LOCUS       NM_005517               1940 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens high mobility group nucleosomal binding domain 2
            (HMGN2), mRNA.
ACCESSION   NM_005517 NM_032749
VERSION     NM_005517.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1940)
  AUTHORS   Bin-Alee,F., Arayataweegool,A., Buranapraditkun,S.,
            Mahattanasakul,P., Tangjaturonrasme,N., Hirankarn,N.,
            Mutirangura,A. and Kitkumthorn,N.
  TITLE     Transcriptomic analysis of peripheral blood mononuclear cells in
            head and neck squamous cell carcinoma patients
  JOURNAL   Oral Dis 27 (6), 1394-1402 (2021)
   PUBMED   32892371
  REMARK    GeneRIF: Transcriptomic analysis of peripheral blood mononuclear
            cells in head and neck squamous cell carcinoma patients.
REFERENCE   2  (bases 1 to 1940)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1940)
  AUTHORS   Craig,J.M., Turner,T.H., Harrell,J.C. and Clevenger,C.V.
  TITLE     Prolactin Drives a Dynamic STAT5A/HDAC6/HMGN2 Cis-Regulatory
            Landscape Exploitable in ER+ Breast Cancer
  JOURNAL   Endocrinology 162 (5) (2021)
   PUBMED   33589921
  REMARK    GeneRIF: Prolactin Drives a Dynamic STAT5A/HDAC6/HMGN2
            Cis-Regulatory Landscape Exploitable in ER+ Breast Cancer.
REFERENCE   4  (bases 1 to 1940)
  AUTHORS   Cui,W., Liu,Y., Tan,Y., Peng,X., Cui,L., Cheng,Z., Dai,Y., Fu,L.,
            Zeng,T. and Liu,Y.
  TITLE     Prognostic value of HMGN family expression in acute myeloid
            leukemia
  JOURNAL   Future Oncol 17 (5), 541-548 (2021)
   PUBMED   33467898
  REMARK    GeneRIF: Prognostic value of HMGN family expression in acute
            myeloid leukemia.
REFERENCE   5  (bases 1 to 1940)
  AUTHORS   Geng,F., Liu,Z., Chen,X., Chen,H., Liu,Y., Yang,J., Zheng,M.,
            Yang,L. and Teng,Y.
  TITLE     High mobility group nucleosomal binding 2 reduces integrin
            alpha5/beta1-mediated adhesion of Klebsiella pneumoniae on human
            pulmonary epithelial cells via nuclear factor I
  JOURNAL   Microbiol Immunol 64 (12), 825-834 (2020)
   PUBMED   33034909
  REMARK    GeneRIF: High mobility group nucleosomal binding 2 reduces integrin
            alpha5/beta1-mediated adhesion of Klebsiella pneumoniae on human
            pulmonary epithelial cells via nuclear factor I.
REFERENCE   6  (bases 1 to 1940)
  AUTHORS   Feng,Y., Huang,N., Wu,Q. and Wang,B.
  TITLE     HMGN2: a novel antimicrobial effector molecule of human mononuclear
            leukocytes?
  JOURNAL   J Leukoc Biol 78 (5), 1136-1141 (2005)
   PUBMED   16204630
  REMARK    GeneRIF: A polypeptide, HMGN2, was isolated and may be an
            antimicrobial effector molecule of mononuclear leukocytes.
REFERENCE   7  (bases 1 to 1940)
  AUTHORS   Giancotti,V., Bandiera,A., Buratti,E., Fusco,A., Marzari,R.,
            Coles,B. and Goodwin,G.H.
  TITLE     Comparison of multiple forms of the high mobility group I proteins
            in rodent and human cells. Identification of the human high
            mobility group I-C protein
  JOURNAL   Eur J Biochem 198 (1), 211-216 (1991)
   PUBMED   2040281
REFERENCE   8  (bases 1 to 1940)
  AUTHORS   Dracopoli,N.C., O'Connell,P., Elsner,T.I., Lalouel,J.M.,
            White,R.L., Buetow,K.H., Nishimura,D.Y., Murray,J.C., Helms,C.,
            Mishra,S.K. et al.
