LOCUS       NM_194247               5710 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3),
            transcript variant 1, mRNA.
ACCESSION   NM_194247 XM_165561
VERSION     NM_194247.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5710)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 5710)
  AUTHORS   Chen,X., Lloyd,S.M., Kweon,J., Gamalong,G.M. and Bao,X.
  TITLE     Epidermal progenitors suppress GRHL3-mediated differentiation
            through intronic polyadenylation promoted by CPSF-HNRNPA3
            collaboration
  JOURNAL   Nat Commun 12 (1), 448 (2021)
   PUBMED   33469008
  REMARK    GeneRIF: Epidermal progenitors suppress GRHL3-mediated
            differentiation through intronic polyadenylation promoted by
            CPSF-HNRNPA3 collaboration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5710)
  AUTHORS   Ou,M.Y., Ju,X.C., Cai,Y.J., Sun,X.Y., Wang,J.F., Fu,X.Q., Sun,Q.
            and Luo,Z.G.
  TITLE     Heterogeneous nuclear ribonucleoprotein A3 controls mitotic
            progression of neural progenitors via interaction with cohesin
  JOURNAL   Development 147 (10) (2020)
   PUBMED   32321712
  REMARK    GeneRIF: Heterogeneous nuclear ribonucleoprotein A3 controls
            mitotic progression of neural progenitors via interaction with
            cohesin.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5710)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   5  (bases 1 to 5710)
  AUTHORS   Mishra,N., Reddy,K.S., Timilsina,U., Gaur,D. and Gaur,R.
  TITLE     Human APOBEC3B interacts with the heterogenous nuclear
            ribonucleoprotein A3 in cancer cells
  JOURNAL   J Cell Biochem 119 (8), 6695-6703 (2018)
   PUBMED   29693745
  REMARK    GeneRIF: results indicated a specific interaction of A3B with hnRNP
            A3 (heterogeneous nuclear ribonucleoprotein). This interaction was
            verified by co-immunoprecipitation and was found to be
            RNA-dependent. Furthermore, A3B and hnRNP A3 colocalized as evident
            from immunofluorescence analysis.
REFERENCE   6  (bases 1 to 5710)
  AUTHORS   Huang,P.R., Tsai,S.T., Hsieh,K.H. and Wang,T.C.
  TITLE     Heterogeneous nuclear ribonucleoprotein A3 binds single-stranded
            telomeric DNA and inhibits telomerase extension in vitro
  JOURNAL   Biochim Biophys Acta 1783 (2), 193-202 (2008)
   PUBMED   17919748
  REMARK    GeneRIF: These biochemical properties of hnRNP A3 suggest that
            hnRNP A3 can participate in telomere regulation in vivo.
REFERENCE   7  (bases 1 to 5710)
  AUTHORS   Makeyev,A.V., Kim,C.B., Ruddle,F.H., Enkhmandakh,B.,
            Erdenechimeg,L. and Bayarsaihan,D.
  TITLE     HnRNP A3 genes and pseudogenes in the vertebrate genomes
  JOURNAL   J Exp Zool A Comp Exp Biol 303 (4), 259-271 (2005)
   PUBMED   15776420
REFERENCE   8  (bases 1 to 5710)
  AUTHORS   Ma,A.S., Moran-Jones,K., Shan,J., Munro,T.P., Snee,M.J., Hoek,K.S.
            and Smith,R.
  TITLE     Heterogeneous nuclear ribonucleoprotein A3, a novel RNA trafficking
            response element-binding protein
  JOURNAL   J Biol Chem 277 (20), 18010-18020 (2002)
   PUBMED   11886857
REFERENCE   9  (bases 1 to 5710)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   10 (bases 1 to 5710)
  AUTHORS   Takiguchi,S., Tokino,T., Imai,T., Tanigami,A., Koyama,K. and
            Nakamura,Y.
  TITLE     Identification and characterization of a cDNA, which is highly
            homologous to the ribonucleoprotein gene, from a locus (D10S102)
            closely linked to MEN2 (multiple endocrine neoplasia type 2)
  JOURNAL   Cytogenet Cell Genet 64 (2), 128-130 (1993)
   PUBMED   8101480
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079305.6.
