LOCUS       NM_002134               1673 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens heme oxygenase 2 (HMOX2), transcript variant 3, mRNA.
ACCESSION   NM_002134
VERSION     NM_002134.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1673)
  AUTHORS   Gamage,S.M.K., Nanayakkara,S., Macfarlane,L., Hewage,D., Cheng,T.,
            Aktar,S., Lu,C.T., Dissabandara,L., Islam,F., Lam,A.K. and
            Gopalan,V.
  TITLE     Heme oxygenase-1 & 2 and their potential contribution in heme
            induced colorectal carcinogenesis
  JOURNAL   Pathol Res Pract 233, 153885 (2022)
   PUBMED   35428017
  REMARK    GeneRIF: Heme oxygenase-1 & 2 and their potential contribution in
            heme induced colorectal carcinogenesis.
REFERENCE   2  (bases 1 to 1673)
  AUTHORS   Hanna,D.A., Moore,C.M., Liu,L., Yuan,X., Dominic,I.M.,
            Fleischhacker,A.S., Hamza,I., Ragsdale,S.W. and Reddi,A.R.
  TITLE     Heme oxygenase-2 (HO-2) binds and buffers labile ferric heme in
            human embryonic kidney cells
  JOURNAL   J Biol Chem 298 (2), 101549 (2022)
   PUBMED   34973332
  REMARK    GeneRIF: Heme oxygenase-2 (HO-2) binds and buffers labile ferric
            heme in human embryonic kidney cells.
REFERENCE   3  (bases 1 to 1673)
  AUTHORS   Fernandez-Fierro,A., Funes,S.C., Rios,M., Covian,C., Gonzalez,J.
            and Kalergis,A.M.
  TITLE     Immune Modulation by Inhibitors of the HO System
  JOURNAL   Int J Mol Sci 22 (1), 294 (2020)
   PUBMED   33396647
  REMARK    GeneRIF: Immune Modulation by Inhibitors of the HO System.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1673)
  AUTHORS   Liu,L., Dumbrepatil,A.B., Fleischhacker,A.S., Marsh,E.N.G. and
            Ragsdale,S.W.
  TITLE     Heme oxygenase-2 is post-translationally regulated by heme
            occupancy in the catalytic site
  JOURNAL   J Biol Chem 295 (50), 17227-17240 (2020)
   PUBMED   33051205
  REMARK    GeneRIF: Heme oxygenase-2 is post-translationally regulated by heme
            occupancy in the catalytic site.
REFERENCE   5  (bases 1 to 1673)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 1673)
  AUTHORS   Saito-Ohara,F., Ikeuchi,T., Matsumoto,M. and Kurata,S.
  TITLE     Assignment of the mouse heme oxygenase genes: heme oxygenase-1
            (Hmox1) to chromosome 10 band C1 and heme oxygenase-2 (Hmox2) to
            chromosome 16 band B1
  JOURNAL   Cytogenet Cell Genet 77 (3-4), 180-181 (1997)
   PUBMED   9284910
REFERENCE   7  (bases 1 to 1673)
  AUTHORS   Takahashi,K., Hara,E., Suzuki,H., Sasano,H. and Shibahara,S.
  TITLE     Expression of heme oxygenase isozyme mRNAs in the human brain and
            induction of heme oxygenase-1 by nitric oxide donors
  JOURNAL   J Neurochem 67 (2), 482-489 (1996)
   PUBMED   8764571
REFERENCE   8  (bases 1 to 1673)
  AUTHORS   Ishikawa,K., Takeuchi,N., Takahashi,S., Matera,K.M., Sato,M.,
            Shibahara,S., Rousseau,D.L., Ikeda-Saito,M. and Yoshida,T.
  TITLE     Heme oxygenase-2. Properties of the heme complex of the purified
            tryptic fragment of recombinant human heme oxygenase-2
  JOURNAL   J Biol Chem 270 (11), 6345-6350 (1995)
   PUBMED   7890772
REFERENCE   9  (bases 1 to 1673)
  AUTHORS   Kutty,R.K., Kutty,G., Rodriguez,I.R., Chader,G.J. and Wiggert,B.
