LOCUS       NM_031372               4372 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens heterogeneous nuclear ribonucleoprotein D like
            (HNRNPDL), transcript variant 2, mRNA.
ACCESSION   NM_031372
VERSION     NM_031372.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4372)
  AUTHORS   Garcia-Pardo,J., Bartolome-Nafria,A., Chaves-Sanjuan,A.,
            Gil-Garcia,M., Visentin,C., Bolognesi,M., Ricagno,S. and Ventura,S.
  TITLE     Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid
            associated with limb-girdle muscular dystrophy D3
  JOURNAL   Nat Commun 14 (1), 239 (2023)
   PUBMED   36646699
  REMARK    GeneRIF: Cryo-EM structure of hnRNPDL-2 fibrils, a functional
            amyloid associated with limb-girdle muscular dystrophy D3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4372)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 4372)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 4372)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4372)
  AUTHORS   Ji,D., Zhang,P., Ma,W., Fei,Y., Xue,W., Wang,Y., Zhang,X., Zhou,H.
            and Zhao,Y.
  TITLE     Oncogenic heterogeneous nuclear ribonucleoprotein D-like modulates
            the growth and imatinib response of human chronic myeloid leukemia
            CD34+ cells via pre-B-cell leukemia homeobox 1
  JOURNAL   Oncogene 39 (2), 443-453 (2020)
   PUBMED   31488872
  REMARK    GeneRIF: HNRPDL transforms hematopoietic cells and a novel
            HNRPDL/PBX1 axis plays an important role in human CML CD34(+) cells
REFERENCE   6  (bases 1 to 4372)
  AUTHORS   Boopathi,E., Lenka,N., Prabu,S.K., Fang,J.K., Wilkinson,F.,
            Atchison,M., Giallongo,A. and Avadhani,N.G.
  TITLE     Regulation of murine cytochrome c oxidase Vb gene expression during
            myogenesis: YY-1 and heterogeneous nuclear ribonucleoprotein D-like
            protein (JKTBP1) reciprocally regulate transcription activity by
            physical interaction with the BERF-1/ZBP-89 factor
  JOURNAL   J Biol Chem 279 (34), 35242-35254 (2004)
   PUBMED   15190078
REFERENCE   7  (bases 1 to 4372)
  AUTHORS   Kawamura,H., Tomozoe,Y., Akagi,T., Kamei,D., Ochiai,M. and
            Yamada,M.
  TITLE     Identification of the nucleocytoplasmic shuttling sequence of
            heterogeneous nuclear ribonucleoprotein D-like protein JKTBP and
            its interaction with mRNA
  JOURNAL   J Biol Chem 277 (4), 2732-2739 (2002)
   PUBMED   11705999
REFERENCE   8  (bases 1 to 4372)
  AUTHORS   Kamei,D., Tsuchiya,N., Yamazaki,M., Meguro,H. and Yamada,M.
  TITLE     Two forms of expression and genomic structure of the human
            heterogeneous nuclear ribonucleoprotein D-like JKTBP gene (HNRPDL)
  JOURNAL   Gene 228 (1-2), 13-22 (1999)
   PUBMED   10072754
REFERENCE   9  (bases 1 to 4372)
  AUTHORS   Doi,A., Shiosaka,T., Takaoka,Y., Yanagisawa,K. and Fujita,S.
  TITLE     Molecular cloning of the cDNA encoding A + U-rich element RNA
            binding factor
  JOURNAL   Biochim Biophys Acta 1396 (1), 51-56 (1998)
   PUBMED   9524220
REFERENCE   10 (bases 1 to 4372)
  AUTHORS   Tsuchiya,N., Kamei,D., Takano,A., Matsui,T. and Yamada,M.
  TITLE     Cloning and characterization of a cDNA encoding a novel
            heterogeneous nuclear ribonucleoprotein-like protein and its
            expression in myeloid leukemia cells
  JOURNAL   J Biochem 123 (3), 499-507 (1998)
   PUBMED   9538234
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC110787.3, AB017019.1,
            BC071944.1, AC124016.3 and CK300994.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 7, 2020 this sequence version replaced NM_031372.3.
            
            Summary: This gene belongs to the subfamily of ubiquitously
            expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The
            hnRNPs are RNA binding proteins and they complex with heterogeneous
            nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs
            in the nucleus and appear to influence pre-mRNA processing and
            other aspects of mRNA metabolism and transport. While all of the
            hnRNPs are present in the nucleus, some seem to shuttle between the
            nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic
            acid binding properties. The protein encoded by this gene has two
            RRM domains that bind to RNAs. Three alternatively spliced
            transcript variants have been described for this gene. One of the
            variants is probably not translated because the transcript is a
            candidate for nonsense-mediated mRNA decay. The protein isoforms
            encoded by this gene are similar to its family member HNRPD.
