LOCUS       NM_001257293            2240 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens heterogeneous nuclear ribonucleoprotein H1 (HNRNPH1),
            transcript variant 1, mRNA.
ACCESSION   NM_001257293
VERSION     NM_001257293.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2240)
  AUTHORS   Schult,P., Kummerer,B.M., Hafner,M. and Paeschke,K.
  TITLE     Viral hijacking of hnRNPH1 unveils a G-quadruplex-driven mechanism
            of stress control
  JOURNAL   Cell Host Microbe 32 (9), 1579-1593 (2024)
   PUBMED   39094585
  REMARK    GeneRIF: Viral hijacking of hnRNPH1 unveils a G-quadruplex-driven
            mechanism of stress control.
REFERENCE   2  (bases 1 to 2240)
  AUTHORS   Ouyang,J., Li,S., Sun,W., Xiao,X., Wang,Y., Jiang,Y. and Zhang,Q.
  TITLE     Variants in HNRNPH1 are associated with high myopia in humans and
            ocular coloboma in zebrafish
  JOURNAL   Clin Genet 102 (5), 424-433 (2022)
   PUBMED   35989590
  REMARK    GeneRIF: Variants in HNRNPH1 are associated with high myopia in
            humans and ocular coloboma in zebrafish.
REFERENCE   3  (bases 1 to 2240)
  AUTHORS   Jiang,F., Lang,X., Chen,N., Jin,L., Liu,L., Wei,X., Pan,J., Yu,F.,
            Blake,A. and Xiao,S.
  TITLE     A novel HNRNPH1::ERG rearrangement in aggressive acute myeloid
            leukemia
  JOURNAL   Genes Chromosomes Cancer 61 (8), 503-508 (2022)
   PUBMED   35503261
  REMARK    GeneRIF: A novel HNRNPH1::ERG rearrangement in aggressive acute
            myeloid leukemia.
REFERENCE   4  (bases 1 to 2240)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 2240)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 2240)
  AUTHORS   Gamberi,C., Izaurralde,E., Beisel,C. and Mattaj,I.W.
  TITLE     Interaction between the human nuclear cap-binding protein complex
            and hnRNP F
  JOURNAL   Mol Cell Biol 17 (5), 2587-2597 (1997)
   PUBMED   9111328
REFERENCE   7  (bases 1 to 2240)
  AUTHORS   Honore,B., Rasmussen,H.H., Vorum,H., Dejgaard,K., Liu,X.,
            Gromov,P., Madsen,P., Gesser,B., Tommerup,N. and Celis,J.E.
  TITLE     Heterogeneous nuclear ribonucleoproteins H, H', and F are members
            of a ubiquitously expressed subfamily of related but distinct
            proteins encoded by genes mapping to different chromosomes
  JOURNAL   J Biol Chem 270 (48), 28780-28789 (1995)
   PUBMED   7499401
REFERENCE   8  (bases 1 to 2240)
  AUTHORS   Matunis,M.J., Xing,J. and Dreyfuss,G.
  TITLE     The hnRNP F protein: unique primary structure, nucleic acid-binding
            properties, and subcellular localization
  JOURNAL   Nucleic Acids Res 22 (6), 1059-1067 (1994)
   PUBMED   7512260
REFERENCE   9  (bases 1 to 2240)
  AUTHORS   Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
            Vandekerckhove,J.
  TITLE     Microsequences of 145 proteins recorded in the two-dimensional gel
            protein database of normal human epidermal keratinocytes
  JOURNAL   Electrophoresis 13 (12), 960-969 (1992)
   PUBMED   1286667
REFERENCE   10 (bases 1 to 2240)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA204744.1, BC001348.2 and
            BQ028714.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001257293.1.
            
            Summary: This gene encodes a member of a subfamily of ubiquitously
            expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The
            hnRNPs are RNA binding proteins that complex with heterogeneous
            nuclear RNA. These proteins are associated with pre-mRNAs in the
            nucleus and appear to influence pre-mRNA processing and other
            aspects of mRNA metabolism and transport. While all of the hnRNPs
            are present in the nucleus, some may shuttle between the nucleus
            and the cytoplasm. The hnRNP proteins have distinct nucleic acid
            binding properties. The protein encoded by this gene has three
            repeats of quasi-RRM domains that bind to RNA and is very similar
            to the family member HNRPF. This gene may be associated with
            hereditary lymphedema type I. Alternatively spliced transcript
            variants have been described [provided by RefSeq, Mar 2012].