  TITLE     The CEPH consortium linkage map of human chromosome 1
  JOURNAL   Genomics 9 (4), 686-700 (1991)
   PUBMED   2037294
REFERENCE   9  (bases 1 to 1940)
  AUTHORS   Popescu,N., Landsman,D. and Bustin,M.
  TITLE     Mapping the human gene coding for chromosomal protein HMG-17
  JOURNAL   Hum Genet 85 (3), 376-378 (1990)
   PUBMED   2394451
REFERENCE   10 (bases 1 to 1940)
  AUTHORS   Abercrombie,B.D., Kneale,G.G., Crane-Robinson,C., Bradbury,E.M.,
            Goodwin,G.H., Walker,J.M. and Johns,E.W.
  TITLE     Studies on the conformational properties of the high-mobility-group
            chromosomal protein HMG 17 and its interaction with DNA
  JOURNAL   Eur J Biochem 84 (1), 173-177 (1978)
   PUBMED   565710
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AU100588.1, BC071707.1,
            BU074476.1, BC110390.1 and AL513365.27.
            
            On Nov 23, 2018 this sequence version replaced NM_005517.3.
            
            Summary: The protein encoded by this gene binds nucleosomal DNA and
            is associated with transcriptionally active chromatin. Along with a
            similar protein, HMGN1, the encoded protein may help maintain an
            open chromatin configuration around transcribable genes. The
            protein has also been found to have antimicrobial activity against
            bacteria, viruses and fungi. [provided by RefSeq, Oct 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.264967.1,
                                           SRR1803617.180791.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000361427.6/
                                                  ENSP00000355228.5
            Protein has antimicrobial activity :: PMID: 16204630
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                AU100588.1         30-107
            79-810              BC071707.1         1-732
            811-1270            BU074476.1         8-467               c
            1271-1354           BC110390.1         1196-1279
            1355-1355           AL513365.27        38287-38287         c
            1356-1940           BC110390.1         1281-1865
FEATURES             Location/Qualifiers
     source          1..1940
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..1940
                     /gene="HMGN2"
                     /gene_synonym="HMG17"
                     /note="high mobility group nucleosomal binding domain 2"
                     /db_xref="GeneID:3151"
                     /db_xref="HGNC:HGNC:4986"
                     /db_xref="MIM:163910"
     exon            1..188
                     /gene="HMGN2"
                     /gene_synonym="HMG17"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..446
                     /gene="HMGN2"
                     /gene_synonym="HMG17"
                     /note="high mobility group protein N2; high-mobility group
                     (nonhistone chromosomal) protein 17; nonhistone
                     chromosomal protein HMG-17; high mobility group
                     nucleosome-binding domain-containing protein 2"
                     /codon_start=1
                     /product="non-histone chromosomal protein HMG-17"
                     /protein_id="NP_005508.1"
                     /db_xref="CCDS:CCDS283.1"
                     /db_xref="GeneID:3151"
                     /db_xref="HGNC:HGNC:4986"
                     /db_xref="MIM:163910"
                     /translation="MPKRKAEGDAKGDKAKVKDEPQRRSARLSAKPAPPKPEPKPKKA
                     PAKKGEKVPKGKKGKADAGKEGNNPAENGDAKTDQAQKAEGAGDAK"
