LOCUS       NM_005968               2477 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens heterogeneous nuclear ribonucleoprotein M (HNRNPM),
            transcript variant 1, mRNA.
ACCESSION   NM_005968
VERSION     NM_005968.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2477)
  AUTHORS   Lee,Y.F., Phua,C.Z.J., Yuan,J., Zhang,B., Lee,M.Y., Kannan,S.,
            Chiu,Y.H.J., Koh,C.W.Q., Yap,C.K., Lim,E.K.H., Chen,J., Lim,Y.,
            Lee,J.J.H., Skanderup,A.J., Wang,Z., Zhai,W., Tan,N.S., Verma,C.S.,
            Tay,Y., Tan,D.S.W. and Tam,W.L.
  TITLE     PARP4 interacts with hnRNPM to regulate splicing during lung cancer
            progression
  JOURNAL   Genome Med 16 (1), 91 (2024)
   PUBMED   39034402
  REMARK    GeneRIF: PARP4 interacts with hnRNPM to regulate splicing during
            lung cancer progression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2477)
  AUTHORS   Zheng,R., Dunlap,M., Bobkov,G.O.M., Gonzalez-Figueroa,C.,
            Patel,K.J., Lyu,J., Harvey,S.E., Chan,T.W., Quinones-Valdez,G.,
            Choudhury,M., Le Roux,C.A., Bartels,M.D., Vuong,A., Flynn,R.A.,
            Chang,H.Y., Van Nostrand,E.L., Xiao,X. and Cheng,C.
  TITLE     hnRNPM protects against the dsRNA-mediated interferon response by
            repressing LINE-associated cryptic splicing
  JOURNAL   Mol Cell 84 (11), 2087-2103 (2024)
   PUBMED   38815579
  REMARK    GeneRIF: hnRNPM protects against the dsRNA-mediated interferon
            response by repressing LINE-associated cryptic splicing.
REFERENCE   3  (bases 1 to 2477)
  AUTHORS   Wang,J., Luo,X. and Liu,D.
  TITLE     Knockdown of HNRNPM inhibits the progression of glioma through
            inducing ferroptosis
  JOURNAL   Cell Cycle 22 (20), 2264-2279 (2023)
   PUBMED   38016815
  REMARK    GeneRIF: Knockdown of HNRNPM inhibits the progression of glioma
            through inducing ferroptosis.
REFERENCE   4  (bases 1 to 2477)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 2477)
  AUTHORS   Zhu,G.Q., Wang,Y., Wang,B., Liu,W.R., Dong,S.S., Chen,E.B.,
            Cai,J.L., Wan,J.L., Du,J.X., Song,L.N., Chen,S.P., Yu,L.,
            Zhou,Z.J., Wang,Z., Zhou,J., Shi,Y.H., Fan,J. and Dai,Z.
  TITLE     Targeting HNRNPM Inhibits Cancer Stemness and Enhances Antitumor
            Immunity in Wnt-activated Hepatocellular Carcinoma
  JOURNAL   Cell Mol Gastroenterol Hepatol 13 (5), 1413-1447 (2022)
   PUBMED   35158098
  REMARK    GeneRIF: Targeting HNRNPM Inhibits Cancer Stemness and Enhances
            Antitumor Immunity in Wnt-activated Hepatocellular Carcinoma.
REFERENCE   6  (bases 1 to 2477)
  AUTHORS   Neubauer,G., King,A., Rappsilber,J., Calvio,C., Watson,M., Ajuh,P.,
            Sleeman,J., Lamond,A. and Mann,M.
  TITLE     Mass spectrometry and EST-database searching allows
            characterization of the multi-protein spliceosome complex
  JOURNAL   Nat Genet 20 (1), 46-50 (1998)
   PUBMED   9731529
REFERENCE   7  (bases 1 to 2477)
  AUTHORS   Gattoni,R., Mahe,D., Mahl,P., Fischer,N., Mattei,M.G., Stevenin,J.
            and Fuchs,J.P.
  TITLE     The human hnRNP-M proteins: structure and relation with early heat
            shock-induced splicing arrest and chromosome mapping
  JOURNAL   Nucleic Acids Res 24 (13), 2535-2542 (1996)
   PUBMED   8692693
REFERENCE   8  (bases 1 to 2477)
  AUTHORS   Blanck,O., Perrin,C., Mziaut,H., Darbon,H., Mattei,M.G. and
            Miquelis,R.
