LOCUS       NP_005959                730 aa            linear   PRI 27-APR-2025
DEFINITION  heterogeneous nuclear ribonucleoprotein M isoform a [Homo sapiens].
ACCESSION   NP_005959
VERSION     NP_005959.2
DBSOURCE    REFSEQ: accession NM_005968.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 730)
  AUTHORS   Lee,Y.F., Phua,C.Z.J., Yuan,J., Zhang,B., Lee,M.Y., Kannan,S.,
            Chiu,Y.H.J., Koh,C.W.Q., Yap,C.K., Lim,E.K.H., Chen,J., Lim,Y.,
            Lee,J.J.H., Skanderup,A.J., Wang,Z., Zhai,W., Tan,N.S., Verma,C.S.,
            Tay,Y., Tan,D.S.W. and Tam,W.L.
  TITLE     PARP4 interacts with hnRNPM to regulate splicing during lung cancer
            progression
  JOURNAL   Genome Med 16 (1), 91 (2024)
   PUBMED   39034402
  REMARK    GeneRIF: PARP4 interacts with hnRNPM to regulate splicing during
            lung cancer progression.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 730)
  AUTHORS   Zheng,R., Dunlap,M., Bobkov,G.O.M., Gonzalez-Figueroa,C.,
            Patel,K.J., Lyu,J., Harvey,S.E., Chan,T.W., Quinones-Valdez,G.,
            Choudhury,M., Le Roux,C.A., Bartels,M.D., Vuong,A., Flynn,R.A.,
            Chang,H.Y., Van Nostrand,E.L., Xiao,X. and Cheng,C.
  TITLE     hnRNPM protects against the dsRNA-mediated interferon response by
            repressing LINE-associated cryptic splicing
  JOURNAL   Mol Cell 84 (11), 2087-2103 (2024)
   PUBMED   38815579
  REMARK    GeneRIF: hnRNPM protects against the dsRNA-mediated interferon
            response by repressing LINE-associated cryptic splicing.
REFERENCE   3  (residues 1 to 730)
  AUTHORS   Wang,J., Luo,X. and Liu,D.
  TITLE     Knockdown of HNRNPM inhibits the progression of glioma through
            inducing ferroptosis
  JOURNAL   Cell Cycle 22 (20), 2264-2279 (2023)
   PUBMED   38016815
  REMARK    GeneRIF: Knockdown of HNRNPM inhibits the progression of glioma
            through inducing ferroptosis.
REFERENCE   4  (residues 1 to 730)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (residues 1 to 730)
  AUTHORS   Zhu,G.Q., Wang,Y., Wang,B., Liu,W.R., Dong,S.S., Chen,E.B.,
            Cai,J.L., Wan,J.L., Du,J.X., Song,L.N., Chen,S.P., Yu,L.,
            Zhou,Z.J., Wang,Z., Zhou,J., Shi,Y.H., Fan,J. and Dai,Z.
  TITLE     Targeting HNRNPM Inhibits Cancer Stemness and Enhances Antitumor
            Immunity in Wnt-activated Hepatocellular Carcinoma
  JOURNAL   Cell Mol Gastroenterol Hepatol 13 (5), 1413-1447 (2022)
   PUBMED   35158098
  REMARK    GeneRIF: Targeting HNRNPM Inhibits Cancer Stemness and Enhances
            Antitumor Immunity in Wnt-activated Hepatocellular Carcinoma.
REFERENCE   6  (residues 1 to 730)
  AUTHORS   Neubauer,G., King,A., Rappsilber,J., Calvio,C., Watson,M., Ajuh,P.,
            Sleeman,J., Lamond,A. and Mann,M.
  TITLE     Mass spectrometry and EST-database searching allows
            characterization of the multi-protein spliceosome complex
  JOURNAL   Nat Genet 20 (1), 46-50 (1998)
   PUBMED   9731529
REFERENCE   7  (residues 1 to 730)
  AUTHORS   Gattoni,R., Mahe,D., Mahl,P., Fischer,N., Mattei,M.G., Stevenin,J.
            and Fuchs,J.P.
