LOCUS       NM_004965               1271 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens high mobility group nucleosome binding domain 1
            (HMGN1), mRNA.
ACCESSION   NM_004965 NM_001080854
VERSION     NM_004965.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1271)
  AUTHORS   Farley,S.J., Grishok,A. and Zeldich,E.
  TITLE     Shaking up the silence: consequences of HMGN1 antagonizing PRC2 in
            the Down syndrome brain
  JOURNAL   Epigenetics Chromatin 15 (1), 39 (2022)
   PUBMED   36463299
  REMARK    GeneRIF: Shaking up the silence: consequences of HMGN1 antagonizing
            PRC2 in the Down syndrome brain.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1271)
  AUTHORS   Page,E.C., Heatley,S.L., Eadie,L.N., McClure,B.J., de Bock,C.E.,
            Omari,S., Yeung,D.T., Hughes,T.P., Thomas,P.Q. and White,D.L.
  TITLE     HMGN1 plays a significant role in CRLF2 driven Down Syndrome
            leukemia and provides a potential therapeutic target in this
            high-risk cohort
  JOURNAL   Oncogene 41 (6), 797-808 (2022)
   PUBMED   34857887
  REMARK    GeneRIF: HMGN1 plays a significant role in CRLF2 driven Down
            Syndrome leukemia and provides a potential therapeutic target in
            this high-risk cohort.
REFERENCE   3  (bases 1 to 1271)
  AUTHORS   Rodriguez-Ortiz,A., Montoya-Villegas,J.C., Garcia-Vallejo,F. and
            Mina-Paz,Y.
  TITLE     Spatial and Temporal Expression of High-Mobility-Group
            Nucleosome-Binding (HMGN) Genes in Brain Areas Associated with
            Cognition in Individuals with Down Syndrome
  JOURNAL   Genes (Basel) 12 (12), 2000 (2021)
   PUBMED   34946949
  REMARK    GeneRIF: Spatial and Temporal Expression of High-Mobility-Group
            Nucleosome-Binding (HMGN) Genes in Brain Areas Associated with
            Cognition in Individuals with Down Syndrome.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1271)
  AUTHORS   Koh,M., Ahmad,I., Ko,Y., Zhang,Y., Martinez,T.F., Diedrich,J.K.,
            Chu,Q., Moresco,J.J., Erb,M.A., Saghatelian,A., Schultz,P.G. and
            Bollong,M.J.
  TITLE     A short ORF-encoded transcriptional regulator
  JOURNAL   Proc Natl Acad Sci U S A 118 (4) (2021)
   PUBMED   33468658
REFERENCE   5  (bases 1 to 1271)
  AUTHORS   Mowery,C.T., Reyes,J.M., Cabal-Hierro,L., Higby,K.J., Karlin,K.L.,
            Wang,J.H., Kimmerling,R.J., Cejas,P., Lim,K., Li,H., Furusawa,T.,
            Long,H.W., Pellman,D., Chapuy,B., Bustin,M., Manalis,S.R.,
            Westbrook,T.F., Lin,C.Y. and Lane,A.A.
  TITLE     Trisomy of a Down Syndrome Critical Region Globally Amplifies
            Transcription via HMGN1 Overexpression
  JOURNAL   Cell Rep 25 (7), 1898-1911 (2018)
   PUBMED   30428356
  REMARK    GeneRIF: Transcriptional amplification downstream of HMGN1 is
            enriched for stage-specific programs of B cells and B cell acute
            lymphoblastic leukemia, dependent on the developmental cellular
            context.
REFERENCE   6  (bases 1 to 1271)
  AUTHORS   Postnikov,Y.V., Trieschmann,L., Rickers,A. and Bustin,M.
  TITLE     Homodimers of chromosomal proteins HMG-14 and HMG-17 in nucleosome
            cores
  JOURNAL   J Mol Biol 252 (4), 423-432 (1995)
   PUBMED   7563062
REFERENCE   7  (bases 1 to 1271)
  AUTHORS   Pash,J., Popescu,N., Matocha,M., Rapoport,S. and Bustin,M.
  TITLE     Chromosomal protein HMG-14 gene maps to the Down syndrome region of
            human chromosome 21 and is overexpressed in mouse trisomy 16
  JOURNAL   Proc Natl Acad Sci U S A 87 (10), 3836-3840 (1990)
   PUBMED   2140193
REFERENCE   8  (bases 1 to 1271)
  AUTHORS   Landsman,D., McBride,O.W., Soares,N., Crippa,M.P., Srikantha,T. and
            Bustin,M.
  TITLE     Chromosomal protein HMG-14. Identification, characterization, and
            chromosome localization of a functional gene from the large human
            multigene family
  JOURNAL   J Biol Chem 264 (6), 3421-3427 (1989)
   PUBMED   2563381
REFERENCE   9  (bases 1 to 1271)
  AUTHORS   Landsman,D., Srikantha,T., Westermann,R. and Bustin,M.
  TITLE     Chromosomal protein HMG-14. Complete human cDNA sequence and
            evidence for a multigene family
  JOURNAL   J Biol Chem 261 (34), 16082-16086 (1986)
   PUBMED   3782107
  REMARK    Erratum:[J Biol Chem 1988 Nov 5;263(31):16512]
REFERENCE   10 (bases 1 to 1271)
  AUTHORS   Leffak,M. and Trempe,J.P.