            [provided by RefSeq, May 2011].
            
            Transcript Variant: This variant (2) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.941983.1,
                                           SRR18074967.510806.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2163105, SAMEA2467146
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295470.10/ ENSP00000295470.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-237               AC110787.3         85-321              c
            238-656             AB017019.1         1-419
            657-2313            BC071944.1         1-1657
            2314-4257           AC124016.3         92761-94704         c
            4258-4372           CK300994.1         23-137              c
FEATURES             Location/Qualifiers
     source          1..4372
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.22"
     gene            1..4372
                     /gene="HNRNPDL"
                     /gene_synonym="HNRNP; HNRPDL; JKTBP; JKTBP2; laAUF1;
                     LGMD1G; LGMDD3"
                     /note="heterogeneous nuclear ribonucleoprotein D like"
                     /db_xref="GeneID:9987"
                     /db_xref="HGNC:HGNC:5037"
                     /db_xref="MIM:607137"
     exon            1..1215
                     /gene="HNRNPDL"
                     /gene_synonym="HNRNP; HNRPDL; JKTBP; JKTBP2; laAUF1;
                     LGMD1G; LGMDD3"
                     /inference="alignment:Splign:2.1.0"
     CDS             773..2035
                     /gene="HNRNPDL"
                     /gene_synonym="HNRNP; HNRPDL; JKTBP; JKTBP2; laAUF1;
                     LGMD1G; LGMDD3"
                     /note="isoform a is encoded by transcript variant 2;
                     A+U-rich element RNA binding factor; hnRNP DL; hnRNP
                     D-like; protein laAUF1; JKT41-binding protein; AU-rich
                     element RNA-binding factor; limb girdle muscular dystrophy
                     1G (autosomal dominant)"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein D-like
                     isoform a"
                     /protein_id="NP_112740.1"
                     /db_xref="CCDS:CCDS3593.1"
                     /db_xref="GeneID:9987"
                     /db_xref="HGNC:HGNC:5037"
                     /db_xref="MIM:607137"
                     /translation="MEVPPRLSHVPPPLFPSAPATLASRSLSHWRPRPPRQLAPLLPS
                     LAPSSARQGARRAQRHVTAQQPSRLAGGAAIKGGRRRRPDLFRRHFKSSSIQRSAAAA
                     AATRTARQHPPADSSVTMEDMNEYSNIEEFAEGSKINASKNQQDDGKMFIGGLSWDTS
                     KKDLTEYLSRFGEVVDCTIKTDPVTGRSRGFGFVLFKDAASVDKVLELKEHKLDGKLI
                     DPKRAKALKGKEPPKKVFVGGLSPDTSEEQIKEYFGAFGEIENIELPMDTKTNERRGF
                     CFITYTDEEPVKKLLESRYHQIGSGKCEIKVAQPKEVYRQQQQQQKGGRGAAAGGRGG
                     TRGRGRGQGQNWNQGFNNYYDQGYGNYNSAYGGDQNYSGYGGYDYTGYNYGNYGYGQG
                     YADYSGQQSTYGKASRGGGNHQNNYQPY"
     exon            1216..1384
                     /gene="HNRNPDL"
                     /gene_synonym="HNRNP; HNRPDL; JKTBP; JKTBP2; laAUF1;
                     LGMD1G; LGMDD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1546
                     /gene="HNRNPDL"
                     /gene_synonym="HNRNP; HNRPDL; JKTBP; JKTBP2; laAUF1;
                     LGMD1G; LGMDD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1678
                     /gene="HNRNPDL"
                     /gene_synonym="HNRNP; HNRPDL; JKTBP; JKTBP2; laAUF1;
                     LGMD1G; LGMDD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1793
                     /gene="HNRNPDL"
                     /gene_synonym="HNRNP; HNRPDL; JKTBP; JKTBP2; laAUF1;