  TITLE     Chromosomal localization of the human heme oxygenase genes: heme
            oxygenase-1 (HMOX1) maps to chromosome 22q12 and heme oxygenase-2
            (HMOX2) maps to chromosome 16p13.3
  JOURNAL   Genomics 20 (3), 513-516 (1994)
   PUBMED   8034330
REFERENCE   10 (bases 1 to 1673)
  AUTHORS   McCoubrey,W.K. Jr., Ewing,J.F. and Maines,M.D.
  TITLE     Human heme oxygenase-2: characterization and expression of a
            full-length cDNA and evidence suggesting that the two HO-2
            transcripts may differ by choice of polyadenylation signal
  JOURNAL   Arch Biochem Biophys 295 (1), 13-20 (1992)
   PUBMED   1575508
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA141643.1 and BC002396.2.
            
            On Nov 23, 2018 this sequence version replaced NM_002134.3.
            
            Summary: Heme oxygenase, an essential enzyme in heme catabolism,
            cleaves heme to form biliverdin, which is subsequently converted to
            bilirubin by biliverdin reductase, and carbon monoxide, a putative
            neurotransmitter. Heme oxygenase activity is induced by its
            substrate heme and by various nonheme substances. Heme oxygenase
            occurs as 2 isozymes, an inducible heme oxygenase-1 and a
            constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme
            oxygenase family. Several alternatively spliced transcript variants
            encoding three different isoforms have been found for this gene.
            [provided by RefSeq, Oct 2013].
            
            Transcript Variant: This variant (3) differs in the 5' UTR and
            coding sequence compared to variant 5. The resulting isoform (b) is
            shorter at the N-terminus compared to isoform a. Variants 1, 2, 3,
            4, 6, 7, and 8 all encode the same isoform (b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.272002.1,
                                           SRR1803616.247016.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000570646.6/ ENSP00000459214.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                DA141643.1         59-84
            27-1673             BC002396.2         1-1647
FEATURES             Location/Qualifiers
     source          1..1673
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..1673
                     /gene="HMOX2"
                     /gene_synonym="HO-2"
                     /note="heme oxygenase 2"
                     /db_xref="GeneID:3163"
                     /db_xref="HGNC:HGNC:5014"
                     /db_xref="MIM:141251"
     exon            1..90
                     /gene="HMOX2"
                     /gene_synonym="HO-2"
                     /inference="alignment:Splign:2.1.0"
     exon            91..217
                     /gene="HMOX2"
                     /gene_synonym="HO-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1082
                     /gene="HMOX2"
                     /gene_synonym="HO-2"
                     /EC_number="1.14.14.18"
                     /note="isoform b is encoded by transcript variant 3; heme
                     oxygenase (decycling) 2"
                     /codon_start=1
                     /product="heme oxygenase 2 isoform b"
                     /protein_id="NP_002125.3"
                     /db_xref="CCDS:CCDS10517.1"
                     /db_xref="GeneID:3163"
                     /db_xref="HGNC:HGNC:5014"
                     /db_xref="MIM:141251"
                     /translation="MSAEVETSEGVDESEKKNSGALEKENQMRMADLSELLKEGTKEA
                     HDRAENTQFVKDFLKGNIKKELFKLATTALYFTYSALEEEMERNKDHPAFAPLYFPME
