LOCUS       NM_004133               4200 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens hepatocyte nuclear factor 4 gamma (HNF4G), transcript
            variant 1, mRNA.
ACCESSION   NM_004133
VERSION     NM_004133.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4200)
  AUTHORS   Zhan,J., Zhang,Q., Tong,X., Liu,X. and Zhao,C.
  TITLE     HNF4G stimulates the development of pancreatic cancer by promoting
            IGF2BP2 transcription
  JOURNAL   Clin Transl Oncol 25 (5), 1472-1481 (2023)
   PUBMED   36607591
  REMARK    GeneRIF: HNF4G stimulates the development of pancreatic cancer by
            promoting IGF2BP2 transcription.
REFERENCE   2  (bases 1 to 4200)
  AUTHORS   Chen,L., Shi,H., Wang,X., Wang,T., Wang,Y., Wu,Z., Zhang,W.,
            Chen,H., Zhong,M., Mao,X., Shi,X. and Li,Q.
  TITLE     Hepatocyte nuclear factor 4 gamma (HNF4G) is correlated with poor
            prognosis and promotes tumor cell growth by inhibiting
            caspase-dependent intrinsic apoptosis in colorectal cancer
  JOURNAL   Eur J Pharmacol 916, 174727 (2022)
   PUBMED   34965388
  REMARK    GeneRIF: Hepatocyte nuclear factor 4 gamma (HNF4G) is correlated
            with poor prognosis and promotes tumor cell growth by inhibiting
            caspase-dependent intrinsic apoptosis in colorectal cancer.
REFERENCE   3  (bases 1 to 4200)
  AUTHORS   Jia,Y.X., Tang,H., Chang,Z.W., Fan,H.J., Guan,X.Y. and Qin,Y.R.
  TITLE     [Expression of hepatocyte nuclear factor 4gamma in gastric
            carcinoma and its role in cell proliferation and stemness]
  JOURNAL   Zhonghua Zhong Liu Za Zhi 43 (11), 1164-1169 (2021)
   PUBMED   34794218
  REMARK    GeneRIF: [Expression of hepatocyte nuclear factor 4gamma in gastric
            carcinoma and its role in cell proliferation and stemness].
REFERENCE   4  (bases 1 to 4200)
  AUTHORS   Ma,Y.S., Shi,B.W., Guo,J.H., Liu,J.B., Yang,X.L., Xin,R., Shi,Y.,
            Zhang,D.D., Lu,G.X., Jia,C.Y., Wang,H.M., Wang,P.Y., Yang,H.Q.,
            Zhang,J.J., Wu,W., Cao,P.S., Yin,Y.Z., Gu,L.P., Tian,L.L., Lv,Z.W.,
            Wu,C.Y., Wang,G.R., Yu,F., Hou,L.K., Jiang,G.X. and Fu,D.
  TITLE     microRNA-320b suppresses HNF4G and IGF2BP2 expression to inhibit
            angiogenesis and tumor growth of lung cancer
  JOURNAL   Carcinogenesis 42 (5), 762-771 (2021)
   PUBMED   33758932
  REMARK    GeneRIF: microRNA-320b suppresses HNF4G and IGF2BP2 expression to
            inhibit angiogenesis and tumor growth of lung cancer.
REFERENCE   5  (bases 1 to 4200)
  AUTHORS   Wang,C., Zhang,T., Liao,Q., Dai,M., Guo,J., Yang,X., Tan,W.,
            Lin,D., Wu,C. and Zhao,Y.
  TITLE     Metformin inhibits pancreatic cancer metastasis caused by SMAD4
            deficiency and consequent HNF4G upregulation
  JOURNAL   Protein Cell 12 (2), 128-144 (2021)
   PUBMED   32737864
  REMARK    GeneRIF: Metformin inhibits pancreatic cancer metastasis caused by
            SMAD4 deficiency and consequent HNF4G upregulation.
REFERENCE   6  (bases 1 to 4200)
  AUTHORS   Ozeki,T., Takahashi,Y., Nakayama,K., Funayama,M., Nagashima,K.,
            Kodama,T. and Kamataki,T.
  TITLE     Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear
            factor-1 alpha as causal factors of interindividual difference in
            the expression of human dihydrodiol dehydrogenase 4 mRNA in human
            livers
  JOURNAL   Pharmacogenetics 13 (1), 49-53 (2003)
   PUBMED   12544512
  REMARK    GeneRIF: results suggest that the expression level of dihydrodiol
            dehydrogenase 4 mRNA is cooperatively regulated by the amounts of
            HNF-1 alpha, HNF-4 alpha and HNF-4 gamma
REFERENCE   7  (bases 1 to 4200)
  AUTHORS   Ozeki,T., Takahashi,Y., Nakayama,K. and Kamataki,T.