                     LGMD1G; LGMDD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1964
                     /gene="HNRNPDL"
                     /gene_synonym="HNRNP; HNRPDL; JKTBP; JKTBP2; laAUF1;
                     LGMD1G; LGMDD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2057
                     /gene="HNRNPDL"
                     /gene_synonym="HNRNP; HNRPDL; JKTBP; JKTBP2; laAUF1;
                     LGMD1G; LGMDD3"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..4372
                     /gene="HNRNPDL"
                     /gene_synonym="HNRNP; HNRPDL; JKTBP; JKTBP2; laAUF1;
                     LGMD1G; LGMDD3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2293..2298
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPDL"
                     /gene_synonym="HNRNP; HNRPDL; JKTBP; JKTBP2; laAUF1;
                     LGMD1G; LGMDD3"
                     /note="hexamer: AATAAA"
     polyA_site      2318
                     /gene="HNRNPDL"
                     /gene_synonym="HNRNP; HNRPDL; JKTBP; JKTBP2; laAUF1;
                     LGMD1G; LGMDD3"
                     /note="major polyA site"
     regulatory      3713..3718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPDL"
                     /gene_synonym="HNRNP; HNRPDL; JKTBP; JKTBP2; laAUF1;
                     LGMD1G; LGMDD3"
                     /note="hexamer: AATAAA"
     polyA_site      3734
                     /gene="HNRNPDL"
                     /gene_synonym="HNRNP; HNRPDL; JKTBP; JKTBP2; laAUF1;
                     LGMD1G; LGMDD3"
                     /note="major polyA site"
     regulatory      4349..4354
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPDL"
                     /gene_synonym="HNRNP; HNRPDL; JKTBP; JKTBP2; laAUF1;
                     LGMD1G; LGMDD3"
                     /note="hexamer: ATTAAA"
     polyA_site      4372
                     /gene="HNRNPDL"
                     /gene_synonym="HNRNP; HNRPDL; JKTBP; JKTBP2; laAUF1;
                     LGMD1G; LGMDD3"
ORIGIN      
        1 aacaaagaag cgaacgcggg agcagggtgc gcgagagcgc gccctccgca gacaggttga
       61 gcgagcggga gaggcccggg gcacgtgcag aaaggagccc cgcgagtggc gcgccgggga
      121 tgtgagtgcc ccttgccctc tactgaatcc agccccctcc ccgcccaccg cctccgcctt
      181 tgcatagata cagtcatctg gccagccccc gcccctcctc ccggcgtcag cccgccagag
      241 gccgcgcggg gcccgggctt cggccgatca gcccgggagg ccccgccgcg cccccttggc
      301 ccgcgcgccc gtggtcacag tggaagaggc gcccgcgctg cgctgcccgg aggagccgtc
      361 gcgcgcccgc ttcctgttcg gctggttcct gccagctcga ggacaaaaca cgcgtgcgcg
      421 cggcgggcga gcgcgctcgc cgcctcagtc gccagcgccg ggcgcagtcc gcctttttcc
      481 ggagcagact ggccgcggtg ctagtcggta gcagcggccg ccgcagcggc tccgcactgg
      541 cgaaccgagg gcagaaaaag gcggggttga cggctttttg gtaggagtgg gctggaccgg
      601 acgccagaga caaaggctcc caaggcaaga gggactgtgg ccctgcgtcg gctctgctcg
      661 ggactgctga ccccaggaat ttacgcccct tcgtttttct cttctgattc ttctcttctc
      721 ccaagcccgc gtcccctcac gcgtggcctc tctccttgcc gggagggccg cgatggaggt
      781 cccgcccagg ctttcccatg tgccgccgcc attgttcccc tccgctcccg ctactttagc
      841 ctcccgcagc ctctcccatt ggcggccgcg gccgccgcgg cagctagccc cgctcctccc
      901 ttcgctcgct cccagctccg cccggcaggg ggcgcgccgg gcccagcgcc acgtcaccgc
      961 ccagcagccc tcccgattgg cgggcggggc ggctataaag ggagggcgca ggcggcgccc
     1021 ggatctcttc cgccgccatt ttaaatccag ctccatacaa cgctccgccg ccgctgctgc
     1081 cgcgacccgg actgcgcgcc agcacccccc tgccgacagc tccgtcacta tggaggatat
     1141 gaacgagtac agcaatatag aggaattcgc agagggatcc aagatcaacg cgagcaagaa
     1201 tcagcaggat gacggtaaaa tgtttattgg aggcttgagc tgggatacaa gcaaaaaaga
     1261 tctgacagag tacttgtctc gatttgggga agttgtagac tgcacaatta aaacagatcc
     1321 agtcactggg agatcaagag gatttggatt tgtgcttttc aaagatgctg ctagtgttga