            
            Transcript Variant: This variant (1) encodes isoform a. Variants 1,
            2, 12-18, and 40 all encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GQ901012.1, BC001348.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393432.9/ ENSP00000377082.4
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DA204744.1         40-51
            13-1629             BC001348.2         1-1617
            1630-2238           BQ028714.1         19-627              c
            2239-2240           BC001348.2         2224-2225
FEATURES             Location/Qualifiers
     source          1..2240
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..2240
                     /gene="HNRNPH1"
                     /gene_synonym="hnRNPH; HNRPH; HNRPH1; NEDCDS"
                     /note="heterogeneous nuclear ribonucleoprotein H1"
                     /db_xref="GeneID:3187"
                     /db_xref="HGNC:HGNC:5041"
                     /db_xref="MIM:601035"
     exon            1..77
                     /gene="HNRNPH1"
                     /gene_synonym="hnRNPH; HNRPH; HNRPH1; NEDCDS"
                     /inference="alignment:Splign:2.1.0"
     exon            78..205
                     /gene="HNRNPH1"
                     /gene_synonym="hnRNPH; HNRPH; HNRPH1; NEDCDS"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1458
                     /gene="HNRNPH1"
                     /gene_synonym="hnRNPH; HNRPH; HNRPH1; NEDCDS"
                     /note="isoform a is encoded by transcript variant 1;
                     heterogeneous nuclear ribonucleoprotein H; heterogeneous
                     nuclear ribonucleoprotein H1 (H); epididymis secretory
                     sperm binding protein"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein H
                     isoform a"
                     /protein_id="NP_001244222.1"
                     /db_xref="CCDS:CCDS4446.1"
                     /db_xref="GeneID:3187"
                     /db_xref="HGNC:HGNC:5041"
                     /db_xref="MIM:601035"
                     /translation="MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIR
                     FIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNNVEMDWVLKHTGP
                     NSPDTANDGFVRLRGLPFGCSKEEIVQFFSGLEIVPNGITLPVDFQGRSTGEAFVQFA
                     SQEIAEKALKKHKERIGHRYIEIFKSSRAEVRTHYDPPRKLMAMQRPGPYDRPGAGRG
                     YNSIGRGAGFERMRRGAYGGGYGGYDDYNGYNDGYGFGSDRFGRDLNYCFSGMSDHRY
                     GDGGSTFQSTTGHCVHMRGLPYRATENDIYNFFSPLNPVRVHIEIGPDGRVTGEADVE
                     FATHEDAVAAMSKDKANMQHRYVELFLNSTAGASGGAYEHRYVELFLNSTAGASGGAY
                     GSQMMGGMGLSNQSSYGGPASQQLSGGYGGGYGGQSSMSGYDQVLQENSSDFQSNIA"
     exon            206..361
                     /gene="HNRNPH1"
                     /gene_synonym="hnRNPH; HNRPH; HNRPH1; NEDCDS"
                     /inference="alignment:Splign:2.1.0"
     exon            362..505
                     /gene="HNRNPH1"
                     /gene_synonym="hnRNPH; HNRPH; HNRPH1; NEDCDS"
                     /inference="alignment:Splign:2.1.0"
     exon            506..644
                     /gene="HNRNPH1"
                     /gene_synonym="hnRNPH; HNRPH; HNRPH1; NEDCDS"
                     /inference="alignment:Splign:2.1.0"
     exon            645..823
                     /gene="HNRNPH1"
                     /gene_synonym="hnRNPH; HNRPH; HNRPH1; NEDCDS"
                     /inference="alignment:Splign:2.1.0"
     exon            824..895
                     /gene="HNRNPH1"
                     /gene_synonym="hnRNPH; HNRPH; HNRPH1; NEDCDS"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1029
                     /gene="HNRNPH1"
                     /gene_synonym="hnRNPH; HNRPH; HNRPH1; NEDCDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1165
                     /gene="HNRNPH1"
                     /gene_synonym="hnRNPH; HNRPH; HNRPH1; NEDCDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1225
