., Sun,J.D. and Xiang,Z.L.
  TITLE     Pan-cancer analysis of the oncogenic role of HNRNPR in human tumors
  JOURNAL   Cell Biol Int 47 (8), 1406-1426 (2023)
   PUBMED   37077028
  REMARK    GeneRIF: Pan-cancer analysis of the oncogenic role of HNRNPR in
            human tumors.
            Erratum:[Cell Biol Int. 2024 Feb;48(2):229. doi:
            10.1002/cbin.12109.. PMID: 38084795]
REFERENCE   3  (bases 1 to 7751)
  AUTHORS   Ji,C., Deng,C., Antor,K., Bischler,T., Schneider,C., Fischer,U.,
            Sendtner,M. and Briese,M.
  TITLE     hnRNP R negatively regulates transcription by modulating the
            association of P-TEFb with 7SK and BRD4
  JOURNAL   EMBO Rep 23 (9), e55432 (2022)
   PUBMED   35856391
  REMARK    GeneRIF: hnRNP R negatively regulates transcription by modulating
            the association of P-TEFb with 7SK and BRD4.
REFERENCE   4  (bases 1 to 7751)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 7751)
  AUTHORS   Szafranski,K., Schindler,S., Taudien,S., Hiller,M., Huse,K.,
            Jahn,N., Schreiber,S., Backofen,R. and Platzer,M.
  TITLE     Violating the splicing rules: TG dinucleotides function as
            alternative 3' splice sites in U2-dependent introns
  JOURNAL   Genome Biol 8 (8), R154 (2007)
   PUBMED   17672918
  REMARK    GeneRIF: validated occurrence of an unusual TG 3' splice site in
            intron 7
REFERENCE   6  (bases 1 to 7751)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
REFERENCE   7  (bases 1 to 7751)
  AUTHORS   Huang,J., Chen,X.H., Wu,K. and Xu,P.
  TITLE     Cloning and expression of a novel isoform of heterogeneous nuclear
            ribonucleoprotein-R
  JOURNAL   Neuroreport 16 (7), 727-730 (2005)
   PUBMED   15858414
REFERENCE   8  (bases 1 to 7751)
  AUTHORS   Rossoll,W., Kroning,A.K., Ohndorf,U.M., Steegborn,C., Jablonka,S.
            and Sendtner,M.
  TITLE     Specific interaction of Smn, the spinal muscular atrophy
            determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role
            for Smn in RNA processing in motor axons?
  JOURNAL   Hum Mol Genet 11 (1), 93-105 (2002)
   PUBMED   11773003
REFERENCE   9  (bases 1 to 7751)
  AUTHORS   Mourelatos,Z., Abel,L., Yong,J., Kataoka,N. and Dreyfuss,G.
  TITLE     SMN interacts with a novel family of hnRNP and spliceosomal
            proteins
  JOURNAL   EMBO J 20 (19), 5443-5452 (2001)
   PUBMED   11574476
REFERENCE   10 (bases 1 to 7751)
  AUTHORS   Hassfeld,W., Chan,E.K., Mathison,D.A., Portman,D., Dreyfuss,G.,
            Steiner,G. and Tan,E.M.
  TITLE     Molecular definition of heterogeneous nuclear ribonucleoprotein R
            (hnRNP R) using autoimmune antibody: immunological relationship
            with hnRNP P
  JOURNAL   Nucleic Acids Res 26 (2), 439-445 (1998)
   PUBMED   9421497
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA496215.1, AF000364.1,
            AL109936.11 and BX647784.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005826.4.
