LOCUS       NM_005342               3507 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens high mobility group box 3 (HMGB3), transcript variant
            2, mRNA.
ACCESSION   NM_005342
VERSION     NM_005342.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3507)
  AUTHORS   Cui,Y., Wen,H., Tang,J., Chen,J., Zhou,J., Hou,M., Rong,X., Lan,Y.
            and Wu,Q.
  TITLE     ELAVL1 regulates glycolysis in nasopharyngeal carcinoma cells
            through the HMGB3/beta-catenin axis
  JOURNAL   Mol Med 30 (1), 172 (2024)
   PUBMED   39390359
  REMARK    GeneRIF: ELAVL1 regulates glycolysis in nasopharyngeal carcinoma
            cells through the HMGB3/beta-catenin axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3507)
  AUTHORS   Zhao,T., He,X., Liang,X., Kellum,A.H. Jr., Tang,F., Yin,J., Guo,S.,
            Wang,Y., Gao,Z. and Wang,Y.
  TITLE     HMGB3 and SUB1 Bind to and Facilitate the Repair of N2-Alkylguanine
            Lesions in DNA
  JOURNAL   J Am Chem Soc 146 (32), 22553-22562 (2024)
   PUBMED   39101269
  REMARK    GeneRIF: HMGB3 and SUB1 Bind to and Facilitate the Repair of
            N[2]-Alkylguanine Lesions in DNA.
REFERENCE   3  (bases 1 to 3507)
  AUTHORS   Chikhirzhina,E., Tsimokha,A., Tomilin,A.N. and Polyanichko,A.
  TITLE     Structure and Functions of HMGB3 Protein
  JOURNAL   Int J Mol Sci 25 (14), 7656 (2024)
   PUBMED   39062899
  REMARK    GeneRIF: Structure and Functions of HMGB3 Protein.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3507)
  AUTHORS   Hu,P., Yan,T., Lv,S., Ye,M., Wu,M., Fang,H. and Xiao,B.
  TITLE     Exosomal HMGB3 released by glioma cells confers the activation of
            NLRP3 inflammasome and pyroptosis in tumor-associated macrophages
  JOURNAL   Tissue Cell 88, 102406 (2024)
   PUBMED   38761792
  REMARK    GeneRIF: Exosomal HMGB3 released by glioma cells confers the
            activation of NLRP3 inflammasome and pyroptosis in tumor-associated
            macrophages.
REFERENCE   5  (bases 1 to 3507)
  AUTHORS   Ma,H., Qi,G., Han,F., Gai,P., Peng,J. and Kong,B.
  TITLE     HMGB3 promotes the malignant phenotypes and stemness of epithelial
            ovarian cancer through the MAPK/ERK signaling pathway
  JOURNAL   Cell Commun Signal 21 (1), 144 (2023)
   PUBMED   37328851
  REMARK    GeneRIF: HMGB3 promotes the malignant phenotypes and stemness of
            epithelial ovarian cancer through the MAPK/ERK signaling pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3507)
  AUTHORS   Nemeth,M.J., Kirby,M.R. and Bodine,D.M.
  TITLE     Hmgb3 regulates the balance between hematopoietic stem cell
            self-renewal and differentiation
  JOURNAL   Proc Natl Acad Sci U S A 103 (37), 13783-13788 (2006)
   PUBMED   16945912
REFERENCE   7  (bases 1 to 3507)
  AUTHORS   Nemeth,M.J., Cline,A.P., Anderson,S.M., Garrett-Beal,L.J. and
            Bodine,D.M.
  TITLE     Hmgb3 deficiency deregulates proliferation and differentiation of
            common lymphoid and myeloid progenitors
  JOURNAL   Blood 105 (2), 627-634 (2005)
   PUBMED   15358624
REFERENCE   8  (bases 1 to 3507)
  AUTHORS   Nemeth,M.J., Curtis,D.J., Kirby,M.R., Garrett-Beal,L.J.,
            Seidel,N.E., Cline,A.P. and Bodine,D.M.
  TITLE     Hmgb3: an HMG-box family member expressed in primitive
            hematopoietic cells that inhibits myeloid and B-cell
            differentiation
  JOURNAL   Blood 102 (4), 1298-1306 (2003)
   PUBMED   12714519
REFERENCE   9  (bases 1 to 3507)
  AUTHORS   Vaccari,T., Beltrame,M., Ferrari,S. and Bianchi,M.E.
  TITLE     Hmg4, a new member of the Hmg1/2 gene family
  JOURNAL   Genomics 49 (2), 247-252 (1998)
   PUBMED   9598312
REFERENCE   10 (bases 1 to 3507)
  AUTHORS   Wilke,K., Wiemann,S., Gaul,R., Gong,W. and Poustka,A.
  TITLE     Isolation of human and mouse HMG2a cDNAs: evidence for an
            HMG2a-specific 3' untranslated region
  JOURNAL   Gene 198 (1-2), 269-274 (1997)
   PUBMED   9370291
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Y10043.1, BC037210.1 and
            AF003626.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005342.3.