            
            On Jun 7, 2021 this sequence version replaced NM_194247.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.1241381.1,
                                           SRR18074967.371364.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392524.7/ ENSP00000376309.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                AC079305.6         106895-106972
            79-201              AC079305.6         109640-109762
            202-348             AC079305.6         109851-109997
            349-559             AC079305.6         110079-110289
            560-649             AC079305.6         110604-110693
            650-745             AC079305.6         110777-110872
            746-826             AC079305.6         110961-111041
            827-967             AC079305.6         111806-111946
            968-1090            AC079305.6         113138-113260
            1091-1158           AC079305.6         113348-113415
            1159-5710           AC079305.6         113509-118060
FEATURES             Location/Qualifiers
     source          1..5710
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.2"
     gene            1..5710
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /note="heterogeneous nuclear ribonucleoprotein A3"
                     /db_xref="GeneID:220988"
                     /db_xref="HGNC:HGNC:24941"
                     /db_xref="MIM:605372"
     exon            1..78
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..1143
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /note="isoform a is encoded by transcript variant 1;
                     epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein A3
                     isoform a"
                     /protein_id="NP_919223.1"
                     /db_xref="CCDS:CCDS2273.1"
                     /db_xref="GeneID:220988"
                     /db_xref="HGNC:HGNC:24941"
                     /db_xref="MIM:605372"
                     /translation="MEVKPPPGRPQPDSGRRRRRRGEEGHDPKEPEQLRKLFIGGLSF
                     ETTDDSLREHFEKWGTLTDCVVMRDPQTKRSRGFGFVTYSCVEEVDAAMCARPHKVDG
                     RVVEPKRAVSREDSVKPGAHLTVKKIFVGGIKEDTEEYNLRDYFEKYGKIETIEVMED
                     RQSGKKRGFAFVTFDDHDTVDKIVVQKYHTINGHNCEVKKALSKQEMQSAGSQRGRGG
                     GSGNFMGRGGNFGGGGGNFGRGGNFGGRGGYGGGGGGSRGSYGGGDGGYNGFGGDGGN
                     YGGGPGYSSRGGYGGGGPGYGNQGGGYGGGGGYDGYNEGGNFGGGNYGGGGNYNDFGN
                     YSGQQQSNYGPMKGGSFGGRSSGSPYGGGYGSGGGSGGYGSRRF"
     exon            79..201
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /inference="alignment:Splign:2.1.0"
     exon            202..348
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /inference="alignment:Splign:2.1.0"
     exon            349..559
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /inference="alignment:Splign:2.1.0"
     exon            560..649
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /inference="alignment:Splign:2.1.0"
     exon            650..745
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /inference="alignment:Splign:2.1.0"
     exon            746..826
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /inference="alignment:Splign:2.1.0"
     exon            827..967
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1090
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1158
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..5710
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2256..2261
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /note="hexamer: AATAAA"
     polyA_site      2285
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /note="major polyA site"
     regulatory      3903..3908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /note="hexamer: AGTAAA"
     polyA_site      3922
