LOCUS       NM_001142556            3016 bp    mRNA    linear   PRI 07-MAY-2024
DEFINITION  Homo sapiens hyaluronan mediated motility receptor (HMMR),
            transcript variant 1, mRNA.
ACCESSION   NM_001142556
VERSION     NM_001142556.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3016)
  AUTHORS   Su,Z., He,Y., You,L., Zhang,G., Chen,J. and Liu,Z.
  TITLE     Coupled scRNA-seq and Bulk-seq reveal the role of HMMR in
            hepatocellular carcinoma
  JOURNAL   Front Immunol 15, 1363834 (2024)
   PUBMED   38633247
  REMARK    GeneRIF: Coupled scRNA-seq and Bulk-seq reveal the role of HMMR in
            hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3016)
  AUTHORS   Hinneh,J.A., Gillis,J.L., Mah,C.Y., Irani,S., Shrestha,R.K.,
            Ryan,N.K., Atsushi,E., Nassar,Z.D., Lynn,D.J., Selth,L.A., Kato,M.,
            Centenera,M.M. and Butler,L.M.
  TITLE     Targeting hyaluronan-mediated motility receptor (HMMR) enhances
            response to androgen receptor signalling inhibitors in prostate
            cancer
  JOURNAL   Br J Cancer 129 (8), 1350-1361 (2023)
   PUBMED   37673961
  REMARK    GeneRIF: Targeting hyaluronan-mediated motility receptor (HMMR)
            enhances response to androgen receptor signalling inhibitors in
            prostate cancer.
REFERENCE   3  (bases 1 to 3016)
  AUTHORS   Tarullo,S.E., He,Y., Daughters,C., Knutson,T.P., Henzler,C.M.,
            Price,M.A., Shanley,R., Witschen,P., Tolg,C., Kaspar,R.E.,
            Hallstrom,C., Gittsovich,L., Sulciner,M.L., Zhang,X., Forster,C.L.,
            Lange,C.A., Shats,O., Desler,M., Cowan,K.H., Yee,D.,
            Schwertfeger,K.L., Turley,E.A., McCarthy,J.B. and Nelson,A.C.
  TITLE     Receptor for hyaluronan-mediated motility (RHAMM) defines an
            invasive niche associated with tumor progression and predicts poor
            outcomes in breast cancer patients
  JOURNAL   J Pathol 260 (3), 289-303 (2023)
   PUBMED   37186300
  REMARK    GeneRIF: Receptor for hyaluronan-mediated motility (RHAMM) defines
            an invasive niche associated with tumor progression and predicts
            poor outcomes in breast cancer patients.
REFERENCE   4  (bases 1 to 3016)
  AUTHORS   Nakano,M., Taguchi,R., Kikushige,Y., Isobe,T., Miyawaki,K.,
            Mizuno,S., Tsuruta,N., Hanamura,F., Yamaguchi,K., Yamauchi,T.,
            Ariyama,H., Kusaba,H., Nakamura,M., Maeda,T., Kuo,C.J., Baba,E. and
            Akashi,K.
  TITLE     RHAMM marks proliferative subpopulation of human colorectal cancer
            stem cells
  JOURNAL   Cancer Sci 114 (7), 2895-2906 (2023)
   PUBMED   36945114
  REMARK    GeneRIF: RHAMM marks proliferative subpopulation of human
            colorectal cancer stem cells.
REFERENCE   5  (bases 1 to 3016)
  AUTHORS   Wang,Q., Wu,G., Fu,L., Li,Z., Wu,Y., Zhu,T. and Yu,G.
  TITLE     Tumor-promoting roles of HMMR in lung adenocarcinoma
  JOURNAL   Mutat Res 826, 111811 (2023)
   PUBMED   36603370
  REMARK    GeneRIF: Tumor-promoting roles of HMMR in lung adenocarcinoma.
