LOCUS       NM_002138               2921 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens heterogeneous nuclear ribonucleoprotein D (HNRNPD),
            transcript variant 3, mRNA.
ACCESSION   NM_002138
VERSION     NM_002138.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2921)
  AUTHORS   Wei,Z., Zhang,C., Song,Y., Han,D., Liu,J., Song,X., Chao,F.,
            Wang,S., Xu,G. and Chen,G.
  TITLE     CircUBE3A(2,3,4,5) promotes adenylate-uridylate-rich binding factor
            1 nuclear translocation to suppress prostate cancer metastasis
  JOURNAL   Cancer Lett 588, 216743 (2024)
   PUBMED   38423246
  REMARK    GeneRIF: CircUBE3A(2,3,4,5) promotes adenylate-uridylate-rich
            binding factor 1 nuclear translocation to suppress prostate cancer
            metastasis.
REFERENCE   2  (bases 1 to 2921)
  AUTHORS   Chang,S., Wang,Y., Wang,X., Liu,H., Zhang,T., Zheng,Y., Wang,X.,
            Shan,G. and Chen,L.
  TITLE     HNRNPD regulates the biogenesis of circRNAs and the ratio of mRNAs
            to circRNAs for a set of genes
  JOURNAL   RNA Biol 21 (1), 1-15 (2024)
   PUBMED   39180763
  REMARK    GeneRIF: HNRNPD regulates the biogenesis of circRNAs and the ratio
            of mRNAs to circRNAs for a set of genes.
REFERENCE   3  (bases 1 to 2921)
  AUTHORS   Wu,Y., Xu,M., Feng,Z., Wu,H., Wu,J., Ha,X., Wu,Y., Chen,S., Xu,F.,
            Wen,H., Li,S. and Wu,X.
  TITLE     AUF1-induced circular RNA hsa_circ_0010467 promotes platinum
            resistance of ovarian cancer through miR-637/LIF/STAT3 axis
  JOURNAL   Cell Mol Life Sci 80 (9), 256 (2023)
   PUBMED   37589744
  REMARK    GeneRIF: AUF1-induced circular RNA hsa_circ_0010467 promotes
            platinum resistance of ovarian cancer through miR-637/LIF/STAT3
            axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2921)
  AUTHORS   Salvato,I., Ricciardi,L., Dal Col,J., Nigro,A., Giurato,G.,
            Memoli,D., Sellitto,A., Lamparelli,E.P., Crescenzi,M.A., Vitale,M.,
            Vatrella,A., Nucera,F., Brun,P., Caicci,F., Dama,P., Stiff,T.,
            Castellano,L., Idrees,S., Johansen,M.D., Faiz,A., Wark,P.A.,
            Hansbro,P.M., Adcock,I.M., Caramori,G. and Stellato,C.
  TITLE     Expression of targets of the RNA-binding protein AUF-1 in human
            airway epithelium indicates its role in cellular senescence and
            inflammation
  JOURNAL   Front Immunol 14, 1192028 (2023)
   PUBMED   37483631
  REMARK    GeneRIF: Expression of targets of the RNA-binding protein AUF-1 in
            human airway epithelium indicates its role in cellular senescence
            and inflammation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2921)
  AUTHORS   Zhang,J., Zhang,T., Guan,G., Wen,J., Chen,C.C., Liu,J., Duan,Y.,
            Liu,Y. and Chen,X.
  TITLE     AUF1 promotes hepatocellular carcinoma progression and
            chemo-resistance by post-transcriptionally upregulating
            alpha-fetoprotein expression
  JOURNAL   Pathol Res Pract 245, 154441 (2023)
   PUBMED   37060820
  REMARK    GeneRIF: AUF1 promotes hepatocellular carcinoma progression and
            chemo-resistance by post-transcriptionally upregulating
            alpha-fetoprotein expression.
REFERENCE   6  (bases 1 to 2921)
  AUTHORS   Kajita,Y., Nakayama,J., Aizawa,M. and Ishikawa,F.
  TITLE     The UUAG-specific RNA binding protein, heterogeneous nuclear
            ribonucleoprotein D0. Common modular structure and binding
            properties of the 2xRBD-Gly family
  JOURNAL   J Biol Chem 270 (38), 22167-22175 (1995)
   PUBMED   7673195
REFERENCE   7  (bases 1 to 2921)
  AUTHORS   Zhang,W., Wagner,B.J., Ehrenman,K., Schaefer,A.W., DeMaria,C.T.,
            Crater,D., DeHaven,K., Long,L. and Brewer,G.
  TITLE     Purification, characterization, and cDNA cloning of an AU-rich
            element RNA-binding protein, AUF1
  JOURNAL   Mol Cell Biol 13 (12), 7652-7665 (1993)
   PUBMED   8246982
REFERENCE   8  (bases 1 to 2921)
  AUTHORS   Ishikawa,F., Matunis,M.J., Dreyfuss,G. and Cech,T.R.
  TITLE     Nuclear proteins that bind the pre-mRNA 3' splice site sequence
            r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n
  JOURNAL   Mol Cell Biol 13 (7), 4301-4310 (1993)
   PUBMED   8321232
REFERENCE   9  (bases 1 to 2921)
  AUTHORS   Tay,N., Chan,S.H. and Ren,E.C.
