LOCUS       NM_014983               5258 bp    mRNA    linear   PRI 14-SEP-2022
DEFINITION  Homo sapiens HMG-box containing 3 (HMGXB3), transcript variant 1,
            mRNA.
ACCESSION   NM_014983 XM_001714730 XM_001717202 XM_001717459
VERSION     NM_014983.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5258)
  AUTHORS   Zhang G, Wang J, Tan W, Han X, Han B, Wang H, Xia Y, Sun Y and Li
            H.
  TITLE     Circular RNA EGLN3 silencing represses renal cell carcinoma
            progression through the miR-1224-3p/HMGXB3 axis
  JOURNAL   Acta Histochem 123 (6), 151752 (2021)
   PUBMED   34274607
  REMARK    GeneRIF: Circular RNA EGLN3 silencing represses renal cell
            carcinoma progression through the miR-1224-3p/HMGXB3 axis.
REFERENCE   2  (bases 1 to 5258)
  AUTHORS   Woo HH and Chambers SK.
  TITLE     Regulation of closely juxtaposed proto-oncogene c-fms and HMGXB3
            gene expression by mRNA 3' end polymorphism in breast cancer cells
  JOURNAL   RNA 27 (9), 1068-1081 (2021)
   PUBMED   34155128
  REMARK    GeneRIF: Regulation of closely juxtaposed proto-oncogene c-fms and
            HMGXB3 gene expression by mRNA 3' end polymorphism in breast cancer
            cells.
REFERENCE   3  (bases 1 to 5258)
  AUTHORS   Fellay J, Ge D, Shianna KV, Colombo S, Ledergerber B, Cirulli ET,
            Urban TJ, Zhang K, Gumbs CE, Smith JP, Castagna A, Cozzi-Lepri A,
            De Luca A, Easterbrook P, Gunthard HF, Mallal S, Mussini C, Dalmau
            J, Martinez-Picado J, Miro JM, Obel N, Wolinsky SM, Martinson JJ,
            Detels R, Margolick JB, Jacobson LP, Descombes P, Antonarakis SE,
            Beckmann JS, O'Brien SJ, Letvin NL, McMichael AJ, Haynes BF,
            Carrington M, Feng S, Telenti A and Goldstein DB.
  CONSRTM   NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI)
  TITLE     Common genetic variation and the control of HIV-1 in humans
  JOURNAL   PLoS Genet 5 (12), e1000791 (2009)
   PUBMED   20041166
REFERENCE   4  (bases 1 to 5258)
  AUTHORS   Andre C, Hampe A, Lachaume P, Martin E, Wang XP, Manus V, Hu WX and
            Galibert F.
  TITLE     Sequence analysis of two genomic regions containing the KIT and the
            FMS receptor tyrosine kinase genes
  JOURNAL   Genomics 39 (2), 216-226 (1997)
   PUBMED   9027509
REFERENCE   5  (bases 1 to 5258)
  AUTHORS   Gastier JM, Brody T, Pulido JC, Businga T, Sunden S, Hu X, Maitra
            S, Buetow KH, Murray JC, Sheffield VC, Boguski M, Duyk GM and
            Hudson TJ.
  TITLE     Development of a screening set for new (CAG/CTG)n dynamic mutations
  JOURNAL   Genomics 32 (1), 75-85 (1996)
   PUBMED   8786123
REFERENCE   6  (bases 1 to 5258)
  AUTHORS   Hampe A, Shamoon BM, Gobet M, Sherr CJ and Galibert F.
  TITLE     Nucleotide sequence and structural organization of the human FMS
            proto-oncogene
  JOURNAL   Oncogene Res 4 (1), 9-17 (1989)
   PUBMED   2524025
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011406.5 and AC011382.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014983.2.