REFERENCE   6  (bases 1 to 3016)
  AUTHORS   Wang,C., Entwistle,J., Hou,G., Li,Q. and Turley,E.A.
  TITLE     The characterization of a human RHAMM cDNA: conservation of the
            hyaluronan-binding domains
  JOURNAL   Gene 174 (2), 299-306 (1996)
   PUBMED   8890751
REFERENCE   7  (bases 1 to 3016)
  AUTHORS   Spicer,A.P., Roller,M.L., Camper,S.A., McPherson,J.D.,
            Wasmuth,J.J., Hakim,S., Wang,C., Turley,E.A. and McDonald,J.A.
  TITLE     The human and mouse receptors for hyaluronan-mediated motility,
            RHAMM, genes (HMMR) map to human chromosome 5q33.2-qter and mouse
            chromosome 11
  JOURNAL   Genomics 30 (1), 115-117 (1995)
   PUBMED   8595891
REFERENCE   8  (bases 1 to 3016)
  AUTHORS   Hall,C.L., Yang,B., Yang,X., Zhang,S., Turley,M., Samuel,S.,
            Lange,L.A., Wang,C., Curpen,G.D., Savani,R.C., Greenberg,A.H. and
            Turley,E.A.
  TITLE     Overexpression of the hyaluronan receptor RHAMM is transforming and
            is also required for H-ras transformation
  JOURNAL   Cell 82 (1), 19-26 (1995)
   PUBMED   7541721
REFERENCE   9  (bases 1 to 3016)
  AUTHORS   Pilarski,L.M., Miszta,H. and Turley,E.A.
  TITLE     Regulated expression of a receptor for hyaluronan-mediated motility
            on human thymocytes and T cells
  JOURNAL   J Immunol 150 (10), 4292-4302 (1993)
   PUBMED   7683315
REFERENCE   10 (bases 1 to 3016)
  AUTHORS   Dawson,S.J. and White,L.A.
  TITLE     Treatment of Haemophilus aphrophilus endocarditis with
            ciprofloxacin
  JOURNAL   J Infect 24 (3), 317-320 (1992)
   PUBMED   1602151
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB091289.1, AY623426.1 and
            AW629232.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001142556.1.
            
            Summary: The protein encoded by this gene is involved in cell
            motility. It is expressed in breast tissue and together with other
            proteins, it forms a complex with BRCA1 and BRCA2, thus is
            potentially associated with higher risk of breast cancer.
            Alternatively spliced transcript variants encoding different
            isoforms have been noted for this gene. [provided by RefSeq, Dec
            2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.160573.1,
                                           SRR1803615.238483.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393915.9/ ENSP00000377492.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-286               DB091289.1         122-407
            287-3010            AY623426.1         231-2954
            3011-3016           AW629232.1         8-13                c
FEATURES             Location/Qualifiers
     source          1..3016
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q34"
     gene            1..3016
                     /gene="HMMR"
                     /gene_synonym="CD168; IHABP; RHAMM"
                     /note="hyaluronan mediated motility receptor"
                     /db_xref="GeneID:3161"
                     /db_xref="HGNC:HGNC:5012"
                     /db_xref="MIM:600936"
     exon            1..107
                     /gene="HMMR"
                     /gene_synonym="CD168; IHABP; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..2239
                     /gene="HMMR"
                     /gene_synonym="CD168; IHABP; RHAMM"
                     /note="isoform a is encoded by transcript variant 1;
                     receptor for hyaluronan-mediated motility; intracellular
                     hyaluronic acid-binding protein"
                     /codon_start=1
                     /product="hyaluronan mediated motility receptor isoform a"
                     /protein_id="NP_001136028.1"
                     /db_xref="CCDS:CCDS47334.1"
                     /db_xref="GeneID:3161"
                     /db_xref="HGNC:HGNC:5012"
