LOCUS       NM_138394               4144 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens heterogeneous nuclear ribonucleoprotein L like
            (HNRNPLL), transcript variant 1, mRNA.
ACCESSION   NM_138394
VERSION     NM_138394.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4144)
  AUTHORS   Sakuma,K., Sasaki,E., Hosoda,W., Komori,K., Shimizu,Y., Yatabe,Y.
            and Aoki,M.
  TITLE     MYB mediates downregulation of the colorectal cancer metastasis
            suppressor heterogeneous nuclear ribonucleoprotein L-like during
            epithelial-mesenchymal transition
  JOURNAL   Cancer Sci 112 (9), 3846-3855 (2021)
   PUBMED   34286904
  REMARK    GeneRIF: MYB mediates downregulation of the colorectal cancer
            metastasis suppressor heterogeneous nuclear ribonucleoprotein
            L-like during epithelial-mesenchymal transition.
REFERENCE   2  (bases 1 to 4144)
  AUTHORS   Zheng,Y.X., Wang,L., Kong,W.S., Chen,H., Wang,X.N., Meng,Q.,
            Zhang,H.N., Guo,S.J., Jiang,H.W. and Tao,S.C.
  TITLE     Nsp2 has the potential to be a drug target revealed by global
            identification of SARS-CoV-2 Nsp2-interacting proteins
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 53 (9), 1134-1141 (2021)
   PUBMED   34159380
REFERENCE   3  (bases 1 to 4144)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4144)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 4144)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4144)
  AUTHORS   Oberdoerffer,S., Moita,L.F., Neems,D., Freitas,R.P., Hacohen,N. and
            Rao,A.
  TITLE     Regulation of CD45 alternative splicing by heterogeneous
            ribonucleoprotein, hnRNPLL
  JOURNAL   Science 321 (5889), 686-691 (2008)
   PUBMED   18669861
  REMARK    GeneRIF: identification of heterogeneous ribonucleoprotein L-like
            (hnRNPLL) as a critical inducible regulator of CD45 alternative
            splicing
REFERENCE   7  (bases 1 to 4144)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   8  (bases 1 to 4144)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   9  (bases 1 to 4144)
  AUTHORS   Shur,I., Ben-Avraham,D. and Benayahu,D.
  TITLE     Alternatively spliced isoforms of a novel stromal RNA regulating
            factor
  JOURNAL   Gene 334, 113-121 (2004)
   PUBMED   15256261
  REMARK    GeneRIF: Participation of SRRF (Stromal RNA Regulating Factor)
            isoforms in post-transcriptional events in bone marrow stromal
            cells; an important role in regulation of the RNA expression that
            directs the bone marrow stromal cells differentiation pathway
REFERENCE   10 (bases 1 to 4144)
  AUTHORS   Lehner,B., Semple,J.I., Brown,S.E., Counsell,D., Campbell,R.D. and
            Sanderson,C.M.
  TITLE     Analysis of a high-throughput yeast two-hybrid system and its use
            to predict the function of intracellular proteins encoded within
            the human MHC class III region
  JOURNAL   Genomics 83 (1), 153-167 (2004)
   PUBMED   14667819
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA760455.1, BC017480.1, AK000155.1, BM972334.1 and AC011247.10.
            
            On Nov 23, 2018 this sequence version replaced NM_138394.3.
