LOCUS       NM_001123366            2102 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens histocompatibility minor serpin domain containing
            (HMSD), mRNA.
ACCESSION   NM_001123366 XM_001720690 XM_001726956 XM_001726965
VERSION     NM_001123366.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2102)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 2102)
  AUTHORS   Kawase,T., Akatsuka,Y., Torikai,H., Morishima,S., Oka,A.,
            Tsujimura,A., Miyazaki,M., Tsujimura,K., Miyamura,K., Ogawa,S.,
            Inoko,H., Morishima,Y., Kodera,Y., Kuzushima,K. and Takahashi,T.
  TITLE     Alternative splicing due to an intronic SNP in HMSD generates a
            novel minor histocompatibility antigen
  JOURNAL   Blood 110 (3), 1055-1063 (2007)
   PUBMED   17409267
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009802.13, BM696260.1 and
            AW205887.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001123366.1.
            
            Summary: This gene encodes a serpin-domain containing protein that
            may function as a serine protease inhibitor. This gene is primarily
            expressed in cells of myeloid lineage. A polymorphism in this gene
            may result in the expression a splice variant that encodes a minor
            histocompatibility antigen. [provided by RefSeq, Oct 2010].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.50298.1,
                                           SRR1660803.34195.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000408945.5/ ENSP00000386207.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AC009802.13        118685-118737       c
            54-671              BM696260.1         1-618
            672-679             AW205887.1         15-22               c
            680-2102            AC009802.13        106203-107625       c
FEATURES             Location/Qualifiers
     source          1..2102
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q22.1"
     gene            1..2102
                     /gene="HMSD"
                     /gene_synonym="ACC-6; ACC6; C18orf53; HSMD-v"
                     /note="histocompatibility minor serpin domain containing"
                     /db_xref="GeneID:284293"
                     /db_xref="HGNC:HGNC:23037"
                     /db_xref="MIM:612086"
     exon            1..100
                     /gene="HMSD"
                     /gene_synonym="ACC-6; ACC6; C18orf53; HSMD-v"
                     /inference="alignment:Splign:2.1.0"
     exon            101..274
                     /gene="HMSD"
                     /gene_synonym="ACC-6; ACC6; C18orf53; HSMD-v"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..622
                     /gene="HMSD"
                     /gene_synonym="ACC-6; ACC6; C18orf53; HSMD-v"
                     /note="minor histocompatibility protein HMSD"
                     /codon_start=1
                     /product="serpin-like protein HMSD"
                     /protein_id="NP_001116838.1"
                     /db_xref="CCDS:CCDS42441.1"
                     /db_xref="GeneID:284293"
                     /db_xref="HGNC:HGNC:23037"
                     /db_xref="MIM:612086"
                     /translation="MSISSALAMVFMGAKGNTAAQMSQALCFSKIGGEDGDIHRGFQS
                     LLVAINRTDTEYVLRTANGLFGEKSYDFLTGFTDSCGKFYQATIKQLDFVNDTEKSTT
                     RVNSWVADKTKGENILLFYFDNILNSFIVSSLQNCQI"
     exon            275..424
                     /gene="HMSD"
                     /gene_synonym="ACC-6; ACC6; C18orf53; HSMD-v"
                     /inference="alignment:Splign:2.1.0"
