LOCUS       NM_002137               3628 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens heterogeneous nuclear ribonucleoprotein A2/B1
            (HNRNPA2B1), transcript variant A2, mRNA.
ACCESSION   NM_002137
VERSION     NM_002137.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3628)
  AUTHORS   Zhang,X., Yan,L.-n., Liu,B.-y., Zhou,C.-m. and Yu,X.-j.
  TITLE     The hnRNP A2B1 is important for the replication of SFTSV and other
            RNA viruses
  JOURNAL   Microbiol Spectr 12 (10), e0082924 (2024)
   PUBMED   39166862
  REMARK    GeneRIF: The hnRNP A2B1 is important for the replication of SFTSV
            and other RNA viruses.
REFERENCE   2  (bases 1 to 3628)
  AUTHORS   Huang,T., Zhu,G. and Chen,F.
  TITLE     The Potential Impact of HNRNPA2B1 on Human Cancers Prognosis and
            Immune Microenvironment
  JOURNAL   J Immunol Res 2024, 5515307 (2024)
   PUBMED   39268079
  REMARK    GeneRIF: The Potential Impact of HNRNPA2B1 on Human Cancers
            Prognosis and Immune Microenvironment.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3628)
  AUTHORS   Wang,H., Shi,Y., Zhou,X., Zhang,L., Yang,A., Zhou,D. and Ma,T.
  TITLE     HNRNPA2B1 stabilizes NFATC3 levels to potentiate its combined
            actions with FOSL1 to mediate vasculogenic mimicry in GBM cells
  JOURNAL   Cell Biol Toxicol 40 (1), 44 (2024)
   PUBMED   38862832
  REMARK    GeneRIF: HNRNPA2B1 stabilizes NFATC3 levels to potentiate its
            combined actions with FOSL1 to mediate vasculogenic mimicry in GBM
            cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3628)
  AUTHORS   Jin,T., Yang,L., Chang,C., Luo,H., Wang,R., Gan,Y., Sun,Y., Guo,Y.,
            Tang,R., Chen,S., Meng,D., Dai,P. and Liu,M.
  TITLE     HnRNPA2B1 ISGylation Regulates m6A-Tagged mRNA Selective Export via
            ALYREF/NXF1 Complex to Foster Breast Cancer Development
  JOURNAL   Adv Sci (Weinh) 11 (24), e2307639 (2024)
   PUBMED   38626369
  REMARK    GeneRIF: HnRNPA2B1 ISGylation Regulates m6A-Tagged mRNA Selective
            Export via ALYREF/NXF1 Complex to Foster Breast Cancer Development.
REFERENCE   5  (bases 1 to 3628)
  AUTHORS   Yang,Y., Zhang,Y., Feng,T. and Zhu,C.
  TITLE     HNRNPA2B1 induces cell proliferation and acts as biomarker in
            breast cancer
  JOURNAL   Cancer Biomark 40 (3-4), 285-296 (2024)
   PUBMED   39177591
  REMARK    GeneRIF: HNRNPA2B1 induces cell proliferation and acts as biomarker
            in breast cancer.
REFERENCE   6  (bases 1 to 3628)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
REFERENCE   7  (bases 1 to 3628)
  AUTHORS   Wilk,H.E., Schaefer,K.P., Agris,P.F., Boak,A.M. and Kovacs,S.A.
  TITLE     U1 SnRNP association with HnRNP involves an initial non-specific
            splice-site independent interaction of U1 SnRNP protein with HnRNA
  JOURNAL   Mol Cell Biochem 106 (1), 55-66 (1991)
   PUBMED   1833625
REFERENCE   8  (bases 1 to 3628)
  AUTHORS   Bauw,G., Rasmussen,H.H., van den Bulcke,M., van Damme,J., Puype,M.,
            Gesser,B., Celis,J.E. and Vandekerckhove,J.
  TITLE     Two-dimensional gel electrophoresis, protein electroblotting and
            microsequencing: a direct link between proteins and genes
  JOURNAL   Electrophoresis 11 (7), 528-536 (1990)
   PUBMED   1699755
REFERENCE   9  (bases 1 to 3628)
  AUTHORS   Burd,C.G., Swanson,M.S., Gorlach,M. and Dreyfuss,G.
  TITLE     Primary structures of the heterogeneous nuclear ribonucleoprotein
            A2, B1, and C2 proteins: a diversity of RNA binding proteins is
            generated by small peptide inserts
  JOURNAL   Proc Natl Acad Sci U S A 86 (24), 9788-9792 (1989)
   PUBMED   2557628
REFERENCE   10 (bases 1 to 3628)
  AUTHORS   Kumar,A., Williams,K.R. and Szer,W.
