LOCUS       NM_031370               3068 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens heterogeneous nuclear ribonucleoprotein D (HNRNPD),
            transcript variant 1, mRNA.
ACCESSION   NM_031370
VERSION     NM_031370.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3068)
  AUTHORS   Wei,Z., Zhang,C., Song,Y., Han,D., Liu,J., Song,X., Chao,F.,
            Wang,S., Xu,G. and Chen,G.
  TITLE     CircUBE3A(2,3,4,5) promotes adenylate-uridylate-rich binding factor
            1 nuclear translocation to suppress prostate cancer metastasis
  JOURNAL   Cancer Lett 588, 216743 (2024)
   PUBMED   38423246
  REMARK    GeneRIF: CircUBE3A(2,3,4,5) promotes adenylate-uridylate-rich
            binding factor 1 nuclear translocation to suppress prostate cancer
            metastasis.
REFERENCE   2  (bases 1 to 3068)
  AUTHORS   Chang,S., Wang,Y., Wang,X., Liu,H., Zhang,T., Zheng,Y., Wang,X.,
            Shan,G. and Chen,L.
  TITLE     HNRNPD regulates the biogenesis of circRNAs and the ratio of mRNAs
            to circRNAs for a set of genes
  JOURNAL   RNA Biol 21 (1), 1-15 (2024)
   PUBMED   39180763
  REMARK    GeneRIF: HNRNPD regulates the biogenesis of circRNAs and the ratio
            of mRNAs to circRNAs for a set of genes.
REFERENCE   3  (bases 1 to 3068)
  AUTHORS   Wu,Y., Xu,M., Feng,Z., Wu,H., Wu,J., Ha,X., Wu,Y., Chen,S., Xu,F.,
            Wen,H., Li,S. and Wu,X.
  TITLE     AUF1-induced circular RNA hsa_circ_0010467 promotes platinum
            resistance of ovarian cancer through miR-637/LIF/STAT3 axis
  JOURNAL   Cell Mol Life Sci 80 (9), 256 (2023)
   PUBMED   37589744
  REMARK    GeneRIF: AUF1-induced circular RNA hsa_circ_0010467 promotes
            platinum resistance of ovarian cancer through miR-637/LIF/STAT3
            axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3068)
  AUTHORS   Salvato,I., Ricciardi,L., Dal Col,J., Nigro,A., Giurato,G.,
            Memoli,D., Sellitto,A., Lamparelli,E.P., Crescenzi,M.A., Vitale,M.,
            Vatrella,A., Nucera,F., Brun,P., Caicci,F., Dama,P., Stiff,T.,
            Castellano,L., Idrees,S., Johansen,M.D., Faiz,A., Wark,P.A.,
            Hansbro,P.M., Adcock,I.M., Caramori,G. and Stellato,C.
  TITLE     Expression of targets of the RNA-binding protein AUF-1 in human
            airway epithelium indicates its role in cellular senescence and
            inflammation
  JOURNAL   Front Immunol 14, 1192028 (2023)
   PUBMED   37483631
  REMARK    GeneRIF: Expression of targets of the RNA-binding protein AUF-1 in
            human airway epithelium indicates its role in cellular senescence
            and inflammation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3068)
  AUTHORS   Zhang,J., Zhang,T., Guan,G., Wen,J., Chen,C.C., Liu,J., Duan,Y.,
            Liu,Y. and Chen,X.
  TITLE     AUF1 promotes hepatocellular carcinoma progression and
            chemo-resistance by post-transcriptionally upregulating
            alpha-fetoprotein expression
  JOURNAL   Pathol Res Pract 245, 154441 (2023)
   PUBMED   37060820
  REMARK    GeneRIF: AUF1 promotes hepatocellular carcinoma progression and
            chemo-resistance by post-transcriptionally upregulating
            alpha-fetoprotein expression.
REFERENCE   6  (bases 1 to 3068)
  AUTHORS   Kajita,Y., Nakayama,J., Aizawa,M. and Ishikawa,F.
