LOCUS       NM_001098272            5350 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens 3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1),
            transcript variant 1, mRNA.
ACCESSION   NM_001098272
VERSION     NM_001098272.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5350)
  AUTHORS   Zhang,M., Du,G., Xie,L., Xu,Y. and Chen,W.
  TITLE     Circular RNA HMGCS1 sponges MIR4521 to aggravate type 2
            diabetes-induced vascular endothelial dysfunction
  JOURNAL   Elife 13, 97267 (2024)
   PUBMED   39235443
  REMARK    GeneRIF: Circular RNA HMGCS1 sponges MIR4521 to aggravate type 2
            diabetes-induced vascular endothelial dysfunction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5350)
  AUTHORS   Chen,L., Huang,D., Huang,Z., Liu,X., He,M., Luo,M., Tang,Z.,
            Tan,G., Guo,Q. and Xiong,H.
  TITLE     Decreased HMGCS1 inhibits proliferation and inflammatory response
            of keratinocytes and ameliorates imiquimod-induced psoriasis via
            the STAT3/IL-23 axis
  JOURNAL   Int Immunopharmacol 133, 112033 (2024)
   PUBMED   38608446
  REMARK    GeneRIF: Decreased HMGCS1 inhibits proliferation and inflammatory
            response of keratinocytes and ameliorates imiquimod-induced
            psoriasis via the STAT3/IL-23 axis.
REFERENCE   3  (bases 1 to 5350)
  AUTHORS   Li,K., Zhang,J., Lyu,H., Yang,J., Wei,W., Wang,Y., Luo,H.,
            Zhang,Y., Jiang,X., Yi,H., Wang,M., Zhang,C., Wu,K., Xiao,L.,
            Wen,W., Xu,H., Li,G., Wan,Y., Yang,F., Yang,R., Fu,X., Qin,B.,
            Zhou,Z., Zhang,H. and Lee,M.H.
  TITLE     CSN6-SPOP-HMGCS1 Axis Promotes Hepatocellular Carcinoma Progression
            via YAP1 Activation
  JOURNAL   Adv Sci (Weinh) 11 (14), e2306827 (2024)
   PUBMED   38308184
  REMARK    GeneRIF: CSN6-SPOP-HMGCS1 Axis Promotes Hepatocellular Carcinoma
            Progression via YAP1 Activation.
REFERENCE   4  (bases 1 to 5350)
  AUTHORS   Zhou,R., Qiu,L., Zhou,L., Geng,R., Yang,S. and Wu,J.
  TITLE     P4HA1 activates HMGCS1 to promote nasopharyngeal carcinoma
            ferroptosis resistance and progression
  JOURNAL   Cell Signal 105, 110609 (2023)
   PUBMED   36702290
  REMARK    GeneRIF: P4HA1 activates HMGCS1 to promote nasopharyngeal carcinoma
            ferroptosis resistance and progression.
REFERENCE   5  (bases 1 to 5350)
  AUTHORS   Shi,S.J., Han,D.H., Zhang,J.L., Li,Y., Yang,A.G. and Zhang,R.
  TITLE     VIM-AS1 promotes proliferation and drives enzalutamide resistance
            in prostate cancer via IGF2BP2-mediated HMGCS1 mRNA stabilization
  JOURNAL   Int J Oncol 62 (3) (2023)
   PUBMED   36734275
  REMARK    GeneRIF: VIMAS1 promotes proliferation and drives enzalutamide
            resistance in prostate cancer via IGF2BP2mediated HMGCS1 mRNA
            stabilization.
REFERENCE   6  (bases 1 to 5350)
  AUTHORS   Russ,A.P., Ruzicka,V., Maerz,W., Appelhans,H. and Gross,W.
  TITLE     Amplification and direct sequencing of a cDNA encoding human
            cytosolic 3-hydroxy-3-methylglutaryl-coenzyme A synthase
  JOURNAL   Biochim Biophys Acta 1132 (3), 329-331 (1992)
   PUBMED   1358203
REFERENCE   7  (bases 1 to 5350)
  AUTHORS   Ayte,J., Gil-Gomez,G., Haro,D., Marrero,P.F. and Hegardt,F.G.