  TITLE     Molecular cloning, cDNA analysis, and localization of a monomer of
            the N-acetylglucosamine-specific receptor of the thyroid, NAGR1, to
            chromosome 19p13.3-13.2
  JOURNAL   Genomics 27 (3), 561 (1995)
   PUBMED   7558047
  REMARK    Correction to:[Genomics. 1994 May 1;21(1):18-26. doi:
            10.1006/geno.1994.1219.. PMID: 8088785]
REFERENCE   9  (bases 1 to 2477)
  AUTHORS   Blanck,O., Perrin,C., Mziaut,H., Darbon,H., Mattei,M.G. and
            Miquelis,R.
  TITLE     Molecular cloning, cDNA analysis, and localization of a monomer of
            the N-acetylglucosamine-specific receptor of the thyroid, NAGR1, to
            chromosome 19p13.3-13.2
  JOURNAL   Genomics 21 (1), 18-26 (1994)
   PUBMED   8088785
  REMARK    Erratum:[Genomics. 1995 Jun 10;27(3):561. doi:
            10.1006/geno.1995.1097.. PMID: 7558047]
REFERENCE   10 (bases 1 to 2477)
  AUTHORS   Datar,K.V., Dreyfuss,G. and Swanson,M.S.
  TITLE     The human hnRNP M proteins: identification of a
            methionine/arginine-rich repeat motif in ribonucleoproteins
  JOURNAL   Nucleic Acids Res 21 (3), 439-446 (1993)
   PUBMED   8441656
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC000138.2 and CN350526.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005968.4.
            
            Summary: This gene belongs to the subfamily of ubiquitously
            expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The
            hnRNPs are RNA binding proteins and they complex with heterogeneous
            nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs
            in the nucleus and appear to influence pre-mRNA processing and
            other aspects of mRNA metabolism and transport. While all of the
            hnRNPs are present in the nucleus, some seem to shuttle between the
            nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic
            acid binding properties. The protein encoded by this gene has three
            repeats of quasi-RRM domains that bind to RNAs. This protein also
            constitutes a monomer of the N-acetylglucosamine-specific receptor
            which is postulated to trigger selective recycling of immature
            GlcNAc-bearing thyroglobulin molecules. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Aug
            2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000138.2, SRR3476690.1032740.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325495.9/ ENSP00000325376.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1805              BC000138.2         18-1822
            1806-2118           CN350526.1         82-394
            2119-2477           BC000138.2         2136-2494
FEATURES             Location/Qualifiers
     source          1..2477
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..2477
                     /gene="HNRNPM"
                     /gene_synonym="CEAR; hnRNP M; HNRNPM4; HNRPM; HNRPM4;
                     HTGR1; NAGR1"
                     /note="heterogeneous nuclear ribonucleoprotein M"
                     /db_xref="GeneID:4670"
                     /db_xref="HGNC:HGNC:5046"
                     /db_xref="MIM:160994"
     exon            1..137
                     /gene="HNRNPM"
                     /gene_synonym="CEAR; hnRNP M; HNRNPM4; HNRPM; HNRPM4;
                     HTGR1; NAGR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..2217
                     /gene="HNRNPM"
                     /gene_synonym="CEAR; hnRNP M; HNRNPM4; HNRPM; HNRPM4;
                     HTGR1; NAGR1"
                     /note="isoform a is encoded by transcript variant 1;
                     N-acetylglucosamine receptor 1; CEA receptor; heterogenous
                     nuclear ribonucleoprotein M4; hnRNA-binding protein M4"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein M
                     isoform a"
                     /protein_id="NP_005959.2"
                     /db_xref="CCDS:CCDS12203.1"
