LOCUS       NM_001330247            5644 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3),
            transcript variant 2, mRNA.
ACCESSION   NM_001330247 XM_005246381
VERSION     NM_001330247.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5644)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 5644)
  AUTHORS   Chen,X., Lloyd,S.M., Kweon,J., Gamalong,G.M. and Bao,X.
  TITLE     Epidermal progenitors suppress GRHL3-mediated differentiation
            through intronic polyadenylation promoted by CPSF-HNRNPA3
            collaboration
  JOURNAL   Nat Commun 12 (1), 448 (2021)
   PUBMED   33469008
  REMARK    GeneRIF: Epidermal progenitors suppress GRHL3-mediated
            differentiation through intronic polyadenylation promoted by
            CPSF-HNRNPA3 collaboration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5644)
  AUTHORS   Ou,M.Y., Ju,X.C., Cai,Y.J., Sun,X.Y., Wang,J.F., Fu,X.Q., Sun,Q.
            and Luo,Z.G.
  TITLE     Heterogeneous nuclear ribonucleoprotein A3 controls mitotic
            progression of neural progenitors via interaction with cohesin
  JOURNAL   Development 147 (10) (2020)
   PUBMED   32321712
  REMARK    GeneRIF: Heterogeneous nuclear ribonucleoprotein A3 controls
            mitotic progression of neural progenitors via interaction with
            cohesin.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5644)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   5  (bases 1 to 5644)
  AUTHORS   Mishra,N., Reddy,K.S., Timilsina,U., Gaur,D. and Gaur,R.
  TITLE     Human APOBEC3B interacts with the heterogenous nuclear
            ribonucleoprotein A3 in cancer cells
  JOURNAL   J Cell Biochem 119 (8), 6695-6703 (2018)
   PUBMED   29693745
  REMARK    GeneRIF: results indicated a specific interaction of A3B with hnRNP
            A3 (heterogeneous nuclear ribonucleoprotein). This interaction was
            verified by co-immunoprecipitation and was found to be
            RNA-dependent. Furthermore, A3B and hnRNP A3 colocalized as evident
            from immunofluorescence analysis.
REFERENCE   6  (bases 1 to 5644)
  AUTHORS   Huang,P.R., Tsai,S.T., Hsieh,K.H. and Wang,T.C.
  TITLE     Heterogeneous nuclear ribonucleoprotein A3 binds single-stranded
            telomeric DNA and inhibits telomerase extension in vitro
  JOURNAL   Biochim Biophys Acta 1783 (2), 193-202 (2008)
   PUBMED   17919748
  REMARK    GeneRIF: These biochemical properties of hnRNP A3 suggest that
            hnRNP A3 can participate in telomere regulation in vivo.
REFERENCE   7  (bases 1 to 5644)
  AUTHORS   Makeyev,A.V., Kim,C.B., Ruddle,F.H., Enkhmandakh,B.,
            Erdenechimeg,L. and Bayarsaihan,D.
  TITLE     HnRNP A3 genes and pseudogenes in the vertebrate genomes
  JOURNAL   J Exp Zool A Comp Exp Biol 303 (4), 259-271 (2005)
   PUBMED   15776420
REFERENCE   8  (bases 1 to 5644)
  AUTHORS   Ma,A.S., Moran-Jones,K., Shan,J., Munro,T.P., Snee,M.J., Hoek,K.S.
            and Smith,R.
  TITLE     Heterogeneous nuclear ribonucleoprotein A3, a novel RNA trafficking
            response element-binding protein
  JOURNAL   J Biol Chem 277 (20), 18010-18020 (2002)
   PUBMED   11886857
REFERENCE   9  (bases 1 to 5644)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   10 (bases 1 to 5644)
  AUTHORS   Takiguchi,S., Tokino,T., Imai,T., Tanigami,A., Koyama,K. and
            Nakamura,Y.
  TITLE     Identification and characterization of a cDNA, which is highly
            homologous to the ribonucleoprotein gene, from a locus (D10S102)
            closely linked to MEN2 (multiple endocrine neoplasia type 2)
  JOURNAL   Cytogenet Cell Genet 64 (2), 128-130 (1993)
   PUBMED   8101480
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079305.6.
