LOCUS       NM_012207               2356 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3),
            transcript variant 2H9, mRNA.
ACCESSION   NM_012207
VERSION     NM_012207.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2356)
  AUTHORS   Liu,M., Sun,X., Zhu,L., Zhu,M., Deng,K., Nie,X., Mo,H., Du,T.,
            Huang,B., Hu,L., Liang,L., Wang,D., Luo,Y., Yi,J., Zhang,J.,
            Zhong,X., Cao,C. and Chen,H.
  TITLE     Long Noncoding RNA RP11-115N4.1 Promotes Inflammatory Responses by
            Interacting With HNRNPH3 and Enhancing the Transcription of HSP70
            in Unexplained Recurrent Spontaneous Abortion
  JOURNAL   Front Immunol 12, 717785 (2021)
   PUBMED   34484222
  REMARK    GeneRIF: Long Noncoding RNA RP11-115N4.1 Promotes Inflammatory
            Responses by Interacting With HNRNPH3 and Enhancing the
            Transcription of HSP70 in Unexplained Recurrent Spontaneous
            Abortion.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2356)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2356)
  AUTHORS   Dogan,S., Ng,C.K.Y., Xu,B., Kumar,R., Wang,L., Edelweiss,M.,
            Scott,S.N., Zehir,A., Drilon,A., Morris,L.G.T., Lee,N.Y.,
            Antonescu,C.R., Ho,A.L., Katabi,N., Berger,M.F. and Reis-Filho,J.S.
  TITLE     The repertoire of genetic alterations in salivary duct carcinoma
            including a novel HNRNPH3-ALK rearrangement
  JOURNAL   Hum Pathol 88, 66-77 (2019)
   PUBMED   30946933
  REMARK    GeneRIF: A novel heterogeneous nuclear ribonucleoprotein H3-ALK
            receptor tyrosine kinase rearrangement was found in one de novo
            salivary duct carcinoma
REFERENCE   4  (bases 1 to 2356)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   5  (bases 1 to 2356)
  AUTHORS   Todd,M.A. and Picketts,D.J.
  TITLE     PHF6 interacts with the nucleosome remodeling and deacetylation
            (NuRD) complex
  JOURNAL   J Proteome Res 11 (8), 4326-4337 (2012)
   PUBMED   22720776
REFERENCE   6  (bases 1 to 2356)
  AUTHORS   Yague,J., Vazquez,J. and Lopez de Castro,J.A.
  TITLE     A post-translational modification of nuclear proteins,
            N(G),N(G)-dimethyl-Arg, found in a natural HLA class I peptide
            ligand
  JOURNAL   Protein Sci 9 (11), 2210-2217 (2000)
   PUBMED   11152131
REFERENCE   7  (bases 1 to 2356)
  AUTHORS   Mahe,D., Fischer,N., Decimo,D. and Fuchs,J.P.
  TITLE     Spatiotemporal regulation of hnRNP M and 2H9 gene expression during
            mouse embryonic development
  JOURNAL   Biochim Biophys Acta 1492 (2-3), 414-424 (2000)
   PUBMED   11004512
REFERENCE   8  (bases 1 to 2356)
  AUTHORS   Honore,B.
  TITLE     The hnRNP 2H9 gene, which is involved in the splicing reaction, is
            a multiply spliced gene
  JOURNAL   Biochim Biophys Acta 1492 (1), 108-119 (2000)
   PUBMED   10858537
REFERENCE   9  (bases 1 to 2356)
  AUTHORS   Mahe,D., Mahl,P., Gattoni,R., Fischer,N., Mattei,M.G., Stevenin,J.
            and Fuchs,J.P.
  TITLE     Cloning of human 2H9 heterogeneous nuclear ribonucleoproteins.
            Relation with splicing and early heat shock-induced splicing arrest
  JOURNAL   J Biol Chem 272 (3), 1827-1836 (1997)
   PUBMED   8999868
REFERENCE   10 (bases 1 to 2356)
  AUTHORS   Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
            Vandekerckhove,J.
  TITLE     Microsequences of 145 proteins recorded in the two-dimensional gel
            protein database of normal human epidermal keratinocytes
  JOURNAL   Electrophoresis 13 (12), 960-969 (1992)
   PUBMED   1286667
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA486117.1, AK223441.1,
            AF132362.1 and AW189387.1.
            
            On Aug 13, 2020 this sequence version replaced NM_012207.2.
