LOCUS       NM_004500               3165 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens heterogeneous nuclear ribonucleoprotein C (HNRNPC),
            transcript variant 2, mRNA.
ACCESSION   NM_004500
VERSION     NM_004500.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3165)
  AUTHORS   Liu,Y.Y., Xia,M., Chen,Z.B., Liao,Y.D., Zhang,C.Y., Yuan,L.,
            Pan,Y.W., Huang,H., Lu,H.W. and Yao,S.Z.
  TITLE     HNRNPC mediates lymphatic metastasis of cervical cancer through
            m6A-dependent alternative splicing of FOXM1
  JOURNAL   Cell Death Dis 15 (10), 732 (2024)
   PUBMED   39375330
  REMARK    GeneRIF: HNRNPC mediates lymphatic metastasis of cervical cancer
            through m6A-dependent alternative splicing of FOXM1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3165)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3165)
  AUTHORS   Wang,Y. and Seliger,B.
  TITLE     Identification of RNA-binding protein hnRNP C targeting the 3'UTR
            of the TAP-associated glycoprotein tapasin in melanoma
  JOURNAL   Oncoimmunology 13 (1), 2370928 (2024)
   PUBMED   38948930
  REMARK    GeneRIF: Identification of RNA-binding protein hnRNP C targeting
            the 3'UTR of the TAP-associated glycoprotein tapasin in melanoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3165)
  AUTHORS   Chen,J.J., Lu,T.Z., Wang,T., Yan,W.H., Zhong,F.Y., Qu,X.H.,
            Gong,X.C., Li,J.G., Tou,F.F., Jiang,L.P. and Han,X.J.
  TITLE     The m6A reader HNRNPC promotes glioma progression by enhancing the
            stability of IRAK1 mRNA through the MAPK pathway
  JOURNAL   Cell Death Dis 15 (6), 390 (2024)
   PUBMED   38830885
  REMARK    GeneRIF: The m6A reader HNRNPC promotes glioma progression by
            enhancing the stability of IRAK1 mRNA through the MAPK pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3165)
  AUTHORS   Ferruzo,P.Y.M., Boell,V.K., Russo,L.C., Oliveira,C.C. and
            Forti,F.L.
  TITLE     DUSP3 modulates IRES-dependent translation of mRNAs through
            dephosphorylation of the HNRNPC protein in cells under genotoxic
            stimulus
  JOURNAL   Biol Cell 116 (5), e2300128 (2024)
   PUBMED   38538536
  REMARK    GeneRIF: DUSP3 modulates IRES-dependent translation of mRNAs
            through dephosphorylation of the HNRNPC protein in cells under
            genotoxic stimulus.
REFERENCE   6  (bases 1 to 3165)
  AUTHORS   Gorlach,M., Wittekind,M., Beckman,R.A., Mueller,L. and Dreyfuss,G.
  TITLE     Interaction of the RNA-binding domain of the hnRNP C proteins with
            RNA
  JOURNAL   EMBO J 11 (9), 3289-3295 (1992)
   PUBMED   1380452
REFERENCE   7  (bases 1 to 3165)
  AUTHORS   Wittekind,M., Gorlach,M., Friedrichs,M., Dreyfuss,G. and Mueller,L.
  TITLE     1H, 13C, and 15N NMR assignments and global folding pattern of the
            RNA-binding domain of the human hnRNP C proteins
  JOURNAL   Biochemistry 31 (27), 6254-6265 (1992)
   PUBMED   1385725
REFERENCE   8  (bases 1 to 3165)
  AUTHORS   Burd,C.G., Swanson,M.S., Gorlach,M. and Dreyfuss,G.
  TITLE     Primary structures of the heterogeneous nuclear ribonucleoprotein
            A2, B1, and C2 proteins: a diversity of RNA binding proteins is
            generated by small peptide inserts
  JOURNAL   Proc Natl Acad Sci U S A 86 (24), 9788-9792 (1989)
   PUBMED   2557628
REFERENCE   9  (bases 1 to 3165)
  AUTHORS   Merrill,B.M., Barnett,S.F., LeStourgeon,W.M. and Williams,K.R.
