LOCUS       NM_021182                381 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens histocompatibility minor HB-1 (HMHB1), mRNA.
ACCESSION   NM_021182
VERSION     NM_021182.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 381)
  AUTHORS   Park,M.J., Choi,H.B. and Kim,T.G.
  TITLE     Improved genotyping of the human minor histocompatibility antigen
            HB-1 by polymerase chain reaction with sequence-specific primers
            using a complementary oligonucleotide
  JOURNAL   Tissue Antigens 76 (6), 482-486 (2010)
   PUBMED   20718936
  REMARK    GeneRIF: Improved genotyping of the human minor histocompatibility
            antigen HB-1 by polymerase chain reaction with sequence-specific
            primers using a complementary oligonucleotide.
REFERENCE   2  (bases 1 to 381)
  AUTHORS   Larsen,M.E., Kornblit,B., Larsen,M.V., Masmas,T.N., Nielsen,M.,
            Thiim,M., Garred,P., Stryhn,A., Lund,O., Buus,S. and Vindelov,L.
  TITLE     Degree of predicted minor histocompatibility antigen mismatch
            correlates with poorer clinical outcomes in nonmyeloablative
            allogeneic hematopoietic cell transplantation
  JOURNAL   Biol Blood Marrow Transplant 16 (10), 1370-1381 (2010)
   PUBMED   20353833
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 381)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 381)
  AUTHORS   Heinold,A., Opelz,G., Scherer,S., Ruhenstroth,A., Laux,G.,
            Doehler,B. and Tran,T.H.
  TITLE     Role of minor histocompatibility antigens in renal transplantation
  JOURNAL   Am J Transplant 8 (1), 95-102 (2008)
   PUBMED   18093280
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 381)
  AUTHORS   Dolstra,H., Fredrix,H., Maas,F., Coulie,P.G., Brasseur,F.,
            Mensink,E., Adema,G.J., de Witte,T.M., Figdor,C.G. and van de
            Wiel-van Kemenade,E.
  TITLE     A human minor histocompatibility antigen specific for B cell acute
            lymphoblastic leukemia
  JOURNAL   J Exp Med 189 (2), 301-308 (1999)
   PUBMED   9892612
  REMARK    GeneRIF: The paper described that non-AUG (CTG) translation
            initiation codon at nucleotide positions 108-110 was used for the
            encoded protein.
REFERENCE   6  (bases 1 to 381)
  AUTHORS   Dolstra,H., Fredrix,H., Preijers,F., Goulmy,E., Figdor,C.G., de
            Witte,T.M. and van de Wiel-van Kemenade,E.
  TITLE     Recognition of a B cell leukemia-associated minor
            histocompatibility antigen by CTL
  JOURNAL   J Immunol 158 (2), 560-565 (1997)
   PUBMED   8992968
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC025765.6.
            
            On Jun 2, 2019 this sequence version replaced NM_021182.2.
            
            Summary: This gene encodes one of the minor histocompatibility
            antigens, which play an important role in the induction of
            cytotoxic T lymphocyte (CTL) reactivity against leukemia after
            human histocompatibility leukocyte antigen (HLA)-identical
            allogeneic bone marrow transplantation (BMT). This gene is only
            expressed in B cell acute lymphoblastic leukemia cells and
            Epstein-Barr virus-transformed B cells. The translation of this
            mRNA initiates at a non-AUG (CUG) codon. [provided by RefSeq, Jul
            2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF103884.1, BC113971.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match       :: ENST00000289448.4/ ENSP00000289448.3
            non-AUG initiation codon :: PMID: 9892612
            RefSeq Select criteria   :: based on single protein-coding
                                        transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               AC025765.6         208050-208193       c
            145-381             AC025765.6         199638-199874       c
FEATURES             Location/Qualifiers
     source          1..381
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..381
                     /gene="HMHB1"
                     /gene_synonym="HB-1; HB-1Y; HLA-HB1"
                     /note="histocompatibility minor HB-1"
                     /db_xref="GeneID:57824"
                     /db_xref="HGNC:HGNC:29677"
                     /db_xref="MIM:609961"
     exon            1..144
                     /gene="HMHB1"
                     /gene_synonym="HB-1; HB-1Y; HLA-HB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..233
                     /gene="HMHB1"
                     /gene_synonym="HB-1; HB-1Y; HLA-HB1"
                     /note="non-AUG (CUG) translation initiation codon; minor
                     histocompatibility antigen HB-1"
                     /codon_start=1
                     /product="minor histocompatibility protein HB-1"
                     /protein_id="NP_067005.1"
                     /db_xref="CCDS:CCDS43376.1"
                     /db_xref="GeneID:57824"
                     /db_xref="HGNC:HGNC:29677"
                     /db_xref="MIM:609961"
                     /translation="MEEQPECREEKRGSLHVWKSELVEVEDDVYLRHSSSLTYRL"
     exon            145..381
                     /gene="HMHB1"
                     /gene_synonym="HB-1; HB-1Y; HLA-HB1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccacatccca ggaggccgag gcggcttgcc ccgcatctca gaagccgggc aggccctgag
       61 ccttctgacc tcacatcctc tgccacacca cagtggagaa accagaactg gaggagcagc
      121 cagaatgcag agaagaaaaa agaggttctc tgcatgtttg gaagtcggaa ttggttgaag
      181 ttgaagatga tgtgtatctg aggcacagct cttccctgac ttataggctt tgacactgct
      241 gttgaggttt gactcgaagc ccagagtttt ggtgtggatg agcagggaca aattgctgag
      301 catgaagaag agtaaaatta agcaagtgga acatatgccc tttgcctctg ctctgcacag
      361 tgaaatgaaa agtcaacctt t
//
