LOCUS       NM_006353               1943 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens high mobility group nucleosomal binding domain 4
            (HMGN4), mRNA.
ACCESSION   NM_006353
VERSION     NM_006353.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1943)
  AUTHORS   Mou,J., Xu,X., Wang,F., Kong,W., Chen,J. and Ren,J.
  TITLE     HMGN4 plays a key role in STAT3-mediated oncogenesis of
            triple-negative breast cancer
  JOURNAL   Carcinogenesis 43 (9), 874-884 (2022)
   PUBMED   35792800
  REMARK    GeneRIF: HMGN4 plays a key role in STAT3-mediated oncogenesis of
            triple-negative breast cancer.
REFERENCE   2  (bases 1 to 1943)
  AUTHORS   Kugler,J., Postnikov,Y.V., Furusawa,T., Kimura,S. and Bustin,M.
  TITLE     Elevated HMGN4 expression potentiates thyroid tumorigenesis
  JOURNAL   Carcinogenesis 38 (4), 391-401 (2017)
   PUBMED   28186538
  REMARK    GeneRIF: HMGN4 may serve as an additional diagnostic marker.
REFERENCE   3  (bases 1 to 1943)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
REFERENCE   4  (bases 1 to 1943)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   5  (bases 1 to 1943)
  AUTHORS   Birger,Y., Ito,Y., West,K.L., Landsman,D. and Bustin,M.
  TITLE     HMGN4, a newly discovered nucleosome-binding protein encoded by an
            intronless gene
  JOURNAL   DNA Cell Biol 20 (5), 257-264 (2001)
   PUBMED   11410162
REFERENCE   6  (bases 1 to 1943)
  AUTHORS   Ruddy,D.A., Kronmal,G.S., Lee,V.K., Mintier,G.A., Quintana,L.,
            Domingo,R. Jr., Meyer,N.C., Irrinki,A., McClelland,E.E., Fullan,A.,
            Mapa,F.A., Moore,T., Thomas,W., Loeb,D.B., Harmon,C.,
            Tsuchihashi,Z., Wolff,R.K., Schatzman,R.C. and Feder,J.N.
  TITLE     A 1.1-Mb transcript map of the hereditary hemochromatosis locus
  JOURNAL   Genome Res 7 (5), 441-456 (1997)
   PUBMED   9149941
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121936.17.
            
            On Nov 26, 2018 this sequence version replaced NM_006353.2.
            
            Summary: The protein encoded by this gene, a member of the HMGN
            protein family, is thought to reduce the compactness of the
            chromatin fiber in nucleosomes, thereby enhancing transcription
            from chromatin templates. [provided by RefSeq, Mar 2013].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.30530.1,
                                           SRR3476690.126472.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377575.3/ ENSP00000366798.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               AL121936.17        75731-75866
            137-1943            AL121936.17        82492-84298
FEATURES             Location/Qualifiers
     source          1..1943
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.2"
     gene            1..1943
                     /gene="HMGN4"
                     /gene_synonym="HMG17L3; NHC"
                     /note="high mobility group nucleosomal binding domain 4"
                     /db_xref="GeneID:10473"
                     /db_xref="HGNC:HGNC:4989"
     exon            1..136
                     /gene="HMGN4"
                     /gene_synonym="HMG17L3; NHC"
                     /inference="alignment:Splign:2.1.0"
     exon            137..1943
                     /gene="HMGN4"
                     /gene_synonym="HMG17L3; NHC"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..489
                     /gene="HMGN4"
                     /gene_synonym="HMG17L3; NHC"