                     /db_xref="MIM:600936"
                     /translation="MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRF
                     KQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQ
                     DRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGN
                     QKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLV
                     SIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSL
                     EENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQERE
                     KLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQK
                     EEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMV
                     QSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQE
                     YVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEK
                     ENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRD
                     SYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLG
                     IKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQESWK"
     exon            108..206
                     /gene="HMMR"
                     /gene_synonym="CD168; IHABP; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            207..286
                     /gene="HMMR"
                     /gene_synonym="CD168; IHABP; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            287..334
                     /gene="HMMR"
                     /gene_synonym="CD168; IHABP; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            335..523
                     /gene="HMMR"
                     /gene_synonym="CD168; IHABP; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            524..610
                     /gene="HMMR"
                     /gene_synonym="CD168; IHABP; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            611..711
                     /gene="HMMR"
                     /gene_synonym="CD168; IHABP; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            712..786
                     /gene="HMMR"
                     /gene_synonym="CD168; IHABP; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            787..965
                     /gene="HMMR"
                     /gene_synonym="CD168; IHABP; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1114
                     /gene="HMMR"
                     /gene_synonym="CD168; IHABP; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1329
                     /gene="HMMR"
                     /gene_synonym="CD168; IHABP; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1446
                     /gene="HMMR"
                     /gene_synonym="CD168; IHABP; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1593
                     /gene="HMMR"
                     /gene_synonym="CD168; IHABP; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1746
                     /gene="HMMR"
                     /gene_synonym="CD168; IHABP; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1846
                     /gene="HMMR"
                     /gene_synonym="CD168; IHABP; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2023
                     /gene="HMMR"
                     /gene_synonym="CD168; IHABP; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2186
                     /gene="HMMR"
                     /gene_synonym="CD168; IHABP; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..3016
                     /gene="HMMR"
                     /gene_synonym="CD168; IHABP; RHAMM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2992..2997
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HMMR"
                     /gene_synonym="CD168; IHABP; RHAMM"
                     /note="hexamer: ATTACA"
     polyA_site      3016
                     /gene="HMMR"
                     /gene_synonym="CD168; IHABP; RHAMM"