            
            On Jun 7, 2021 this sequence version replaced NM_001330247.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.3418609.1,
                                           SRR18074969.983045.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC079305.6         106895-106906
            13-135              AC079305.6         109640-109762
            136-282             AC079305.6         109851-109997
            283-493             AC079305.6         110079-110289
            494-583             AC079305.6         110604-110693
            584-679             AC079305.6         110777-110872
            680-760             AC079305.6         110961-111041
            761-901             AC079305.6         111806-111946
            902-1024            AC079305.6         113138-113260
            1025-1092           AC079305.6         113348-113415
            1093-5644           AC079305.6         113509-118060
FEATURES             Location/Qualifiers
     source          1..5644
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.2"
     gene            1..5644
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /note="heterogeneous nuclear ribonucleoprotein A3"
                     /db_xref="GeneID:220988"
                     /db_xref="HGNC:HGNC:24941"
                     /db_xref="MIM:605372"
     exon            1..12
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..1077
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /note="isoform b is encoded by transcript variant 2;
                     epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoprotein A3
                     isoform b"
                     /protein_id="NP_001317176.1"
                     /db_xref="CCDS:CCDS82536.1"
                     /db_xref="GeneID:220988"
                     /db_xref="HGNC:HGNC:24941"
                     /db_xref="MIM:605372"
                     /translation="MEGHDPKEPEQLRKLFIGGLSFETTDDSLREHFEKWGTLTDCVV
                     MRDPQTKRSRGFGFVTYSCVEEVDAAMCARPHKVDGRVVEPKRAVSREDSVKPGAHLT
                     VKKIFVGGIKEDTEEYNLRDYFEKYGKIETIEVMEDRQSGKKRGFAFVTFDDHDTVDK
                     IVVQKYHTINGHNCEVKKALSKQEMQSAGSQRGRGGGSGNFMGRGGNFGGGGGNFGRG
                     GNFGGRGGYGGGGGGSRGSYGGGDGGYNGFGGDGGNYGGGPGYSSRGGYGGGGPGYGN
                     QGGGYGGGGGYDGYNEGGNFGGGNYGGGGNYNDFGNYSGQQQSNYGPMKGGSFGGRSS
                     GSPYGGGYGSGGGSGGYGSRRF"
     exon            13..135
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /inference="alignment:Splign:2.1.0"
     exon            136..282
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /inference="alignment:Splign:2.1.0"
     exon            283..493
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /inference="alignment:Splign:2.1.0"
     exon            494..583
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /inference="alignment:Splign:2.1.0"
     exon            584..679
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /inference="alignment:Splign:2.1.0"
     exon            680..760
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /inference="alignment:Splign:2.1.0"
     exon            761..901
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1024
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1092
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..5644
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2190..2195
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /note="hexamer: AATAAA"
     polyA_site      2219
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /note="major polyA site"
     regulatory      3837..3842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /note="hexamer: AGTAAA"
     polyA_site      3856
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /note="major polyA site"