            
            Summary: HNRNPLL is a master regulator of activation-induced
            alternative splicing in T cells. In particular, it alters splicing
            of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for
            T-cell development and activation (Oberdoerffer et al., 2008
            [PubMed 18669861]).[supplied by OMIM, Aug 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            CCDS Note: The coding region has been updated to represent
            alternative splice sites that are more supported by the available
            transcript and protein data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.90388.1,
                                           SRR1660803.244598.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000449105.8/ ENSP00000390625.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                DA760455.1         109-154
            47-2081             BC017480.1         1-2035
            2082-2605           AK000155.1         1838-2361
            2606-2927           BM972334.1         19-340              c
            2928-4144           AC011247.10        119441-120657       c
FEATURES             Location/Qualifiers
     source          1..4144
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p22.1"
     gene            1..4144
                     /gene="HNRNPLL"
                     /gene_synonym="HNRPLL; SRRF"
                     /note="heterogeneous nuclear ribonucleoprotein L like"
                     /db_xref="GeneID:92906"
                     /db_xref="HGNC:HGNC:25127"
                     /db_xref="MIM:611208"
     exon            1..491
                     /gene="HNRNPLL"
                     /gene_synonym="HNRPLL; SRRF"
                     /inference="alignment:Splign:2.1.0"
     CDS             303..1931
                     /gene="HNRNPLL"
                     /gene_synonym="HNRPLL; SRRF"
                     /note="isoform 1 is encoded by transcript variant 1;
                     stromal RNA regulating factor"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein L-like
                     isoform 1"
                     /protein_id="NP_612403.2"
                     /db_xref="CCDS:CCDS1796.2"
                     /db_xref="GeneID:92906"
                     /db_xref="HGNC:HGNC:25127"
                     /db_xref="MIM:611208"
                     /translation="MSSSSSSPRETYEEDREYESQAKRLKTEEGEIDYSAEEGENRRE
                     ATPRGGGDGGGGGRSFSQPEAGGSHHKVSVSPVVHVRGLCESVVEADLVEALEKFGTI
                     CYVMMMPFKRQALVEFENIDSAKECVTFAADEPVYIAGQQAFFNYSTSKRITRPGNTD
                     DPSGGNKVLLLSIQNPLYPITVDVLYTVCNPVGKVQRIVIFKRNGIQAMVEFESVLCA
                     QKAKAALNGADIYAGCCTLKIEYARPTRLNVIRNDNDSWDYTKPYLGRRDRGKGRQRQ
                     AILGEHPSSFRHDGYGSHGPLLPLPSRYRMGSRDTPELVAYPLPQASSSYMHGGNPSG
                     SVVMVSGLHQLKMNCSRVFNLFCLYGNIEKVKFMKTIPGTALVEMGDEYAVERAVTHL
                     NNVKLFGKRLNVCVSKQHSVVPSQIFELEDGTSSYKDFAMSKNNRFTSAGQASKNIIQ
                     PPSCVLHYYNVPLCVTEETFTKLCNDHEVLTFIKYKVFDAKPSAKTLSGLLEWECKTD
                     AVEALTALNHYQIRVPNGSNPYTLKLCFSTSSHL"
     exon            492..610
                     /gene="HNRNPLL"
                     /gene_synonym="HNRPLL; SRRF"
                     /inference="alignment:Splign:2.1.0"
     exon            611..848
                     /gene="HNRNPLL"
                     /gene_synonym="HNRPLL; SRRF"
                     /inference="alignment:Splign:2.1.0"
     exon            849..934
                     /gene="HNRNPLL"
                     /gene_synonym="HNRPLL; SRRF"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1031
                     /gene="HNRNPLL"
                     /gene_synonym="HNRPLL; SRRF"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1104
                     /gene="HNRNPLL"
                     /gene_synonym="HNRPLL; SRRF"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1176
                     /gene="HNRNPLL"
