LOCUS       NM_001533               2142 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens heterogeneous nuclear ribonucleoprotein L (HNRNPL),
            transcript variant 1, mRNA.
ACCESSION   NM_001533
VERSION     NM_001533.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2142)
  AUTHORS   Lv,J., Li,K., Yu,H., Han,J., Zhuang,J., Yu,R., Cheng,Y., Song,Q.,
            Bai,K., Cao,Q., Yang,H., Yang,X. and Lu,Q.
  TITLE     HNRNPL induced circFAM13B increased bladder cancer immunotherapy
            sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway
  JOURNAL   J Exp Clin Cancer Res 42 (1), 41 (2023)
   PUBMED   36747239
  REMARK    GeneRIF: HNRNPL induced circFAM13B increased bladder cancer
            immunotherapy sensitivity via inhibiting glycolysis through
            IGF2BP1/PKM2 pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2142)
  AUTHORS   Kerschbamer,E., Arnoldi,M., Tripathi,T., Pellegrini,M., Maturi,S.,
            Erdin,S., Salviato,E., Di Leva,F., Sebestyen,E., Dassi,E.,
            Zarantonello,G., Benelli,M., Campos,E., Basson,M.A., Gusella,J.F.,
            Gustincich,S., Piazza,S., Demichelis,F., Talkowski,M.E., Ferrari,F.
            and Biagioli,M.
  TITLE     CHD8 suppression impacts on histone H3 lysine 36 trimethylation and
            alters RNA alternative splicing
  JOURNAL   Nucleic Acids Res 50 (22), 12809-12828 (2022)
   PUBMED   36537238
REFERENCE   3  (bases 1 to 2142)
  AUTHORS   Wu,Q., Zhang,H., Yang,D., Min,Q., Wang,Y., Zhang,W. and Zhan,Q.
  TITLE     The m6A-induced lncRNA CASC8 promotes proliferation and
            chemoresistance via upregulation of hnRNPL in esophageal squamous
            cell carcinoma
  JOURNAL   Int J Biol Sci 18 (13), 4824-4836 (2022)
   PUBMED   35982900
  REMARK    GeneRIF: The m6A-induced lncRNA CASC8 promotes proliferation and
            chemoresistance via upregulation of hnRNPL in esophageal squamous
            cell carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2142)
  AUTHORS   Xu,P., Zhang,J., Wang,M., Liu,B., Li,R., Li,H., Zhai,N., Liu,W.,
            Lv,C. and Song,X.
  TITLE     hnRNPL-activated circANKRD42 back-splicing and circANKRD42-mediated
            crosstalk of mechanical stiffness and biochemical signal in lung
            fibrosis
  JOURNAL   Mol Ther 30 (6), 2370-2387 (2022)
   PUBMED   35278674
  REMARK    GeneRIF: hnRNPL-activated circANKRD42 back-splicing and
            circANKRD42-mediated crosstalk of mechanical stiffness and
            biochemical signal in lung fibrosis.
REFERENCE   5  (bases 1 to 2142)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 2142)
  AUTHORS   Hahm,B., Cho,O.H., Kim,J.E., Kim,Y.K., Kim,J.H., Oh,Y.L. and
            Jang,S.K.
  TITLE     Polypyrimidine tract-binding protein interacts with HnRNP L
  JOURNAL   FEBS Lett 425 (3), 401-406 (1998)
   PUBMED   9563502
REFERENCE   7  (bases 1 to 2142)
  AUTHORS   Funke,B., Zuleger,B., Benavente,R., Schuster,T., Goller,M.,
            Stevenin,J. and Horak,I.
  TITLE     The mouse poly(C)-binding protein exists in multiple isoforms and
            interacts with several RNA-binding proteins
  JOURNAL   Nucleic Acids Res 24 (19), 3821-3828 (1996)
   PUBMED   8871564
REFERENCE   8  (bases 1 to 2142)
  AUTHORS   Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
            Vandekerckhove,J.
  TITLE     Microsequences of 145 proteins recorded in the two-dimensional gel
            protein database of normal human epidermal keratinocytes
  JOURNAL   Electrophoresis 13 (12), 960-969 (1992)
   PUBMED   1286667
REFERENCE   9  (bases 1 to 2142)
  AUTHORS   Pinol-Roma,S., Swanson,M.S., Gall,J.G. and Dreyfuss,G.
  TITLE     A novel heterogeneous nuclear RNP protein with a unique
            distribution on nascent transcripts
  JOURNAL   J Cell Biol 109 (6 Pt 1), 2575-2587 (1989)
   PUBMED   2687284
REFERENCE   10 (bases 1 to 2142)
  AUTHORS   Dreyfuss,G., Choi,Y.D. and Adam,S.A.
  TITLE     The ribonucleoprotein structures along the pathway of mRNA
            formation
  JOURNAL   Endocr Res 15 (4), 441-474 (1989)
   PUBMED   2576798
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008982.5 and AB044547.1.
            
            On Jul 24, 2020 this sequence version replaced NM_001533.2.