  TITLE     Hepatocyte nuclear factor (HNF)-4 alpha/gamma, HNF-1 alpha, and
            vHNF-1 regulate the cell-specific expression of the human
            dihydrodiol dehydrogenase (DD)4/AKR1C4 gene
  JOURNAL   Arch Biochem Biophys 405 (2), 185-190 (2002)
   PUBMED   12220531
REFERENCE   8  (bases 1 to 4200)
  AUTHORS   Wisely,G.B., Miller,A.B., Davis,R.G., Thornquest,A.D. Jr.,
            Johnson,R., Spitzer,T., Sefler,A., Shearer,B., Moore,J.T.,
            Miller,A.B., Willson,T.M. and Williams,S.P.
  TITLE     Hepatocyte nuclear factor 4 is a transcription factor that
            constitutively binds fatty acids
  JOURNAL   Structure 10 (9), 1225-1234 (2002)
   PUBMED   12220494
  REMARK    GeneRIF: 2.7 A X-ray crystalography results suggest that the HNF4s
            may be transcription factors that are constitutively bound to fatty
            acids
REFERENCE   9  (bases 1 to 4200)
  AUTHORS   Plengvidhya,N., Antonellis,A., Wogan,L.T., Poleev,A.,
            Borgschulze,M., Warram,J.H., Ryffel,G.U., Krolewski,A.S. and
            Doria,A.
  TITLE     Hepatocyte nuclear factor-4gamma: cDNA sequence, gene organization,
            and mutation screening in early-onset autosomal-dominant type 2
            diabetes
  JOURNAL   Diabetes 48 (10), 2099-2102 (1999)
   PUBMED   10512380
REFERENCE   10 (bases 1 to 4200)
  AUTHORS   Drewes,T., Senkel,S., Holewa,B. and Ryffel,G.U.
  TITLE     Human hepatocyte nuclear factor 4 isoforms are encoded by distinct
            and differentially expressed genes
  JOURNAL   Mol Cell Biol 16 (3), 925-931 (1996)
   PUBMED   8622695
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC040917.6 and BX571750.1.
            
            On Aug 2, 2019 this sequence version replaced NM_004133.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX571750.1, HQ692842.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000396423.4/
                                                ENSP00000379701.3
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                AC040917.6         34083-34181
            100-2669            BX571750.1         1-2570
            2670-4200           AC040917.6         59518-61048
FEATURES             Location/Qualifiers
     source          1..4200
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.13"
     gene            1..4200
                     /gene="HNF4G"
                     /gene_synonym="NR2A2; NR2A3"
                     /note="hepatocyte nuclear factor 4 gamma"
                     /db_xref="GeneID:3174"
                     /db_xref="HGNC:HGNC:5026"
                     /db_xref="MIM:605966"
     exon            1..212
                     /gene="HNF4G"
                     /gene_synonym="NR2A2; NR2A3"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1462
                     /gene="HNF4G"
                     /gene_synonym="NR2A2; NR2A3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     HNF-4-gamma; nuclear receptor subfamily 2 group A member
                     2"
                     /codon_start=1
                     /product="hepatocyte nuclear factor 4-gamma isoform 1"
                     /protein_id="NP_004124.5"
                     /db_xref="CCDS:CCDS6220.3"
                     /db_xref="GeneID:3174"
                     /db_xref="HGNC:HGNC:5026"
                     /db_xref="MIM:605966"
                     /translation="MMRVSEPILDMDMANYSEVLDPTYTTLEFETMQILYNSSDSSAP
                     ETSMNTTDNGVNCLCAICGDRATGKHYGASSCDGCKGFFRRSIRKSHVYSCRFSRQCV
                     VDKDKRNQCRYCRLRKCFRAGMKKEAVQNERDRISTRRSTFDGSNIPSINTLAQAEVR
                     SRQISVSSPGSSTDINVKKIASIGDVCESMKQQLLVLVEWAKYIPAFCELPLDDQVAL
                     LRAHAGEHLLLGATKRSMMYKDILLLGNNYVIHRNSCEVEISRVANRVLDELVRPFQE
