LOCUS       NM_001201363             958 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens high mobility group nucleosomal binding domain 3
            (HMGN3), transcript variant 4, mRNA.
ACCESSION   NM_001201363
VERSION     NM_001201363.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 958)
  AUTHORS   Bian,Y., Li,J., Shen,H., Li,Y., Hou,Y., Huang,L., Song,G. and
            Qiao,C.
  TITLE     WTAP dysregulation-mediated HMGN3-m6A modification inhibited
            trophoblast invasion in early-onset preeclampsia
  JOURNAL   FASEB J 36 (12), e22617 (2022)
   PUBMED   36412513
  REMARK    GeneRIF: WTAP dysregulation-mediated HMGN3-m6A modification
            inhibited trophoblast invasion in early-onset preeclampsia.
REFERENCE   2  (bases 1 to 958)
  AUTHORS   Sorin,S., Kubota,S., Hamidi,S., Yokomizo-Nakano,T.,
            Vaeteewoottacharn,K., Wongkham,S., Waraasawapati,S., Pairojkul,C.,
            Bai,J., Morii,M., Sheng,G., Sawanyawisuth,K. and Sashida,G.
  TITLE     HMGN3 represses transcription of epithelial regulators to promote
            migration of cholangiocarcinoma in a SNAI2-dependent manner
  JOURNAL   FASEB J 36 (7), e22345 (2022)
   PUBMED   35635715
  REMARK    GeneRIF: HMGN3 represses transcription of epithelial regulators to
            promote migration of cholangiocarcinoma in a SNAI2-dependent
            manner.
REFERENCE   3  (bases 1 to 958)
  AUTHORS   Koh,M., Ahmad,I., Ko,Y., Zhang,Y., Martinez,T.F., Diedrich,J.K.,
            Chu,Q., Moresco,J.J., Erb,M.A., Saghatelian,A., Schultz,P.G. and
            Bollong,M.J.
  TITLE     A short ORF-encoded transcriptional regulator
  JOURNAL   Proc Natl Acad Sci U S A 118 (4) (2021)
   PUBMED   33468658
REFERENCE   4  (bases 1 to 958)
  AUTHORS   Lei,S.F., Shen,H., Yang,T.L., Guo,Y., Dong,S.S., Xu,X.H.,
            Deng,F.Y., Tian,Q., Liu,Y.J., Liu,Y.Z., Li,J. and Deng,H.W.
  TITLE     Genome-wide association study identifies HMGN3 locus for spine bone
            size variation in Chinese
  JOURNAL   Hum Genet 131 (3), 463-469 (2012)
   PUBMED   21947420
  REMARK    GeneRIF: The SNPs in the region of HMGN3 gene formed a tightly
            combined haplotype block in both Chinese and Caucasians. The
            results suggest that the genomic region containing HMGN3 gene may
            be associated with spine BS in Chinese.
REFERENCE   5  (bases 1 to 958)
  AUTHORS   Ueda,T., Furusawa,T., Kurahashi,T., Tessarollo,L. and Bustin,M.
  TITLE     The nucleosome binding protein HMGN3 modulates the transcription
            profile of pancreatic beta cells and affects insulin secretion
  JOURNAL   Mol Cell Biol 29 (19), 5264-5276 (2009)
   PUBMED   19651901
  REMARK    GeneRIF: loss of HMGN3 impairs glucose-stimulated insulin secretion
            and leads to a diabetic phenotype.
REFERENCE   6  (bases 1 to 958)
  AUTHORS   West,K.L., Castellini,M.A., Duncan,M.K. and Bustin,M.
  TITLE     Chromosomal proteins HMGN3a and HMGN3b regulate the expression of
            glycine transporter 1
  JOURNAL   Mol Cell Biol 24 (9), 3747-3756 (2004)
   PUBMED   15082770
REFERENCE   7  (bases 1 to 958)
  AUTHORS   Leong,P.W., Liew,K., Lim,W. and Chow,V.T.
  TITLE     Differential display RT-PCR analysis of enterovirus-71-infected
            rhabdomyosarcoma cells reveals mRNA expression responses of
            multiple human genes with known and novel functions
  JOURNAL   Virology 295 (1), 147-159 (2002)
   PUBMED   12033773
REFERENCE   8  (bases 1 to 958)
  AUTHORS   West,K.L., Ito,Y., Birger,Y., Postnikov,Y., Shirakawa,H. and
            Bustin,M.
  TITLE     HMGN3a and HMGN3b, two protein isoforms with a tissue-specific
            expression pattern, expand the cellular repertoire of
            nucleosome-binding proteins
  JOURNAL   J Biol Chem 276 (28), 25959-25969 (2001)
   PUBMED   11356838
REFERENCE   9  (bases 1 to 958)
  AUTHORS   Lee,J.W., Choi,H.S., Gyuris,J., Brent,R. and Moore,D.D.