            
            Summary: Heterogeneous nuclear RNAs (hnRNAs) which include mRNA
            precursors and mature mRNAs are associated with specific proteins
            to form heterogenous ribonucleoprotein (hnRNP) complexes.
            Heterogeneous nuclear ribonucleoprotein L is among the proteins
            that are stably associated with hnRNP complexes and along with
            other hnRNP proteins is likely to play a major role in the
            formation, packaging, processing, and function of mRNA.
            Heterogeneous nuclear ribonucleoprotein L is present in the
            nucleoplasm as part of the HNRP complex. HNRP proteins have also
            been identified outside of the nucleoplasm. Exchange of hnRNP for
            mRNA-binding proteins accompanies transport of mRNA from the
            nucleus to the cytoplasm. Since HNRP proteins have been shown to
            shuttle between the nucleus and the cytoplasm, it is possible that
            they also have cytoplasmic functions. Two transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GQ900947.1, AB044547.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221419.10/ ENSP00000221419.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC008982.5         41865-41878         c
            15-1205             AB044547.1         1-1191
            1206-1206           AC008982.5         32035-32035         c
            1207-1910           AB044547.1         1193-1896
            1911-1913           AC008982.5         28491-28493         c
            1914-1979           AB044547.1         1897-1962
            1980-2142           AC008982.5         28262-28424         c
FEATURES             Location/Qualifiers
     source          1..2142
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..2142
                     /gene="HNRNPL"
                     /gene_synonym="hnRNP-L; HNRPL; P/OKcl.14"
                     /note="heterogeneous nuclear ribonucleoprotein L"
                     /db_xref="GeneID:3191"
                     /db_xref="HGNC:HGNC:5045"
                     /db_xref="MIM:603083"
     exon            1..287
                     /gene="HNRNPL"
                     /gene_synonym="hnRNP-L; HNRPL; P/OKcl.14"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1790
                     /gene="HNRNPL"
                     /gene_synonym="hnRNP-L; HNRPL; P/OKcl.14"
                     /note="isoform a is encoded by transcript variant 1; hnRNP
                     L; epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein L
                     isoform a"
                     /protein_id="NP_001524.2"
                     /db_xref="CCDS:CCDS33015.1"
                     /db_xref="GeneID:3191"
                     /db_xref="HGNC:HGNC:5045"
                     /db_xref="MIM:603083"
                     /translation="MSRRLLPRAEKRRRRLEQRQQPDEQRRRSGAMVKMAAAGGGGGG
                     GRYYGGGSEGGRAPKRLKTDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHKTPASP
                     VVHIRGLIDGVVEADLVEALQEFGPISYVVVMPKKRQALVEFEDVLGACNAVNYAADN
                     QIYIAGHPAFVNYSTSQKISRPGDSDDSRSVNSVLLFTILNPIYSITTDVLYTICNPC
                     GPVQRIVIFRKNGVQAMVEFDSVQSAQRAKASLNGADIYSGCCTLKIEYAKPTRLNVF
                     KNDQDTWDYTNPNLSGQGDPGSNPNKRQRQPPLLGDHPAEYGGPHGGYHSHYHDEGYG
                     PPPPHYEGRRMGPPVGGHRRGPSRYGPQYGHPPPPPPPPEYGPHADSPVLMVYGLDQS
                     KMNCDRVFNVFCLYGNVEKVKFMKSKPGAAMVEMADGYAVDRAITHLNNNFMFGQKLN
                     VCVSKQPAIMPGQSYGLEDGSCSYKDFSESRNNRFSTPEQAAKNRIQHPSNVLHFFNA
                     PLEVTEENFFEICDELGVKRPSSVKVFSGKSERSSSGLLEWESKSDALETLGFLNHYQ
                     MKNPNGPYPYTLKLCFSTAQHAS"
     exon            288..406
                     /gene="HNRNPL"
                     /gene_synonym="hnRNP-L; HNRPL; P/OKcl.14"
                     /inference="alignment:Splign:2.1.0"
     exon            407..644
                     /gene="HNRNPL"
                     /gene_synonym="hnRNP-L; HNRPL; P/OKcl.14"
                     /inference="alignment:Splign:2.1.0"
     exon            645..730
                     /gene="HNRNPL"
                     /gene_synonym="hnRNP-L; HNRPL; P/OKcl.14"
                     /inference="alignment:Splign:2.1.0"
     exon            731..827
                     /gene="HNRNPL"
                     /gene_synonym="hnRNP-L; HNRPL; P/OKcl.14"