                     IQIDDNEYACLKAIVFFDPDAKGLSDPVKIKNMRFQVQIGLEDYINDRQYDSRGRFGE
                     LLLLLPTLQSITWQMIEQIQFVKLFGMVKIDNLLQEMLLGGASNDGSHLHHPMHPHLS
                     QDPLTGQTILLGPMSTLVHADQISTPETPLPSPPQGSGQEQYKIAANQASVISHQHLS
                     KQKQL"
     exon            213..381
                     /gene="HNF4G"
                     /gene_synonym="NR2A2; NR2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            382..476
                     /gene="HNF4G"
                     /gene_synonym="NR2A2; NR2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            477..583
                     /gene="HNF4G"
                     /gene_synonym="NR2A2; NR2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            584..739
                     /gene="HNF4G"
                     /gene_synonym="NR2A2; NR2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            740..827
                     /gene="HNF4G"
                     /gene_synonym="NR2A2; NR2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            828..980
                     /gene="HNF4G"
                     /gene_synonym="NR2A2; NR2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1217
                     /gene="HNF4G"
                     /gene_synonym="NR2A2; NR2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1340
                     /gene="HNF4G"
                     /gene_synonym="NR2A2; NR2A3"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..4200
                     /gene="HNF4G"
                     /gene_synonym="NR2A2; NR2A3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1917..1922
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNF4G"
                     /gene_synonym="NR2A2; NR2A3"
                     /note="hexamer: AATAAA"
     polyA_site      1937
                     /gene="HNF4G"
                     /gene_synonym="NR2A2; NR2A3"
     regulatory      4127..4132
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HNF4G"
                     /gene_synonym="NR2A2; NR2A3"
                     /note="hexamer: ATTAAA"
     polyA_site      4149
                     /gene="HNF4G"
                     /gene_synonym="NR2A2; NR2A3"
                     /note="major polyA site"
ORIGIN      
        1 ggattagcac tcacagattg aaagcaaaac acatcaaaac actcatcacg cactctgggc
       61 ttgtggtgcc acttgtatgt gtgtttctaa atcaatgatg agggtatcag aaccaatact
      121 ggacatggac atggcaaatt acagtgaagt tttggaccca acttacacaa ctttggagtt
      181 tgaaactatg cagattctat ataattcaag tgatagttct gccccagaga caagtatgaa
      241 taccacagac aacggtgtca actgtctgtg tgctatctgt ggggacagag caacaggaaa
      301 acactatggg gcatccagct gtgatgggtg caagggtttc ttcagacgca gcattcgtaa
      361 gagtcacgtt tattcttgca ggttcagtcg gcaatgtgtt gttgacaagg acaaaaggaa
      421 tcaatgtaga tattgtcgat taagaaagtg ttttagagcg ggaatgaaaa aagaagctgt
      481 acaaaatgaa cgtgacagaa taagcaccag aagaagcaca tttgatggca gcaacatccc
      541 ctccattaac acactggcac aagctgaagt tcggtctcgc cagatctcag tctcaagccc
      601 tgggtcaagc actgacataa acgttaagaa aattgcaagt attggtgatg tctgtgaatc
      661 tatgaaacag cagctcttag tcttggtgga atgggctaaa tatattcctg ccttctgtga
      721 attaccattg gatgatcagg tggcactgtt gagagctcac gcaggggagc acttactgct
      781 tggagctaca aagagatcca tgatgtataa agatattttg cttttgggaa acaactatgt
      841 tattcaccgc aacagctgtg aagttgagat tagccgtgtg gccaatcgtg ttctagatga
      901 gctggttaga ccatttcaag aaatccagat tgatgacaat gagtatgctt gtttaaaggc
      961 aattgtattt tttgatccag atgcaaaagg gctaagcgat ccagtaaaaa ttaagaacat
     1021 gaggttccaa gtgcagatcg gtttggagga ctacatcaat gatcggcagt atgactcccg
     1081 ggggaggttt ggagagttgc ttctgctcct gcccacactg cagagcatca cgtggcaaat
     1141 gattgagcaa atacagtttg ttaaactttt tgggatggtt aaaattgaca atctacttca