  TITLE     Rat mitochondrial and cytosolic 3-hydroxy-3-methylglutaryl-CoA
            synthases are encoded by two different genes
  JOURNAL   Proc Natl Acad Sci U S A 87 (10), 3874-3878 (1990)
   PUBMED   1971108
REFERENCE   8  (bases 1 to 5350)
  AUTHORS   Gil,G., Smith,J.R., Goldstein,J.L. and Brown,M.S.
  TITLE     Optional exon in the 5'-untranslated region of
            3-hydroxy-3-methylglutaryl coenzyme A synthase gene: conserved
            sequence and splicing pattern in humans and hamsters
  JOURNAL   Proc Natl Acad Sci U S A 84 (7), 1863-1866 (1987)
   PUBMED   3470763
REFERENCE   9  (bases 1 to 5350)
  AUTHORS   Mehrabian,M., Callaway,K.A., Clarke,C.F., Tanaka,R.D.,
            Greenspan,M., Lusis,A.J., Sparkes,R.S., Mohandas,T., Edmond,J.,
            Fogelman,A.M. et al.
  TITLE     Regulation of rat liver 3-hydroxy-3-methylglutaryl coenzyme A
            synthase and the chromosomal localization of the human gene
  JOURNAL   J Biol Chem 261 (34), 16249-16255 (1986)
   PUBMED   2877984
REFERENCE   10 (bases 1 to 5350)
  AUTHORS   Leonard,S., Arbogast,D., Geyer,D., Jones,C. and Sinensky,M.
  TITLE     Localization of the gene encoding
            3-hydroxy-3-methylglutaryl-coenzyme A synthase to human chromosome
            5
  JOURNAL   Proc Natl Acad Sci U S A 83 (7), 2187-2189 (1986)
   PUBMED   2870496
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK315593.1 and AC114947.2.
            
            On Nov 22, 2018 this sequence version replaced NM_001098272.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.216745.1,
                                           SRR1803615.11048.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325110.11/ ENSP00000322706.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1689              AK315593.1         29-1717
            1690-5350           AC114947.2         79755-83415         c
FEATURES             Location/Qualifiers
     source          1..5350
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p12"
     gene            1..5350
                     /gene="HMGCS1"
                     /gene_synonym="HMGCS"
                     /note="3-hydroxy-3-methylglutaryl-CoA synthase 1"
                     /db_xref="GeneID:3157"
                     /db_xref="HGNC:HGNC:5007"
                     /db_xref="MIM:142940"
     exon            1..57
                     /gene="HMGCS1"
                     /gene_synonym="HMGCS"
                     /inference="alignment:Splign:2.1.0"
     exon            58..116
                     /gene="HMGCS1"
                     /gene_synonym="HMGCS"
                     /inference="alignment:Splign:2.1.0"
     exon            117..574
                     /gene="HMGCS1"
                     /gene_synonym="HMGCS"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1689
                     /gene="HMGCS1"
                     /gene_synonym="HMGCS"
                     /EC_number="2.3.3.10"
                     /note="isoform 1 is encoded by transcript variant 1;
                     3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase;
                     3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
                     (soluble); hydroxymethylglutaryl-CoA synthase,
                     cytoplasmic; 3-hydroxy-3-methylglutaryl-CoA synthase 1