            
            Summary: This gene is one of the non-canonical high mobility group
            (HMG) genes. The encoded protein contains an HMG-box domain found
            in DNA binding proteins such as transcription factors and
            chromosomal proteins. [provided by RefSeq, Aug 2011].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051025.1, BC092520.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000502717.6/ ENSP00000421917.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-441               AC011406.5         51645-52085         c
            442-580             AC011406.5         47835-47973         c
            581-755             AC011406.5         46177-46351         c
            756-1253            AC011406.5         42216-42713         c
            1254-1352           AC011406.5         40471-40569         c
            1353-1484           AC011406.5         34127-34258         c
            1485-1903           AC011406.5         28144-28562         c
            1904-2079           AC011406.5         25943-26118         c
            2080-2177           AC011406.5         25707-25804         c
            2178-2276           AC011406.5         21985-22083         c
            2277-2426           AC011406.5         20221-20370         c
            2427-2728           AC011406.5         15887-16188         c
            2729-2856           AC011406.5         15297-15424         c
            2857-2988           AC011406.5         11945-12076         c
            2989-3173           AC011406.5         10855-11039         c
            3174-3393           AC011406.5         7139-7358           c
            3394-3527           AC011406.5         5067-5200           c
            3528-3644           AC011406.5         4139-4255           c
            3645-3854           AC011406.5         2363-2572           c
            3855-4953           AC011406.5         1-1099              c
            4954-5258           AC011382.4         5157-5461
FEATURES             Location/Qualifiers
     source          1..5258
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q32"
     gene            1..5258
                     /gene="HMGXB3"
                     /gene_synonym="HMGX3; SMF"
                     /note="HMG-box containing 3"
                     /db_xref="GeneID:22993"
                     /db_xref="HGNC:HGNC:28982"
                     /db_xref="MIM:619800"
     exon            1..441
                     /gene="HMGXB3"
                     /gene_synonym="HMGX3; SMF"
                     /inference="alignment:Splign:2.1.0"
     exon            442..580
                     /gene="HMGXB3"
                     /gene_synonym="HMGX3; SMF"
                     /inference="alignment:Splign:2.1.0"
     CDS             444..4322
                     /gene="HMGXB3"
                     /gene_synonym="HMGX3; SMF"
                     /note="isoform 1 is encoded by transcript variant 1; HMG
                     domain-containing protein 3; HMG box domain containing 3"
                     /codon_start=1
                     /product="HMG domain-containing protein 3 isoform 1"
                     /protein_id="NP_055798.3"
                     /db_xref="CCDS:CCDS54935.1"
                     /db_xref="GeneID:22993"
                     /db_xref="HGNC:HGNC:28982"
                     /db_xref="MIM:619800"
                     /translation="MDASYDGTEVTVVMEEIEEAYCYTSPGPPKKKKKYKIHGEKTKK
                     PRSAYLLYYYDIYLKVQQELPHLPQSEINKKISESWRLLSVAERSYYLEKAKLEKEGL
                     DPNSKLSALTAVVPDIPGFRKILPRSDYIIIPKSSLQEDRSCPQLELCVAQNQMSPKG
                     PPLVSNTAPETVPSHAGMAEQCLAVEALAEEVGALTQSGAVQEIATSEILSQDVLLED
                     ASLEVGESHQPYQTSLVIEETLVNGSPDLPTGSLAVPHPQVGESVSVVTVMRDSSESS
