LOCUS       NM_031266               1770 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB),
            transcript variant 1, mRNA.
ACCESSION   NM_031266
VERSION     NM_031266.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1770)
  AUTHORS   Lei,K., Sun,M., Chen,X., Wang,J., Liu,X., Ning,Y., Ping,S.,
            Gong,R., Zhang,Y., Qing,G., Zhao,C. and Ren,H.
  TITLE     hnRNPAB Promotes Pancreatic Ductal Adenocarcinoma Extravasation and
            Liver Metastasis by Stabilizing MYC mRNA
  JOURNAL   Mol Cancer Res 22 (11), 1022-1035 (2024)
   PUBMED   38967522
  REMARK    GeneRIF: hnRNPAB Promotes Pancreatic Ductal Adenocarcinoma
            Extravasation and Liver Metastasis by Stabilizing MYC mRNA.
REFERENCE   2  (bases 1 to 1770)
  AUTHORS   Wang,M., Wang,X., Cui,Y. and Wen,X.
  TITLE     Impact of heterogeneous nuclear ribonucleoprotein A/B subtype
            overexpression on the expression of cancer stem cell markers CD133
            and CD44 and cellular proliferation capacity
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (14), 101-108 (2023)
   PUBMED   38279469
  REMARK    GeneRIF: Impact of heterogeneous nuclear ribonucleoprotein A/B
            subtype overexpression on the expression of cancer stem cell
            markers CD133 and CD44 and cellular proliferation capacity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1770)
  AUTHORS   Zhou,J., Chen,S., Liu,J., Du,J. and Li,J.
  TITLE     Knockdown of hnRNPAB reduces the stem cell properties and enhances
            the chemosensitivity of human colorectal cancer stem cells
  JOURNAL   Oncol Rep 49 (6) (2023)
   PUBMED   37165920
  REMARK    GeneRIF: Knockdown of hnRNPAB reduces the stem cell properties and
            enhances the chemosensitivity of human colorectal cancer stem
            cells.
REFERENCE   4  (bases 1 to 1770)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 1770)
  AUTHORS   Chen,Z.Q., Yuan,T., Jiang,H., Yang,Y.Y., Wang,L., Fu,R.M.,
            Luo,S.Q., Zhang,T., Wu,Z.Y. and Wen,K.M.
  TITLE     MicroRNA-8063 targets heterogeneous nuclear ribonucleoprotein AB to
            inhibit the self-renewal of colorectal cancer stem cells via the
            Wnt/beta-catenin pathway
  JOURNAL   Oncol Rep 46 (4) (2021)
   PUBMED   34396427
  REMARK    GeneRIF: MicroRNA8063 targets heterogeneous nuclear
            ribonucleoprotein AB to inhibit the selfrenewal of colorectal
            cancer stem cells via the Wnt/betacatenin pathway.
REFERENCE   6  (bases 1 to 1770)
  AUTHORS   Hay,D.C., Kemp,G.D., Dargemont,C. and Hay,R.T.
  TITLE     Interaction between hnRNPA1 and IkappaBalpha is required for
            maximal activation of NF-kappaB-dependent transcription
  JOURNAL   Mol Cell Biol 21 (10), 3482-3490 (2001)
   PUBMED   11313474
REFERENCE   7  (bases 1 to 1770)
  AUTHORS   Blanc,V., Navaratnam,N., Henderson,J.O., Anant,S., Kennedy,S.,
            Jarmuz,A., Scott,J. and Davidson,N.O.
  TITLE     Identification of GRY-RBP as an apolipoprotein B RNA-binding
            protein that interacts with both apobec-1 and apobec-1
            complementation factor to modulate C to U editing
  JOURNAL   J Biol Chem 276 (13), 10272-10283 (2001)
   PUBMED   11134005
REFERENCE   8  (bases 1 to 1770)
  AUTHORS   Lau,P.P., Zhu,H.J., Nakamuta,M. and Chan,L.
  TITLE     Cloning of an Apobec-1-binding protein that also interacts with
            apolipoprotein B mRNA and evidence for its involvement in RNA
            editing
  JOURNAL   J Biol Chem 272 (3), 1452-1455 (1997)
   PUBMED   8999813
REFERENCE   9  (bases 1 to 1770)
  AUTHORS   Gress,T.M., Muller-Pillasch,F., Geng,M., Zimmerhackl,F.,
            Zehetner,G., Friess,H., Buchler,M., Adler,G. and Lehrach,H.