            
            Summary: This gene encodes an RNA-binding protein that is a member
            of the spliceosome C complex, which functions in pre-mRNA
            processing and transport. The encoded protein also promotes
            transcription at the c-fos gene. Alternative splicing results in
            multiple transcript variants. There are pseudogenes for this gene
            on chromosomes 4, 11, and 10. [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (2, also known as R1) uses an
            alternate in-frame splice site, compared to variant 1. The encoded
            isoform (2) is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.75867.1,
                                           SRR1803614.110364.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302271.11/ ENSP00000304405.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                DA496215.1         81-102
            23-2651             AF000364.1         1-2629
            2652-5654           AL109936.11        69300-72302         c
            5655-7751           BX647784.1         5472-7568
FEATURES             Location/Qualifiers
     source          1..7751
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.12"
     gene            1..7751
                     /gene="HNRNPR"
                     /gene_synonym="hnRNP-R; HNRPR; NEDDFSB"
                     /note="heterogeneous nuclear ribonucleoprotein R"
                     /db_xref="GeneID:10236"
                     /db_xref="HGNC:HGNC:5047"
                     /db_xref="MIM:607201"
     exon            1..74
                     /gene="HNRNPR"
                     /gene_synonym="hnRNP-R; HNRPR; NEDDFSB"
                     /inference="alignment:Splign:2.1.0"
     exon            75..240
                     /gene="HNRNPR"
                     /gene_synonym="hnRNP-R; HNRPR; NEDDFSB"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1985
                     /gene="HNRNPR"
                     /gene_synonym="hnRNP-R; HNRPR; NEDDFSB"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein R
                     isoform 2"
                     /protein_id="NP_005817.1"
                     /db_xref="CCDS:CCDS232.1"
                     /db_xref="GeneID:10236"
                     /db_xref="HGNC:HGNC:5047"
                     /db_xref="MIM:607201"
                     /translation="MANQVNGNAVQLKEEEEPMDTSSVTHTEHYKTLIEAGLPQKVAE
                     RLDEIFQTGLVAYVDLDERAIDALREFNEEGALSVLQQFKESDLSHVQNKSAFLCGVM
                     KTYRQREKQGSKVQESTKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGVQ
                     PGIGTEVFVGKIPRDLYEDELVPLFEKAGPIWDLRLMMDPLSGQNRGYAFITFCGKEA
                     AQEAVKLCDSYEIRPGKHLGVCISVANNRLFVGSIPKNKTKENILEEFSKVTEGLVDV
                     ILYHQPDDKKKNRGFCFLEYEDHKSAAQARRRLMSGKVKVWGNVVTVEWADPVEEPDP
                     EVMAKVKVLFVRNLATTVTEEILEKSFSEFGKLERVKKLKDYAFVHFEDRGAAVKAMD
                     EMNGKEIEGEEIEIVLAKPPDKKRKERQAARQASRSTAYEDYYYHPPPRMPPPIRGRG
                     RGGGRGGYGYPPDYYGYEDYYDDYYGYDYHDYRGGYEDPYYGYDDGYAVRGRGGGRGG
