LOCUS       NM_002133               1554 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens heme oxygenase 1 (HMOX1), mRNA.
ACCESSION   NM_002133
VERSION     NM_002133.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1554)
  AUTHORS   Chudy,P., Kochan,J., Wawro,M., Nguyen,P., Gorczyca,M., Varanko,A.,
            Retka,A., Ghadei,S.S., Napieralska,E., Grochot-Przeczek,A.,
            Szade,K., Berendes,L.S., Park,J., Sokolowski,G., Yu,Q.,
            Jozkowicz,A., Nowak,W.N. and Krzeptowski,W.
  TITLE     Heme oxygenase-1 protects cells from replication stress
  JOURNAL   Redox Biol 75, 103247 (2024)
   PUBMED   39047636
  REMARK    GeneRIF: Heme oxygenase-1 protects cells from replication stress.
REFERENCE   2  (bases 1 to 1554)
  AUTHORS   Salloom,R.J., Ahmad,I.M., Sahtout,D.Z., Baine,M.J. and Abdalla,M.Y.
  TITLE     Heme Oxygenase-1 and Prostate Cancer: Function, Regulation, and
            Implication in Cancer Therapy
  JOURNAL   Int J Mol Sci 25 (17), 9195 (2024)
   PUBMED   39273143
  REMARK    GeneRIF: Heme Oxygenase-1 and Prostate Cancer: Function,
            Regulation, and Implication in Cancer Therapy.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1554)
  AUTHORS   Zhao,Y., Wang,L., Li,X., Jiang,J., Ma,Y., Guo,S., Zhou,J. and Li,Y.
  TITLE     Programmed Cell Death-Related Gene Signature Associated with
            Prognosis and Immune Infiltration and the Roles of HMOX1 in the
            Proliferation and Apoptosis were Investigated in Uveal Melanoma
  JOURNAL   Genes Genomics 46 (7), 785-801 (2024)
   PUBMED   38767825
  REMARK    GeneRIF: Programmed Cell Death-Related Gene Signature Associated
            with Prognosis and Immune Infiltration and the Roles of HMOX1 in
            the Proliferation and Apoptosis were Investigated in Uveal
            Melanoma.
REFERENCE   4  (bases 1 to 1554)
  AUTHORS   Chu,M., Chen,G., Chen,K., Zhu,P., Wang,Z., Qian,Z., Tao,H., Xu,Y.
            and Geng,D.
  TITLE     Heme oxygenase 1 linked to inactivation of subchondral osteoclasts
            in osteoarthritis
  JOURNAL   J Zhejiang Univ Sci B 25 (6), 513-528 (2024)
   PUBMED   38910496
  REMARK    GeneRIF: Heme oxygenase 1 linked to inactivation of subchondral
            osteoclasts in osteoarthritis.
REFERENCE   5  (bases 1 to 1554)
  AUTHORS   Chen,J., Li,J., Wang,X., Fu,X., Ke,J., Li,J., Wen,J., Cheng,K.,
            Li,S. and Shi,Z.
  TITLE     Heme Oxygenase-1 Gene (GT)n Polymorphism Linked to Deep White
            Matter Hyperintensities, Not Periventricular Hyperintensities
  JOURNAL   J Am Heart Assoc 13 (11), e033981 (2024)
   PUBMED   38818928
  REMARK    GeneRIF: Heme Oxygenase-1 Gene (GT)n Polymorphism Linked to Deep
            White Matter Hyperintensities, Not Periventricular
            Hyperintensities.
REFERENCE   6  (bases 1 to 1554)
  AUTHORS   Schipper,H.M., Cisse,S. and Stopa,E.G.
  TITLE     Expression of heme oxygenase-1 in the senescent and
            Alzheimer-diseased brain
  JOURNAL   Ann Neurol 37 (6), 758-768 (1995)
   PUBMED   7778849
REFERENCE   7  (bases 1 to 1554)
  AUTHORS   Wilks,A., Black,S.M., Miller,W.L. and Ortiz de Montellano,P.R.