  TITLE     The UUAG-specific RNA binding protein, heterogeneous nuclear
            ribonucleoprotein D0. Common modular structure and binding
            properties of the 2xRBD-Gly family
  JOURNAL   J Biol Chem 270 (38), 22167-22175 (1995)
   PUBMED   7673195
REFERENCE   7  (bases 1 to 3068)
  AUTHORS   Zhang,W., Wagner,B.J., Ehrenman,K., Schaefer,A.W., DeMaria,C.T.,
            Crater,D., DeHaven,K., Long,L. and Brewer,G.
  TITLE     Purification, characterization, and cDNA cloning of an AU-rich
            element RNA-binding protein, AUF1
  JOURNAL   Mol Cell Biol 13 (12), 7652-7665 (1993)
   PUBMED   8246982
REFERENCE   8  (bases 1 to 3068)
  AUTHORS   Ishikawa,F., Matunis,M.J., Dreyfuss,G. and Cech,T.R.
  TITLE     Nuclear proteins that bind the pre-mRNA 3' splice site sequence
            r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n
  JOURNAL   Mol Cell Biol 13 (7), 4301-4310 (1993)
   PUBMED   8321232
REFERENCE   9  (bases 1 to 3068)
  AUTHORS   Tay,N., Chan,S.H. and Ren,E.C.
  TITLE     Identification and cloning of a novel heterogeneous nuclear
            ribonucleoprotein C-like protein that functions as a
            transcriptional activator of the hepatitis B virus enhancer II
  JOURNAL   J Virol 66 (12), 6841-6848 (1992)
   PUBMED   1433497
REFERENCE   10 (bases 1 to 3068)
  AUTHORS   Lahiri,D.K. and Thomas,J.O.
  TITLE     A cDNA clone of the hnRNP C proteins and its homology with the
            single-stranded DNA binding protein UP2
  JOURNAL   Nucleic Acids Res 14 (10), 4077-4094 (1986)
   PUBMED   3754960
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM825808.1, BC023977.2,
            BC002401.1, AF039575.1, BG180865.1, BG180941.1, BM832779.1,
            BF693760.1 and AC124016.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_031370.2.
            
            Summary: This gene belongs to the subfamily of ubiquitously
            expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The
            hnRNPs are nucleic acid binding proteins and they complex with
            heterogeneous nuclear RNA (hnRNA). These proteins are associated
            with pre-mRNAs in the nucleus and appear to influence pre-mRNA
            processing and other aspects of mRNA metabolism and transport.
            While all of the hnRNPs are present in the nucleus, some seem to
            shuttle between the nucleus and the cytoplasm. The hnRNP proteins
            have distinct nucleic acid binding properties. The protein encoded
            by this gene has two repeats of quasi-RRM domains that bind to
            RNAs. It localizes to both the nucleus and the cytoplasm. This
            protein is implicated in the regulation of mRNA stability.