     1201 ggaaatgcta ttaggtgggg cttccaatga tggcagtcat ctccatcatc caatgcatcc
     1261 acatttgtct caagacccat taactggaca aactatactt ttaggtccca tgtcaacact
     1321 ggttcatgca gaccagatct caactcctga aaccccactc ccttccccac cacaaggctc
     1381 tgggcaagaa cagtacaaaa tagctgcaaa ccaagcatca gtcatttcac accagcatct
     1441 ctccaaacaa aagcaattgt gaaaatgtgt ttacttcaga acggcactac ataaatgtga
     1501 aaagttgttg atcttgaaat atctcaggat agcacttttg gcaaactctt agccaaggct
     1561 tcttcattgg tgctgttata agatggtgtc ctattttctt gtttatacgt tcattctgtt
     1621 tgttattgct actatgtaaa actttcacat gcaaccaatg tatatctgag tttgaagatg
     1681 tttatatagg gtattttttc caactgcccc tgcattgtgc ctgaaccaat tgaatcttat
     1741 gtatgagttt catttgtttt attaatgtta atttaaatct gtaaataatt gctttattgt
     1801 gatgtgatac agaacaaagt gttcgttttt gactgaaaat agtagatcag aaatctcagt
     1861 ttaatataaa atgagctaag tttttaaaaa taaattataa acttggagat tagaaaaata
     1921 aagcagttgc tgtagaatag gctgtatctt tttcaagaag aatctcttat ggacagtctg
     1981 tggtaaagaa gcaactcttt gctttagagt taaatattcc tatcttaagt ttagaaaaat
     2041 acaaaaaacc attccaagga tgactggata ctttttgaaa tctgactttc tttgaagatg
     2101 tatgttaagc aaaaacatgt tgcttttatc agttaggata cagggtgaac tgtaacaaag
     2161 aaacccctaa aacagtgact aaatcaagag aggaatctat ttctttctcc tgaaacaatt
     2221 tagaaaatag ttatccattg actagaaatt agtacatgcc cacagctggc tcccacggta
     2281 gccaggagaa ttatctatag gtggaaagtc tgtgtcagcc aaagccatgt cactctgaga
     2341 gaactgattc tgaggacaag ttagccatct accacccatg tcccttattt ggtcctcaca
     2401 ataacacttt aggagagata tcattatcgc tgttttataa ataagggaaa ctttagcttg
     2461 agggtttaag gaacataacc aaagttcaca aacataacga gtgagagaaa cacattcaag
     2521 cccaggtcta gttgacttta atgaatcttt ggtgtggaat gaaaaatgtg aacttcttac
     2581 tcatagtgtg gtttttaaat atatgcagtt gagtgatgat tggatactat tcatcatatt
     2641 gcctataata tatatttacc gataagcagt gagtgtaaaa ttgttgtagc ttgaataaga
     2701 aaccactttt gtagttttaa ccagactttc tcttaaaaac attagataaa ataaaagatt
     2761 caccggatgg attctgatga aaacgaaaac aaagtaaaat gactggctta gcagattctt
     2821 tgaaatgtag cagcccaggg atgtaccaaa tgtcgaattc tagactgagg agtagagttc
     2881 attggagtct taaactctct gatatcactt aaagctggag tttattttaa aacaaatgaa
     2941 gcatgggcca cctcatgatg cagtggctcc tctctggttg aggagaggga aaattggaaa
     3001 aactggtcga gtaattatca ataatttttt ttaaaaagag gatcccaaac tgtaaaagat
     3061 tgaaataatc tttctcagga ttttttaaat gtctaagatt atgatgtcat atctcccact
     3121 taccttataa gtaaaaaggt taatatcaag taacttatta gctcttaaag taaaattgaa
     3181 cttattaaaa gctatctatg atttaataga tttaataaaa ttccttcacg acctggtacc
     3241 cttgtgaaac tgtaaaatat atcatatggg gggagttttt taactcttat tttttgaaaa
     3301 tttactgtag cttctatttc gtgaataaga atgttttgat tttgatcata caaataactt
     3361 ttgtagattt ttgtttactt ttgggggggt tcccttagaa gacattaaaa aaaaatactg
     3421 ccttggtctg tgcaggctgc tgtaatgaaa tactatgaac ttggcagctt ataaacaaca
     3481 gaaatttatt tctcgctgtt ctcaatggtg ggaagtccaa gattaaggga tcaacaaatt
     3541 aggcctctgg atcatacatg gcattttcta gctgtgtcct tatacataaa aggaaaaagg
     3601 tagctctctc gagtctcttt aataaagata ctaattctca tgactgaatc accctccaaa
     3661 ggccccacct cctaatacca tcactctggg gactaggtgt cagcatgtga attttggaaa
     3721 acacaaaaat tcagaacata gcaaatacct ttgaagtata aaagataaaa ttcattttta
     3781 gtgaaccctg taatttattc gtgtatattt actaaacagc tgtatctttg aaattgttag
     3841 taatgattct gcttcaataa ctatggtcag ggaatttata atattatatt tttatatact
     3901 gaactgccat agatgctgga aaaaaggaac tgatgttttc agcatatttt caaaatattg
     3961 ataagggaag ttattacttt tatatagtat tcaacttttt tcaggtaata gaagtgaata
     4021 atttattgtg aaataattca ttttataaat gtataattat ttttataaat tttattgttg
     4081 gaaatcaaaa attagtagat tttttaccat gttaaattat agtgagatta aagtattact
     4141 aaactgtgat gctatgtttg tttcactaaa ctttctaaat aaaaactgag aaaaaaaaaa
//