  TITLE     Expression and characterization of truncated human heme oxygenase
            (hHO-1) and a fusion protein of hHO-1 with human cytochrome P450
            reductase
  JOURNAL   Biochemistry 34 (13), 4421-4427 (1995)
   PUBMED   7703255
REFERENCE   8  (bases 1 to 1554)
  AUTHORS   Shibahara,S., Sato,M., Muller,R.M. and Yoshida,T.
  TITLE     Structural organization of the human heme oxygenase gene and the
            function of its promoter
  JOURNAL   Eur J Biochem 179 (3), 557-563 (1989)
   PUBMED   2537723
REFERENCE   9  (bases 1 to 1554)
  AUTHORS   Keyse,S.M. and Tyrrell,R.M.
  TITLE     Heme oxygenase is the major 32-kDa stress protein induced in human
            skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium
            arsenite
  JOURNAL   Proc Natl Acad Sci U S A 86 (1), 99-103 (1989)
   PUBMED   2911585
REFERENCE   10 (bases 1 to 1554)
  AUTHORS   Yoshida,T., Biro,P., Cohen,T., Muller,R.M. and Shibahara,S.
  TITLE     Human heme oxygenase cDNA and induction of its mRNA by hemin
  JOURNAL   Eur J Biochem 171 (3), 457-461 (1988)
   PUBMED   3345742
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP288767.1, X06985.1 and
            CA306357.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002133.2.
            
            Summary: Heme oxygenase, an essential enzyme in heme catabolism,
            cleaves heme to form biliverdin, which is subsequently converted to
            bilirubin by biliverdin reductase, and carbon monoxide, a putative
            neurotransmitter. Heme oxygenase activity is induced by its
            substrate heme and by various nonheme substances. Heme oxygenase
            occurs as 2 isozymes, an inducible heme oxygenase-1 and a
            constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme
            oxygenase family. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1099521.1, X06985.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216117.9/ ENSP00000216117.8
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                BP288767.1         30-43
            15-1173             X06985.1           17-1175
            1174-1554           CA306357.1         24-404              c
FEATURES             Location/Qualifiers
     source          1..1554
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.3"
     gene            1..1554
                     /gene="HMOX1"
                     /gene_synonym="bK286B10; HMOX1D; HO-1; HSP32"
                     /note="heme oxygenase 1"
                     /db_xref="GeneID:3162"
                     /db_xref="HGNC:HGNC:5013"
                     /db_xref="MIM:141250"
     exon            1..101
                     /gene="HMOX1"
                     /gene_synonym="bK286B10; HMOX1D; HO-1; HSP32"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..945
                     /gene="HMOX1"
                     /gene_synonym="bK286B10; HMOX1D; HO-1; HSP32"
                     /EC_number="1.14.14.18"
                     /note="heat shock protein, 32-kD; heme oxygenase
                     (decycling) 1"
                     /codon_start=1
                     /product="heme oxygenase 1"
                     /protein_id="NP_002124.1"
                     /db_xref="CCDS:CCDS13914.1"
                     /db_xref="GeneID:3162"
                     /db_xref="HGNC:HGNC:5013"
                     /db_xref="MIM:141250"
                     /translation="MERPQPDSMPQDLSEALKEATKEVHTQAENAEFMRNFQKGQVTR
