LOCUS       NM_001379301             713 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens high mobility group box 4 (HMGB4), transcript variant
            3, mRNA.
ACCESSION   NM_001379301
VERSION     NM_001379301.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 713)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 713)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   3  (bases 1 to 713)
  AUTHORS   Malki,K., Uher,R., Paya-Cano,J., Binder,E., Rietschel,M., Zobel,A.,
            Mors,O., Hauser,J., Henigsberg,N., Jerman,B., Souery,D.,
            Placentino,A., Ng,M.Y., Cohen-Woods,S., Sluyter,F., Farmer,A.,
            Aitchison,K.J., Craig,I.W., Lewis,C.M., McGuffin,P. and
            Schalkwyk,L.C.
  TITLE     Convergent animal and human evidence suggests a role of PPM1A gene
            in response to antidepressants
  JOURNAL   Biol Psychiatry 69 (4), 360-365 (2011)
   PUBMED   20970119
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL121980.14.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1 and 3 encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript is intronless :: DQ207367.1, BC021180.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000681531.1/ ENSP00000505691.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-713               AL121980.14        50092-50804
FEATURES             Location/Qualifiers
     source          1..713
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.1"
     gene            1..713
                     /gene="HMGB4"
                     /gene_synonym="dJ1007G16.5"
                     /note="high mobility group box 4"
                     /db_xref="GeneID:127540"
                     /db_xref="HGNC:HGNC:24954"
                     /db_xref="MIM:617285"
     exon            1..713
                     /gene="HMGB4"
                     /gene_synonym="dJ1007G16.5"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..674
                     /gene="HMGB4"
                     /gene_synonym="dJ1007G16.5"
                     /note="isoform 1 is encoded by transcript variant 3; high
                     mobility group protein B4; HMG2 like"
                     /codon_start=1
                     /product="high mobility group protein B4 isoform 1"
                     /protein_id="NP_001366230.1"
                     /db_xref="CCDS:CCDS30668.1"
                     /db_xref="GeneID:127540"
                     /db_xref="HGNC:HGNC:24954"
                     /db_xref="MIM:617285"
                     /translation="MGKEIQLKPKANVSSYVHFLLNYRNKFKEQQPNTYVGFKEFSRK
                     CSEKWRSISKHEKAKYEALAKLDKARYQEEMMNYVGKRKKRRKRDPQEPRRPPSSFLL
                     FCQDHYAQLKRENPNWSVVQVAKATGKMWSTATDLEKHPYEQRVALLRAKYFEELELY
                     RKQCNARKKYRMSARNRCRGKRVRQS"
     regulatory      692..697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HMGB4"
                     /gene_synonym="dJ1007G16.5"
                     /note="hexamer: AACAAA"
     polyA_site      713
                     /gene="HMGB4"
                     /gene_synonym="dJ1007G16.5"
                     /note="major polyA site"
ORIGIN      
        1 agacagaaaa attcgctgca agtacagcac tttctagatt gctcctggag tgtgggaaca
       61 acagtctctc ctgtccacgt tactgaatcc agaaaaaagg tgaacttacg aacatgggaa
      121 aagaaatcca gctaaagcct aaggcaaatg tctcttctta cgttcacttt ttgctgaatt
      181 acagaaacaa attcaaggag cagcagccaa atacctatgt tggctttaaa gagttctcta
      241 gaaagtgttc ggaaaaatgg agatccatct caaagcatga aaaggccaaa tatgaagccc
      301 tggccaaact cgacaaagcc cgataccagg aagaaatgat gaattatgtt ggcaagagga
      361 agaaacggag aaagcgggat ccccaggaac ccagacggcc tccatcatcc ttcctactct
      421 tctgccaaga ccactatgct cagctgaaga gggagaaccc gaactggtcg gtggtgcagg
      481 tggccaaggc cacagggaag atgtggtcaa cagcgacaga cctggagaag cacccttatg
      541 agcaaagagt ggctctcctg agagctaagt acttcgagga acttgaactc taccgtaaac
      601 aatgtaatgc caggaagaag taccgaatgt cagctagaaa ccggtgcaga gggaaaagag
      661 tcaggcagag ctgatggatc cagtttgaaa aaacaaaatg ccattcaacc gta
//