                     LHRKEALTKDMEYFFGENWEEQVQCPKAAQKYVERIHYIGQNEPELLVAHAYTRYMGD
                     LSGGQVLKKVAQRALKLPSTGEGTQFYLFENVDNAQQFKQLYRARMNALDLNMKTKER
                     IVEEANKAFEYNMQIFNELDQAGSTLARETLEDGFPVHDGKGDMRKCPFYAAEQDKGA
                     LEGSSCPFRTAMAVLRKPSLQFILAAGVALAAGLLAWYYM"
     exon            218..335
                     /gene="HMOX2"
                     /gene_synonym="HO-2"
                     /inference="alignment:Splign:2.1.0"
     exon            336..827
                     /gene="HMOX2"
                     /gene_synonym="HO-2"
                     /inference="alignment:Splign:2.1.0"
     exon            828..954
                     /gene="HMOX2"
                     /gene_synonym="HO-2"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1673
                     /gene="HMOX2"
                     /gene_synonym="HO-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1209..1214
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HMOX2"
                     /gene_synonym="HO-2"
                     /note="hexamer: AATAAA"
     polyA_site      1228
                     /gene="HMOX2"
                     /gene_synonym="HO-2"
                     /note="major polyA site"
     regulatory      1651..1656
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HMOX2"
                     /gene_synonym="HO-2"
                     /note="hexamer: AATAAA"
     polyA_site      1673
                     /gene="HMOX2"
                     /gene_synonym="HO-2"
ORIGIN      
        1 gctgggctgc agggactgcg gcgcctgagg gagtcgctga cgggcacgct gactggaggc
       61 tggcggacag gcgacagcga cctgcggcag gaccagagga gcgagagcag caagaaccac
      121 acccagcagc aatgtcagcg gaagtggaaa cctcagaggg ggtagacgag tcagaaaaaa
      181 agaactctgg ggccctagaa aaggagaacc aaatgagaat ggctgacctc tcggagctcc
      241 tgaaggaagg gaccaaggaa gcacacgacc gggcagaaaa cacccagttt gtcaaggact
      301 tcttgaaagg caacattaag aaggagctgt ttaagctggc caccacggca ctttacttca
      361 catactcagc cctcgaggag gaaatggagc gcaacaagga ccatccagcc tttgcccctt
      421 tgtacttccc catggagctg caccggaagg aggcgctgac caaggacatg gagtatttct
      481 ttggtgaaaa ctgggaggag caggtgcagt gccccaaggc tgcccagaag tacgtggagc
      541 ggatccacta catagggcag aacgagccgg agctactggt ggcccatgca tacacccgct
      601 acatggggga tctctcgggg ggccaggtgc tgaagaaggt ggcccagcga gcactgaaac
      661 tccccagcac aggggaaggg acccagttct acctgtttga gaatgtggac aatgcccagc
      721 agttcaagca gctctaccgg gccaggatga acgccctgga cctgaacatg aagaccaaag
      781 agaggatcgt ggaggaggcc aacaaggctt ttgagtataa catgcagata ttcaatgaac
      841 tggaccaggc cggctccaca ctggccagag agaccttgga ggatgggttc cctgtacacg
      901 atgggaaagg agacatgcgt aaatgccctt tctacgctgc tgaacaagac aaaggtgccc
      961 tggagggcag cagctgtccc ttccgaacag ctatggctgt gctgaggaag cccagcctcc
     1021 agttcatcct ggccgctggt gtggccctag ctgctggact cttggcctgg tactacatgt
     1081 gaagcaccca tcatgccaca ccggtaccct cctcccgact gaccactggc ctaccccttt
     1141 ctccagccct gactaaacta ccacctcagg tgacttttta aaaaatgctg ggtttaagaa
     1201 aggcaaccaa taaaagccag atgctagagc ctctgcctga cagcatcctc tctatgggcc
     1261 atattccgca ctgggcacag gccgtcaccc tgggagcagt cggcacagtg cagcaagcct
     1321 ggcccccgac ccagctctac tccaggcttc cacacttctg ggccctaggc tgcttccggt
     1381 agtccctgtt tttgcagtac atgggtgact atctcccctg ttggaggtga gtggcctgta
     1441 agtccaagct gtgcgagggg gccttgctgg atgctgctgt acaacttctg ggcctctctt
     1501 ggaccctggg agtgagggtg ggtgtgggtg gaagcctcag aggccttggg agctcatccc
     1561 tctcacccag aatccctcta accccttggg tgcggtttgc tcagccccag cttatctcct
     1621 cctccgcgct gtgtaaatgc tccagcactc aataaagtgg gctttgcaag cta
//