                     RGAPPPPRGRGAPPPRGRAGYSQRGAPLGPPRGSRGGRGGPAQQQRGRGSRGSRGNRG
                     GNVGGKRKADGYNQPDSKRRQTNNQQNWGSQPIAQQPLQQGGDYSGNYGYNNDNQEFY
                     QDTYGQQWK"
     exon            241..359
                     /gene="HNRNPR"
                     /gene_synonym="hnRNP-R; HNRPR; NEDDFSB"
                     /inference="alignment:Splign:2.1.0"
     exon            360..467
                     /gene="HNRNPR"
                     /gene_synonym="hnRNP-R; HNRPR; NEDDFSB"
                     /inference="alignment:Splign:2.1.0"
     exon            468..581
                     /gene="HNRNPR"
                     /gene_synonym="hnRNP-R; HNRPR; NEDDFSB"
                     /inference="alignment:Splign:2.1.0"
     exon            582..758
                     /gene="HNRNPR"
                     /gene_synonym="hnRNP-R; HNRPR; NEDDFSB"
                     /inference="alignment:Splign:2.1.0"
     exon            759..894
                     /gene="HNRNPR"
                     /gene_synonym="hnRNP-R; HNRPR; NEDDFSB"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1100
                     /gene="HNRNPR"
                     /gene_synonym="hnRNP-R; HNRPR; NEDDFSB"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1250
                     /gene="HNRNPR"
                     /gene_synonym="hnRNP-R; HNRPR; NEDDFSB"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1372
                     /gene="HNRNPR"
                     /gene_synonym="hnRNP-R; HNRPR; NEDDFSB"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..7751
                     /gene="HNRNPR"
                     /gene_synonym="hnRNP-R; HNRPR; NEDDFSB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2632..2637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPR"
                     /gene_synonym="hnRNP-R; HNRPR; NEDDFSB"
                     /note="hexamer: ACTAAA"
     polyA_site      2653
                     /gene="HNRNPR"
                     /gene_synonym="hnRNP-R; HNRPR; NEDDFSB"
                     /note="major polyA site"
     regulatory      7729..7734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPR"
                     /gene_synonym="hnRNP-R; HNRPR; NEDDFSB"
                     /note="hexamer: AATAAA"
     polyA_site      7751
                     /gene="HNRNPR"
                     /gene_synonym="hnRNP-R; HNRPR; NEDDFSB"
ORIGIN      
        1 gccatttcta gtcgttttca aagcgcctcg cgctgattct cacgggcccg gctgccggcc
       61 cccgctctgc cctgcataat aaaatggcta atcaggtgaa tggtaatgcg gtacagttaa
      121 aagaagagga agaaccaatg gatacttcca gtgtaactca cacagaacac tacaagacac
      181 tgatagaggc aggcctccca cagaaggtgg cagaaagact tgatgaaata tttcagacag
      241 gattggtagc ttatgtcgat cttgatgaaa gagcaattga tgctctcagg gaatttaatg
      301 aagaaggagc tctgtctgta ctacagcagt tcaaggaaag tgacttatca catgttcaga
      361 acaaaagtgc atttttatgt ggagttatga agacctacag gcagagagag aaacagggga
      421 gcaaggtgca agagtccaca aagggacctg atgaagcgaa gatcaaggcc ttgcttgaga