  TITLE     The human hnRNP-M proteins: structure and relation with early heat
            shock-induced splicing arrest and chromosome mapping
  JOURNAL   Nucleic Acids Res 24 (13), 2535-2542 (1996)
   PUBMED   8692693
REFERENCE   8  (residues 1 to 730)
  AUTHORS   Blanck,O., Perrin,C., Mziaut,H., Darbon,H., Mattei,M.G. and
            Miquelis,R.
  TITLE     Molecular cloning, cDNA analysis, and localization of a monomer of
            the N-acetylglucosamine-specific receptor of the thyroid, NAGR1, to
            chromosome 19p13.3-13.2
  JOURNAL   Genomics 27 (3), 561 (1995)
   PUBMED   7558047
  REMARK    Correction to:[Genomics. 1994 May 1;21(1):18-26. doi:
            10.1006/geno.1994.1219. PMID: 8088785]
REFERENCE   9  (residues 1 to 730)
  AUTHORS   Blanck,O., Perrin,C., Mziaut,H., Darbon,H., Mattei,M.G. and
            Miquelis,R.
  TITLE     Molecular cloning, cDNA analysis, and localization of a monomer of
            the N-acetylglucosamine-specific receptor of the thyroid, NAGR1, to
            chromosome 19p13.3-13.2
  JOURNAL   Genomics 21 (1), 18-26 (1994)
   PUBMED   8088785
  REMARK    Erratum:[Genomics. 1995 Jun 10;27(3):561. doi:
            10.1006/geno.1995.1097. PMID: 7558047]
REFERENCE   10 (residues 1 to 730)
  AUTHORS   Datar,K.V., Dreyfuss,G. and Swanson,M.S.
  TITLE     The human hnRNP M proteins: identification of a
            methionine/arginine-rich repeat motif in ribonucleoproteins
  JOURNAL   Nucleic Acids Res 21 (3), 439-446 (1993)
   PUBMED   8441656
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC000138.2 and CN350526.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2001 this sequence version replaced NP_005959.1.
            
            Summary: This gene belongs to the subfamily of ubiquitously
            expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The
            hnRNPs are RNA binding proteins and they complex with heterogeneous
            nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs
            in the nucleus and appear to influence pre-mRNA processing and
            other aspects of mRNA metabolism and transport. While all of the
            hnRNPs are present in the nucleus, some seem to shuttle between the
            nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic
            acid binding properties. The protein encoded by this gene has three
            repeats of quasi-RRM domains that bind to RNAs. This protein also
            constitutes a monomer of the N-acetylglucosamine-specific receptor
            which is postulated to trigger selective recycling of immature
            GlcNAc-bearing thyroglobulin molecules. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Aug
            2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000138.2, SRR3476690.1032740.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325495.9/ ENSP00000325376.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..730
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     Protein         1..730
                     /product="heterogeneous nuclear ribonucleoprotein M
                     isoform a"
                     /note="N-acetylglucosamine receptor 1; CEA receptor;
                     heterogenous nuclear ribonucleoprotein M4; hnRNA-binding
                     protein M4"
                     /calculated_mol_wt=77385
     Region          1..62
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P52272.3)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine. /evidence=ECO:0000269|Ref.5,
                     ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895;
                     propagated from UniProtKB/Swiss-Prot (P52272.3)"
     Site            29
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21406692,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P52272.3)"
     Region          41..70
                     /region_name="HnRNP_M_NLS"
                     /note="HnRNP M nuclear localization signal; pfam11532"
                     /db_xref="CDD:463289"
     Region          72..147
                     /region_name="RRM1_hnRNPM"
                     /note="RNA recognition motif 1 (RRM1) found in vertebrate
                     heterogeneous nuclear ribonucleoprotein M (hnRNP M);
                     cd12657"
                     /db_xref="CDD:410058"
     Site            86
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P52272.3)"
     Site            134
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q9D0E1; propagated from
                     UniProtKB/Swiss-Prot (P52272.3)"
     Region          204..279
                     /region_name="RRM2_hnRNPM"
                     /note="RNA recognition motif 2 (RRM2) found in vertebrate
                     heterogeneous nuclear ribonucleoprotein M (hnRNP M);
                     cd12659"
                     /db_xref="CDD:410060"
     Site            204
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P52272.3)"
     Site            277