                     /gene_synonym="HNRPLL; SRRF"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1394
                     /gene="HNRNPLL"
                     /gene_synonym="HNRPLL; SRRF"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1516
                     /gene="HNRNPLL"
                     /gene_synonym="HNRPLL; SRRF"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1718
                     /gene="HNRNPLL"
                     /gene_synonym="HNRPLL; SRRF"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1776
                     /gene="HNRNPLL"
                     /gene_synonym="HNRPLL; SRRF"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1875
                     /gene="HNRNPLL"
                     /gene_synonym="HNRPLL; SRRF"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..4144
                     /gene="HNRNPLL"
                     /gene_synonym="HNRPLL; SRRF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2056..2061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPLL"
                     /gene_synonym="HNRPLL; SRRF"
                     /note="hexamer: AATAAA"
     regulatory      2076..2081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPLL"
                     /gene_synonym="HNRPLL; SRRF"
                     /note="hexamer: AGTAAA"
     polyA_site      2081
                     /gene="HNRNPLL"
                     /gene_synonym="HNRPLL; SRRF"
                     /note="major polyA site"
     polyA_site      2098
                     /gene="HNRNPLL"
                     /gene_synonym="HNRPLL; SRRF"
                     /note="major polyA site"
     regulatory      2587..2592
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPLL"
                     /gene_synonym="HNRPLL; SRRF"
                     /note="hexamer: TATAAA"
     polyA_site      2605
                     /gene="HNRNPLL"
                     /gene_synonym="HNRPLL; SRRF"
                     /note="major polyA site"
     regulatory      2905..2910
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPLL"
                     /gene_synonym="HNRPLL; SRRF"
                     /note="hexamer: ATTAAA"
     polyA_site      2924
                     /gene="HNRNPLL"
                     /gene_synonym="HNRPLL; SRRF"
     regulatory      3534..3539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPLL"
                     /gene_synonym="HNRPLL; SRRF"
                     /note="hexamer: AATAAA"
     polyA_site      3558
                     /gene="HNRNPLL"
                     /gene_synonym="HNRPLL; SRRF"
     regulatory      4117..4122
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPLL"
                     /gene_synonym="HNRPLL; SRRF"
                     /note="hexamer: AATAAA"
     polyA_site      4144
                     /gene="HNRNPLL"
                     /gene_synonym="HNRPLL; SRRF"
ORIGIN      
        1 atccttagat tcgctcctcc gggcagggag cggagacgga ggaggaggag ggagaggctg
       61 aatgttggct cggtaattga gaggagcggc cgctccagag cttcctcccg gggcgccccc
      121 ctcagtccgt ccgcgcttct cagccgccag tctcctggcc gcgcagtccc cgcggacggc
      181 cgggccgcgg agaccctcgc agaagaggcg ctgccggcgg cgaggactgg ccggcggcat
      241 ccgaggcgcg cgccccaccg ccacccccac ccgcctgcca gccggtccct ccggccgccg
      301 ccatgtcctc ctcctcttcc tcccccaggg agacgtacga ggaggaccgg gagtacgaga
      361 gccaggccaa gcgtctcaag accgaggagg gggagatcga ctactcggcc gaggaaggcg
      421 agaaccgccg ggaagcgacg ccccggggcg ggggcgatgg cggcggcggc ggccggagct
      481 tctctcagcc ggaggcaggt ggaagtcatc ataaagtttc tgtttcaccc gtcgtccatg
      541 ttcgaggact ctgtgaatct gtggtggaag cagacctcgt ggaagcgctg gaaaaatttg
      601 ggacaatatg ctatgtgatg atgatgccat ttaaacgaca ggctctagtg gaatttgaaa
      661 acatagatag tgccaaagaa tgtgtgacat ttgctgcaga tgaacccgtg tacattgctg
      721 gtcaacaggc ttttttcaac tattctacaa gcaaaaggat cactcggcca ggaaatactg
      781 atgatccatc aggaggcaac aaagttcttc tgctctcaat tcagaatccg ctttatccaa
      841 ttacagtgga tgttttatat actgtatgca accctgttgg caaagtgcaa cgtattgtta
      901 tattcaagag aaatgggata caagcaatgg ttgagtttga atcagtcctt tgtgcccaga