                     /note="major polyA site"
ORIGIN      
        1 aatccgcatt cagttgtcga ggagtgccag tcaccttcag tttctggagc tggccgtcaa
       61 catgtccttt cctaaggcgc ccttgaaacg attcaatgac ccttctggtt gtgcaccatc
      121 tccaggtgct tatgatgtta aaactttaga agtattgaaa ggaccagtat cctttcagaa
      181 atcacaaaga tttaaacaac aaaaagaatc taaacaaaat cttaatgttg acaaagatac
      241 taccttgcct gcttcagcta gaaaagttaa gtcttcggaa tcaaagaagg aatctcaaaa
      301 gaatgataaa gatttgaaga tattagagaa agagattcgt gttcttctac aggaacgtgg
      361 tgcccaggac aggcggatcc aggatctgga aactgagttg gaaaagatgg aagcaaggct
      421 aaatgctgca ctaagggaaa aaacatctct ctctgcaaat aatgctacac tggaaaaaca
      481 acttattgaa ttgaccagga ctaatgaact actaaaatct aagttttctg aaaatggtaa
      541 ccagaagaat ttgagaattc taagcttgga gttgatgaaa cttagaaaca aaagagaaac
      601 aaagatgagg ggtatgatgg ctaagcaaga aggcatggag atgaagctgc aggtcaccca
      661 aaggagtctc gaagagtctc aagggaaaat agcccaactg gagggaaaac ttgtttcaat
      721 agagaaagaa aagattgatg aaaaatctga aacagaaaaa ctcttggaat acatcgaaga
      781 aattagttgt gcttcagatc aagtggaaaa atacaagcta gatattgccc agttagaaga
      841 aaatttgaaa gagaagaatg atgaaatttt aagccttaag cagtctcttg aggagaatat
      901 tgttatatta tctaaacaag tagaagatct aaatgtgaaa tgtcagctgc ttgaaaaaga
      961 aaaagaagac catgtcaaca ggaatagaga acacaacgaa aatctaaatg cagagatgca
     1021 aaacttaaaa cagaagttta ttcttgaaca acaggaacgt gaaaagcttc aacaaaaaga
     1081 attacaaatt gattcacttc tgcaacaaga gaaagaatta tcttcgagtc ttcatcagaa
     1141 gctctgttct tttcaagagg aaatggttaa agagaagaat ctgtttgagg aagaattaaa
     1201 gcaaacactg gatgagcttg ataaattaca gcaaaaggag gaacaagctg aaaggctggt
     1261 caagcaattg gaagaggaag caaaatctag agctgaagaa ttaaaactcc tagaagaaaa
     1321 gctgaaaggg aaggaggctg aactggagaa aagtagtgct gctcataccc aggccaccct
     1381 gcttttgcag gaaaagtatg acagtatggt gcaaagcctt gaagatgtta ctgctcaatt
     1441 tgaaagctat aaagcgttaa cagccagtga gatagaagat cttaagctgg agaactcatc
     1501 attacaggaa aaagcggcca aggctgggaa aaatgcagag gatgttcagc atcagatttt
     1561 ggcaactgag agctcaaatc aagaatatgt aaggatgctt ctagatctgc agaccaagtc
     1621 agcactaaag gaaacagaaa ttaaagaaat cacagtttct tttcttcaaa aaataactga
     1681 tttgcagaac caactcaagc aacaggagga agactttaga aaacagctgg aagatgaaga
     1741 aggaagaaaa gctgaaaaag aaaatacaac agcagaatta actgaagaaa ttaacaagtg
     1801 gcgtctcctc tatgaagaac tatataataa aacaaaacct tttcagctac aactagatgc
     1861 ttttgaagta gaaaaacagg cattgttgaa tgaacatggt gcagctcagg aacagctaaa
     1921 taaaataaga gattcatatg ctaaattatt gggtcatcag aatttgaaac aaaaaatcaa
     1981 gcatgttgtg aagttgaaag atgaaaatag ccaactcaaa tcggaagtat caaaactccg
     2041 ctgtcagctt gctaaaaaaa aacaaagtga gacaaaactt caagaggaat tgaataaagt
     2101 tctaggtatc aaacactttg atccttcaaa ggcttttcat catgaaagta aagaaaattt
     2161 tgccctgaag accccattaa aagaaggcaa tacaaactgt taccgagctc ctatggagtg
     2221 tcaagaatca tggaagtaaa catctgagaa acctgttgaa gattatttca ttcgtcttgt
     2281 tgttattgat gttgctgtta ttatatttga catgggtatt ttataatgtt gtatttaatt
     2341 ttaactgcca atccttaaat atgtgaaagg aacatttttt accaaagtgt cttttgacat
     2401 tttatttttt cttgcaaata cctcctccct aatgctcacc tttatcacct cattctgaac
     2461 cctttcgctg gctttccagc ttagaatgca tctcatcaac ttaaaagtca gtatcatatt
     2521 attatcctcc tgttctgaaa ccttagtttc aagagtctaa accccagatt cttcagcttg
     2581 atcctggagg tcttttctag tctgagcttc tttagctagg ctaaaacacc ttggcttgtt
     2641 attgcctcta ctttgattct gataatgctc acttggtcct acctattatc cttctacttg
     2701 tccagttcaa ataagaaata aggacaagcc taacttcata gaaacctctc tatttttaat
     2761 cagttgttta ataatttaca ggttcttagg ctccatcctg tttgtatgaa attataatct
     2821 gtggattggc ctttaagcct gcattcttaa caaactcttc agttaattct tagatacact
     2881 aaaaatctga gaaactctac atgtaactat ttcttcagag tttgtcatat actgcttgtc
     2941 atctgcatgt ctactcagca tttgattaac atttgtgtaa tatgaaataa aattacacag
     3001 taagtcattt aaccaa
//