      481 gaactggtta tactctggat gtaaccacag gacagaggaa gtatggtggt cctccaccag
      541 acagtgtgta ctctggcgtg caacctggaa ttggaacgga ggtatttgta ggcaaaatac
      601 caagggattt atatgaggat gagttggtgc ccctttttga gaaggccgga cccatttggg
      661 atctacgtct tatgatggat ccactgtccg gtcagaatag agggtatgca tttatcacct
      721 tctgtggaaa ggaagctgca caggaagccg tgaaactgtg tgacagctat gaaattcgcc
      781 ctggtaaaca ccttggagtg tgcatttctg tggcaaacaa cagacttttt gttggatcca
      841 ttccgaagaa taagactaaa gaaaacattt tggaagaatt cagtaaagtc acagagggtt
      901 tggtggacgt tattctctat catcaacccg atgacaaaaa gaagaatcgg gggttctgct
      961 tccttgaata tgaggatcac aagtcagcag cacaagccag acgccggctg atgagtggaa
     1021 aagtaaaagt gtggggaaat gtagttacag ttgaatgggc tgaccctgtg gaagaaccag
     1081 atccagaagt catggctaag gtaaaagttt tgtttgtgag aaacttggct actacggtga
     1141 cagaagaaat attggaaaag tcattttctg aatttggaaa actcgaaaga gtaaagaagt
     1201 tgaaagatta tgcatttgtt cattttgaag acagaggagc agctgttaag gctatggatg
     1261 aaatgaatgg caaagaaata gaaggggaag aaattgaaat agtcttagcc aagccaccag
     1321 acaagaaaag gaaagagcgc caagctgcta gacaggcctc cagaagcact gcgtatgaag
     1381 attattacta ccaccctcct cctcgcatgc cacctccaat tagaggtcgg ggtcgtggtg
     1441 gggggagagg tggatatggc taccctccag attactacgg ctatgaagat tactatgatg
     1501 attactatgg ttatgattat cacgactatc gtggaggcta tgaagatccc tactacggct
     1561 atgatgatgg ctatgcagta agaggaagag gaggaggaag gggagggcga ggtgctccac
     1621 caccaccaag ggggagggga gcaccacctc caagaggtag agctggctat tcacagaggg
     1681 gggcaccttt gggaccacca agaggctcta ggggtggcag agggggtcct gctcaacagc
     1741 agagaggccg tggttcccgt ggatctcggg gcaatcgtgg gggcaatgta ggaggcaaga
     1801 gaaaggcaga tgggtacaac cagcctgatt ccaagcgtcg tcagaccaac aaccaacaga
     1861 actggggttc ccaacccatc gctcagcagc cgcttcagca aggtggtgac tattctggta
     1921 actatggtta caataatgac aaccaggaat tttatcagga tacttatggg caacagtgga
     1981 agtagacaag taagggcttg aaaatgatac tggcaagata cgattggctc tagatctaca
     2041 ttcttcaaaa aaaaaaattg gcttaactgt ttcatcttta agtagcattt tgctgccatt
     2101 tgtattgggc tgaagaaatc actattgtgt atatactcaa gtctttttat ttttcctctt
     2161 ttcataaatg ctcttggaca ttattgggct tgcagagttc ccttattctg gggattacaa
     2221 tgcttttatc gtttcaggct tcattttagc ttcaaaacaa gctgggcaca ctgttaaatc
     2281 atgattttgc agaacctttg gttttggaca gtttcatttt tttggatttg ggatagatta
     2341 cataggagta tggagtatgc tgtaaataaa aatacaagct agtgctttgt cttagtagtt
     2401 ttaagaaatt aaagcaaaca aatttaagtt ttcttgtatt gaaaataacc tatgattgta
     2461 tgttttgcat tcctagaagt aggttaactg tgtttttaaa ttgttataac ttcacacctt
     2521 tttgaaatct gccctacaaa atttgtttgg cttaaacgtc aaaagccgtg acaatttgtt
     2581 ctttgatgtg attgtatttc caatttcttg ttcatgtaag atttcaataa aactaaaaaa
     2641 tctattcaaa acattaccta tttcaaattc aattgtgtcc taaaacatta ttttattcgt
     2701 aatccttgca aggaatattg ttttcaaagt ataactgcct atgtgagtga tcaaattcat
     2761 gcaaaatttc ttgtttattc caacatgtgt tgtggatatt agactgagga ttagtctaaa
     2821 ttcaagtatt tattccaatt agcactttca ttgattggtg ttctctcata gtctcttcta
     2881 attttgaaat tttatctttt attaaaaaaa aaaaaacagg ttcatagact tttgagcatt