  TITLE     Identification and cloning of a novel heterogeneous nuclear
            ribonucleoprotein C-like protein that functions as a
            transcriptional activator of the hepatitis B virus enhancer II
  JOURNAL   J Virol 66 (12), 6841-6848 (1992)
   PUBMED   1433497
REFERENCE   10 (bases 1 to 2921)
  AUTHORS   Lahiri,D.K. and Thomas,J.O.
  TITLE     A cDNA clone of the hnRNP C proteins and its homology with the
            single-stranded DNA binding protein UP2
  JOURNAL   Nucleic Acids Res 14 (10), 4077-4094 (1986)
   PUBMED   3754960
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM825808.1, BC023977.2,
            AF039575.1, BF693760.1 and AC124016.3.
            
            On Aug 13, 2020 this sequence version replaced NM_002138.3.
            
            Summary: This gene belongs to the subfamily of ubiquitously
            expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The
            hnRNPs are nucleic acid binding proteins and they complex with
            heterogeneous nuclear RNA (hnRNA). These proteins are associated
            with pre-mRNAs in the nucleus and appear to influence pre-mRNA
            processing and other aspects of mRNA metabolism and transport.
            While all of the hnRNPs are present in the nucleus, some seem to
            shuttle between the nucleus and the cytoplasm. The hnRNP proteins
            have distinct nucleic acid binding properties. The protein encoded
            by this gene has two repeats of quasi-RRM domains that bind to
            RNAs. It localizes to both the nucleus and the cytoplasm. This
            protein is implicated in the regulation of mRNA stability.
            Alternative splicing of this gene results in four transcript
            variants. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) lacks an alternate in-frame
            segment, compared to variant 1. The resulting isoform (c), also
            known as p40, is shorter than isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF039575.1, BC023977.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142670, SAMEA2146236
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BM825808.1         6-25
            21-1590             BC023977.2         1-1570
            1591-2078           AF039575.1         1254-1741
            2079-2105           BF693760.1         287-313
            2106-2921           AC124016.3         22575-23390         c
FEATURES             Location/Qualifiers
     source          1..2921
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.22"
     gene            1..2921
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
                     /note="heterogeneous nuclear ribonucleoprotein D"
                     /db_xref="GeneID:3184"
                     /db_xref="HGNC:HGNC:5036"
                     /db_xref="MIM:601324"
     exon            1..546
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..1234
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
                     /note="isoform c is encoded by transcript variant 3;
                     ARE-binding protein AUFI, type A; heterogeneous nuclear
                     ribonucleoprotein D0; hnRNP D0; AU-rich element RNA
                     binding protein 1, 37kDa; AU-rich RNA-binding factor 1"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein D0
                     isoform c"
                     /protein_id="NP_002129.2"
                     /db_xref="CCDS:CCDS3590.1"
                     /db_xref="GeneID:3184"
                     /db_xref="HGNC:HGNC:5036"
                     /db_xref="MIM:601324"
                     /translation="MSEEQFGGDGAAAAATAAVGGSAGEQEGAMVAATQGAAAAAGSG
                     AGTGGGTASGGTEGGSAESEGAKIDASKNEEDEGHSNSSPRHSEAATAQREEWKMFIG
                     GLSWDTTKKDLKDYFSKFGEVVDCTLKLDPITGRSRGFGFVLFKESESVDKVMDQKEH
                     KLNGKVIDPKRAKAMKTKEPVKKIFVGGLSPDTPEEKIREYFGGFGEVESIELPMDNK
                     TNKRRGFCFITFKEEEPVKKIMEKKYHNVGLSKCEIKVAMSKEQYQQQQQWGSRGGFA
                     GRARGRGGDQQSGYGKVSRRGGHQNSYKPY"
     exon            547..603
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
                     /inference="alignment:Splign:2.1.0"
     exon            604..772
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
                     /inference="alignment:Splign:2.1.0"
     exon            773..934
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1066
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1166
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1264
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..2921