     regulatory      5520..5525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /note="hexamer: ATTAAA"
     polyA_site      5542
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
     regulatory      5622..5627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /note="hexamer: AATAAA"
     polyA_site      5644
                     /gene="HNRNPA3"
                     /gene_synonym="2610510D13Rik; D10S102; FBRNP; HNRPA3"
                     /note="major polyA site"
ORIGIN      
        1 ctcaaaatgg agggccatga tccaaaggaa ccagagcagt tgagaaaact gtttattggt
       61 ggtctgagct ttgaaactac agatgatagt ttacgagaac attttgagaa atggggcaca
      121 ctcacagatt gtgtggtaat gagagacccc caaacaaaac gttccagggg ctttggtttt
      181 gtgacttatt cttgtgttga agaggtggat gcagcaatgt gtgctcgacc acacaaggtt
      241 gatgggcgtg tagtggaacc aaagagagct gtttctagag aggattctgt aaagcctggt
      301 gcccatctaa cagtgaagaa aatttttgtt ggtggtatta aagaagatac agaagaatat
      361 aatttgagag actactttga aaagtatggc aagattgaaa ccatagaagt tatggaagac
      421 aggcagagtg gaaaaaagag aggatttgct tttgtaactt ttgatgatca tgatacagtt
      481 gataaaattg ttgttcagaa ataccacact attaatgggc ataattgtga agtgaaaaag
      541 gccctttcta aacaagagat gcagtctgct ggatcacaga gaggtcgtgg aggtggatct
      601 ggcaatttta tgggtcgcgg agggaacttt ggaggtggtg gaggtaattt tggccgtggt
      661 ggaaactttg gtggaagagg aggctatggt ggtggaggtg gtggcagcag aggtagttat
      721 ggaggaggtg atggtggata taatggattt ggaggtgatg gtggcaacta tggcggtggt
      781 cctggttata gtagtagagg gggctatggt ggtggtggac caggatatgg aaaccaaggt
      841 ggtggatatg gtggaggtgg aggatatgat ggttacaatg aaggaggaaa ttttggcggt
      901 ggtaactatg gtggtggtgg gaactataat gattttggaa attatagtgg acaacagcaa
      961 tcaaattatg gacccatgaa agggggcagt tttggtggaa gaagctcggg cagtccctat
     1021 ggtggtggtt atggatctgg tggtggaagt ggtggatatg gtagcagaag gttctaaaaa
     1081 cagcagaaaa gggctacagt tcttagcagg agagagagcg aggagttgtc aggaaagctg
     1141 caggttactt tgagacagtc gtcccaaatg cattagagga actgtaaaaa tctgccacag
     1201 aaggaacgat gatccatagt cagaaaagtt actgcagctt aaacaggaaa cccttcttgt
     1261 tcaggactgt catagccaca gtttgcaaaa agtgcagcta ttgattaatg caatgtagtg
     1321 tcaattagat gtacattcct gaggtctttt atctgttgta gctttgtctt tttctttttc
     1381 ttttcattac atcaggtata ttgccctgta aattgtggta gtggtaccag gaataaaaaa
     1441 ttaaggaatt tttaactttt caatatttgt gtagttcagt ttttctacat tttagtacag
     1501 aaactttaac aaaatgcagt ttcgaaggtg tttccttgtg agttaacaag taaagaagat
     1561 cattgttaat tactattttg tatgaatttt gctaaagtta actgtaaaga aacacctgct
     1621 gacttgcagt ttaaggggaa tctattctcc ccatttccaa accatgatat gaatgggcgc
     1681 tgacatgtgg agagaataga taatttgtgt gtttgcaatg tgtgttttag ataaatagga
     1741 ttgggtattt aaattagcat ttgtgaattt aatagcatta agattacctt caaatgaaaa
     1801 aaaatctcaa aatttctatt tggtttttgt gcattttctt ttaaaatgta atcatatgat
     1861 tttagtgtgt tagacttgct gagtcctagc tgtgtttaga acatctctat tctacattta
     1921 ccttggtcaa atttgaactg ctgccatagg ttttgggtgt aaagaatgtt tactgccctc
     1981 catttaaatt ctgaaaaggg atggtggatg ttttccctct cctacgttag aaaccattct
     2041 taaaaacttt tgaaaatata gaaccattaa gcctgctata tctgagcaaa ttagtgggta
     2101 cctttttttt cttatttaaa gcacaagagg cccataaatc ttgagttact ttaaattctt
     2161 ttttttgata caagttttca gagcaagaga ataaaaatca tgtgttatta aacccctaac
     2221 tggctggcat gctttcctgt ttgtattcta tacattttgc tggatgaaac caaggatagt
     2281 tcaggtataa ttgtccaaaa taacctaact gcagcagaaa tgtagcacag ttgcttagta
     2341 caggcttctc acttcctaca gacctgaatt caaatttgga tagtctgagt tcttaaattc
     2401 ccaaagaaca cactgttatt tcttgtgtat atttcaacat aaatcatgtt gttaccaatt
     2461 tgtttggaag gccctggttg agaagagttt tagttaataa ggtcatatat acatatatta
     2521 atataaacca atgtctactg ttttgctcca gctagtgctt acagtttcat tcgagccctg
     2581 agtatgtgcc ctgctgttac tctctttggt agttgaacgt tgaattcaag tcttttgttt