     2941 cttgcaggca ttggataatt tgcattaaaa caaataaaat gtggctggga aagcagactg
     3001 caatttattt tgacccacat tctttataag ggataatttg tgactgaaga ccttatttgc
     3061 tggataagtg aatgtacata cagggaaaat tgttagtact gtggcgtcaa ttgcactgcg
     3121 gactttagtt ttagtgaaaa tgatcgtgac taccatttca gttactggtt taggaatata
     3181 atttcctatt actatgtaaa tttgctttga gaaacattca tgccttgtaa gagaggctta
     3241 aaaatatcca gtagtaatac ctttgacttt ctgttaacac ttcgtttatt tttatttatc
     3301 tgctatccct gatgcccaaa ttttttgttg gccaagacat aacatctatt tccctatttc
     3361 ctttagaaat tctgatttat tctaatgact tttttgcttg agaatgagag gaacaaaaga
     3421 atctaagctt tacggtacag aaaagtgaat cactttcaaa ttactattaa gttttcccct
     3481 ccatcttatt cttacgtggt tctcaaatgt ttttataatg ataaaaatat cagaagccat
     3541 tggggaataa ttaaaatgga tacaccatta ttctgtgttt tgttcctgtt tggtgtcttt
     3601 gtgataggaa tattagattt caaaatcata agccacttaa ttccgtgtaa tcttggctag
     3661 atcatattgg gtttcatggc ttcttttcat ttcaatttaa gattactatt tactgatgaa
     3721 agtcaatata tttcatttct ttttcaaagt acactcatta cacagtatag tcatttaaca
     3781 gaccttattg atattttagt tttttggaaa ctgataaagg aattatggtc tgttgtatga
     3841 tagttttgag ttaacatggg tatttctttg gtaagacaga tccagttgtt tttcttatgc
     3901 ccatgtatgc aagtaaagac accaaacatt ctttaaatgc tgcttttaaa ctttgaaagt
     3961 acaatttgaa gttgtaacta tacatctaat tagacttaag taaaaccctg atttttttcc
     4021 tggaaagaac aaaatctaca aataaaattt gagttgtttg tatttcttaa ttaggtgtta
     4081 caagctacaa agttgtcata aagaatgcta agaatgggga tagaaatgat tctgagaaaa
     4141 caaaccctcg caaaaacata agattaaaac ttgggttcca tgtcaaaatc ctttccttta
     4201 attgcaaatt atattttgaa ttttaaagtg gccacctcct cctctgtcct tttcactaat
     4261 taaaaatata tttgcagagg taccctctaa tatttggttt ataggttttg tggctatttt
     4321 aaattgtaaa gcataatcct ataaacatta aaactcaaga gcttttcttc tttcatgtct
     4381 tgtaaattaa cactgtagca gcattcagag aaaatagatt cagagctcaa cttttcacat
     4441 aaataaatct aacagtgtaa tatataaacc tgaaaaatgt cagttgaggg aggtctttat
     4501 tctagattgg catttttttt tttttaaatt aggtacaaat tatgagtgta aggaatttgg
     4561 tttcctgctc tcctgtcttt ccatcttttt tgttccccaa gctaattgat ttggctttat
     4621 ttatgagcct gttacagtaa agtgtgtgtt gggaaatata ttgaggtata gagctattct
     4681 ttgtaggtac cctggtgaga ccgatacaaa tatgcccctc cccataatgg aatactaatt
     4741 tttatttgat cactcattta tagcagttgc ttaaatgtat gtatttatat gaaggtattt
     4801 taatttttaa gagcaaaaaa gttctaataa gttgccagat ttctaataaa tgcaggttta
     4861 tttggtgaaa agataaggaa aatgagttat gattctgtag tttttttaaa atgagttcag
     4921 cataattgtt tttcaggttt ttttagttac tggggttatt ctgcataaga aagcccaatg
     4981 ctttctgata gtaggagata atttttctct cttttgactt tgaaatctga cttaggagat
     5041 gaattctttt taaaaaggtc agcatgcaaa aaaataaatt atatatttta aattctaaaa
     5101 gagaagggac ataaaatttc actcctagca taaagccata taatattatt cttgaaactc
     5161 attacatcat ttgcctcctg cccatttgaa tataatcata cctacgtttt attaattgtg
     5221 catttgtaaa accaaaccct tccagtaaat acttgctata aggctattgc ttgtcaatta
     5281 tcaaggcttc taaatatgtt aaaacttgtc attttgattt ttcaaagata attttattat