  TITLE     A pancreatic cancer-specific expression profile
  JOURNAL   Oncogene 13 (8), 1819-1830 (1996)
   PUBMED   8895530
REFERENCE   10 (bases 1 to 1770)
  AUTHORS   Khan,F.A., Jaiswal,A.K. and Szer,W.
  TITLE     Cloning and sequence analysis of a human type A/B hnRNP protein
  JOURNAL   FEBS Lett 290 (1-2), 159-161 (1991)
   PUBMED   1717314
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK097657.1 and BC001616.1.
            
            On Nov 22, 2018 this sequence version replaced NM_031266.2.
            
            Summary: This gene belongs to the subfamily of ubiquitously
            expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The
            hnRNPs are produced by RNA polymerase II and are components of the
            heterogeneous nuclear RNA (hnRNA) complexes. They are associated
            with pre-mRNAs in the nucleus and appear to influence pre-mRNA
            processing and other aspects of mRNA metabolism and transport.
            While all of the hnRNPs are present in the nucleus, some seem to
            shuttle between the nucleus and the cytoplasm. The hnRNP proteins
            have distinct nucleic acid binding properties. The protein encoded
            by this gene, which binds to one of the components of the
            multiprotein editosome complex, has two repeats of quasi-RRM (RNA
            recognition motif) domains that bind to RNAs. Two alternatively
            spliced transcript variants encoding different isoforms have been
            described for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the full length
            isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK223425.1, AK097657.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358344.8/ ENSP00000351108.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1768              AK097657.1         28-1795
            1769-1770           BC001616.1         1613-1614
FEATURES             Location/Qualifiers
     source          1..1770
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..1770
                     /gene="HNRNPAB"
                     /gene_synonym="ABBP1; HNRPAB"
                     /note="heterogeneous nuclear ribonucleoprotein A/B"
                     /db_xref="GeneID:3182"
                     /db_xref="HGNC:HGNC:5034"
                     /db_xref="MIM:602688"
     exon            1..208
                     /gene="HNRNPAB"
                     /gene_synonym="ABBP1; HNRPAB"
                     /inference="alignment:Splign:2.1.0"
     exon            209..440
                     /gene="HNRNPAB"
                     /gene_synonym="ABBP1; HNRPAB"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..1230
                     /gene="HNRNPAB"
                     /gene_synonym="ABBP1; HNRPAB"
                     /note="isoform a is encoded by transcript variant 1; hnRNP
                     type A/B protein; apolipoprotein B mRNA editing enzyme,
                     catalytic polypeptide 1-binding protein 1; apobec-1
                     binding protein 1; ABBP-1; hnRNP A/B; APOBEC1-binding
                     protein 1"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein A/B
                     isoform a"
                     /protein_id="NP_112556.2"
                     /db_xref="CCDS:CCDS34309.1"
                     /db_xref="GeneID:3182"
                     /db_xref="HGNC:HGNC:5034"
                     /db_xref="MIM:602688"
                     /translation="MSEAGEEQPMETTGATENGHEAVPEGESPAGAGTGAAAGAGGAT
                     AAPPSGNQNGAEGDQINASKNEEDAGKMFVGGLSWDTSKKDLKDYFTKFGEVVDCTIK
                     MDPNTGRSRGFGFILFKDAASVEKVLDQKEHRLDGRVIDPKKAMAMKKDPVKKIFVGG
                     LNPEATEEKIREYFGEFGEIEAIELPMDPKLNKRRGFVFITFKEEEPVKKVLEKKFHT