                     (soluble)"
                     /codon_start=1
                     /product="hydroxymethylglutaryl-CoA synthase, cytoplasmic
                     isoform 1"
                     /protein_id="NP_001091742.1"
                     /db_xref="CCDS:CCDS34154.1"
                     /db_xref="GeneID:3157"
                     /db_xref="HGNC:HGNC:5007"
                     /db_xref="MIM:142940"
                     /translation="MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDA
                     GKYTIGLGQAKMGFCTDREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSK
                     SVKTNLMQLFEESGNTDIEGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDI
                     AVYATGNARPTGGVGAVALLIGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDG
                     KLSIQCYLSALDRCYSVYCKKIHAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLA
                     RMLLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTKAS
                     LLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKRIGVFSYGSGLAATLYSLKVTQDA
                     TPGSALDKITASLCDLKSRLDSRTGVAPDVFAENMKLREDTHHLVNYIPQGSIDSLFE
                     GTWYLVRVDEKHRRTYARRPTPNDDTLDEGVGLVHSNIATEHIPSPAKKVPRLPATAA
                     EPEAAVISNGEH"
     exon            575..700
                     /gene="HMGCS1"
                     /gene_synonym="HMGCS"
                     /inference="alignment:Splign:2.1.0"
     exon            701..865
                     /gene="HMGCS1"
                     /gene_synonym="HMGCS"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1031
                     /gene="HMGCS1"
                     /gene_synonym="HMGCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1202
                     /gene="HMGCS1"
                     /gene_synonym="HMGCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1309
                     /gene="HMGCS1"
                     /gene_synonym="HMGCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1435
                     /gene="HMGCS1"
                     /gene_synonym="HMGCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1599
                     /gene="HMGCS1"
                     /gene_synonym="HMGCS"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..5350
                     /gene="HMGCS1"
                     /gene_synonym="HMGCS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3401..3406
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HMGCS1"
                     /gene_synonym="HMGCS"
                     /note="hexamer: AATAAA"
     polyA_site      3425
                     /gene="HMGCS1"
                     /gene_synonym="HMGCS"
                     /note="major polyA site"
     regulatory      5331..5336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HMGCS1"
                     /gene_synonym="HMGCS"
                     /note="hexamer: AATAAA"
     polyA_site      5350
                     /gene="HMGCS1"
                     /gene_synonym="HMGCS"
ORIGIN      
        1 gcggactgtc ctttcgtggc tcactccctt tcctctgctg ccgctcggtc acgcttgtgc
       61 ccgaaggagg aaacagtgac agacctggag actgcagttc tctatccttc acacagctct
      121 ttcaccatgc ctggatcact tcctttgaat gcagaagctt gctggccaaa agatgtggga