  TITLE     Primary structure differences between proteins C1 and C2 of HeLa
            40S nuclear ribonucleoprotein particles
  JOURNAL   Nucleic Acids Res 17 (21), 8441-8449 (1989)
   PUBMED   2587210
REFERENCE   10 (bases 1 to 3165)
  AUTHORS   Swanson,M.S., Nakagawa,T.Y., LeVan,K. and Dreyfuss,G.
  TITLE     Primary structure of human nuclear ribonucleoprotein particle C
            proteins: conservation of sequence and domain structures in
            heterogeneous nuclear RNA, mRNA, and pre-rRNA-binding proteins
  JOURNAL   Mol Cell Biol 7 (5), 1731-1739 (1987)
   PUBMED   3110598
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB449514.1, BC003394.1 and
            AL135744.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 21, 2020 this sequence version replaced NM_004500.3.
            
            Summary: This gene belongs to the subfamily of ubiquitously
            expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The
            hnRNPs are RNA binding proteins and they complex with heterogeneous
            nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs
            in the nucleus and appear to influence pre-mRNA processing and
            other aspects of mRNA metabolism and transport. While all of the
            hnRNPs are present in the nucleus, some seem to shuttle between the
            nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic
            acid binding properties. The protein encoded by this gene can act
            as a tetramer and is involved in the assembly of 40S hnRNP
            particles. Multiple transcript variants encoding at least two
            different isoforms have been described for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            segment compared to variant 1. The resulting isoform (b, also known
            as isoform C1) has the same N- and C-termini but is shorter
            compared to isoform a. Variants 2 and 4 both encode isoform b.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK225032.1, SRR11853565.8564.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000553300.6/ ENSP00000450544.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                DB449514.1         38-69
            33-1766             BC003394.1         1-1734
            1767-3165           AL135744.4         10087-11485         c
FEATURES             Location/Qualifiers
     source          1..3165
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..3165
                     /gene="HNRNPC"
                     /gene_synonym="C1; C2; HNRNP; HNRPC; MRD74; SNRPC"
                     /note="heterogeneous nuclear ribonucleoprotein C"
                     /db_xref="GeneID:3183"
                     /db_xref="HGNC:HGNC:5035"
                     /db_xref="MIM:164020"
     exon            1..145
                     /gene="HNRNPC"
                     /gene_synonym="C1; C2; HNRNP; HNRPC; MRD74; SNRPC"
                     /inference="alignment:Splign:2.1.0"
     exon            146..171
                     /gene="HNRNPC"
                     /gene_synonym="C1; C2; HNRNP; HNRPC; MRD74; SNRPC"
                     /inference="alignment:Splign:2.1.0"
     exon            172..448
                     /gene="HNRNPC"
                     /gene_synonym="C1; C2; HNRNP; HNRPC; MRD74; SNRPC"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..1089
                     /gene="HNRNPC"
                     /gene_synonym="C1; C2; HNRNP; HNRPC; MRD74; SNRPC"
                     /note="isoform b is encoded by transcript variant 2;