     5341 actgagctac caatattctt aaagaaaact aaccaaagtt aatattagtg tagtccatta
     5401 ttatgtggac aattattatg tggaatctct taagtgagca actaagaaaa agccttatag
     5461 aaagactaca ctggatttat aagtgtgttt atgtttctct aagaatggga gcttctgtta
     5521 acttaggggt ggagttgttc tgaggaaacc agtagattgg atgactgact ggagaatcca
     5581 gaataacaaa tccattagcc agacatgttt acttttatat tagaagtttg ttgattaggt
     5641 cttaattttc aaacgcaaac accaagcttt aaaaatattg catatacaat gtattggtca
     5701 gcaatttaat aatatttaat ttgaagttaa ttattgttaa tccttctaga aaagtttttt
     5761 ttctttaaat aaaagtacat atatatactt ttttatttag aggttaccag aagctctggt
     5821 tttgttttgt tttgttttgt ttttttgttt ttttaatcat tttcagatgt tatccagaaa
     5881 tctgcaagtg tacttttcct gttttaactc cttcctttta tcacctgact atcagggaag
     5941 cgaggttgag gctgccctga cctgacatgt catgatgtcg acttgctagg tggggttcgc
     6001 tggggacgat aaccagtgga attgttggta agaacttttt tttcctattt ttttttttat
     6061 cagtagtggg gcattaagtg tgggagaatg cccatatcct ataagtgggc aattatgtca
     6121 gccttgtaga aaaataggac tttaatatta aattattttg ttcttaatag gaacatataa
     6181 taacacttca cttactttta aattggtagc agatcagcag gaaaggcctg caagtatgaa
     6241 gtaatgaaat actcagggta tattttaagt gagcaaaata gacaccttat aatcttaaaa
     6301 agtctcttgg agagacaata aatttgcttt aactgtcatt tcagtctagt attatatttt
     6361 ctatattttg ttggatagat taacatataa tgcatcttaa agagatattt attgcacact
     6421 aattttagtg aaaacaagaa gacattgata gaatggaggg cttaaacacc aaagatacta
     6481 tttttaaaaa tcttccaaag taatcttaac actgtaaaat gaaactttaa aaagttttag
     6541 cagtttgaca ataatggcct caatttagag atatgttgag acaatgactt tgggtcaaga
     6601 ggaaattaca tagctgaaat attaagacct tgaacatagc agaaacataa acctatgaac
     6661 aacttgtgtt ttgtgtgaaa gctagggtag ctgataggat tagcagatat tggtagaatt
     6721 aagagtcaat atttaaatta ttgctaaaga ttaaaatccc tcatcttata gtttgtaggg
     6781 gattccatga tggtaaggta tagattgaaa ttaaatttag taactaggca tttctgacca
     6841 taccatataa aaaataattg taatatggta taaacactga ttaaaagtaa ttatggattt
     6901 tcatgcctga agaaccttct cagtattctt acagcactgt atcttcttta ttggttgaga
     6961 atatcagtct agaaagactt tcctagatgt taaatgtgct agtcagtgtc atgaatataa
     7021 acccttactt gtaagtttgc tatagactag ttgtacaaca ctagaatgaa attatgtaat
     7081 acttttaaga attgtagtga ttgcagggtt gtgttaaggt aacattttat gcatgtgtca
     7141 gtgacagaaa ggatcagggt ataaaactta gcactaaata gcatgctcct taggaagttt
     7201 taaggtaagc agtaggaata ttcatgtaat tctgatgagt ttatgtaagt taaggaaaat
     7261 gcaatgccag tttgttgact ttaaacacta aaaacaaaat acattttgtg gaaccaacaa
     7321 aggagacatt ctggggaaaa acttaaattg ctcaaattta aataagggct ctcactttat
     7381 atagtagatt tgtcaggatc ccatgaacat tgcttttctt gatttctcac atatgagggt
     7441 tgggcaaaag ggacttctct agcctcttcg ataatgtagg tagacttgta cttagtgaat
     7501 cccattataa tgttaggtac tatgttctaa gactatttct ataattggac tgaaggctcc
     7561 tgcaaacata aattgctgat atggatatag taacataaga aataccaaaa tagggacatt
     7621 tgcaagacct tttccattta atcatcagtt taataaaaat catgcttttg gtacagtgtt
     7681 catgtaccat aactgtattg gaatatttgt acgatgttaa atatttttaa taaaatttaa
     7741 catgttcaaa a
//