  TITLE     Purification and domain structure of core hnRNP proteins A1 and A2
            and their relationship to single-stranded DNA-binding proteins
  JOURNAL   J Biol Chem 261 (24), 11266-11273 (1986)
   PUBMED   3733753
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB244417.1, M29065.1 and
            AC004520.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_002137.3.
            
            Summary: This gene belongs to the A/B subfamily of ubiquitously
            expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The
            hnRNPs are RNA binding proteins and they complex with heterogeneous
            nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs
            in the nucleus and appear to influence pre-mRNA processing and
            other aspects of mRNA metabolism and transport. While all of the
            hnRNPs are present in the nucleus, some seem to shuttle between the
            nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic
            acid binding properties. The protein encoded by this gene has two
            repeats of quasi-RRM domains that bind to RNAs. This gene has been
            described to generate two alternatively spliced transcript variants
            which encode different isoforms. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (A2) lacks 36 bases at the
            beginning of the coding region compared to variant B1. The
            N-terminus of isoform A2 is thus different from isoform B1. This
            isoform (A2) is the predominant protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.114214.1,
                                           SRR1803612.96491.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000618183.5/ ENSP00000478691.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                DB244417.1         48-61
            15-1711             M29065.1           1-1697
            1712-3619           AC004520.2         130059-131966       c
            3620-3628           AC004520.2         130050-130058       c
FEATURES             Location/Qualifiers
     source          1..3628
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p15.2"
     gene            1..3628
                     /gene="HNRNPA2B1"
                     /gene_synonym="HNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1;
                     IBMPFD2; OPMD2; RNPA2; SNRPB1"
                     /note="heterogeneous nuclear ribonucleoprotein A2/B1"
                     /db_xref="GeneID:3181"
                     /db_xref="HGNC:HGNC:5033"
                     /db_xref="MIM:600124"
     exon            1..175
                     /gene="HNRNPA2B1"
                     /gene_synonym="HNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1;
                     IBMPFD2; OPMD2; RNPA2; SNRPB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..1195
                     /gene="HNRNPA2B1"
                     /gene_synonym="HNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1;
                     IBMPFD2; OPMD2; RNPA2; SNRPB1"
                     /note="isoform A2 is encoded by transcript variant A2;
                     nuclear ribonucleoprotein particle A2 protein;
                     heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2 /
                     hnRNP B1; HNRNPA2B1/MYC fusion; epididymis secretory sperm
                     binding protein"
                     /codon_start=1
                     /product="heterogeneous nuclear ribonucleoproteins A2/B1
                     isoform A2"
                     /protein_id="NP_002128.1"
                     /db_xref="CCDS:CCDS5397.1"
                     /db_xref="GeneID:3181"
                     /db_xref="HGNC:HGNC:5033"
                     /db_xref="MIM:600124"
                     /translation="MEREKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDP
                     ASKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREESGKPGAHVTVKKL
                     FVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQ
                     KYHTINGHNAEVRKALSRQEMQEVQSSRSGRGGNFGFGDSRGGGGNFGPGPGSNFRGG
                     SDGYGSGRGFGDGYNGYGGGPGGGNFGGSPGYGGGRGGYGGGGPGYGNQGGGYGGGYD
                     NYGGGNYGSGNYNDFGNYNQQPSNYGPMKSGNFGGSRNMGGPYGGGNYGPGGSGGSGG
                     YGGRSRY"
     exon            176..286
                     /gene="HNRNPA2B1"
                     /gene_synonym="HNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1;