                     /gene="HNRNPH1"
                     /gene_synonym="hnRNPH; HNRPH; HNRPH1; NEDCDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1315
                     /gene="HNRNPH1"
                     /gene_synonym="hnRNPH; HNRPH; HNRPH1; NEDCDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1408
                     /gene="HNRNPH1"
                     /gene_synonym="hnRNPH; HNRPH; HNRPH1; NEDCDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1458
                     /gene="HNRNPH1"
                     /gene_synonym="hnRNPH; HNRPH; HNRPH1; NEDCDS"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..2240
                     /gene="HNRNPH1"
                     /gene_synonym="hnRNPH; HNRPH; HNRPH1; NEDCDS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2215..2220
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPH1"
                     /gene_synonym="hnRNPH; HNRPH; HNRPH1; NEDCDS"
                     /note="hexamer: AATAAA"
     polyA_site      2240
                     /gene="HNRNPH1"
                     /gene_synonym="hnRNPH; HNRPH; HNRPH1; NEDCDS"
                     /note="major polyA site"
ORIGIN      
        1 catttcgtct tagccacgca gaagtcgcgt gtctaggtga gtcgcggtgg gtcctcgctt
       61 gcagttcagc gaccacgttt gtttcgacgc cggaccgcgt aagagacgat gatgttgggc
      121 acggaaggtg gagagggatt cgtggtgaag gtccggggct tgccctggtc ttgctcggcc
      181 gatgaagtgc agaggttttt ttctgactgc aaaattcaaa atggggctca aggtattcgt
      241 ttcatctaca ccagagaagg cagaccaagt ggcgaggctt ttgttgaact tgaatcagaa
      301 gatgaagtca aattggccct gaaaaaagac agagaaacta tgggacacag atatgttgaa
      361 gtattcaagt caaacaacgt tgaaatggat tgggtgttga agcatactgg tccaaatagt
      421 cctgacacgg ccaatgatgg ctttgtacgg cttagaggac ttccctttgg atgtagcaag
      481 gaagaaattg ttcagttctt ctcagggttg gaaatcgtgc caaatgggat aacattgccg
      541 gtggacttcc aggggaggag tacgggggag gccttcgtgc agtttgcttc acaggaaata
      601 gctgaaaagg ctctaaagaa acacaaggaa agaatagggc acaggtatat tgaaatcttt
      661 aagagcagta gagctgaagt tagaactcat tatgatccac cacgaaagct tatggccatg
      721 cagcggccag gtccttatga cagacctggg gctggtagag ggtataacag cattggcaga
      781 ggagctggct ttgagaggat gaggcgtggt gcttatggtg gaggctatgg aggctatgat
      841 gattacaatg gctataatga tggctatgga tttgggtcag atagatttgg aagagacctc
      901 aattactgtt tttcaggaat gtctgatcac agatacgggg atggtggctc tactttccag
      961 agcacaacag gacactgtgt acacatgcgg ggattacctt acagagctac tgagaatgac
     1021 atttataatt ttttttcacc gctcaaccct gtgagagtac acattgaaat tggtcctgat
     1081 ggcagagtaa ctggtgaagc agatgtcgag ttcgcaactc atgaagatgc tgtggcagct
     1141 atgtcaaaag acaaagcaaa tatgcaacac agatatgtag aactcttctt gaattctaca
     1201 gcaggagcaa gcggtggtgc ttacgaacac agatatgtag aactcttctt gaattctaca
     1261 gcaggagcaa gcggtggtgc ttatggtagc caaatgatgg gaggcatggg cttgtcaaac
     1321 cagtccagct acgggggccc agccagccag cagctgagtg ggggttacgg aggcggctac
     1381 ggtggccaga gcagcatgag tggatacgac caagttttac aggaaaactc cagtgatttt
     1441 caatcaaaca ttgcataggt aaccaaggag cagtgaacag cagctactac agtagtggaa
     1501 gccgtgcatc tatgggcgtg aacggaatgg gagggttgtc tagcatgtcc agtatgagtg
     1561 gtggatgggg aatgtaattg atcgatcctg atcactgact cttggtcaac cttttttttt
     1621 tttttttttt tttctttaag aaaacttcag tttaacagtt tctgcaatac aagcttgtga
     1681 tttatgctta ctctaagtgg aaatcaggat tgttatgaag acttaaggcc cagtattttt
     1741 gaatacaata ctcatctagg atgtaacagt gaagctgagt aaactataac tgttaaactt
     1801 aagttccagc ttttctcaag ttagttatag gatgtactta agcagtaagc gtatttaggt
     1861 aaaagcagtt gaattatgtt aaatgttgcc ctttgccacg ttaaattgaa cactgttttg
     1921 gatgcatgtt gaaagacatg cttttatttt tttgtaaaac aatataggag ctgtgtctac
     1981 tattaaaagt gaaacatttt ggcatgtttg ttaattctag tttcatttaa taacctgtaa
     2041 ggcacgtaag tttaagcttt tttttttttt aagttaatgg gaaaaatttg agacgcaata
     2101 ccaatactta ggattttggt cttggtgttt gtatgaaatt ctgaggcctt gatttaaatc
     2161 tttcattgta ttgtgatttc cttttaggta tattgcgcta agtgaaactt gtcaaataaa
     2221 tcctcctttt aaaaactgca
//