            
            Summary: This gene belongs to the subfamily of ubiquitously
            expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The
            hnRNPs are RNA binding proteins and they complex with heterogeneous
            nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs
            in the nucleus and appear to influence pre-mRNA processing and
            other aspects of mRNA metabolism and transport. While all of the
            hnRNPs are present in the nucleus, some seem to shuttle between the
            nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic
            acid binding properties. The protein encoded by this gene has two
            repeats of quasi-RRM domains that bind to RNAs. It is localized in
            nuclear bodies of the nucleus. This protein is involved in the
            splicing process and it also participates in early heat
            shock-induced splicing arrest by transiently leaving the hnRNP
            complexes. Several alternatively spliced transcript variants have
            been noted for this gene, however, not all are fully characterized.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2H9) encodes the longest isoform
            (a). Variants 2H9, 3, 4, and 5 all encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853564.3465.1,
                                           SRR14038193.3665666.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265866.12/ ENSP00000265866.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-288               DA486117.1         54-341
            289-574             AK223441.1         294-579
            575-2337            AF132362.1         529-2291
            2338-2356           AW189387.1         19-37               c
FEATURES             Location/Qualifiers
     source          1..2356
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q21.3"
     gene            1..2356
                     /gene="HNRNPH3"
                     /gene_synonym="2H9; HNRPH3"
                     /note="heterogeneous nuclear ribonucleoprotein H3"
                     /db_xref="GeneID:3189"
                     /db_xref="HGNC:HGNC:5043"
                     /db_xref="MIM:602324"
     exon            1..153
                     /gene="HNRNPH3"
                     /gene_synonym="2H9; HNRPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            154..288
                     /gene="HNRNPH3"
                     /gene_synonym="2H9; HNRPH3"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..1217
                     /gene="HNRNPH3"
                     /gene_synonym="2H9; HNRPH3"
                     /note="isoform a is encoded by transcript variant 2H9;
                     hnRNP H3; hnRNP 2H9; heterogeneous nuclear
                     ribonucleoprotein 2H9"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein H3
                     isoform a"
                     /protein_id="NP_036339.1"
                     /db_xref="CCDS:CCDS7278.1"
                     /db_xref="GeneID:3189"
                     /db_xref="HGNC:HGNC:5043"
                     /db_xref="MIM:602324"
                     /translation="MDWVMKHNGPNDASDGTVRLRGLPFGCSKEEIVQFFQGLEIVPN
                     GITLTMDYQGRSTGEAFVQFASKEIAENALGKHKERIGHRYIEIFRSSRSEIKGFYDP
                     PRRLLGQRPGPYDRPIGGRGGYYGAGRGSMYDRMRRGGDGYDGGYGGFDDYGGYNNYG
                     YGNDGFDDRMRDGRGMGGHGYGGAGDASSGFHGGHFVHMRGLPFRATENDIANFFSPL
                     NPIRVHIDIGADGRATGEADVEFVTHEDAVAAMSKDKNNMQHRYIELFLNSTPGGGSG
                     MGGSGMGGYGRDGMDNQGGYGSVGRMGMGNNYSGGYGTPDGLGGYGRGGGGSGGYYGQ
                     GGMSGGGWRGMY"
     exon            289..427
                     /gene="HNRNPH3"
                     /gene_synonym="2H9; HNRPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            428..612
                     /gene="HNRNPH3"
                     /gene_synonym="2H9; HNRPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            613..699
                     /gene="HNRNPH3"
                     /gene_synonym="2H9; HNRPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            700..815
                     /gene="HNRNPH3"
                     /gene_synonym="2H9; HNRPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            816..951