                     DGFKLVMASLYHIYVALEEEIERNKESPVFAPVYFPEELHRKAALEQDLAFWYGPRWQ
                     EVIPYTPAMQRYVKRLHEVGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALDLPSS
                     GEGLAFFTFPNIASATKFKQLYRSRMNSLEMTPAVRQRVIEEAKTAFLLNIQLFEELQ
                     ELLTHDTKDQSPSRAPGLRQRASNKVQDSAPVETPRGKPPLNTRSQAPLLRWVLTLSF
                     LVATVAVGLYAM"
     exon            102..222
                     /gene="HMOX1"
                     /gene_synonym="bK286B10; HMOX1D; HO-1; HSP32"
                     /inference="alignment:Splign:2.1.0"
     exon            223..714
                     /gene="HMOX1"
                     /gene_synonym="bK286B10; HMOX1D; HO-1; HSP32"
                     /inference="alignment:Splign:2.1.0"
     exon            715..814
                     /gene="HMOX1"
                     /gene_synonym="bK286B10; HMOX1D; HO-1; HSP32"
                     /inference="alignment:Splign:2.1.0"
     exon            815..1554
                     /gene="HMOX1"
                     /gene_synonym="bK286B10; HMOX1D; HO-1; HSP32"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1531..1536
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HMOX1"
                     /gene_synonym="bK286B10; HMOX1D; HO-1; HSP32"
                     /note="hexamer: AATAAA"
     polyA_site      1554
                     /gene="HMOX1"
                     /gene_synonym="bK286B10; HMOX1D; HO-1; HSP32"
                     /note="major polyA site"
ORIGIN      
        1 aacgcctgcc tcctctcgag cgtcctcagc gcagccgccg cccgcggagc cagcacgaac
       61 gagcccagca ccggccggat ggagcgtccg caacccgaca gcatgcccca ggatttgtca
      121 gaggccctga aggaggccac caaggaggtg cacacccagg cagagaatgc tgagttcatg
      181 aggaactttc agaagggcca ggtgacccga gacggcttca agctggtgat ggcctccctg
      241 taccacatct atgtggccct ggaggaggag attgagcgca acaaggagag cccagtcttc
      301 gcccctgtct acttcccaga agagctgcac cgcaaggctg ccctggagca ggacctggcc
      361 ttctggtacg ggccccgctg gcaggaggtc atcccctaca caccagccat gcagcgctat
      421 gtgaagcggc tccacgaggt ggggcgcaca gagcccgagc tgctggtggc ccacgcctac
      481 acccgctacc tgggtgacct gtctgggggc caggtgctca aaaagattgc ccagaaagcc
      541 ctggacctgc ccagctctgg cgagggcctg gccttcttca ccttccccaa cattgccagt
      601 gccaccaagt tcaagcagct ctaccgctcc cgcatgaact ccctggagat gactcccgca
      661 gtcaggcaga gggtgataga agaggccaag actgcgttcc tgctcaacat ccagctcttt
      721 gaggagttgc aggagctgct gacccatgac accaaggacc agagcccctc acgggcacca
      781 gggcttcgcc agcgggccag caacaaagtg caagattctg cccccgtgga gactcccaga
      841 gggaagcccc cactcaacac ccgctcccag gctccgcttc tccgatgggt ccttacactc
      901 agctttctgg tggcgacagt tgctgtaggg ctttatgcca tgtgaatgca ggcatgctgg
      961 ctcccagggc catgaacttt gtccggtgga aggccttctt tctagagagg gaattctctt
     1021 ggctggcttc cttaccgtgg gcactgaagg ctttcagggc ctccagccct ctcactgtgt
     1081 ccctctctct ggaaaggagg aaggagccta tggcatcttc cccaacgaaa agcacatcca
     1141 ggcaatggcc taaacttcag agggggcgaa gggatcagcc ctgcccttca gcatcctcag
     1201 ttcctgcagc agagcctgga agacacccta atgtggcagc tgtctcaaac ctccaaaagc
     1261 cctgagtttc aagtatcctt gttgacacgg ccatgaccac tttccccgtg ggccatggca
     1321 atttttacac aaacctgaaa agatgttgtg tcttgtgttt ttgtcttatt tttgttggag
     1381 ccactctgtt cctggctcag cctcaaatgc agtatttttg ttgtgttctg ttgtttttat
     1441 agcagggttg gggtggtttt tgagccatgc gtgggtgggg agggaggtgt ttaacggcac
     1501 tgtggccttg gtctaacttt tgtgtgaaat aataaacaac attgtctgat agta
//