     exon            189..233
                     /gene="HMGN2"
                     /gene_synonym="HMG17"
                     /inference="alignment:Splign:2.1.0"
     exon            234..263
                     /gene="HMGN2"
                     /gene_synonym="HMG17"
                     /inference="alignment:Splign:2.1.0"
     exon            264..314
                     /gene="HMGN2"
                     /gene_synonym="HMG17"
                     /inference="alignment:Splign:2.1.0"
     exon            315..410
                     /gene="HMGN2"
                     /gene_synonym="HMG17"
                     /inference="alignment:Splign:2.1.0"
     exon            411..1940
                     /gene="HMGN2"
                     /gene_synonym="HMG17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1924..1929
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HMGN2"
                     /gene_synonym="HMG17"
                     /note="hexamer: AGTAAA"
     polyA_site      1940
                     /gene="HMGN2"
                     /gene_synonym="HMG17"
                     /note="major polyA site"
ORIGIN      
        1 gaaatccggt tctaaccggt ccggggctcc cagcgctata aaaactttat aaaccccccg
       61 gagcccgagc agtgtgaaga agaggcgaga acgacccccg gaccgaccaa agcccgcgcg
      121 ccgctgcatc ccgcgtccag cacctacgtc ccgctgccgt cgccgccgcc accatgccca
      181 agagaaaggc tgaaggggat gctaagggag ataaagcaaa ggtgaaggac gaaccacaga
      241 gaagatccgc gaggttgtct gctaaacctg ctcctccaaa gccagagccc aagcctaaaa
      301 aggcccctgc aaagaaggga gagaaggtac ccaaagggaa aaagggaaaa gctgatgctg
      361 gcaaggaggg gaataaccct gcagaaaatg gagatgccaa aacagaccag gcacagaaag
      421 ctgaaggtgc tggagatgcc aagtgaagtg tgtgcatttt tgataactgt gtacttctgg
      481 tgactgtaca gtttgaaata ctatttttta tcaagtttta taaaaatgca gaattttgtt
      541 ttactttttt ttttttttta aaagctatgt tgttagcaca cagaacactt cattgttgtt
      601 tttgggggaa ggggcatatg tcactaatag aatgtctcca aagctggatt gatgtggaga
      661 aaacaccttt cccttctagt tttgagagac ttcctcttgg ctcccaggag gagggattcc
      721 ctgactttga cacacatggc caccttggca caaaagcctt gtggtataga aaaacaaatt
      781 tgtttttatg tcctcttctc cctttccatc gttcagcata gacttaactc ccttaagccc
      841 agacatctgt tgagacctga cccctagtca ttggttacca gtgtgtcagg caatctggac
      901 tttccagtga tgccactgag atggcacctg tcaaaagagc agtggttcca tttctagatt
      961 gtggatcttc agataaattc tgccattttc atttcacttc ctgaaagtca gggtcggctt
     1021 gtgaaaagtt gttaaacaac atgctaaatg tgaaatgtca accctcactc taaactttcc
     1081 ctgttcagag catcagatga agacttcatt gggttttata gtggctttct gatttttggt
     1141 agtccattga agaagggagt ttgaaagttg ttgtatactg ttaacgattg tctgcccatg
     1201 tcctgcctga aataccatga ttgtttatgg aaagtatctt taataaagct ggatacagtt
     1261 tggcttggaa tgctgcctct gatcttttcc cacaagtggg gtaacctggt ttatccaagt
     1321 ctcttggaac agggtacgtt ctgctttgag gtactccatg tacagtctaa tgatgatctt
     1381 tcactgattt atagtcagct tccaaaacac acagtgctag gtgcagttag gaaggattcc
     1441 aggagtagac ttagctgatg gtgaaaggct gggagtatgg agtgatttct gtacttggtt
     1501 atgcagcatt ccctgcagtg tttgtttttt gcatgactcc gaatacatga agtgtattaa
     1561 atgcagattt ttggtagatc tgcggttttg gctgggtagc tgacaggagc ctctctactt
     1621 ccatctgcat ttgcaacttc tataaaatta gcaaattaat agactcatgt cagagagtgt
     1681 ctctgtgaat gtgtacacag ttgtccattt gtaaggtaga tgacactttg ctcctaagta
     1741 gacctgcaaa caaagacaat ggggtctttc ctgattcctt tagtttggag atgcagagaa
     1801 ccccacgttt ctctaagtga aatggcaaga agttatttgt tagaatatgg aactggtaac
     1861 aaattcatgt ttgcaccttg aatttgcttt cacagacctg gctgtattgt tggacaggaa
     1921 taaagtaaat tggagactaa
//