                     /db_xref="GeneID:4670"
                     /db_xref="HGNC:HGNC:5046"
                     /db_xref="MIM:160994"
                     /translation="MAAGVEAAAEVAATEIKMEEESGAPGVPSGNGAPGPKGEGERPA
                     QNEKRKEKNIKRGGNRFEPYANPTKRYRAFITNIPFDVKWQSLKDLVKEKVGEVTYVE
                     LLMDAEGKSRGCAVVEFKMEESMKKAAEVLNKHSLSGRPLKVKEDPDGEHARRAMQKV
                     MATTGGMGMGPGGPGMITIPPSILNNPNIPNEIIHALQAGRLGSTVFVANLDYKVGWK
                     KLKEVFSMAGVVVRADILEDKDGKSRGIGTVTFEQSIEAVQAISMFNGQLLFDRPMHV
                     KMDERALPKGDFFPPERPQQLPHGLGGIGMGLGPGGQPIDANHLNKGIGMGNIGPAGM
                     GMEGIGFGINKMGGMEGPFGGGMENMGRFGSGMNMGRINEILSNALKRGEIIAKQGGG
                     GGGGSVPGIERMGPGIDRLGGAGMERMGAGLGHGMDRVGSEIERMGLVMDRMGSVERM
                     GSGIERMGPLGLDHMASSIERMGQTMERIGSGVERMGAGMGFGLERMAAPIDRVGQTI
                     ERMGSGVERMGPAIERMGLSMERMVPAGMGAGLERMGPVMDRMATGLERMGANNLERM
                     GLERMGANSLERMGLERMGANSLERMGPAMGPALGAGIERMGLAMGGGGGASFDRAIE
                     MERGNFGGSFAGSFGGAGGHAPGVARKACQIFVRNLPFDFTWKMLKDKFNECGHVLYA
                     DIKMENGKSKGCGVVKFESPEVAERACRMMNGMKLSGREIDVRIDRNA"
     exon            138..307
                     /gene="HNRNPM"
                     /gene_synonym="CEAR; hnRNP M; HNRNPM4; HNRPM; HNRPM4;
                     HTGR1; NAGR1"
                     /inference="alignment:Splign:2.1.0"
     exon            308..360
                     /gene="HNRNPM"
                     /gene_synonym="CEAR; hnRNP M; HNRNPM4; HNRPM; HNRPM4;
                     HTGR1; NAGR1"
                     /inference="alignment:Splign:2.1.0"
     exon            361..368
                     /gene="HNRNPM"
                     /gene_synonym="CEAR; hnRNP M; HNRNPM4; HNRPM; HNRPM4;
                     HTGR1; NAGR1"
                     /inference="alignment:Splign:2.1.0"
     exon            369..462
                     /gene="HNRNPM"
                     /gene_synonym="CEAR; hnRNP M; HNRNPM4; HNRPM; HNRPM4;
                     HTGR1; NAGR1"
                     /inference="alignment:Splign:2.1.0"
     exon            463..654
                     /gene="HNRNPM"
                     /gene_synonym="CEAR; hnRNP M; HNRNPM4; HNRPM; HNRPM4;
                     HTGR1; NAGR1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..808
                     /gene="HNRNPM"
                     /gene_synonym="CEAR; hnRNP M; HNRNPM4; HNRPM; HNRPM4;
                     HTGR1; NAGR1"
                     /inference="alignment:Splign:2.1.0"
     exon            809..858
                     /gene="HNRNPM"
                     /gene_synonym="CEAR; hnRNP M; HNRNPM4; HNRPM; HNRPM4;
                     HTGR1; NAGR1"
                     /inference="alignment:Splign:2.1.0"
     exon            859..919
                     /gene="HNRNPM"
                     /gene_synonym="CEAR; hnRNP M; HNRNPM4; HNRPM; HNRPM4;
                     HTGR1; NAGR1"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1021
                     /gene="HNRNPM"
                     /gene_synonym="CEAR; hnRNP M; HNRNPM4; HNRPM; HNRPM4;
                     HTGR1; NAGR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1066
                     /gene="HNRNPM"
                     /gene_synonym="CEAR; hnRNP M; HNRNPM4; HNRPM; HNRPM4;
                     HTGR1; NAGR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1144
                     /gene="HNRNPM"
                     /gene_synonym="CEAR; hnRNP M; HNRNPM4; HNRPM; HNRPM4;
                     HTGR1; NAGR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1198
                     /gene="HNRNPM"
                     /gene_synonym="CEAR; hnRNP M; HNRNPM4; HNRPM; HNRPM4;
                     HTGR1; NAGR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..2001
                     /gene="HNRNPM"
                     /gene_synonym="CEAR; hnRNP M; HNRNPM4; HNRPM; HNRPM4;
                     HTGR1; NAGR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2053