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1412..1417
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
                     /note="hexamer: ATTAAA"
     polyA_site      1432
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
     regulatory      1569..1574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
                     /note="hexamer: AATAAA"
     polyA_site      1590
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
                     /note="major polyA site"
     regulatory      2068..2073
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
                     /note="hexamer: ATTAAA"
     polyA_site      2088
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
     regulatory      2899..2904
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
                     /note="hexamer: AATAAA"
     polyA_site      2921
                     /gene="HNRNPD"
                     /gene_synonym="AUF1; AUF1A; hnRNPD0; HNRPD; P37"
ORIGIN      
        1 gtcggccatt ttaggtggtc cgcggcggcg ccattaaagc gaggaggagg cgagagcggc
       61 cgccgctggt gcttattctt ttttagtgca gcgggagaga gcgggagtgt gcgccgcgcg
      121 agagtgggag gcgaaggggg caggccaggg agaggcgcag gagcctttgc agccacgcgc
      181 gcgccttccc tgtcttgtgt gcttcgcgag gtagagcggg cgcgcggcag cggcggggat
      241 tactttgctg ctagtttcgg ttcgcggcag cggcgggtgt agtctcggcg gcagcggcgg
      301 agacactagc actatgtcgg aggagcagtt cggcggggac ggggcggcgg cagcggcaac
      361 ggcggcggta ggcggctcgg cgggcgagca ggagggagcc atggtggcgg cgacacaggg
      421 ggcagcggcg gcggcgggaa gcggagccgg gaccgggggc ggaaccgcgt ctggaggcac
      481 cgaagggggc agcgccgagt cggagggggc gaagattgac gccagtaaga acgaggagga
      541 tgaaggccat tcaaactcct ccccacgaca ctctgaagca gcgacggcac agcgggaaga
      601 atggaaaatg tttataggag gccttagctg ggacactaca aagaaagatc tgaaggacta
      661 cttttccaaa tttggtgaag ttgtagactg cactctgaag ttagatccta tcacagggcg
      721 atcaaggggt tttggctttg tgctatttaa agaatcggag agtgtagata aggtcatgga
      781 tcaaaaagaa cataaattga atgggaaggt gattgatcct aaaagggcca aagccatgaa
      841 aacaaaagag ccggttaaaa aaatttttgt tggtggcctt tctccagata cacctgaaga
      901 gaaaataagg gagtactttg gtggttttgg tgaggtggaa tccatagagc tccccatgga
      961 caacaagacc aataagaggc gtgggttctg ctttattacc tttaaggaag aagaaccagt
     1021 gaagaagata atggaaaaga aataccacaa tgttggtctt agtaaatgtg aaataaaagt
     1081 agccatgtcg aaggaacaat atcagcaaca gcaacagtgg ggatctagag gaggatttgc
     1141 aggaagagct cgtggaagag gtggtgacca gcagagtggt tatgggaagg tatccaggcg
     1201 aggtggtcat caaaatagct acaaaccata ctaaattatt ccatttgcaa cttatcccca
     1261 acaggtggtg aagcagtatt ttccaatttg aagattcatt tgaaggtggc tcctgccacc
     1321 tgctaatagc agttcaaact aaattttttg tatcaagtcc ctgaatggaa gtatgacgtt
     1381 gggtccctct gaagtttaat tctgagttct cattaaaaga aatttgcttt cattgtttta
     1441 tttcttaatt gctatgcttc agaatcaatt tgtgttttat gccctttccc ccagtattgt
     1501 agagcaagtc ttgtgttaaa agcccagtgt gacagtgtca tgatgtagta gtgtcttact
     1561 ggttttttaa taaatccttt tgtataaaaa tgtattggct cttttatcat cagaatagga
     1621 aaaattgtca tggattcaag ttattaaaag cataagtttg gaagacaggc ttgccgaaat
     1681 tgaggacatg attaaaattg cagtgaagtt tgaaatgttt ttagcaaaat ctaatttttg
     1741 ccataatgtg tcctccctgt ccaaattggg aatgacttaa tgtcaatttg tttgttggtt
     1801 gttttaataa tacttcctta tgtagccatt aagatttata tgaatatttt cccaaatgcc
     1861 cagtttttgc ttaatatgta ttgtgctttt tagaacaaat ctggataaat gtgcaaaagt
     1921 acccctttgc acagatagtt aatgttttat gcttccatta aataaaaagg acttaaaatc
     1981 tgttaattat aatagaaatg cggctagttc agagagattt ttagagctgt ggtggacttc
     2041 atagatgaat tcaagtgttg agggaggatt aaagaaatat ataccgtgtt tatgtgtgtg
     2101 tgcttatttg tttgaatgat tttattttcc atttctcaaa ggttttattt ttttggttag
     2161 ggccttaaaa tttcaggact gtgattatta gtatgtgtgc ctaaggaact ttttgagtca
     2221 ctcttaagaa agtgaaactg aagagtctaa gtgataacta taggattaag tcagaattgt
     2281 ttttcctgtc atttgttgga agcttcttga gttctgttat tagcattcag ggaattgata
     2341 cccatcaact tgaatggaaa atcgtttgta ggtattactt aagtgaatgt taagagttcc
     2401 accctgagtg gtaatctaag gctgtgcagt cagttacttc agactgctca gaatagttca
     2461 ttagaaaggt aacaaatgag aaatgtatta ttatacagtt ctatagtagt gaagtgatgg
     2521 aatacctttc ttacttttgt ggagttacat ctgatgctaa gaatttgacc tccaactaag
     2581 caaacatttt aatgagcaaa agttagtgtt attaaagttt ttttatgata gatccaaatt
     2641 gaggacctgt gtcctgtttt tataagattg caacccagct atgctcattt gtttatgttt
     2701 tgtatatggc tgcttttgtg ttacagtggt agagtttagt agttaggaca gagacctgca
     2761 aagcaaaata atttacagtc tggcccttta cagaaaagtt tgctgactca tggtcaaaat
     2821 aaatgaaaat tttttgtgtt agggttgtta agctagggtt ctttttggta tcatatgctt
     2881 attttatgta aatctctcaa taaaaaatta tttttaagag a
//