     2641 taagaagtac taagcaaaca agcaataaaa aggggaatgg ggtgtgctag tgtttgaata
     2701 tgctctcttg ttgctctaat tctgtgcctc tgtgcattaa tatttggatg catgcaatgc
     2761 cagcatggaa attggtcttc acacatactg cagttttcca gaaacattca caaaccaata
     2821 aatgtaacag acattccatt tgttaatggg catatatgtg aaaagcagtg tagaaaatag
     2881 gctaatatta gaaaatggtt aagtcctaaa taacttcaag tgtggttata taatggacac
     2941 tgtcaatgtt cataacttaa acctgggtac ctggtcaaaa taatgcttgg gaaacattaa
     3001 aattgagcta aattgtctca agttctttta ttcatataaa taaagtttaa aggaatgggg
     3061 gagattaaca tttcctgttt tatgtttgtg aaattgtttg acacaacctt gacagtatcc
     3121 tttaatggca tgaggttaat tgtactgtta accaactttc tatgttctgg aactagtatt
     3181 atagtgaaaa catttacagt aagttgatgt ttacaaccta taagcaggtg aaatctgtgt
     3241 atgtgacctg tttataagtt gtattagctt agctcttgtg aacagtgtgg aaaagtaagc
     3301 catgaggaga gcgatttaac cacctttaaa ggacctaaga tgtgcttttt aagcacagtg
     3361 tggatcacag aaactcacta agacaggact tcagcagcct tttgtgtttg gacaagtcag
     3421 cataaataaa gaatgacaag gcagcagcaa gagcttcaac tacagagaag tgaaggcata
     3481 agatactatg atgatagtga gcaactttcc aaaagctagt taaatctgct tattacaact
     3541 gaaatatcga agaaagtcta gcaggaagga gctcttcgcc ttttggaaca tcaatgagag
     3601 atagttgcca cagtcactag gtctagcatt tagacctgca aggaagggca ataagcatta
     3661 ggtaaggctt gaatttgaat tttttcacta attaaagagt aattttttgt aaagcaaggt
     3721 aagagtaatc tttttgattt gcaggttgaa tgagaaccct acttgcctaa atgaggaatg
     3781 tctttcctac catctaaaat acgaaggttt ctggctgggt aaggtttgta gttgacagta
     3841 aaacctgatg acaccatttg tttccctgca agtctacatt acatatttca caactttgtc
     3901 cctctctagt aggcacattg gaaaaattct tcaactgaaa actaccttgg taccatgtcc
     3961 tacacgtttt aaaccttagt tttaaaaatt cccctgcgaa atagccataa gtattcatat
     4021 caagtcagtt gtgactcctt gtgtatacaa ttcatttttt gtgtcttcag ggtaaactca
     4081 atttttggta aagtggtttc agcttttgtg aaaaccgttt tggtgtgtaa gcatgacaca
     4141 caacagactc agtaagctgc ccatcctcat actaggaaaa caccttcaaa ggaacattaa
     4201 aagttaccag ggccaggcac agtggctcac gcctgtaatc ccagcacttt gggaggctga
     4261 ggcagatgga tcccaagtcc aggaatttga gacgagcctg ggcaacatag tgagagcctg
     4321 tcaacaaaaa atagaaaaat tagttgggct tggtgataca catctgtagt cccagctatt
     4381 tgggaggctg ccttgatatc aggcagtcga ggctgcagtg agctgactgc cccactgtat
     4441 tccagcctgg gtgaccccat ctcaaagaag aaaagttacc agatgtcatg ggtaaaggtt
     4501 ggtcttcaag tggcctcata agttgtcttg catttaaatt cagggaattc attggaccaa
     4561 taggttacat tttcgttcct tttttgtttt ggttcatctg ttaagcagtg ggggcctaat
     4621 tactgctcct ttgtaaaaac acattttccc aaagaacact gaattaccgt tcaaactggt
     4681 tgttgatggg taataagggc tgtttttgct gccccaaaag ggcttaacaa tttagtcgga
     4741 tagtttactt aaaaaaaaaa atcctttgga gacatactga aaatgcaaac tagtttctaa
     4801 attatcaatt ccctacatga agaagcagtt tgccagagtt tagtctcaga aaatgactgg
     4861 ttggctctat ttaaatcaga acccaatttc tacgcgtgtt gaataaggta acagcctttg
     4921 atgaatttcc ttcacaacat ggttttagtg aagcaaacat ttttttttta agggcattgt
     4981 tctttctagt ttatttcttt ttatgaaata aaattatttt atttaaacag ttccattgtc
     5041 gtttctgaaa actacagtat tctcagaagt tgtagcagca gtaaaaaaaa aaaagttgtt
     5101 atataagtga ttggggcaga tttaactgat tttgttaaac caatttgtaa gttactgctt
     5161 ctaatattac acttctaaaa agctgaattt atactcatgt cctaaaggag aatatgtggt
     5221 aataaagtat atttgttaag taactaattg aaataggctt ggttttaaga gttccagtat
     5281 ataataatca caaattgaaa cctgacagta tcttgggagt tccagtaatg tcacaaatta
     5341 gtgaataagc atgccagtgt gcaagggtaa tgtaaggatt gttagcctat ctaaatattc
     5401 aaaattactt taaaacttaa gtatgttttc tgatttttaa gaattcagaa gtgttctgta
     5461 atggattcag atgtttcatt tgtagtataa tgaaatgttt acagaaagat aactttttca
     5521 ttaaaatatt tttagaaatg tgtgtgttgt tttgtcactt cacaatgttc atgtgactta
     5581 aacactatag gtgaatattt tgacttattt taccagtaag taataaaaca acaggaaact
     5641 tgga
//