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (P52272.3)"
     Site            365
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163,
                     ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (P52272.3)"
     Site            377
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P52272.3)"
     Site            397
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163,
                     ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (P52272.3)"
     Region          400..608
                     /region_name="27 X 6 AA repeats of
                     [GEVSTPAN]-[ILMV]-[DE]-[RH]-[MLVI]-[GAV]"
                     /note="propagated from UniProtKB/Swiss-Prot (P52272.3)"
     Site            432
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21406692,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P52272.3)"
     Site            452
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21406692; propagated from
                     UniProtKB/Swiss-Prot (P52272.3)"
     Site            468
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P52272.3)"
     Site            481
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21406692; propagated from
                     UniProtKB/Swiss-Prot (P52272.3)"
     Site            496
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0007744|PubMed:24129315; propagated from
                     UniProtKB/Swiss-Prot (P52272.3)"
     Site            528
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21406692; propagated from
                     UniProtKB/Swiss-Prot (P52272.3)"
     Site            575
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18691976,
                     ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P52272.3)"
     Site            588
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18691976,
                     ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P52272.3)"
     Site            618
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17081983,
                     ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19690332,
                     ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692,
                     ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569;
                     propagated from UniProtKB/Swiss-Prot (P52272.3)"
     Site            633
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569;
                     propagated from UniProtKB/Swiss-Prot (P52272.3)"
     Site            637
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569;
                     propagated from UniProtKB/Swiss-Prot (P52272.3)"
     Region          654..730
                     /region_name="RRM3_hnRNPM"
                     /note="RNA recognition motif 3 (RRM3) found in vertebrate
                     heterogeneous nuclear ribonucleoprotein M (hnRNP M);
                     cd12661"
                     /db_xref="CDD:410062"
     Site            665
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P52272.3)"
     Site            672
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9D0E1; propagated from
                     UniProtKB/Swiss-Prot (P52272.3)"
     Site            698
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (P52272.3)"
     Site            701
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17081983,
                     ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231,
                     ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163;
                     propagated from UniProtKB/Swiss-Prot (P52272.3)"
     CDS             1..730
                     /gene="HNRNPM"
                     /gene_synonym="CEAR; hnRNP M; HNRNPM4; HNRPM; HNRPM4;
                     HTGR1; NAGR1"
                     /coded_by="NM_005968.5:25..2217"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS12203.1"
                     /db_xref="GeneID:4670"
                     /db_xref="HGNC:HGNC:5046"
                     /db_xref="MIM:160994"
ORIGIN      
        1 maagveaaae vaateikmee esgapgvpsg ngapgpkgeg erpaqnekrk eknikrggnr
       61 fepyanptkr yrafitnipf dvkwqslkdl vkekvgevty vellmdaegk srgcavvefk
      121 meesmkkaae vlnkhslsgr plkvkedpdg eharramqkv mattggmgmg pggpgmitip
      181 psilnnpnip neiihalqag rlgstvfvan ldykvgwkkl kevfsmagvv vradiledkd
      241 gksrgigtvt feqsieavqa ismfngqllf drpmhvkmde ralpkgdffp perpqqlphg
      301 lggigmglgp ggqpidanhl nkgigmgnig pagmgmegig fginkmggme gpfgggmenm
      361 grfgsgmnmg rineilsnal krgeiiakqg ggggggsvpg iermgpgidr lggagmermg
      421 aglghgmdrv gseiermglv mdrmgsverm gsgiermgpl gldhmassie rmgqtmerig
      481 sgvermgagm gfglermaap idrvgqtier mgsgvermgp aiermglsme rmvpagmgag
      541 lermgpvmdr matglermga nnlermgler mganslermg lermgansle rmgpamgpal
      601 gagiermgla mgggggasfd raiemergnf ggsfagsfgg agghapgvar kacqifvrnl
      661 pfdftwkmlk dkfnecghvl yadikmengk skgcgvvkfe spevaeracr mmngmklsgr
      721 eidvridrna
//