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /note="major polyA site"
     regulatory      5586..5591
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /note="hexamer: ATTAAA"
     polyA_site      5608
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
     regulatory      5688..5693
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /note="hexamer: AATAAA"
     polyA_site      5710
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /note="major polyA site"
ORIGIN      
        1 ctcaaaatgg aggtaaaacc gccgcccggt cgcccccagc ccgactccgg ccgtcgccgt
       61 cgccgccggg gggaggaggg ccatgatcca aaggaaccag agcagttgag aaaactgttt
      121 attggtggtc tgagctttga aactacagat gatagtttac gagaacattt tgagaaatgg
      181 ggcacactca cagattgtgt ggtaatgaga gacccccaaa caaaacgttc caggggcttt
      241 ggttttgtga cttattcttg tgttgaagag gtggatgcag caatgtgtgc tcgaccacac
      301 aaggttgatg ggcgtgtagt ggaaccaaag agagctgttt ctagagagga ttctgtaaag
      361 cctggtgccc atctaacagt gaagaaaatt tttgttggtg gtattaaaga agatacagaa
      421 gaatataatt tgagagacta ctttgaaaag tatggcaaga ttgaaaccat agaagttatg
      481 gaagacaggc agagtggaaa aaagagagga tttgcttttg taacttttga tgatcatgat
      541 acagttgata aaattgttgt tcagaaatac cacactatta atgggcataa ttgtgaagtg
      601 aaaaaggccc tttctaaaca agagatgcag tctgctggat cacagagagg tcgtggaggt
      661 ggatctggca attttatggg tcgcggaggg aactttggag gtggtggagg taattttggc
      721 cgtggtggaa actttggtgg aagaggaggc tatggtggtg gaggtggtgg cagcagaggt
      781 agttatggag gaggtgatgg tggatataat ggatttggag gtgatggtgg caactatggc
      841 ggtggtcctg gttatagtag tagagggggc tatggtggtg gtggaccagg atatggaaac
      901 caaggtggtg gatatggtgg aggtggagga tatgatggtt acaatgaagg aggaaatttt
      961 ggcggtggta actatggtgg tggtgggaac tataatgatt ttggaaatta tagtggacaa
     1021 cagcaatcaa attatggacc catgaaaggg ggcagttttg gtggaagaag ctcgggcagt
     1081 ccctatggtg gtggttatgg atctggtggt ggaagtggtg gatatggtag cagaaggttc
     1141 taaaaacagc agaaaagggc tacagttctt agcaggagag agagcgagga gttgtcagga
     1201 aagctgcagg ttactttgag acagtcgtcc caaatgcatt agaggaactg taaaaatctg
     1261 ccacagaagg aacgatgatc catagtcaga aaagttactg cagcttaaac aggaaaccct
     1321 tcttgttcag gactgtcata gccacagttt gcaaaaagtg cagctattga ttaatgcaat
     1381 gtagtgtcaa ttagatgtac attcctgagg tcttttatct gttgtagctt tgtctttttc
     1441 tttttctttt cattacatca ggtatattgc cctgtaaatt gtggtagtgg taccaggaat
     1501 aaaaaattaa ggaattttta acttttcaat atttgtgtag ttcagttttt ctacatttta
     1561 gtacagaaac tttaacaaaa tgcagtttcg aaggtgtttc cttgtgagtt aacaagtaaa
     1621 gaagatcatt gttaattact attttgtatg aattttgcta aagttaactg taaagaaaca
     1681 cctgctgact tgcagtttaa ggggaatcta ttctccccat ttccaaacca tgatatgaat
     1741 gggcgctgac atgtggagag aatagataat ttgtgtgttt gcaatgtgtg ttttagataa
     1801 ataggattgg gtatttaaat tagcatttgt gaatttaata gcattaagat taccttcaaa
     1861 tgaaaaaaaa tctcaaaatt tctatttggt ttttgtgcat tttcttttaa aatgtaatca
     1921 tatgatttta gtgtgttaga cttgctgagt cctagctgtg tttagaacat ctctattcta
     1981 catttacctt ggtcaaattt gaactgctgc cataggtttt gggtgtaaag aatgtttact
     2041 gccctccatt taaattctga aaagggatgg tggatgtttt ccctctccta cgttagaaac
     2101 cattcttaaa aacttttgaa aatatagaac cattaagcct gctatatctg agcaaattag
     2161 tgggtacctt ttttttctta tttaaagcac aagaggccca taaatcttga gttactttaa
     2221 attctttttt ttgatacaag ttttcagagc aagagaataa aaatcatgtg ttattaaacc
     2281 cctaactggc tggcatgctt tcctgtttgt attctataca ttttgctgga tgaaaccaag
     2341 gatagttcag gtataattgt ccaaaataac ctaactgcag cagaaatgta gcacagttgc
     2401 ttagtacagg cttctcactt cctacagacc tgaattcaaa tttggatagt ctgagttctt
     2461 aaattcccaa agaacacact gttatttctt gtgtatattt caacataaat catgttgtta
     2521 ccaatttgtt tggaaggccc tggttgagaa gagttttagt taataaggtc atatatacat
     2581 atattaatat aaaccaatgt ctactgtttt gctccagcta gtgcttacag tttcattcga
     2641 gccctgagta tgtgccctgc tgttactctc tttggtagtt gaacgttgaa ttcaagtctt