                     IBMPFD2; OPMD2; RNPA2; SNRPB1"
                     /inference="alignment:Splign:2.1.0"
     exon            287..433
                     /gene="HNRNPA2B1"
                     /gene_synonym="HNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1;
                     IBMPFD2; OPMD2; RNPA2; SNRPB1"
                     /inference="alignment:Splign:2.1.0"
     exon            434..644
                     /gene="HNRNPA2B1"
                     /gene_synonym="HNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1;
                     IBMPFD2; OPMD2; RNPA2; SNRPB1"
                     /inference="alignment:Splign:2.1.0"
     exon            645..746
                     /gene="HNRNPA2B1"
                     /gene_synonym="HNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1;
                     IBMPFD2; OPMD2; RNPA2; SNRPB1"
                     /inference="alignment:Splign:2.1.0"
     exon            747..827
                     /gene="HNRNPA2B1"
                     /gene_synonym="HNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1;
                     IBMPFD2; OPMD2; RNPA2; SNRPB1"
                     /inference="alignment:Splign:2.1.0"
     exon            828..890
                     /gene="HNRNPA2B1"
                     /gene_synonym="HNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1;
                     IBMPFD2; OPMD2; RNPA2; SNRPB1"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1010
                     /gene="HNRNPA2B1"
                     /gene_synonym="HNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1;
                     IBMPFD2; OPMD2; RNPA2; SNRPB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1133
                     /gene="HNRNPA2B1"
                     /gene_synonym="HNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1;
                     IBMPFD2; OPMD2; RNPA2; SNRPB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1216
                     /gene="HNRNPA2B1"
                     /gene_synonym="HNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1;
                     IBMPFD2; OPMD2; RNPA2; SNRPB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..3628
                     /gene="HNRNPA2B1"
                     /gene_synonym="HNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1;
                     IBMPFD2; OPMD2; RNPA2; SNRPB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1695..1700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPA2B1"
                     /gene_synonym="HNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1;
                     IBMPFD2; OPMD2; RNPA2; SNRPB1"
                     /note="hexamer: AATAAT"
     polyA_site      1711
                     /gene="HNRNPA2B1"
                     /gene_synonym="HNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1;
                     IBMPFD2; OPMD2; RNPA2; SNRPB1"
                     /note="major polyA site"
     regulatory      3220..3225
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPA2B1"
                     /gene_synonym="HNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1;
                     IBMPFD2; OPMD2; RNPA2; SNRPB1"
                     /note="hexamer: AATAAA"
     polyA_site      3251
                     /gene="HNRNPA2B1"
                     /gene_synonym="HNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1;
                     IBMPFD2; OPMD2; RNPA2; SNRPB1"
     regulatory      3408..3413
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPA2B1"
                     /gene_synonym="HNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1;
                     IBMPFD2; OPMD2; RNPA2; SNRPB1"
                     /note="hexamer: AATAAA"
     polyA_site      3430
                     /gene="HNRNPA2B1"
                     /gene_synonym="HNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1;
                     IBMPFD2; OPMD2; RNPA2; SNRPB1"
     regulatory      3601..3606
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNRNPA2B1"
                     /gene_synonym="HNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1;
                     IBMPFD2; OPMD2; RNPA2; SNRPB1"
                     /note="hexamer: AATAAA"
     polyA_site      3628
                     /gene="HNRNPA2B1"
                     /gene_synonym="HNRNPA2; HNRNPB1; HNRPA2; HNRPA2B1; HNRPB1;
                     IBMPFD2; OPMD2; RNPA2; SNRPB1"
ORIGIN      
        1 agtagcagca gcgccgggtc ccgtgcggag gtgctcctcg cagagttgtt tctcgagcag