                     nuclear ribonucleoprotein particle C2 protein; nuclear
                     ribonucleoprotein particle C1 protein; heterogeneous
                     nuclear ribonucleoprotein C (C1/C2); hnRNP C1/C2"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoproteins C1/C2
                     isoform b"
                     /protein_id="NP_004491.2"
                     /db_xref="CCDS:CCDS45079.1"
                     /db_xref="GeneID:3183"
                     /db_xref="HGNC:HGNC:5035"
                     /db_xref="MIM:164020"
                     /translation="MASNVTNKTDPRSMNSRVFIGNLNTLVVKKSDVEAIFSKYGKIV
                     GCSVHKGFAFVQYVNERNARAAVAGEDGRMIAGQVLDINLAAEPKVNRGKAGVKRSAA
                     EMYGSSFDLDYDFQRDYYDRMYSYPARVPPPPPIARAVVPSKRQRVSGNTSRRGKSGF
                     NSKSGQRGSSKSGKLKGDDLQAIKKELTQIKQKVDSLLENLEKIEKEQSKQAVEMKND
                     KSEEEQSSSSVKKDETNVKMESEGGADDSAEEGDLLDDDDNEDRGDDQLELIKDDEKE
                     AEEGEDDRDSANGEDDS"
     exon            449..524
                     /gene="HNRNPC"
                     /gene_synonym="C1; C2; HNRNP; HNRPC; MRD74; SNRPC"
                     /inference="alignment:Splign:2.1.0"
     exon            525..572
                     /gene="HNRNPC"
                     /gene_synonym="C1; C2; HNRNP; HNRPC; MRD74; SNRPC"
                     /inference="alignment:Splign:2.1.0"
     exon            573..730
                     /gene="HNRNPC"
                     /gene_synonym="C1; C2; HNRNP; HNRPC; MRD74; SNRPC"
                     /inference="alignment:Splign:2.1.0"
     exon            731..844
                     /gene="HNRNPC"
                     /gene_synonym="C1; C2; HNRNP; HNRPC; MRD74; SNRPC"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1005
                     /gene="HNRNPC"
                     /gene_synonym="C1; C2; HNRNP; HNRPC; MRD74; SNRPC"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..3165
                     /gene="HNRNPC"
                     /gene_synonym="C1; C2; HNRNP; HNRPC; MRD74; SNRPC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1352..1357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPC"
                     /gene_synonym="C1; C2; HNRNP; HNRPC; MRD74; SNRPC"
                     /note="hexamer: AATAAA"
     polyA_site      1375
                     /gene="HNRNPC"
                     /gene_synonym="C1; C2; HNRNP; HNRPC; MRD74; SNRPC"
                     /note="major polyA site"
     regulatory      2908..2913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPC"
                     /gene_synonym="C1; C2; HNRNP; HNRPC; MRD74; SNRPC"
                     /note="hexamer: AATAAA"
     polyA_site      2928
                     /gene="HNRNPC"
                     /gene_synonym="C1; C2; HNRNP; HNRPC; MRD74; SNRPC"
     regulatory      3141..3146
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPC"
                     /gene_synonym="C1; C2; HNRNP; HNRPC; MRD74; SNRPC"
                     /note="hexamer: ATTAAA"
     polyA_site      3165
                     /gene="HNRNPC"
                     /gene_synonym="C1; C2; HNRNP; HNRPC; MRD74; SNRPC"
ORIGIN      
        1 agaggagact cgggggccat tttgtgaaga gacgaagact gagcggttgt ggccgcgttg
       61 ccgacctcca gcagcagtcg gcttctctac gcagaacccg ggagtaggag actcagaatc
      121 gaatctcttc tccctcccct tcttgtgaga tttttttgat cttcagctac attttcggct
      181 ttgtgagaaa ccttaccatc aaacacgatg gccagcaacg ttaccaacaa gacagatcct
      241 cgctccatga actcccgtgt attcattggg aatctcaaca ctcttgtggt caagaaatct
      301 gatgtggagg caatcttttc gaagtatggc aaaattgtgg gctgctctgt tcataagggc