            Alternative splicing of this gene results in four transcript
            variants. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a), also known as p45.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.58311.1,
                                           SRR1660803.102111.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146236 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313899.12/ ENSP00000313199.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BM825808.1         6-25
            21-1166             BC023977.2         1-1146
            1167-1737           BC002401.1         918-1488
            1738-2225           AF039575.1         1254-1741
            2226-2230           BG180865.1         561-565
            2231-2235           BG180941.1         579-583
            2236-2238           BM832779.1         384-386
            2239-2252           BF693760.1         300-313
            2253-3068           AC124016.3         22575-23390         c
FEATURES             Location/Qualifiers
     source          1..3068
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.22"
     gene            1..3068
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
                     /note="heterogeneous nuclear ribonucleoprotein D"
                     /db_xref="GeneID:3184"
                     /db_xref="HGNC:HGNC:5036"
                     /db_xref="MIM:601324"
     exon            1..546
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..1381
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
                     /note="isoform a is encoded by transcript variant 1;
                     ARE-binding protein AUFI, type A; heterogeneous nuclear
                     ribonucleoprotein D0; hnRNP D0; AU-rich element RNA
                     binding protein 1, 37kDa; AU-rich RNA-binding factor 1"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein D0
                     isoform a"
                     /protein_id="NP_112738.1"
                     /db_xref="CCDS:CCDS3592.1"
                     /db_xref="GeneID:3184"
                     /db_xref="HGNC:HGNC:5036"
                     /db_xref="MIM:601324"
                     /translation="MSEEQFGGDGAAAAATAAVGGSAGEQEGAMVAATQGAAAAAGSG
                     AGTGGGTASGGTEGGSAESEGAKIDASKNEEDEGHSNSSPRHSEAATAQREEWKMFIG
                     GLSWDTTKKDLKDYFSKFGEVVDCTLKLDPITGRSRGFGFVLFKESESVDKVMDQKEH
                     KLNGKVIDPKRAKAMKTKEPVKKIFVGGLSPDTPEEKIREYFGGFGEVESIELPMDNK
                     TNKRRGFCFITFKEEEPVKKIMEKKYHNVGLSKCEIKVAMSKEQYQQQQQWGSRGGFA
                     GRARGRGGGPSQNWNQGYSNYWNQGYGNYGYNSQGYGGYGGYDYTGYNNYYGYGDYSN
                     QQSGYGKVSRRGGHQNSYKPY"
     exon            547..603
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
                     /inference="alignment:Splign:2.1.0"
     exon            604..772
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
                     /inference="alignment:Splign:2.1.0"
     exon            773..934
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1066
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1166
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1313
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1411
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..3068
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1559..1564
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
                     /note="hexamer: ATTAAA"
     polyA_site      1579
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
     regulatory      1716..1721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
                     /note="hexamer: AATAAA"
     polyA_site      1737
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
                     /note="major polyA site"
     regulatory      2215..2220
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
                     /note="hexamer: ATTAAA"
     polyA_site      2235
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
     regulatory      3046..3051