     2701 ttgttttaag aagtactaag caaacaagca ataaaaaggg gaatggggtg tgctagtgtt
     2761 tgaatatgct ctcttgttgc tctaattctg tgcctctgtg cattaatatt tggatgcatg
     2821 caatgccagc atggaaattg gtcttcacac atactgcagt tttccagaaa cattcacaaa
     2881 ccaataaatg taacagacat tccatttgtt aatgggcata tatgtgaaaa gcagtgtaga
     2941 aaataggcta atattagaaa atggttaagt cctaaataac ttcaagtgtg gttatataat
     3001 ggacactgtc aatgttcata acttaaacct gggtacctgg tcaaaataat gcttgggaaa
     3061 cattaaaatt gagctaaatt gtctcaagtt cttttattca tataaataaa gtttaaagga
     3121 atgggggaga ttaacatttc ctgttttatg tttgtgaaat tgtttgacac aaccttgaca
     3181 gtatccttta atggcatgag gttaattgta ctgttaacca actttctatg ttctggaact
     3241 agtattatag tgaaaacatt tacagtaagt tgatgtttac aacctataag caggtgaaat
     3301 ctgtgtatgt gacctgttta taagttgtat tagcttagct cttgtgaaca gtgtggaaaa
     3361 gtaagccatg aggagagcga tttaaccacc tttaaaggac ctaagatgtg ctttttaagc
     3421 acagtgtgga tcacagaaac tcactaagac aggacttcag cagccttttg tgtttggaca
     3481 agtcagcata aataaagaat gacaaggcag cagcaagagc ttcaactaca gagaagtgaa
     3541 ggcataagat actatgatga tagtgagcaa ctttccaaaa gctagttaaa tctgcttatt
     3601 acaactgaaa tatcgaagaa agtctagcag gaaggagctc ttcgcctttt ggaacatcaa
     3661 tgagagatag ttgccacagt cactaggtct agcatttaga cctgcaagga agggcaataa
     3721 gcattaggta aggcttgaat ttgaattttt tcactaatta aagagtaatt ttttgtaaag
     3781 caaggtaaga gtaatctttt tgatttgcag gttgaatgag aaccctactt gcctaaatga
     3841 ggaatgtctt tcctaccatc taaaatacga aggtttctgg ctgggtaagg tttgtagttg
     3901 acagtaaaac ctgatgacac catttgtttc cctgcaagtc tacattacat atttcacaac
     3961 tttgtccctc tctagtaggc acattggaaa aattcttcaa ctgaaaacta ccttggtacc
     4021 atgtcctaca cgttttaaac cttagtttta aaaattcccc tgcgaaatag ccataagtat
     4081 tcatatcaag tcagttgtga ctccttgtgt atacaattca ttttttgtgt cttcagggta
     4141 aactcaattt ttggtaaagt ggtttcagct tttgtgaaaa ccgttttggt gtgtaagcat
     4201 gacacacaac agactcagta agctgcccat cctcatacta ggaaaacacc ttcaaaggaa
     4261 cattaaaagt taccagggcc aggcacagtg gctcacgcct gtaatcccag cactttggga
     4321 ggctgaggca gatggatccc aagtccagga atttgagacg agcctgggca acatagtgag
     4381 agcctgtcaa caaaaaatag aaaaattagt tgggcttggt gatacacatc tgtagtccca
     4441 gctatttggg aggctgcctt gatatcaggc agtcgaggct gcagtgagct gactgcccca
     4501 ctgtattcca gcctgggtga ccccatctca aagaagaaaa gttaccagat gtcatgggta
     4561 aaggttggtc ttcaagtggc ctcataagtt gtcttgcatt taaattcagg gaattcattg
     4621 gaccaatagg ttacattttc gttccttttt tgttttggtt catctgttaa gcagtggggg
     4681 cctaattact gctcctttgt aaaaacacat tttcccaaag aacactgaat taccgttcaa
     4741 actggttgtt gatgggtaat aagggctgtt tttgctgccc caaaagggct taacaattta
     4801 gtcggatagt ttacttaaaa aaaaaaatcc tttggagaca tactgaaaat gcaaactagt
     4861 ttctaaatta tcaattccct acatgaagaa gcagtttgcc agagtttagt ctcagaaaat
     4921 gactggttgg ctctatttaa atcagaaccc aatttctacg cgtgttgaat aaggtaacag
     4981 cctttgatga atttccttca caacatggtt ttagtgaagc aaacattttt tttttaaggg
     5041 cattgttctt tctagtttat ttctttttat gaaataaaat tattttattt aaacagttcc
     5101 attgtcgttt ctgaaaacta cagtattctc agaagttgta gcagcagtaa aaaaaaaaaa
     5161 gttgttatat aagtgattgg ggcagattta actgattttg ttaaaccaat ttgtaagtta
     5221 ctgcttctaa tattacactt ctaaaaagct gaatttatac tcatgtccta aaggagaata
     5281 tgtggtaata aagtatattt gttaagtaac taattgaaat aggcttggtt ttaagagttc
     5341 cagtatataa taatcacaaa ttgaaacctg acagtatctt gggagttcca gtaatgtcac
     5401 aaattagtga ataagcatgc cagtgtgcaa gggtaatgta aggattgtta gcctatctaa
     5461 atattcaaaa ttactttaaa acttaagtat gttttctgat ttttaagaat tcagaagtgt
     5521 tctgtaatgg attcagatgt ttcatttgta gtataatgaa atgtttacag aaagataact
     5581 ttttcattaa aatattttta gaaatgtgtg tgttgttttg tcacttcaca atgttcatgt
     5641 gacttaaaca ctataggtga atattttgac ttattttacc agtaagtaat aaaacaacag
     5701 gaaacttgga
//