      361 tttgccttcg ttcagtatgt taatgagaga aatgcccggg ctgctgtagc aggagaggat
      421 ggcagaatga ttgctggcca ggttttagat attaacctgg ctgcagagcc aaaagtgaac
      481 cgaggaaaag caggtgtgaa acgatctgca gcggagatgt acggctcctc ttttgacttg
      541 gactatgact ttcaacggga ctattatgat aggatgtaca gttacccagc acgtgtacct
      601 cctcctcctc ctattgctcg ggctgtagtg ccctcgaaac gtcagcgtgt atcaggaaac
      661 acttcacgaa ggggcaaaag tggcttcaat tctaagagtg gacagcgggg atcttccaag
      721 tctggaaagt tgaaaggaga tgaccttcag gccattaaga aggagctgac ccagataaaa
      781 caaaaagtgg attctctcct ggaaaacctg gaaaaaattg aaaaggaaca gagcaaacaa
      841 gcagtagaga tgaagaatga taagtcagaa gaggagcaga gcagcagctc cgtgaagaaa
      901 gatgagacta atgtgaagat ggagtctgag gggggtgcag atgactctgc tgaggagggg
      961 gacctactgg atgatgatga taatgaagat cggggggatg accagctgga gttgatcaag
     1021 gatgatgaaa aagaggctga ggaaggagag gatgacagag acagcgccaa tggcgaggat
     1081 gactcttaag cacatagtgg ggtttagaaa tcttatccca ttatttcttt acctaggcgc
     1141 ttgtctaaga tcaaattttt caccagatcc tctcccctag tatcttcagc acatgctcac
     1201 tgttctcccc atccttgtcc ttcccatgtt cattaattca tattgccccg cgcctagtcc
     1261 cattttcact tcctttgacg ctcctagtag ttttgttaag tcttaccctg taatttttgc
     1321 ttttaatttt gatacctctt tatgacttaa caataaaaag gatgtatggt ttttatcaac
     1381 tgtctccaaa ataatctctt gttatgcagg gagtacagtt cttttcattc atacataagt
     1441 tcagtagttg cttccctaac tgcaaaggca atctcattta gttgagtagc tcttgaaagc
     1501 agctttgagt tagaagtatg tgtgttacac cctcacatta gtgtgctgtg tggggcagtt
     1561 caacacaaat gtaacaatgt atttttgtga atgagagttg gcatgtcaaa tgcatcctct
     1621 agaaaaataa ttagtgttat agtcttaaga tttgttttct aaagttgata ctgtgggtta
     1681 tttttgtgaa cagcctgatg tttgggacct tttttcctca aaataaacaa gtccttatta
     1741 aaccaggaat ttggagaaaa aaaaaaccct ggttttttat ttttgtattt tattattgtt
     1801 tacttcaaac tttgttttac agcgtcctcc acaaaacctc tagaatgcac tagatatatt
     1861 tttcttggag tcataatcat gatgcatacc aacacaacac tactcaaatt atatttcatt
     1921 gagatgcatg ttgcattgag gagtcaactt gacatagagt ggagactttt tcaaaatggc
     1981 ttttacatcc taatgaaagt ttgggaagta tatcctctct gccttttcat cagtgctttg
     2041 tggtccagct ggcacccttt ctgaggtttg tgttttgtgc taaatggttt tgtccttaaa
     2101 taggagaggc tcaaaaacat caagatttca ggaaaatggc gacagctgca taatggaacc
     2161 cccctgcttc tattttgttc ttttaattac tatttatagc cccagttacc ttctgaattc
     2221 tgaagtgtat atacctccat gttcctgaaa acaagaaaac tcttacttcc tgatattcca
     2281 tagactgcct tcccaggtga ttgagaacat agagaatgtt acacatttat tttactctaa
     2341 atgatctttt acccctgtta gctaatcttt gtgttttcct caactttatt aattacagtg
     2401 attgcatttt tagcatccag ttgtaagatg aatatattaa acagctacca gtgttggtga
     2461 tacctcatcc ttgaaaggct tagttcattt gtgttttata cttcagtttt tccagcatag
     2521 cagaaaatgc cgcttataat ttttgtgcac acaaaccttg gattcccctg taaagttgct
     2581 attgtttcat agcatgcggc actggccttt tttcatccta ctcattacag gcaaaactca
     2641 tgtcttattt atgaggattt tatagatcat tttctgtaac aggtgacaaa agcagaaaag
     2701 aatgaagagg ctgaagtatg aactaccctt ggagcccata tacatgatat aggcaatttc
     2761 ttttgtatgt taattcagtc aaaaatacta cccacttgat gttttctaat ctgatgtgag
     2821 ctcatgttac acagactttt agtaagtaac ccgtgactag aaaataaact ggatgcttag
     2881 gagagagtgt cagatgtata agatgctaat aaaacctgtt taatattatt gttagctgta
     2941 agtttttggg aaatactgaa caaattagtc cacaatcaag tgtctacttt tcccttcact
     3001 gtagggcctc tccctgcaca gagcagtctg tttagctgtg aacaccacaa tctgcagatg
     3061 ttcaagtccc ttacataaaa tggcatagta tttatatgta acctatgcat attctcctgt
     3121 atattttaaa tcatctctac attaaaatac ctgataaaat gtaaa
//