                     VSGSKCEIKVAQPKEVYQQQQYGSGGRGNRNRGNRGSGGGGGGGGQSQSWNQGYGNYW
                     NQGYGYQQGYGPGYGGYDYSPYGYYGYGPGYDYSQGSTNYGKSQRRGGHQNNYKPY"
     exon            441..609
                     /gene="HNRNPAB"
                     /gene_synonym="ABBP1; HNRPAB"
                     /inference="alignment:Splign:2.1.0"
     exon            610..768
                     /gene="HNRNPAB"
                     /gene_synonym="ABBP1; HNRPAB"
                     /inference="alignment:Splign:2.1.0"
     exon            769..900
                     /gene="HNRNPAB"
                     /gene_synonym="ABBP1; HNRPAB"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1018
                     /gene="HNRNPAB"
                     /gene_synonym="ABBP1; HNRPAB"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1159
                     /gene="HNRNPAB"
                     /gene_synonym="ABBP1; HNRPAB"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1770
                     /gene="HNRNPAB"
                     /gene_synonym="ABBP1; HNRPAB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1749..1754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPAB"
                     /gene_synonym="ABBP1; HNRPAB"
                     /note="hexamer: AATAAA"
     polyA_site      1770
                     /gene="HNRNPAB"
                     /gene_synonym="ABBP1; HNRPAB"
                     /note="major polyA site"
ORIGIN      
        1 aggcggcggc accgcgcggg acggagcttg gctgttggtc ggtgggttcc cgtgcggcgg
       61 cggccaagga ggaggagaca cagttggagc agctccgtgg gctgactggg gcgaggcctc
      121 agcagcgcga gcttgagtgc ggccgagcct gcggcgcctt cccctgcggg tggggacgag
      181 cgggccccgc ggcgtcatcg gcggcgagga gccgccgcgc ctcggcctag catgtcggaa
      241 gcgggcgagg agcagcccat ggagacgacg ggcgccaccg agaacggaca tgaggccgtc
      301 cccgaaggcg agtcgccggc cggggctggc acgggcgccg cggcgggggc tggaggcgcg
      361 accgcggcgc ccccgagcgg gaatcagaac ggcgccgagg gcgaccagat caacgccagc
      421 aagaacgagg aggacgcggg aaaaatgttc gttggtggcc tgagctggga tactagcaaa
      481 aaagatttaa aagactattt tactaaattt ggagaggtcg ttgactgtac aataaaaatg
      541 gatcccaaca ctggacggtc aagagggttt gggtttatcc tgttcaaaga tgcagccagt
      601 gtggagaagg tcctagacca gaaggagcac aggctggatg gccgtgtcat tgaccctaaa
      661 aaggccatgg ctatgaagaa ggacccggtg aagaaaatct tcgttggggg tctgaatcct
      721 gaagccactg aggaaaagat cagggagtac tttggcgagt ttggggagat tgaggccatt
      781 gaattgccaa tggatccaaa gttgaacaaa agacgaggtt ttgtgtttat cacctttaaa
      841 gaagaagaac ccgtgaagaa ggttctggag aaaaagttcc atactgtcag tggaagcaag
      901 tgtgagatca aggtggccca gcccaaagaa gtctatcagc agcagcagta tggctctggg
      961 ggccgtggaa accgcaaccg agggaaccga ggcagcggag gtggtggtgg aggtggaggt
     1021 cagagtcaga gttggaatca gggctacggc aactactgga accagggcta cggctaccag
     1081 cagggctacg ggcctggcta tggcggctac gactactcgc cctatggcta ttacggctac
     1141 ggccccggct acgactacag tcagggtagt acaaactacg gcaagagcca gcgacgtggt
     1201 ggccatcaga ataactacaa gccatactga ggcggcagca ggagcgacca actgatcgca
     1261 cacatgcttt gtttggatat ggagtgaaca caattatgta ccaaatttaa cttggcaaac
     1321 tttctattgc ctgtcccatg tgcatcttat ttaaaatttc ccccatggaa atcactctcc
     1381 tgttgactat ttccagagct ctaggtgttt aggcagcgtg tggtgtctga gaggccatag
     1441 cgccatcatg ggctgatttt tattaccagg tcccccagaa gcaggtggga ggctctgctt
     1501 cctgctgccg ctctgcagcc tggacctgtg gaccctggtt gtaaagagta aattgtatct
     1561 taggaaacca gtgtcacctt tttttcacct tttaatttta tattatttgc gtcatacatt
     1621 tcctgtaacg gaagtgttaa ttttactgta ctttttggta ccttttggga atctaatgta
     1681 ttgtaaggta ttttacacgt gtcctgattt tgccacaacc tggatattga agctatccaa
     1741 gcttttgaaa taaaatttaa aaacccccaa
//