                     /note="high-mobility group (nonhistone chromosomal)
                     protein 17-like 3; high mobility group protein N4;
                     high-mobility group protein 17-like 3; non-histone
                     chromosomal protein HMG-17-like 3"
                     /codon_start=1
                     /product="high mobility group nucleosome-binding
                     domain-containing protein 4"
                     /protein_id="NP_006344.1"
                     /db_xref="CCDS:CCDS4615.1"
                     /db_xref="GeneID:10473"
                     /db_xref="HGNC:HGNC:4989"
                     /translation="MPKRKAKGDAKGDKAKVKDEPQRRSARLSAKPAPPKPEPRPKKA
                     SAKKGEKLPKGRKGKADAGKDGNNPAKNRDASTLQSQKAEGTGDAK"
     regulatory      1921..1926
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HMGN4"
                     /gene_synonym="HMG17L3; NHC"
                     /note="hexamer: AATAAA"
     polyA_site      1943
                     /gene="HMGN4"
                     /gene_synonym="HMG17L3; NHC"
                     /note="major polyA site"
ORIGIN      
        1 ctgttcctgg cggagccggg ctccgctcgt cttctctgtc ttagggctgg tgctggccct
       61 gcccacgcct agggctccgg cgcgtcacgg gcctcagctg ggattcccgc gcccctcgga
      121 cggccacgag actcggacat ctttccagga acagcgtgag gaggacagaa gcacccaaca
      181 ggactgctca agccacctgc gaacactgct gctaccatgc ccaagagaaa ggcaaaagga
      241 gatgctaaag gtgataaagc aaaggtgaag gatgagccac agaggagatc agctcggttg
      301 tctgctaaac cagctcctcc aaaaccagag cccaggccta aaaaggcctc tgcaaagaag
      361 ggagagaagc ttcccaaagg gagaaagggg aaagcagatg ctggaaagga tgggaacaac
      421 cctgcaaaaa accgagatgc ctctacactc cagtcccaga aagcggaagg cactggggat
      481 gccaagtgaa atgtacattt ttgagagctc tgtacttata gtgactctac tgtttgaaat
      541 actatttttt taaatcaagt tttataaaag tgtagaattt tggctttttt aagttatgtt
      601 gttagcacac aggacacttc cttgttgtct tttgtggaaa gggcaagtac cactaatagg
      661 gtgtatctca gaaactgaat tgaaataagg gaaaatagga ttttctgtcc tggtttttga
      721 agattgttct tgattccctt gattcccagg agagattctc tgacattcac gtgtcagcca
      781 ctttggcacg gaagccttac agtgtgggga accaaaactt cgtgtctccc ctttccccga
      841 tgccatcagc atagacttga cttccttaaa ccgagagttt tgatgtggcc ttggcaaccc
      901 taaaatcagc tgtgttaggt aacaaaactc aggctttctg ttgatgacat cgagatggtg
      961 tcacttaaaa gagccaagat tcctgttttc agtttgtgga ttcatcctgc tggttttact
     1021 ttagtccctc catgtcaaag tgggcctgag aaaagctcat acatgcctca tgtgaagtgt
     1081 ccaccctctc tgaaaatctt tcttgttcaa aacagcaacg acatatcttg ttaactttta
     1141 cggtgacttt tggaggaggg gagtttggaa attgtaaaat gttatagatt gttgcctatt
     1201 tcctgctgaa agtaaatgtt tttaaaaagt atcatataaa gctgaataca aattggtttg
     1261 gggggagatc ctttcctacc caaagtcata aatatattct ttactgcctt gtggaaattt
     1321 tatagttttg cctttcacat ttgtctttag tctgtcctga actgattttt gtgaaaatta
     1381 tgagttagaa attcaactta acatttttca tattcgaagt ggttgtctct gcactattta
     1441 ctgaaaagtt catcctttcc ccagtgattt gtaacactgc ctctttcata aattaaattt
     1501 ttgtgtatgt gtgtgggtct tttgatggtt tctattctga ctgacatcaa tttgtctaat
     1561 cttgtagcag tacagtacag tcctgattat tgcaacttta ggaaaaggtc tgataaaaac
     1621 caagatgcct ccacattttg tcataattgt aaccaatttc acctctgtct ccagtatcac
     1681 cacaaaattg ttcttccttg gagtgtcttg gctattctta gccaactgtt cctccatatt
     1741 acttctagaa ttagaccaac aatttataaa tcaaacaaac ccaagagcat tgaaattttg
     1801 attggatttg tattgaattt atagattaat ctggtaaacc atgtcatctt tacaatgttg
     1861 tcttccaata catgaatatg gtacagctct tcatttactt aggcctttga aatatctttc
     1921 aataaagttt ataattttct cca
//