       61 cggcagttct cactacagcg ccaggacgag tccggttcgt gttcgtccgc ggagatctct
      121 ctcatctcgc tcggctgcgg gaaatcgggc tgaagcgact gagtccgcga tggagagaga
      181 aaaggaacag ttccgtaagc tctttattgg tggcttaagc tttgaaacca cagaagaaag
      241 tttgaggaac tactacgaac aatggggaaa gcttacagac tgtgtggtaa tgagggatcc
      301 tgcaagcaaa agatcaagag gatttggttt tgtaactttt tcatccatgg ctgaggttga
      361 tgctgccatg gctgcaagac ctcattcaat tgatgggaga gtagttgagc caaaacgtgc
      421 tgtagcaaga gaggaatctg gaaaaccagg ggctcatgta actgtgaaga agctgtttgt
      481 tggcggaatt aaagaagata ctgaggaaca tcaccttaga gattactttg aggaatatgg
      541 aaaaattgat accattgaga taattactga taggcagtct ggaaagaaaa gaggctttgg
      601 ctttgttact tttgatgacc atgatcctgt ggataaaatc gtattgcaga aataccatac
      661 catcaatggt cataatgcag aagtaagaaa ggctttgtct agacaagaaa tgcaggaagt
      721 tcagagttct aggagtggaa gaggaggcaa ctttggcttt ggggattcac gtggtggcgg
      781 tggaaatttc ggaccaggac caggaagtaa ctttagagga ggatctgatg gatatggcag
      841 tggacgtgga tttggggatg gctataatgg gtatggagga ggacctggag gtggcaattt
      901 tggaggtagc cccggttatg gaggaggaag aggaggatat ggtggtggag gacctggata
      961 tggcaaccag ggtgggggct acggaggtgg ttatgacaac tatggaggag gaaattatgg
     1021 aagtggaaat tacaatgatt ttggaaatta taaccagcaa ccttctaact acggtccaat
     1081 gaagagtgga aactttggtg gtagcaggaa catgggggga ccatatggtg gaggaaacta
     1141 tggtccagga ggcagtggag gaagtggggg ttatggtggg aggagccgat actgagcttc
     1201 ttcctatttg ccatgggctt cactgtataa ataggagagg atgagagccc agaggtaaca
     1261 gaacagcttc aggttatcga aataacaatg ttaaggaaac tcttatctca gtcatgcata
     1321 aatatgcagt gatatggcag aagacaccag agcagatgca gagagccatt ttgtgaatgg
     1381 attggattat ttaataacat taccttactg tggaggaagg attgtaaaaa aaaatgcctt
     1441 tgagacagtt tcttagcttt ttaattgttg tttctttcta gtggtctttg taagagtgta
     1501 gaagcattcc ttctttgata atgttaaatt tgtaagtttc aggtgacatg tgaaaccttt
     1561 tttaagattt ttctcaaagt tttgaaaagc tattagccag gatcatggtg taataagaca
     1621 taacgttttt cctttaaaaa aatttaagtg cgtgtgtaga gttaagaagc tgttgtacat
     1681 ttatgattta ataaaataat tctaaaggaa attgtgtaat tatagacttt ttattttaaa
     1741 taagttaagg agtgggtagt ataattaagg tccgttgcaa agctgttgtt atatttgtat
     1801 aagataaatg ctggtcagat gtaagtgtgt tgtctgcaat tcatcaggat taaattatgt
     1861 agataactta agggatatct ctgcaaggag aaacaccttt ttagatcttt tagatgctgc
     1921 ttcttcaatg caaggaaagg aaataacccc agcgaggtac tcttcaggga cacaggtcta
     1981 gtacaagaga actcttgacg gctactaagt tcagccagtc ttaaaaaact gtgctgtttc
     2041 tacaaaactt taactacagt agtttataag gatgccaacg aaagctgagg gtgtagagca
     2101 aaatagttct aagcttcagt taaacttctt taggtaagat cttatttact tttcctttct
     2161 taattttcct ccctaaaaga taaactaata ctcttaaatg gtctttcagt atagtggttc
     2221 ttacgtagtt taacatagct ataaattgag tttaacaatt tataaactca agagaataat
     2281 ttttataaac cctgttttcc aatctgtcat ttacttaaat tattttggtt gtttttccct
     2341 ttttttcctt cttttcccac cccctccccc tccatgtgaa gatttgggtg cttaacatat
     2401 catttttttc cctgccggaa ttttagcatt gatatgaacc atggacaagt atattctgct
     2461 gccacaaaga ctgtaaagtg cttcatttca acagctgagg caagccaagt gatcattaat
     2521 aaagcttttc ttggttcctt cagtggtgtt ggtagtaaaa tggtaggtaa aagttaggct
     2581 gcaagttcaa taaatcatga gatttcccat cgttacaccc ttgtgtattc acatttcttg
     2641 gatcaaacat tttgagtgaa ctaggggttt ttattaaaga catttgttgt atttatggtt
     2701 gtaactgtac atgcttatca ggatgagact gaaagaaggt agggcaaaaa tggttgaatc
     2761 tattttcaga tagtagttca tacttgagtg aagtgtcttg tctgcattat gaagcctggt
     2821 atgtatccag tactaaatag gtgggttaaa tgtggtaatt ctagttcagt gtcttaccct
     2881 gaagagaaag ttgtaggttg gctgttgaaa ttcattcctt agatatgatc agtttgattg
     2941 cccggcttta ttgcctttac aggaatgtga tactcagggc ttactctata caccaatgag
     3001 tcttctttga tcctaagacc accactgaag ttgtttaggt tcttttggac aaacatgata
     3061 aacttcttca gatacttttt ttttcctttg gcaggaaggt gtcttgctgc aggtaactaa
     3121 tgaagaagtg gtcaaccaca gagtcttcaa gaaataagaa attctgtacc atctgaaagt
     3181 agttcttgtt ggtgccttca tttaaaaagc actctttaaa ataaaaggga aatgttttct
     3241 gataaaacaa acatttagtt gaggttcttg atataaaaca attacaaaat gagtgttgtt
     3301 tgtaaaacag taacatcaaa ttggctagag agataaatgt atcatgtttt aaattaggtt
     3361 ttgtgagtag acagattaca attctatttt aaatataaag tttataaaat aaatactttt
     3421 tgtatccaaa tacttggtgt aatgtttaca cataaaatgt gtgaatcttg ttctataaat
     3481 atttggttgt ctaaaagatc accatcccct aaatttttaa aagcagtttc acaaagctat
     3541 gcatatttta atattaacag gtaaatgaga agagcattgt ggacattatt ggctgtcccc
     3601 aataaaatgc tgttcattat gcactgta
//