                     /inference="alignment:Splign:2.1.0"
     exon            828..900
                     /gene="HNRNPL"
                     /gene_synonym="hnRNP-L; HNRPL; P/OKcl.14"
                     /inference="alignment:Splign:2.1.0"
     exon            901..972
                     /gene="HNRNPL"
                     /gene_synonym="hnRNP-L; HNRPL; P/OKcl.14"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1253
                     /gene="HNRNPL"
                     /gene_synonym="hnRNP-L; HNRPL; P/OKcl.14"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1375
                     /gene="HNRNPL"
                     /gene_synonym="hnRNP-L; HNRPL; P/OKcl.14"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1577
                     /gene="HNRNPL"
                     /gene_synonym="hnRNP-L; HNRPL; P/OKcl.14"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1635
                     /gene="HNRNPL"
                     /gene_synonym="hnRNP-L; HNRPL; P/OKcl.14"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1731
                     /gene="HNRNPL"
                     /gene_synonym="hnRNP-L; HNRPL; P/OKcl.14"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..2142
                     /gene="HNRNPL"
                     /gene_synonym="hnRNP-L; HNRPL; P/OKcl.14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2112..2117
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPL"
                     /gene_synonym="hnRNP-L; HNRPL; P/OKcl.14"
                     /note="hexamer: AATAAA"
     polyA_site      2142
                     /gene="HNRNPL"
                     /gene_synonym="hnRNP-L; HNRPL; P/OKcl.14"
                     /note="major polyA site"
ORIGIN      
        1 gaggcgggtt ctgcgccgcc atgtcgcgga ggctgctgcc ccgggcggag aagcggcgtc
       61 ggcggctgga gcagaggcag cagccggacg agcagcggag gcggtcggga gcgatggtga
      121 agatggcggc ggcgggcggc ggaggcggcg gtggccgcta ctacggcggc ggcagtgagg
      181 gcggccgggc ccctaagcgg ctcaagactg acaacgccgg cgaccagcac ggaggcggcg
      241 gcggtggcgg tggaggagcc ggggcggcgg gcggcggcgg cggtggggag aactacgatg
      301 acccgcacaa aacccctgcc tccccagttg tccacatcag gggcctgatt gacggtgtgg
      361 tggaagcaga ccttgtggag gccttgcagg agtttggacc catcagctat gtggtggtaa
      421 tgcctaaaaa gagacaagca ctggtggagt ttgaagatgt gttgggggct tgcaacgcag
      481 tgaactacgc agccgacaac caaatataca ttgctggtca cccagctttt gtcaactact
      541 ctaccagcca gaagatctcc cgccctgggg actcggatga ctcccggagc gtgaacagtg
      601 tgcttctctt taccatcctg aaccccattt attcgatcac cacggatgtt ctttacacta
      661 tctgtaatcc ttgtggccct gtccagagaa ttgtcatttt caggaagaat ggagttcagg
      721 cgatggtgga atttgactca gttcaaagtg cccagcgggc caaggcctct ctcaatgggg
      781 ctgatatcta ttctggctgt tgcactctga agatcgaata cgcaaagcct acacgcttga
      841 atgtgttcaa gaatgatcag gatacttggg actacacaaa ccccaatctc agtggacaag
      901 gtgaccctgg cagcaacccc aacaaacgcc agaggcagcc ccctctcctg ggagatcacc
      961 ccgcagaata tggagggccc cacggtgggt accacagcca ttaccatgat gagggctacg
     1021 ggcccccccc acctcactac gaagggagaa ggatgggtcc accagtgggg ggtcaccgtc
     1081 ggggcccaag tcgctacggc ccccagtatg ggcacccccc accccctccc ccaccacccg
     1141 agtatggccc tcacgccgac agccctgtgc tcatggtcta tggcttggat caatctaaga
     1201 tgaactgtga ccgagtcttc aatgtcttct gcttatatgg caatgtggag aaggtgaaat
     1261 tcatgaaaag caagccgggg gccgccatgg tggagatggc tgatggctac gctgtagacc
     1321 gggccattac ccacctcaac aacaacttca tgtttgggca gaagctgaat gtctgtgtct
     1381 ccaagcagcc agccatcatg cctggtcagt catacgggtt ggaagacggg tcttgcagtt
     1441 acaaagactt cagtgaatcc cggaacaatc ggttctccac cccagagcag gcagccaaga
     1501 accgcatcca gcaccccagc aacgtgctgc acttcttcaa cgccccgctg gaggtgaccg
     1561 aggagaactt ctttgagatc tgcgatgagc tgggagtgaa gcggccatct tctgtgaaag
     1621 tattctcagg caaaagtgag cgcagctcct ctggactgct ggagtgggaa tccaagagcg
     1681 atgccctgga gactctgggc ttcctgaacc attaccagat gaaaaaccca aatggtccat
     1741 acccttacac tctgaagttg tgtttctcca ctgctcagca cgcctcctaa ttaggtgcct
     1801 aggaagagtc ccatctgagc aggaagacat ttctctttcc tttatgccat tttttgtttt
     1861 tgttatttgc aaaagatctt gtattccttt tttttttttt tttttttttt tttaaatgct
     1921 aggtttgtag aggcttactt aaccttaatg gaaacgctgg aaatctgcag ggggagggag
     1981 aggggaactg ttatctccca agattaacct tcacttttaa aaaattattg tacatgtgat
     2041 tttttttttt cctgttcata catttgtgct gcccatgtac tcttggcaca tttcaataaa
     2101 attgtttgga aaataaacac agcacttgct gggattccag ga
//