                     /gene="HNRNPH3"
                     /gene_synonym="2H9; HNRPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1047
                     /gene="HNRNPH3"
                     /gene_synonym="2H9; HNRPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1140
                     /gene="HNRNPH3"
                     /gene_synonym="2H9; HNRPH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..2356
                     /gene="HNRNPH3"
                     /gene_synonym="2H9; HNRPH3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1415..1420
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPH3"
                     /gene_synonym="2H9; HNRPH3"
                     /note="hexamer: AATAAA"
     polyA_site      1437
                     /gene="HNRNPH3"
                     /gene_synonym="2H9; HNRPH3"
                     /note="major polyA site"
     regulatory      2331..2336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPH3"
                     /gene_synonym="2H9; HNRPH3"
                     /note="hexamer: AATAAA"
     polyA_site      2356
                     /gene="HNRNPH3"
                     /gene_synonym="2H9; HNRPH3"
                     /note="major polyA site"
ORIGIN      
        1 agtagctgtg ctgcgcagct ccctaagcgg ttgtcaccgc tggagacggt tgggagaacc
       61 gttgtggcga gcgctacacg aggcaaacga cttctccctt ctttgaactg gaccccgcga
      121 gcaccagagt cggcgtaact atcgcctgac aggcatttaa atcaaacggt attgagatgg
      181 attgggttat gaaacataat ggtccaaatg acgctagtga tgggacagta cgacttcgtg
      241 gactaccatt tggttgcagc aaagaggaaa tagttcagtt ctttcaaggg ttggaaatcg
      301 tgccaaatgg gataacattg acgatggact accaggggag aagcacaggg gaggccttcg
      361 tgcagtttgc ttcaaaggag atagcagaaa atgctctggg gaaacacaag gaaagaatag
      421 ggcacaggta tattgagatc ttcagaagta gcaggagtga aatcaaagga ttttatgatc
      481 caccaagaag attgctggga cagcgaccgg gaccatatga tagaccaata ggaggaagag
      541 ggggttatta tggagctggg cgtggaagta tgtatgacag aatgcgacga ggaggtgatg
      601 gatatgatgg tggttatgga ggttttgatg actatggtgg ctataataat tacggctatg
      661 ggaatgatgg ctttgatgac agaatgagag atggaagagg tatgggagga catggctatg
      721 gtggagctgg tgatgcaagt tcaggttttc atggtggtca tttcgtacat atgagagggt
      781 tgccttttcg tgcaactgaa aatgacattg ctaatttctt ctcaccacta aatccaatac
      841 gagttcatat tgatattgga gctgatggca gagccacagg agaagcagat gtagagtttg
      901 tgacacatga agatgcagta gctgccatgt ctaaagataa aaataacatg caacatcgat
      961 atattgaact cttcttgaat tctactcctg gaggcggctc tggcatggga ggttctggaa
     1021 tgggaggcta cggaagagat ggaatggata atcagggagg ctatggatca gttggaagaa
     1081 tgggaatggg gaacaattac agtggaggat atggtactcc tgatggtttg ggtggttatg
     1141 gccgtggtgg tggaggcagt ggaggttact atgggcaagg cggcatgagt ggaggtggat
     1201 ggcgtgggat gtactgaaag caaaaacacc aacatacaag tcttgacaac agcatctggt
     1261 ctactagact ttcttacaga tttaatttct tttgtatttt aagaacttta taatgactga
     1321 aggaatgtgt tttcaaaata ttatttggta aagcaacaga ttgtgatggg aaaatgtttt
     1381 ctgtaggttt atttgttgca tactttgact taaaaataaa tttttatatt caaaccactg
     1441 atgttgatac tttttatata ctagttactc ctaaagatgt gctgccttca taagatttgg
     1501 gttgatgtat tttactatta gttctacaag aagtagtgtg gtgtaatttt agaggataat
     1561 ggttcacctc tgcgtaaact gcaagtctta agcagacatc tggaatagag cttgacaaat
     1621 aattagtgta acttttttct ttagttcctc ctggacaaca ctgtaaatat aaagcctaaa
     1681 gatgaagtgg cttcaggagt ataaattcag ctaattattt ctatattatt atttttcaaa
     1741 tgtcatttat caggcatagc tctgaaacat tgatgatcta agaggtattg atttctgaat
     1801 attcataatt gtgttacctg ggtatgagag tgttggaagc tgaattctag ccctagattt
     1861 tggagtaaaa ccccttcagc acttgaccga aataccaaaa atgtctccaa aaaattgata
     1921 gttgcaggtt atcgcaagat gtcttagagt agggttaagg ttctcagtga cacaagaatt
     1981 cagtattaag tacataggta tttactatgg agtataattc tcacaattgt attttcagtt
     2041 ttctgcccaa tagagtttaa ataactgtat aaatgatgac tttaaaaaaa tgtaagcaac
     2101 aagtccatgt catagtcaat aaaaacaatc ctgcagttgg gttttgtatc tgatccctgc
     2161 ttggagtttt agtttaaaga atctatatgt agcaaggaaa aggtgctttt taattttaat
     2221 ccctttgatc aatatggctt ttttccaaat tggctaatgg atcaaaatga aacctgttga
     2281 tgtgaattca gttattgaac ttgttacttg tttttgccag aaatgttatt aataaatgtc
     2341 attgtgggag ataata
//