                     SSAPATQFIMLPLPAYSVVENPTSIKLTTTYTRRGHGTCTSPGCSFTYVTRHKPPKCP
                     TCGNFLGGKWIPKEKPAKVKVELASGVSSKGSVVKRNQQPVTTEQNSSKENASKLTLE
                     NSEAVSQLLNVAPPREVGEESEWEEVIISDAHVLVKEAPGNCGTAVTKTPVVKSGVQP
                     EVTLGTTDNDSPGADVPTPSEGTSTSSPLPAPKKPTGADLLTPGSRAPELKGRARGKP
                     SLLAAARPMRAILPAPVNVGRGSSMGLPRARQAFSLSDKTPSVRTCGLKPSTLKQLGQ
                     PIQQPSGPGEVKLPSGPSNRTSQVKVVEVKPDMFPPYKYSCTVTLDLGLATSRGRGKC
                     KNPSCSYVYTNRHKPRICPSCGVNLAKDRTEKTTKAIEVSSPLPDVLNATEPLSTAQR
                     EIQRQSTLQLLRKVLQIPENESELAEVFALIHELNSSRLILSNVSEETVTIEQTSWSN
                     YYESPSTQCLLCSSPLFKGGQNSLAGPQECWLLTASRLQTVTAQVKMCLNPHCLALHS
                     FIDIYTGLFNVGNKLLVSLDLLFAIRNQIKLGEDPRVSINVVLKSVQEQTEKTLTSEE
                     LSQLQELLCNGYWAFECLTVRDYNDMICGICGVAPKVEMAQRSEENVLALKSVEFTWP
                     EFLGSNEVNVEDFWATMETEVIEQVAFPASIPITKFDASVIAPFFPPLMRGAVVVNTE
                     KDKNLDVQPVPGSGSALVRLLQEGTCKLDEIGSYSEEKLQHLLRQCGIPFGAEDSKDQ
                     LCFSLLALYESVQNGARAIRPPRHFTGGKIYKVCPHQVVCGSKYLVRGESARDHVDLL
                     ASSRHWPPVYVVDMATSVALCADLCYPELTNQMWGRNQGCFSSPTEPPVSVSCPELLD
                     QHYTVDMTETEHSIQHPVTKTATRRIVHAGLQPNPGDPSAGHHSLALCPELAPYATIL
                     ASIVDSKPNGVRQRPIAFDNATHYYLYNRLMDFLTSREIVNRQIHDIVQSCQPGEVVI
                     RDTLYRLGVAQIKTETEEEGEEEEVAAVAE"
     exon            581..755
                     /gene="HMGXB3"
                     /gene_synonym="HMGX3; SMF"
                     /inference="alignment:Splign:2.1.0"
     exon            756..1253
                     /gene="HMGXB3"
                     /gene_synonym="HMGX3; SMF"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1352
                     /gene="HMGXB3"
                     /gene_synonym="HMGX3; SMF"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1484
                     /gene="HMGXB3"
                     /gene_synonym="HMGX3; SMF"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1903
                     /gene="HMGXB3"
                     /gene_synonym="HMGX3; SMF"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2079
                     /gene="HMGXB3"
                     /gene_synonym="HMGX3; SMF"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2177
                     /gene="HMGXB3"
                     /gene_synonym="HMGX3; SMF"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2276
                     /gene="HMGXB3"
                     /gene_synonym="HMGX3; SMF"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2426
                     /gene="HMGXB3"
                     /gene_synonym="HMGX3; SMF"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2728
                     /gene="HMGXB3"
                     /gene_synonym="HMGX3; SMF"
                     /inference="alignment:Splign:2.1.0"
     exon            2729..2856
                     /gene="HMGXB3"
                     /gene_synonym="HMGX3; SMF"
                     /inference="alignment:Splign:2.1.0"
     exon            2857..2988
                     /gene="HMGXB3"
                     /gene_synonym="HMGX3; SMF"
                     /inference="alignment:Splign:2.1.0"
     exon            2989..3173
                     /gene="HMGXB3"
                     /gene_synonym="HMGX3; SMF"
                     /inference="alignment:Splign:2.1.0"
     exon            3174..3393
                     /gene="HMGXB3"
                     /gene_synonym="HMGX3; SMF"
                     /inference="alignment:Splign:2.1.0"
     exon            3394..3527
                     /gene="HMGXB3"
                     /gene_synonym="HMGX3; SMF"
                     /inference="alignment:Splign:2.1.0"