     exon            425..2102
                     /gene="HMSD"
                     /gene_synonym="ACC-6; ACC6; C18orf53; HSMD-v"
                     /inference="alignment:Splign:2.1.0"
     regulatory      659..664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HMSD"
                     /gene_synonym="ACC-6; ACC6; C18orf53; HSMD-v"
                     /note="hexamer: ATTAAA"
     polyA_site      679
                     /gene="HMSD"
                     /gene_synonym="ACC-6; ACC6; C18orf53; HSMD-v"
                     /note="major polyA site"
     regulatory      2082..2087
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HMSD"
                     /gene_synonym="ACC-6; ACC6; C18orf53; HSMD-v"
                     /note="hexamer: AATAAA"
     polyA_site      2102
                     /gene="HMSD"
                     /gene_synonym="ACC-6; ACC6; C18orf53; HSMD-v"
                     /note="major polyA site"
ORIGIN      
        1 attcactggg aactaacacc cggcgccgct cagacatctc tattcccgcc tctccgaccc
       61 ggtctcactt cgctcctggg cagctgcgcg gagaactggg gctcaccgtc atggatgctc
      121 tatcagaagc aaatggcaca tttgcattaa accttttgaa aaagctaggg gaaaacaact
      181 caaacaactt atttttttcc ccatgagcat atcatcagcc ttggccatgg ttttcatggg
      241 ggcaaaggga aacactgcag ctcagatgtc tcaggcactt tgttttagta aaatcggagg
      301 tgaagatgga gatattcatc gaggttttca gtcacttctt gttgcaatta acagaactga
      361 cactgaatat gtgcttagaa ctgccaacgg gctctttgga gaaaagtctt atgatttcct
      421 cacaggtttt acagattcct gtggcaaatt ctaccaagca acgataaaac agctagactt
      481 tgtgaatgat acagagaagt ccacaacacg tgtaaactcc tgggttgctg ataaaactaa
      541 aggtgaaaat atattgttat tctatttcga taatatttta aacagtttta tagtcagttc
      601 tttacaaaac tgtcaaatat aaaaaggagt ccttttttct ctaaacaact atgcaaacat
      661 taaaaccttt ctttggaaat attgccaact cgtagacctt ttctctagct ttagcttttc
      721 ccttatcaag tatctgtgat gtctctctag atgaaataat ctcttccagg tttttttgct
      781 tgttaatatt aggtagtttt tcttttcaca aatagcgtta aaatttgaat ttaaaaattt
      841 ctagctgtct ccctcactgg tattgccata ctgtatggtt tacaggcttg aaatgcaact
      901 gctgtgatca gtgataaggg aacacactga tgatttagat tgaacaggga gagttatatt
      961 gttttctagg gcacagctaa aaagacattc catcaacccc cttgcagcca gaaagaccct
     1021 gagccctcag aacttcactg acacaaccca tattttcttt ccataactgg ccaacttttc
     1081 cctttgtacc aaagccagct acttagcttc agggagagaa tgagactgaa gattacaagg
     1141 agacatccac attatatgtg ggctgagaga ggaaagaggg agtatcagag gttgccgggt
     1201 ttgctactct cattcctctt cctcctctgc ccaacacttg gacttggaaa gaagtctgaa
     1261 aggtggggaa taatcagccc atatgattct tccactgcag agagagcctc tgagtgttac
     1321 agccaggagc aacagggtgg caccctcttc ttcagggaaa cacacacctc tttgcactgc
     1381 cttgtggata gtccagtcaa gtggagtaag aggtgggagt ggggagtgta aatggagtaa
     1441 cctctaagta tccaagcagg agggtgtttt ttttttttct ttcctggaat gaggataatc
     1501 aaatcatttc aatatgaatt atgaaaatga atgataatgg ttttatctgt tatagaaata
     1561 taatataatc agactttagc catgtaaatc ataaaacata gagataacaa tatgcatatt
     1621 gttcctagag ggtcttgtga aattttgttt gtcatattct ctttgaagag ttatcattca
     1681 ctattttatt tctgtcttgt aaagcctgaa agctcatgtg ctgccttgac atctatgggc
     1741 ttctcagggc ctcagaggcc tggccatgaa gtcccctgct cttgtcagat atgtgcaccc
     1801 tattcaccca ctgagcagga aggctcttcc cccttctaag ttcccttacc aggcagtcag
     1861 ctgtaccctc cctgggtctc aacgtggctc acttccctcc agcctggaaa attattcaaa
     1921 caagcctgtc acatctggag gagccaggaa tcgcctcttc ctcttgttac tgcaaagcct
     1981 gccttccaca gcccctactg gttcactcta ttcccaaatg caactctcct gtgaccccgc
     2041 atggcatgtg gtgacctccc tccctgtgag cagttgtgac taataaactg ccgccaattt
     2101 ca
//