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
                     /note="hexamer: AATAAA"
     polyA_site      3068
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
ORIGIN      
        1 gtcggccatt ttaggtggtc cgcggcggcg ccattaaagc gaggaggagg cgagagcggc
       61 cgccgctggt gcttattctt ttttagtgca gcgggagaga gcgggagtgt gcgccgcgcg
      121 agagtgggag gcgaaggggg caggccaggg agaggcgcag gagcctttgc agccacgcgc
      181 gcgccttccc tgtcttgtgt gcttcgcgag gtagagcggg cgcgcggcag cggcggggat
      241 tactttgctg ctagtttcgg ttcgcggcag cggcgggtgt agtctcggcg gcagcggcgg
      301 agacactagc actatgtcgg aggagcagtt cggcggggac ggggcggcgg cagcggcaac
      361 ggcggcggta ggcggctcgg cgggcgagca ggagggagcc atggtggcgg cgacacaggg
      421 ggcagcggcg gcggcgggaa gcggagccgg gaccgggggc ggaaccgcgt ctggaggcac
      481 cgaagggggc agcgccgagt cggagggggc gaagattgac gccagtaaga acgaggagga
      541 tgaaggccat tcaaactcct ccccacgaca ctctgaagca gcgacggcac agcgggaaga
      601 atggaaaatg tttataggag gccttagctg ggacactaca aagaaagatc tgaaggacta
      661 cttttccaaa tttggtgaag ttgtagactg cactctgaag ttagatccta tcacagggcg
      721 atcaaggggt tttggctttg tgctatttaa agaatcggag agtgtagata aggtcatgga
      781 tcaaaaagaa cataaattga atgggaaggt gattgatcct aaaagggcca aagccatgaa
      841 aacaaaagag ccggttaaaa aaatttttgt tggtggcctt tctccagata cacctgaaga
      901 gaaaataagg gagtactttg gtggttttgg tgaggtggaa tccatagagc tccccatgga
      961 caacaagacc aataagaggc gtgggttctg ctttattacc tttaaggaag aagaaccagt
     1021 gaagaagata atggaaaaga aataccacaa tgttggtctt agtaaatgtg aaataaaagt
     1081 agccatgtcg aaggaacaat atcagcaaca gcaacagtgg ggatctagag gaggatttgc
     1141 aggaagagct cgtggaagag gtggtggccc cagtcaaaac tggaaccagg gatatagtaa
     1201 ctattggaat caaggctatg gcaactatgg atataacagc caaggttacg gtggttatgg
     1261 aggatatgac tacactggtt acaacaacta ctatggatat ggtgattata gcaaccagca
     1321 gagtggttat gggaaggtat ccaggcgagg tggtcatcaa aatagctaca aaccatacta
     1381 aattattcca tttgcaactt atccccaaca ggtggtgaag cagtattttc caatttgaag
     1441 attcatttga aggtggctcc tgccacctgc taatagcagt tcaaactaaa ttttttgtat
     1501 caagtccctg aatggaagta tgacgttggg tccctctgaa gtttaattct gagttctcat
     1561 taaaagaaat ttgctttcat tgttttattt cttaattgct atgcttcaga atcaatttgt
     1621 gttttatgcc ctttccccca gtattgtaga gcaagtcttg tgttaaaagc ccagtgtgac
     1681 agtgtcatga tgtagtagtg tcttactggt tttttaataa atccttttgt ataaaaatgt
     1741 attggctctt ttatcatcag aataggaaaa attgtcatgg attcaagtta ttaaaagcat
     1801 aagtttggaa gacaggcttg ccgaaattga ggacatgatt aaaattgcag tgaagtttga
     1861 aatgttttta gcaaaatcta atttttgcca taatgtgtcc tccctgtcca aattgggaat
     1921 gacttaatgt caatttgttt gttggttgtt ttaataatac ttccttatgt agccattaag
     1981 atttatatga atattttccc aaatgcccag tttttgctta atatgtattg tgctttttag
     2041 aacaaatctg gataaatgtg caaaagtacc cctttgcaca gatagttaat gttttatgct
     2101 tccattaaat aaaaaggact taaaatctgt taattataat agaaatgcgg ctagttcaga
     2161 gagattttta gagctgtggt ggacttcata gatgaattca agtgttgagg gaggattaaa
     2221 gaaatatata ccgtgtttat gtgtgtgtgc ttatttgttt gaatgatttt attttccatt
     2281 tctcaaaggt tttatttttt tggttagggc cttaaaattt caggactgtg attattagta
     2341 tgtgtgccta aggaactttt tgagtcactc ttaagaaagt gaaactgaag agtctaagtg
     2401 ataactatag gattaagtca gaattgtttt tcctgtcatt tgttggaagc ttcttgagtt
     2461 ctgttattag cattcaggga attgataccc atcaacttga atggaaaatc gtttgtaggt
     2521 attacttaag tgaatgttaa gagttccacc ctgagtggta atctaaggct gtgcagtcag
     2581 ttacttcaga ctgctcagaa tagttcatta gaaaggtaac aaatgagaaa tgtattatta
     2641 tacagttcta tagtagtgaa gtgatggaat acctttctta cttttgtgga gttacatctg
     2701 atgctaagaa tttgacctcc aactaagcaa acattttaat gagcaaaagt tagtgttatt
     2761 aaagtttttt tatgatagat ccaaattgag gacctgtgtc ctgtttttat aagattgcaa
     2821 cccagctatg ctcatttgtt tatgttttgt atatggctgc ttttgtgtta cagtggtaga
     2881 gtttagtagt taggacagag acctgcaaag caaaataatt tacagtctgg ccctttacag
     2941 aaaagtttgc tgactcatgg tcaaaataaa tgaaaatttt ttgtgttagg gttgttaagc
     3001 tagggttctt tttggtatca tatgcttatt ttatgtaaat ctctcaataa aaaattattt
     3061 ttaagaga
//