  TITLE     Two classes of proteins dependent on either the presence or absence
            of thyroid hormone for interaction with the thyroid hormone
            receptor
  JOURNAL   Mol Endocrinol 9 (2), 243-254 (1995)
   PUBMED   7776974
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL355796.11.
            
            On Mar 26, 2019 this sequence version replaced NM_001201363.1.
            
            Summary: The protein encoded by this gene binds thyroid hormone
            receptor beta in the presence of thyroid hormone. The encoded
            protein, a member of the HMGN protein family, is thought to reduce
            the compactness of the chromatin fiber in nucleosomes, thereby
            enhancing transcription from chromatin templates. Alternatively
            spliced transcript variants encoding different isoforms have been
            found for this gene. There is a related pseudogene on chromosome 1.
            [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (4) contains an alternate in-frame
            exon in the 3' coding region compared to variant 1. The resulting
            isoform (d) is longer than isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.112093.1, BF790582.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267760 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000620514.2/ ENSP00000482613.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               AL355796.11        102794-102930       c
            138-188             AL355796.11        83220-83270         c
            189-218             AL355796.11        76795-76824         c
            219-269             AL355796.11        71828-71878         c
            270-383             AL355796.11        70524-70637         c
            384-476             AL355796.11        70311-70403         c
            477-958             AL355796.11        69493-69974         c
FEATURES             Location/Qualifiers
     source          1..958
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q14.1"
     gene            1..958
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /note="high mobility group nucleosomal binding domain 3"
                     /db_xref="GeneID:9324"
                     /db_xref="HGNC:HGNC:12312"
                     /db_xref="MIM:604502"
     exon            1..137
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..515
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /note="isoform d is encoded by transcript variant 4;
                     thyroid hormone receptor interacting protein 7; high
                     mobility group nucleosome-binding domain-containing
                     protein 3; TR-interacting protein 7"
                     /codon_start=1
                     /product="high mobility group nucleosome-binding
                     domain-containing protein 3 isoform d"
                     /protein_id="NP_001188292.1"
                     /db_xref="CCDS:CCDS75485.1"
                     /db_xref="GeneID:9324"
                     /db_xref="HGNC:HGNC:12312"
                     /db_xref="MIM:604502"
                     /translation="MPKRKSPENTEGKDGSKVTKQEPTRRSARLSAKPAPPKPEPKPR
                     KTSAKKEPGAKISRGAKGKKEEKQEAGKEGTAPSENGETKAEEIHISRSTVNVSTSRG
                     TPPSTLSVKGQIETVRAQKTESVDNEGE"
     exon            138..188
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /inference="alignment:Splign:2.1.0"
     exon            189..218
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /inference="alignment:Splign:2.1.0"
     exon            219..269
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /inference="alignment:Splign:2.1.0"
     exon            270..383
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /inference="alignment:Splign:2.1.0"
     exon            384..476
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /inference="alignment:Splign:2.1.0"
     exon            477..958
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      933..938
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /note="hexamer: AATAAA"
     polyA_site      958
                     /gene="HMGN3"
                     /gene_synonym="PNAS-24; PNAS-25; TRIP7"
                     /note="major polyA site"
ORIGIN      
        1 gaagaggccg ggctacgtcg tgccctgcgc gtgagcagct gcagaggcag aggcagcatc
       61 cagcggcggc gccagcagtt ccagtccgtt gctttacttt ttgcttcacc gacatagtca
      121 ttatgccgaa gagaaagtct ccagagaata cagagggcaa agatggatcc aaagtaacta
      181 aacaggagcc cacaagacgg tctgccagat tgtcagcgaa acctgctcca ccaaaacctg
      241 aacccaaacc aagaaaaaca tctgctaaga aagaacctgg agcaaagatt agcagaggtg
      301 ctaaagggaa gaaggaggaa aagcaggaag ctggaaagga aggtactgca ccatctgaaa
      361 atggtgaaac taaagctgaa gagatccaca tctctcgctc aactgttaat gtctcaacct
      421 ccagaggcac cccacccagc acactgtcag taaaggggca gattgaaaca gtgagagcac
      481 agaaaactga atctgtagat aacgagggag aatgaattgt catgaaaaat tggggttgat
      541 tttatgtatc tcttgggaca acttttaaaa gctattttta ccaagtattt tgtaaatgct
      601 aattttttag gactctacta gttggcatac gaaaatatat aaggatggac attttatcgt
      661 ctcatagtca tgctttttgg aaatttacat catcctcaag taaaataaat atcagttaaa
      721 tattggaagc tgtgtgtaag attgattcag cattccatgc acttgcttta aaatttagtc
      781 ctgtgcatac tgtggtgttt ttactgtgca tatttgaatt tttcatgcag tttttctaga
      841 gcaataatca gtggtgcttt tgtacctagg ttttatgtga ttttaatgaa acatggatag
      901 ttgtggccac ctgctgacta tttgtggttt aaaataaaag gtttacttgt ctgcagaa
//