                     /gene="HNRNPM"
                     /gene_synonym="CEAR; hnRNP M; HNRNPM4; HNRPM; HNRPM4;
                     HTGR1; NAGR1"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2477
                     /gene="HNRNPM"
                     /gene_synonym="CEAR; hnRNP M; HNRNPM4; HNRPM; HNRPM4;
                     HTGR1; NAGR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2456..2461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPM"
                     /gene_synonym="CEAR; hnRNP M; HNRNPM4; HNRPM; HNRPM4;
                     HTGR1; NAGR1"
                     /note="hexamer: AATAAA"
     polyA_site      2477
                     /gene="HNRNPM"
                     /gene_synonym="CEAR; hnRNP M; HNRNPM4; HNRPM; HNRPM4;
                     HTGR1; NAGR1"
                     /note="major polyA site"
ORIGIN      
        1 acacaaagcc cagacgcgga gaaaatggcg gcaggggtcg aagcggcggc ggaggtggcg
       61 gcgacggaga tcaaaatgga ggaagagagc ggcgcgcccg gcgtgccgag cggcaacggg
      121 gctccgggcc ctaagggtga aggagaacga cctgctcaga atgagaagag gaaggagaaa
      181 aacataaaaa gaggaggcaa tcgctttgag ccatatgcca atccaactaa aagatacaga
      241 gccttcatta caaacatacc ttttgatgtg aaatggcagt cacttaaaga cctggttaaa
      301 gaaaaagttg gtgaggtaac atacgtggag ctcttaatgg acgctgaagg aaagtcaagg
      361 ggatgtgctg ttgttgaatt caagatggaa gagagcatga aaaaagctgc ggaagtccta
      421 aacaagcata gtctgagcgg aagaccactg aaagtcaaag aagatcctga tggtgaacat
      481 gccaggagag caatgcaaaa ggtgatggct acgactggtg ggatgggtat gggaccaggt
      541 ggcccaggaa tgattactat cccacccagt atcctaaata atcccaacat cccaaatgag
      601 attatccatg cattacaggc tggaagactt ggaagcacag tatttgtagc aaatctggat
      661 tataaagttg gctggaagaa actgaaggaa gtatttagta tggctggtgt ggtggtccga
      721 gcagacattc ttgaagataa agatggaaaa agtcgtggaa taggcactgt tacttttgaa
      781 cagtccattg aagctgtgca agctatatct atgttcaatg gccagctgct atttgataga
      841 ccaatgcacg tcaagatgga tgagagggcc ttaccaaaag gagatttctt ccctcctgag
      901 cgtccacaac aacttcccca tggccttggt ggtattggca tggggttagg accaggaggg
      961 caacccattg atgccaatca cctgaataaa ggcatcggaa tgggaaacat aggtcccgca
     1021 ggaatgggaa tggaaggcat aggatttgga ataaataaaa tgggaggaat ggaggggccc
     1081 tttggtggtg gtatggaaaa catgggtcga tttggatctg ggatgaacat gggcaggata
     1141 aatgaaatcc taagtaatgc actgaagaga ggagagatca ttgcaaagca gggaggaggt
     1201 ggaggtggag gaagcgtccc tgggatcgag aggatgggtc ctggcattga ccgcctcggg
     1261 ggtgccggca tggagcgcat gggcgcgggc ctgggccacg gcatggatcg cgtgggctcc
     1321 gagatcgagc gcatgggcct ggtcatggac cgcatgggct ccgtggagcg catgggctcc
     1381 ggcattgagc gcatgggccc gctgggcctc gaccacatgg cctccagcat tgagcgcatg
     1441 ggccagacca tggagcgcat tggctctggc gtggagcgca tgggtgccgg catgggcttc
     1501 ggccttgagc gcatggccgc tcccatcgac cgtgtgggcc agaccattga gcgcatgggc
     1561 tctggcgtgg agcgcatggg ccctgccatc gagcgcatgg gcctgagcat ggagcgcatg
     1621 gtgcccgcag gtatgggagc tggcctggag cgcatgggcc ccgtgatgga tcgcatggcc
     1681 accggcctgg agcgcatggg cgccaacaat ctggagcgga tgggcctgga gcgcatgggc
     1741 gccaacagcc tcgagcgcat gggcctggag cgcatgggtg ccaacagcct cgagcgcatg
     1801 ggccctgcca tgggcccggc cctgggcgct ggcattgagc gcatgggcct ggccatgggt
     1861 ggcggtggcg gtgccagctt tgaccgtgcc atcgagatgg agcgtggcaa cttcggagga
     1921 agcttcgcag gttcctttgg tggagctgga ggccatgctc ctggggtggc caggaaggcc
     1981 tgccagatat ttgtgagaaa tctgccattc gatttcacat ggaagatgct aaaggacaaa
     2041 ttcaacgagt gcggccacgt gctgtacgcc gacatcaaga tggagaatgg gaagtccaag
     2101 gggtgtggcg tggttaagtt cgagtcgcca gaggtggccg agagagcctg ccggatgatg
     2161 aatggcatga agctgagtgg ccgagagatt gacgttcgaa ttgatagaaa cgcttaagca
     2221 gttgcctttt ttaaacatcg atacgagacc tctgaatttg tattttttct tgttaaccat
     2281 tttaatttgt tggctggatg tataaagatg tttaaaaaat tcagttgctt tttggggtaa
     2341 tttgaattac ttttttaatg actggggttc catttgactg tttgcattga gattgcaatg
     2401 tgcgcaattt tttttgtagt tgtggcatct tgttgacatc gaatatgact ttgataataa
     2461 ataccggttc ctgaaaa
//