  TITLE     Histone H1 and HMG 14/17 are deposited nonrandomly in the nucleus
  JOURNAL   Nucleic Acids Res 13 (13), 4853-4869 (1985)
   PUBMED   4022776
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BE779939.1, BC070154.1 and
            AL582106.2.
            
            On Nov 23, 2018 this sequence version replaced NM_004965.6.
            
            Summary: The protein encoded by this gene binds nucleosomal DNA and
            is associated with transcriptionally active chromatin. Along with a
            similar protein, HMG17, the encoded protein may help maintain an
            open chromatin configuration around transcribable genes. [provided
            by RefSeq, Aug 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.353005.1, BC107741.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380749.10/ ENSP00000370125.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-334               BE779939.1         93-426
            335-954             BC070154.1         286-905
            955-1189            AL582106.2         52-286              c
            1190-1271           BC070154.1         1145-1226
FEATURES             Location/Qualifiers
     source          1..1271
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.2"
     gene            1..1271
                     /gene="HMGN1"
                     /gene_synonym="HMG14"
                     /note="high mobility group nucleosome binding domain 1"
                     /db_xref="GeneID:3150"
                     /db_xref="HGNC:HGNC:4984"
                     /db_xref="MIM:163920"
     exon            1..186
                     /gene="HMGN1"
                     /gene_synonym="HMG14"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..474
                     /gene="HMGN1"
                     /gene_synonym="HMG14"
                     /note="high-mobility group nucleosome binding 1;
                     high-mobility group (nonhistone chromosomal) protein 14;
                     nonhistone chromosomal protein HMG-14; high mobility group
                     nucleosome-binding domain-containing protein 1"
                     /codon_start=1
                     /product="non-histone chromosomal protein HMG-14"
                     /protein_id="NP_004956.5"
                     /db_xref="CCDS:CCDS33559.1"
                     /db_xref="GeneID:3150"
                     /db_xref="HGNC:HGNC:4984"
                     /db_xref="MIM:163920"
                     /translation="MPKRKVSSAEGAAKEEPKRRSARLSAKPPAKVEAKPKKAAAKDK
                     SSDKKVQTKGKRGAKGKQAEVANQETKEDLPAENGETKTEESPASDEAGEKEAKSD"
     exon            187..219
                     /gene="HMGN1"
                     /gene_synonym="HMG14"
                     /inference="alignment:Splign:2.1.0"
     exon            220..249
                     /gene="HMGN1"
                     /gene_synonym="HMG14"
                     /inference="alignment:Splign:2.1.0"
     exon            250..297
                     /gene="HMGN1"
                     /gene_synonym="HMG14"
                     /inference="alignment:Splign:2.1.0"
     exon            298..426
                     /gene="HMGN1"
                     /gene_synonym="HMG14"
                     /inference="alignment:Splign:2.1.0"
     exon            427..1271
                     /gene="HMGN1"
                     /gene_synonym="HMG14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1248..1253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HMGN1"
                     /gene_synonym="HMG14"
                     /note="hexamer: AATAAA"
     polyA_site      1271
                     /gene="HMGN1"
                     /gene_synonym="HMG14"
                     /note="major polyA site"
ORIGIN      
        1 atccggttct cccaccgccc ccgctgtggg tctcagcagc tcgggcggcg ggaggagtgg
       61 cagcggcaag gcagcccagt ttcgcgaagg ctgtcggcgc gccgcggccc gcaggcaccc
      121 ggcacgcgcc ttccccgcag gcacccggca cgcgccttcc ccgccgccac gatgcccaag
      181 aggaaggtca gctccgccga aggcgccgcc aaggaagagc ccaagaggag atcggcgcgg
      241 ttgtcagcta aacctcctgc aaaagtggaa gcgaagccga aaaaggcagc agcgaaggat
      301 aaatcttcag acaaaaaagt gcaaacaaaa gggaaaaggg gagcaaaggg aaaacaggcc
      361 gaagtggcta accaagaaac taaagaagac ttacctgcgg aaaacgggga aacgaagact
      421 gaggagagtc cagcctctga tgaagcagga gagaaagaag ccaagtctga ttaataacca
      481 tataccatgt cttatcagtg gtccctgtct cccttcttgt acaatccaga ggaatatttt
      541 tatcaactat tttgtaaatg caagtttttt agtagctcta gaaacatttt taagaaggag
      601 ggaatcccac ctcatcccat tttttaagtg taaatgcttt tttttaagag gtgaaatcat
      661 ttgctggttg tttatttttt ggtacaacca gaaaatagtg tgggatattg aattatggga
      721 ggctctgact gtctcgggtg tcagcttaac attccacaga tggggggtta gtttttatat
      781 cctataatac aaagcatatt aaatggcaat atggagtcag tcctgcattt aatgtcttga
      841 acattttaaa ttacttctat taccatgttg ttttttagta gaattgtttc ctaaagaaaa
      901 ccactctttg atcatggctc tctctgccag aattgtgtgc actctgtaac atctttgtgg
      961 tagtcctgtt ttcctaataa ctttgttact gtgctgtgaa agattacaga tttgaacatg
     1021 tagtgtacgt gctgttgagt tgtgaactgg tgggccgtat gtaacagctg accaacgtga
     1081 agatactggt acttgatagc ctcttaagga aaatttgctt ccaaatttta agctggaaag
     1141 tcactggaat aactttaaaa aagaattaca atacatggct ttttagaatt tcgttacgta
     1201 tgttaagatt tgtgtacaaa ttgaaatgtc tgtactgatc ctcaaccaat aaaatctcag
     1261 ttatgaaaat a
//