     exon            3528..3644
                     /gene="HMGXB3"
                     /gene_synonym="HMGX3; SMF"
                     /inference="alignment:Splign:2.1.0"
     exon            3645..3854
                     /gene="HMGXB3"
                     /gene_synonym="HMGX3; SMF"
                     /inference="alignment:Splign:2.1.0"
     exon            3855..5258
                     /gene="HMGXB3"
                     /gene_synonym="HMGX3; SMF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5240..5245
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HMGXB3"
                     /gene_synonym="HMGX3; SMF"
                     /note="hexamer: AATAAA"
     polyA_site      5258
                     /gene="HMGXB3"
                     /gene_synonym="HMGX3; SMF"
                     /note="major polyA site"
ORIGIN      
        1 gatccgtggt gtgccgctac tgccggtgca gccgccaaac cggtgcctcg gtgacgaccg
       61 tgtccctgcc gtcttcctcg agctccccgg ggcttgaccc ccggggccct cggcaggcat
      121 cggtgaggag cctgcggagc gaacctgtgc tcctattctt gcccttcagg accccatatc
      181 gcgactccga ggaggggaag cgagaggggc tgtcgcgact ccgcgccgtg tgtcgccggg
      241 cggggccgcg gggccggggc tccttcagcc cccgggatgc gcgcgcgagc cctcgcctcc
      301 acttccttgt tgctgctgtc acgactggag ccgcctctcg ccgacagcgg ggagcgcgag
      361 tgcgccagcc atccccctcg tccagccgcc gggccaagcg cctccgggaa tgtgagcggc
      421 gcagcttgca cgctcctccg gccatggacg catcatatga tggtactgag gtaactgtcg
      481 tgatggagga aattgaggaa gcctattgtt acacctctcc tgggccaccc aagaagaaga
      541 aaaagtataa aatacatgga gaaaagacaa agaaacccag gtctgcttac cttctgtact
      601 attacgacat ctacctgaaa gtgcagcagg agctccccca cctccctcag tctgagatca
      661 ataagaagat tagtgagagt tggaggcttc tcagcgtggc cgagaggagt tactacttgg
      721 agaaagccaa actagagaag gaaggtttgg atcctaactc taagctctct gcactgactg
      781 ctgtggttcc ggacatccca ggtttccgca agatcctccc acgctcagat tatatcatca
      841 tccccaagag cagcctgcag gaggaccgga gctgccctca gctagagcta tgtgtggctc
      901 agaaccagat gtccccgaaa ggacctcctc ttgtgtccaa cactgccccg gagacagtgc
      961 ccagccatgc aggcatggca gagcagtgcc tggctgtgga ggccctggct gaggaggtgg
     1021 gagcccttac ccagtcaggt gctgtacagg agattgccac ctcagagatc ctcagccagg
     1081 atgtgctcct agaggacgct tccctagaag taggggagag ccaccaacct taccagacaa
     1141 gcctggtaat tgaagagacc ttggtgaatg gctcaccaga cctccccact ggaagcctgg
     1201 ctgtgcccca cccccaggtt ggggagagtg tatcagtggt aacagtcatg agggattcca
     1261 gtgagagtag ctcctctgca ccagccacac agttcatcat gttgcctctg cctgcctact
     1321 cggttgtgga gaaccccacc tccatcaaac tgaccactac atatacccgc cggggccatg
     1381 ggacatgcac cagcccaggg tgctccttta catatgtcac caggcacaag ccacctaagt
     1441 gccctacctg tggtaacttc ctaggaggga agtggatccc aaaggaaaag ccagccaaag
     1501 taaaagtgga attggcttct ggcgtctctt ccaaaggctc tgtggtgaaa agaaatcagc
     1561 aacctgtcac cactgagcaa aattcctcta aggaaaatgc ctccaaactg actctggaga
     1621 attcggaagc tgtaagccag ctcctgaacg tagctcctcc cagagaagta ggtgaggaga
     1681 gtgagtggga ggaagtgatc atctccgatg cccatgtttt ggttaaggaa gctcccggga
     1741 attgtggtac agcagtcact aagacgccag tcgtcaaaag tggtgtgcag cctgaggtca
     1801 ctctggggac aactgacaat gacagtcctg gagcagacgt accaacacca tccgagggga
     1861 caagtacctc cagtccactc cctgctccta aaaaacctac aggagctgac ctgcttaccc
     1921 ctgggtccag agctccagag cttaaaggca gagcacgggg caagccctca ttactggctg
     1981 cagcaagacc catgagagca attttgccag ccccagttaa cgtggggcga ggcagcagca
     2041 tgggactgcc cagggccagg caggcctttt ccctgagtga taagactccc tctgtgagga
     2101 cttgtggtct gaagccaagc acactgaagc agctgggcca gcccattcaa cagccatctg
     2161 gccctggtga ggtgaagcta ccaagtggcc catccaacag gacttctcag gtgaaagttg
     2221 tggaggtcaa gcccgatatg tttcctccat ataagtacag ctgcactgtc acattggatt