     1381 taaggttttg gaactgaaag aacacaaact ggatggcaaa ttgatagatc ccaaaagggc
     1441 caaagcttta aaagggaaag aacctcccaa aaaggttttt gtgggtggat tgagcccgga
     1501 tacttctgaa gaacaaatta aagaatattt tggagccttt ggagagattg aaaatattga
     1561 acttcccatg gatacaaaaa caaatgaaag aagaggattt tgttttatca catatactga
     1621 tgaagagcca gtaaaaaaat tgttagaaag cagataccat caaattggtt ctgggaagtg
     1681 tgaaatcaaa gttgcacaac ccaaagaggt atataggcag caacagcaac aacaaaaagg
     1741 tggaagaggt gctgcagctg gtggacgagg tggtacgagg ggtcgtggcc gaggtcaggg
     1801 ccaaaactgg aaccaaggat ttaataacta ttatgatcaa ggatatggaa attacaatag
     1861 tgcctatggt ggtgatcaaa actatagtgg ctatggcgga tatgattata ctgggtataa
     1921 ctatgggaac tatggatatg gacagggata tgcagactac agtggccaac agagcactta
     1981 tggcaaggca tctcgagggg gtggcaatca ccaaaacaat taccagccat actaaaggag
     2041 aacattggag aaaacaggag gagatgttaa agtaacccat cttgcaggac gacattgaag
     2101 attggtcttc tgttgatcta agatgattat tttgtaaaag actttctagt gtacaagaca
     2161 ccattgtgtc caactgtata tagctgccaa ttagttttct ttgtttttac tttgtccttt
     2221 gctatctgtg ttatgactca atgtggattt gtttatacac attttatttg tatcatttca
     2281 tgttaaacct caaataaatg cttccttatg tgattgcttt tctgcgtcag gtactacata
     2341 gctctgtaaa aaatgtaatt taaaataagc aataattaag gcacagttga ttttgtagag
     2401 tattggtcca tacagagaaa ctgtggtcct ttataaatag ccagccagcg tcaccctctt
     2461 ctccaatttg taggtgtatt ttatgctctt aaggcttcat cttctccctg taactgagat
     2521 ttctaccaca cctttgaaca atgttctttc ccttctggtt atctgaagac tgtcctgaaa
     2581 ggaagacata agtgttgtga ttagtagaag ctttctagta gaccatattt cttctggatt
     2641 gtaataaaat tgttagtagc tccttttact ttgttcctgt ctctggaaag ccatttttga
     2701 attgctgatt actttggctt taatcagtgg tcacctagaa aaagctttgt aatcataaca
     2761 caatgagtaa ttcttgataa aagttcagat acaaaaggag cactgtaaaa ctggtaggag
     2821 ctatggttta agagcattgg aagtagttac aactcaagga ttttggtaga aaggtatgag
     2881 tttggtcgaa aaattaaaat agtggcaaaa taagatttag ttgtgttttc tcagagccgc
     2941 cacaagattg aacaaaatgt tttctgtttg ggcatcctga ggaagttgta ttagctgtta
     3001 atgctctgtg agtttagaaa aagtcttgat agtaaatcta gtttttgaca cagtgcatga
     3061 actaagtagt taaatattta catattcaga aaggaatagt ggaaaaggta tcttggttat
     3121 gacaaagtca ttacaaatgt gactaagtca ttacaaatgt gactgagtca ttacagtgga
     3181 ccctctgggt gcattgaaaa gaatccgttt tatatccagg tttcagagga cctggaataa
     3241 taaaaagctt tggattttgc attcagtgta gttggatttt gggaccttgg cctcagtgtt
     3301 atttactggg attggcatac gtgttcacag gcagagtagt tgatctcaca caacgggtga
     3361 tctcacaaaa ctggtaagtt tcttatgctc atgagccctc cctttttttt tttaatttgg
     3421 tgcctgcaac tttcttaaca atgattctac ttcctgggct atcacattat aatgctcttg
     3481 gcctcttttt tgctgctgtt ttgctattct taaacttagg ccaagtacca atgttggctg
     3541 ttagaaggga ttctgttcat tcaacatgca actttaggga atggaagtaa gttcattttt
     3601 aagttgtgtt gtcagtaggt gcggtgtcta gggtagtgaa tcctgtaagt tcaaatttat
     3661 gattaggtga cgagttgaca ttgagattgt ccttttccct gatcaaaaaa tgaataaagc
     3721 ctttttaaac aaaatccaaa cttttaatca agtcttgata tgtatgactg agaaaaaata
     3781 cactacatct agagatgatt gagatgtttt gcaaagaatt gaagggggag tgagaattgg
     3841 tttttcttgc aggggctttg aactctagat ttgggctttg aactctagat ttaattcaga
     3901 tttcagggtc tatcagttca ccaactgatg caaatttgaa cagatactct aaggctaagt
     3961 gtcctaggtt ggatgaactg aagctactat caagatctcg ttcccaagga ttaatttaga
     4021 acaaagtaat tggacaagtt tattggggag gggatagaaa tgaattctaa agtacctata
     4081 acaaatactc tgtgtatgtt ttttacatcg tatttgcctt ttacattgtt tagaccaaat
     4141 tctgtgtgat gttatcctcg ggaagaggat agaaattaat tctaaagtac ctataacaaa
     4201 tgctcggttt gtatatgttt ttatacatcg tatttgcctt ttgcattgtt cagaccaaat
     4261 tctgtgtgat gttatcctaa caaaacacct tagtaatttc tttggttaac atgttaatct
     4321 gtaatctcac ttttataaga tgaggactat taaaatgaga tgtctgttgg ga
//