      181 attgttgccc ttgagatcta ttttccttct caatatgttg atcaagcaga gttggaaaaa
      241 tatgatggtg tagatgctgg aaagtatacc attggcttgg gccaggccaa gatgggcttc
      301 tgcacagata gagaagatat taactctctt tgcatgactg tggttcagaa tcttatggag
      361 agaaataacc tttcctatga ttgcattggg cggctggaag ttggaacaga gacaatcatc
      421 gacaaatcaa agtctgtgaa gactaatttg atgcagctgt ttgaagagtc tgggaataca
      481 gatatagaag gaatcgacac aactaatgca tgctatggag gcacagctgc tgtcttcaat
      541 gctgttaact ggattgagtc cagctcttgg gatggacggt atgccctggt agttgcagga
      601 gatattgctg tatatgccac aggaaatgct agacctacag gtggagttgg agcagtagct
      661 ctgctaattg ggccaaatgc tcctttaatt tttgaacgag ggcttcgtgg gacacatatg
      721 caacatgcct atgattttta caagcctgat atgctatctg aatatcctat agtagatgga
      781 aaactctcca tacagtgcta cctcagtgca ttagaccgct gctattctgt ctactgcaaa
      841 aagatccatg cccagtggca gaaagaggga aatgataaag attttacctt gaatgatttt
      901 ggcttcatga tctttcactc accatattgt aaactggttc agaaatctct agctcggatg
      961 ttgctgaatg acttccttaa tgaccagaat agagataaaa atagtatcta tagtggcctg
     1021 gaagcctttg gggatgttaa attagaagac acctactttg atagagatgt ggagaaggca
     1081 tttatgaagg ctagctctga actcttcagt cagaaaacaa aggcatcttt acttgtatca
     1141 aatcaaaatg gaaatatgta cacatcttca gtatatggtt cccttgcatc tgttctagca
     1201 cagtactcac ctcagcaatt agcagggaag agaattggag tgttttctta tggttctggt
     1261 ttggctgcca ctctgtactc tcttaaagtc acacaagatg ctacaccggg gtctgctctt
     1321 gataaaataa cagcaagttt atgtgatctt aaatcaaggc ttgattcaag aactggtgtg
     1381 gcaccagatg tcttcgctga aaacatgaag ctcagagagg acacccatca tttggtcaac
     1441 tatattcccc agggttcaat agattcactc tttgaaggaa cgtggtactt agttagggtg
     1501 gatgaaaagc acagaagaac ttacgctcgg cgtcccactc caaatgatga cactttggat
     1561 gaaggagtag gacttgtgca ttcaaacata gcaactgagc atattccaag ccctgccaag
     1621 aaagtaccaa gactccctgc cacagcagca gaacctgaag cagctgtcat tagtaatggg
     1681 gaacattaag atactctgtg aggtgcaaga cttcagggtg gggtgggcat ggggtggggg
     1741 tatgggaaca gttggaggaa tgggatatct ggggataatt ttaaaggatt acatgttatg
     1801 taaattttta tgtgactgac atggagcctg gatgactatc gtgtacttgg gaaagtctct
     1861 ttgctctatt tgctgacatg cttcctgttg tggtctggcc aatgccaaat gtactcgaat
     1921 gatgttaagg gctctgtaaa acttcatacc tctttggcca tttgtatgca tgatgtttgg
     1981 tttttaaaca tggtataatg aattgtgtac ttctgtcaga agaaagcaga ggtactaatc
     2041 tccaattaaa aaatttttta acatgtaaga attttgtact ttgaacaaca agattacaga
     2101 aagtacctgt ggtttttgga aaacatttct agcttgggga atgtgacaac attccccagt
     2161 gtggtaaaat tggggtaaaa tgtggtaaaa tgtgatacgc acaaaccctt tgaaaatagc
     2221 aaaacaaaca tgcccttttt ctaaaattga taaatcctaa agaggaagaa aagagctggg
     2281 acaataaaac actggctctg gaatctggaa tgttaagtcc aggccagcag tgacaaaagt
     2341 tattgtaatg acctctgaac agagaaacac tgccattgaa gaggcttctg gtatagaaaa
     2401 catggtacat tcaggagctg tgaatatagc tctaggtgtg ctcctgaatc agttcatggt
     2461 agattatgct gaacaacagt gagatgttat tggaggtgtg gatgagggag tttgttgttg
     2521 cagtccttct ttgcacctta ttttaaagaa taaatgaaac atttttctgg ttactttttt
     2581 aaaaatttaa aatggaaggg aagaataggg gcagggcatt attaggctat ttctgatgct
     2641 tcagtgttat aaattcaaca tagaggctga caacctaaat tcatggtgta acacagctct
     2701 tttccttttc cttttttttt tttttttggt atctgttcaa tgaaaataag gtatgaccca