     2281 tgggcctggc tacatcaaga ggccggggaa agtgcaagaa tccctcttgt agctatgtct
     2341 acaccaacag gcacaaacct cgaatttgtc ccagctgtgg tgttaacctt gccaaagacc
     2401 ggactgagaa aaccaccaag gctatcgagg tgagctcacc actcccagat gtactgaatg
     2461 ccacagagcc cctgagcaca gcccagaggg agatccagcg ccagtccaca ctgcagctgc
     2521 tgcgcaaagt cctgcagatt cctgagaatg agtcagagct ggctgaggtc ttcgccttga
     2581 ttcatgaact caacagctct cgacttatct tgtccaacgt gagtgaggag acagtcacca
     2641 tcgagcaaac ctcttggtcg aattattatg agtctccgtc cacgcagtgc cttctctgta
     2701 gcagcccatt attcaaaggg ggacaaaact ccctggctgg gccccaggag tgctggctgc
     2761 tgacagccag ccgtctgcag acagtgactg cccaggtgaa gatgtgtctg aacccccatt
     2821 gtctggccct gcacagcttc atagacatct acacaggtct ctttaatgtg gggaacaagc
     2881 tgctggtaag cctggacttg ctttttgcaa tcagaaatca gatcaagctc ggagaggacc
     2941 ccagagtgtc catcaatgtt gttctgaagt cggtgcagga gcagacagag aagactctga
     3001 cctcggagga gctgagccag ctgcaggagc tgctgtgcaa tggctattgg gcctttgagt
     3061 gcctcactgt ccgagactac aatgacatga tctgtggcat ctgtggtgtg gcccccaaag
     3121 tggaaatggc tcagaggagt gaagagaatg tgctagcact gaagagcgtg gagttcacct
     3181 ggcctgaatt cctgggctct aatgaggtaa atgtggagga cttttgggcc acgatggaga
     3241 cagaggtgat tgagcaggtg gcatttcctg ccagcatccc tatcaccaaa tttgatgcgt
     3301 ctgttattgc ccccttcttc ccaccactca tgagaggagc tgtggtcgtc aacactgaga
     3361 aagacaaaaa cctggatgtg cagccagtac ctggcagtgg cagtgccttg gtgaggctgc
     3421 tccaggaggg cacctgcaag cttgatgaga ttggctccta cagtgaagag aagctgcagc
     3481 acctgctaag gcagtgtgga atcccctttg gggcagaaga ctccaaggac cagctctgct
     3541 tctccttgtt ggccctctac gaatctgtac agaatggagc tagagctata cggcccccac
     3601 gtcacttcac aggtggtaaa atctacaagg tgtgccccca tcaggtggtc tgcggctcca
     3661 agtatcttgt gcgaggtgag agtgcccgtg accatgtgga cctgcttgcc tcttcccgcc
     3721 actggccgcc tgtctatgtg gtagatatgg ccacgtcagt ggccctgtgt gctgacctct
     3781 gctacccaga gctgactaac cagatgtggg ggaggaacca gggctgtttc tctagcccca
     3841 cagagccacc tgtgagtgtg tcctgcccag agctcttgga ccagcattat actgtggaca
     3901 tgacagaaac tgagcactct atccagcacc cagtcaccaa gactgccacg cggcgcatcg
     3961 tccatgcagg cctacagccc aatcctggtg accccagtgc tgggcaccac tccttggccc
     4021 tgtgccctga attggcacct tacgcaacca tcctggcctc catcgtggac agcaaaccaa
     4081 acggtgtccg ccagcggccc attgccttcg acaatgccac tcactattac ctctacaacc
     4141 gcctcatgga cttcctcacc agccgcgaaa ttgtcaatcg tcagatccat gacattgtac
     4201 agagctgcca gcctggtgag gtggtcattc gtgacaccct ctaccgcctt ggggttgctc
     4261 agatcaagac agagacagag gaggagggtg aggaagagga ggtggccgca gtggcagaat
     4321 aagccaggct gttgtacagg gactacacca tctctcaagc catagtaagg cccttgcctg
     4381 aggcagagct atccagggga cctgcagaag tggtctcctg tggggagggc ctctgactgc
     4441 tgggactgac caaagagctt ccattccctg agcatggtgg gacccagggt cctcagttct
     4501 caaccctcca ggggtcagga gtggtaccag gaaacctctt ctggccccga gagagcactt
     4561 gggggacacg gtatgtttaa tggaggggag gctgagggaa aggctcgtag ctggtgggtt
     4621 ccgtggggcc tgcggtgtgg gtcagggtgg aggtcctggg tgggctaagg cgtgagcccc
     4681 agcactaggt gggaaggctg ctgaggtctc tcccacccct gaggagccct ggtttcagcc
     4741 ccctcagtct gatgaattgc ttagcctgtt gcctttgact aggggcctgg gtggcctcat
     4801 taactctagg ggtccctttg ggctcttgat tctccctgaa ggagggatgc atttctctct
     4861 tgctcttcct gtacccacat ttgggggaag ctgaggaggg aggaacagtc agccacagct
     4921 ctcttccagc actgtcctct ccaccccaag ctttgaggaa gagcatcccc ttcctccttt
     4981 ccctggccac tgctgctgca gccaatatcc tctctgggcc tgggaccctc tccacagagg
     5041 ggatgtggtc cctggtcatg acataaccta gcagcagtag gaaaaactcc cttctatgaa
     5101 ggggaagcag actgggccat aaggaaacag caggactggc tcaagtgccc aaggtttgtt
     5161 tagggcctgg gaattggcca tgtgttaatt tattgagtgg agtaggtggc tttttttccc
     5221 tccctcttcc cccaacaaga ataaagttta ttaaatta
//