      961 aagctaaagc agcactcaat ggagctgata tatatgctgg atgttgcaca ctaaaaattg
     1021 aatatgcacg gccaactcgt ctaaatgtta ttaggaatga caatgacagt tgggactaca
     1081 ctaaaccata tttgggaaga cgagatagag gaaagggtcg ccagagacaa gccattttgg
     1141 gagaacaccc ttcttcgttt agacatgatg gctatggatc ccatggtcca ttattgcctt
     1201 taccaagtcg ttacagaatg ggctctcgag atacacctga acttgttgct tatccattac
     1261 cacaggcttc ttcctcttac atgcatggag gaaatccctc tggttcagtt gtaatggtta
     1321 gtggattaca tcaactaaaa atgaattgtt caagagtctt caacctgttc tgcttatatg
     1381 gaaatattga gaaggtaaaa tttatgaaga ccattcctgg tacagcactg gtagaaatgg
     1441 gtgatgagta tgctgtagaa agagctgtca cacaccttaa taatgtcaaa ttatttggga
     1501 aaagacttaa tgtttgcgtg tctaaacaac attcagttgt tccaagtcaa atatttgagc
     1561 tggaggatgg taccagcagc tacaaagatt ttgcaatgag caaaaataat cgctttacaa
     1621 gtgctggcca agcatctaag aatataatcc agccaccctc ctgtgttttg cattattata
     1681 atgttccatt gtgtgtcaca gaagagacct tcacaaagtt gtgtaatgac catgaagttc
     1741 ttacattcat caaatataaa gtgtttgatg caaaaccttc agccaaaaca ctttctgggc
     1801 tattagaatg ggagtgcaaa actgatgcag tagaagccct tacggcactg aatcactatc
     1861 agataagagt gccgaatggt tccaatccct atacattgaa gctttgcttt tctacatcat
     1921 cccatttata agaagagaag agcatgttag aatttatgtt cacctttatt acaatttcaa
     1981 agctacactt cattaaaaaa aaatctaaaa tggttgatct catgttgcct tgcttacttt
     2041 aagatcctgt tctgtaataa acatattttg ccttgagtaa atttgttgta agcttaaata
     2101 ttgaattgtt ttcattttaa gatagaatat cataatgtag actatctaca gcttcattgt
     2161 agattataca gatatatgat ttctaacctt attactggaa tttttcttcc acagtaaaaa
     2221 tatatttgca ttcttaatgc taattatctg caagtatttt ttcattgtgt aagagattaa
     2281 tgcaggtgaa agtattgcat tttaatatag aattcctatt atatgtttag atgtttaagt
     2341 atgttgcagt tactcatatt aaacataact tgtatattta ttattttaat gaagtttgag
     2401 aataacgtta catatgttga attttaagta ctacagattt aactgatttt atatttctga
     2461 aaggctaaca gacatggata cacgtgtaca gtatgcattc aaacttattt aaattggtgt
     2521 attttttttt aagtcactgt ccatttgtat tgacatgcct ctgtttctag tccagtttgg
     2581 agattttata aagttataac aatgagttaa tgtgttcatt ttcatttgtt gcatgtgact
     2641 taaatacagc tagtatttgg cattgagatt ttaatagagg ttataattaa cagttcctct
     2701 tatagataat aatctgggat ccatgggtgg gcttcagaga atctgtgtac cccctaaaat
     2761 tgtatgtaga attttggata tttacatttt tattttttaa ctcttggatc catcagtaat
     2821 atgtattttt ctatatggta caagatttaa ggatctaatt ttatttttat tccaaacaga
     2881 tagctatttg tctcaatacc atttattaaa cattctttct cccactggat ctgttttttt
     2941 tttcttttta agataataga ttttatacat aggcaagtaa gatttaagga ccaaacatgg
     3001 tattaagaga ctatagcacg attgttacca agttcacagc ttttttacaa tagaaaaact
     3061 gatgtggcca ttttgttttc atctttaaaa gaagggagaa tatgtgtcat ctacctagaa
     3121 taactgatat cagtagttga caatatcagt tttgtaatcc tgacactttt aaacaaattt
     3181 gtaaatgaaa gttccattta gatcttttgt aaagacttta ttttaaattt taatataaaa
     3241 aatcctttta gaaataaggc aggcatttac aattttagag ctgtttaata ggaagtttag
     3301 atggaaacta aacacacatt aacatttatt tcccctcatt ttgatggcag tggaccagca
     3361 tttagccctc taaagataaa gaaaaaatta aatttaatct agaagtattt tagaccctta
     3421 tcacagaacc cagtaagtta tgccaagggt aactgtgtga actgtgttcg atactgggct
     3481 atgtatgttt cttattcatt gccaatttaa tacctaagtt tatctaactt tacaataaag
     3541 ctttttttcc cctataaata cttttctacc tcttttgaaa aattgaaata ccttaatttt
     3601 ggtttatgta atagttgtct acgttccttc ctcctctgaa aattaatgtg ggttgtcaga
     3661 attacagact ttttaatgcc taagatttta agaaataaac ctgtaggtgt tggcaggact
     3721 tatttcattt agattttaat tagtttagat gtgtagaaat gatttttatc tgtaaggctc
     3781 tctctccacc aaaataagtg aattgtttgg gagtaaacta gttggtaagt tgggccttgc
     3841 tgatagattt atacactggt gtgtaagccc tatactgctg ctgtcactaa tgtttttgat
     3901 agtttactta ggcatgactg ctgttaatga agtttgcttt gtgaatactc tctctttcct
     3961 tagccttggc aacattcttc tctgtgctat ctttatgctt ttagaagaac tagaaaaagc
     4021 agatttaaga actgtaaaga aataatacta gctttgagtt tttaaaaaaa atattgaaat
     4081 cccatctctg tatccaaatc ctactacaca tttgataata aatctgccaa actgagttat
     4141 ggaa
//