     2761 agtttttacc tagtctgact agaagtattc cacttcaagg tctgaagtag gacttttacc
     2821 ttaaaaaaca acaacaaaca aaactatcac acaggataga taagaagatt ggttaaacag
     2881 ttttgtgtag atctttttgg tgctgaacta tgacatgagc cttatagatt gtaaaatagg
     2941 gatagttgga actaatgtac agaactaaat tttttaaact ttatttgctg ttaaattctg
     3001 tgaagtttca gttatctaaa ataaatatac acaaatatga aatataatgt ttcagattgc
     3061 aaggtaatat gtaatagtag tgtttgtaag atactcttgt ctaatattaa ctagtagtat
     3121 tttgatttgt acagtcataa tttgttaaaa tgacttcatt taacattcac tgatgtagat
     3181 taataatgta agttctgatt taaagaatgg tggcaaaatg gtgcatgtaa tacttttgca
     3241 agtgttgggg agatcggtat gttttgaaaa gagtaattta acttttgggt gccaggaaat
     3301 gggttttctc aaagtccatt gccggcaatg ggcaggcctg caaatactgg cacagagcat
     3361 taatcataca ccttattaac ggtgaggtga ataactttga aataaagttt tagagaaatg
     3421 tttcagatac ttgagtattc tttttcactc ttgaactaac aacttcggca agaaatcagc
     3481 taatattcta tttttaaata tgggcattaa tttcatttca gttcgttcac tcattccatt
     3541 catttatcat ttcacaaaca tttgaaatcc taatataagc aaggtgctct gtttaaggca
     3601 gaaatttgaa aatgtacaag atatatggtc ttgtctttaa ggagctgttc atctagaatg
     3661 gaggaattta cactgataat tattcctaca cttgaaacaa agaaattaac tctcaaattg
     3721 cgtggcaagc atatatagac tttgctataa atatttatga aatgagttac tgttttcctt
     3781 aaaaaagcta agactaaggg ctggcaatca aataagagca aatttagtgg tgaacgtaga
     3841 actgcccact accagctaga gtctccaacc taaaagtccc atgttgctag tgatccccag
     3901 gggttttata gaaggaatcc ctgcattggc agtaattttg gattagatga tccctaagag
     3961 caccatcaag tcttaggatt ctatgaatta ggaaataaac caaattatat attttctaat
     4021 actgatcagc tcatatttta tcatcatgtc atgtctggct ttcatactta gtcataattt
     4081 actttctggg tcatttagag gctagcgttc tctaaggtca cttctgcttg cacattgtag
     4141 gatattattt agtatggctt taagaattca atctttcccc ctctccttta tggaatgtgt
     4201 gtttcctcta tttgtacact taaccttttg tcctaagttt ttatttttat ggatactaat
     4261 gagtaacttt gaggttgaca ctagacccaa acagatgcaa acagccactt tctgtcctct
     4321 tgtgacacag ttgaaacact ttatctcttg tctgctgttt ggagtgtcct gaaagaaaca
     4381 ctgaagtggc agtcaacaga gcaagggtaa caggatcttt aaataattta aagttgtctg
     4441 atcttgacat aaaagtgaac cctttcttta aaatttctag caactgctct taagtcatag
     4501 gttcctcatt ttttctttgc tggtagtggg agaaaatagt tgatctgtga tttttgtttt
     4561 catctcccca aactatgtta taaaggcagt aatttgatgc tgaagattat gattagaaat
     4621 cctcagatgg gttatatatt ggggctttat cttttaatat taaaaagaat gtctttcctg
     4681 gactacttta ttcagtagta agcactattc attctatgta tattccttat tcagccttgc
     4741 agactcctgt gggatctgat ctcttcctgc ttcaactcag taccatactc accaaggctt
     4801 agtatgtctt cacccactct cccttctctt gcattcctca aacatgctga gtttattcca
     4861 gccttaagcc tttgatctac gcatcagaaa tgttgggccc cacttcagat cttctctgcc
     4921 ctgccttcta ctccagtcac tgctgtggta actaattcca tgaagtcttt gaccaggttc
     4981 tcagagaata tgatagtacc tctctttgga ttctagctgt atacctttca cttcagcctc
     5041 cctgacgtgg aatgtctgca gaacttgttt ggtactccca attgcacagc ccaaaggtgc
     5101 aggggagtta ggtgcccatg gggccatcct tgacctaggt ggaaagttgc tagtggataa
     5161 ctgattactc ttttcatcac ctgggcagac agttctgaaa tgcatttcgt aagtctcctc
     5221 aaaagaggag gagacttctg tggcgggttt ggcaataacc atccttatat tggctttcct
     5281 cttttgtttc actcctgtgc atctctcttg catcctggga tcgcttctca aataaatgac
     5341 tttcattcaa
//