            
            Summary: This gene encodes a member of a family of proteins
            containing one or more high mobility group DNA-binding motifs. The
            encoded protein plays an important role in maintaining stem cell
            populations, and may be aberrantly expressed in tumor cells. A
            mutation in this gene was associated with microphthalmia, syndromic
            13. There are numerous pseudogenes of this gene on multiple
            chromosomes. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to vaiant 1. Variants 1, 2, and 3 encode the same isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA236625.1, SRR1803617.204072.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325307.12/ ENSP00000359393.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                Y10043.1           40-83
            45-668              BC037210.1         10-633
            669-1300            Y10043.1           708-1339
            1301-3507           AF003626.2         69789-71995
FEATURES             Location/Qualifiers
     source          1..3507
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..3507
                     /gene="HMGB3"
                     /gene_synonym="HMG-2a; HMG-4; HMG2A; HMG4"
                     /note="high mobility group box 3"
                     /db_xref="GeneID:3149"
                     /db_xref="HGNC:HGNC:5004"
                     /db_xref="MIM:300193"
     exon            1..42
                     /gene="HMGB3"
                     /gene_synonym="HMG-2a; HMG-4; HMG2A; HMG4"
                     /inference="alignment:Splign:2.1.0"
     exon            43..197
                     /gene="HMGB3"
                     /gene_synonym="HMG-2a; HMG-4; HMG2A; HMG4"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..650
                     /gene="HMGB3"
                     /gene_synonym="HMG-2a; HMG-4; HMG2A; HMG4"
                     /note="isoform a is encoded by transcript variant 2;
                     high-mobility group (nonhistone chromosomal) protein 4;
                     high mobility group protein B3; high mobility group
                     protein 2a"
                     /codon_start=1
                     /product="high mobility group protein B3 isoform a"
                     /protein_id="NP_005333.2"
                     /db_xref="CCDS:CCDS35428.1"
                     /db_xref="GeneID:3149"
                     /db_xref="HGNC:HGNC:5004"
                     /db_xref="MIM:300193"
                     /translation="MAKGDPKKPKGKMSAYAFFVQTCREEHKKKNPEVPVNFAEFSKK
                     CSERWKTMSGKEKSKFDEMAKADKVRYDREMKDYGPAKGGKKKKDPNAPKRPPSGFFL
                     FCSEFRPKIKSTNPGISIGDVAKKLGEMWNNLNDSEKQPYITKAAKLKEKYEKDVADY
                     KSKGKFDGAKGPAKVARKKVEEEDEEEEEEEEEEEEEEDE"
     exon            198..337
                     /gene="HMGB3"
                     /gene_synonym="HMG-2a; HMG-4; HMG2A; HMG4"
                     /inference="alignment:Splign:2.1.0"
     exon            338..512
                     /gene="HMGB3"
                     /gene_synonym="HMG-2a; HMG-4; HMG2A; HMG4"
                     /inference="alignment:Splign:2.1.0"
     exon            513..3507
                     /gene="HMGB3"
                     /gene_synonym="HMG-2a; HMG-4; HMG2A; HMG4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1481..1486
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HMGB3"
                     /gene_synonym="HMG-2a; HMG-4; HMG2A; HMG4"
                     /note="hexamer: AATAAA"
     polyA_site      1505
                     /gene="HMGB3"
                     /gene_synonym="HMG-2a; HMG-4; HMG2A; HMG4"
                     /note="major polyA site"
     regulatory      3477..3482
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HMGB3"
                     /gene_synonym="HMG-2a; HMG-4; HMG2A; HMG4"
                     /note="hexamer: AATAAA"
     polyA_site      3507
                     /gene="HMGB3"
                     /gene_synonym="HMG-2a; HMG-4; HMG2A; HMG4"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgtcgtg ccctgcgctg cccagactag cgaacaatac agtcaggatg gctaaaggtg
       61 accccaagaa accaaagggc aagatgtccg cttatgcctt ctttgtgcag acatgcagag
      121 aagaacataa gaagaaaaac ccagaggtcc ctgtcaattt tgcggaattt tccaagaagt
      181 gctctgagag gtggaagacg atgtccggga aagagaaatc taaatttgat gaaatggcaa
      241 aggcagataa agtgcgctat gatcgggaaa tgaaggatta tggaccagct aagggaggca
      301 agaagaagaa ggatcctaat gctcccaaaa ggccaccgtc tggattcttc ctgttctgtt
      361 cagaattccg ccccaagatc aaatccacaa accccggcat ctctattgga gacgtggcaa
      421 aaaagctggg tgagatgtgg aataatttaa atgacagtga aaagcagcct tacatcacta
      481 aggcggcaaa gctgaaggag aagtatgaga aggatgttgc tgactataag tcgaaaggaa
      541 agtttgatgg tgcaaagggt cctgctaaag ttgcccggaa aaaggtggaa gaggaagatg
      601 aagaagagga ggaggaagaa gaggaggagg aggaggagga ggatgaataa agaaactgtt
      661 tatctgtctc cttgtgaata cttagagtag gggagcgccg taattgacac atctcttatt
      721 tgagaagtgt ctgttgccct cattaggttt aattacaaaa tttgatcacg atcatattgt
      781 agtctctcaa agtgctctag aaattgtcag tggtttacat gaagtggcca tgggtgtctg
      841 gagcaccctg aaactgtatc aaagttgtac atatttccaa acatttttaa aatgaaaagg
      901 cactctcgtg ttctcctcac tctgtgcact ttgctgttgg tgtgacaagg catttaaaga
      961 tgtttctggc attttctttt tatttgtaag gtggtggtaa ctatggttat tggctagaaa
     1021 tcctgagttt tcaactgtat atatctatag tttgtaaaaa gaacaaaaca accgagacaa
     1081 acccttgatg ctccttgctc ggcgttgagg ctgtggggaa gatgcctttt gggagaggct
     1141 gtagctcagg gcgtgcactg tgaggctgga cctgttgact ctgcaggggg catccattta
     1201 gcttcaggtt gtcttgtttc tgtatatagt gacatagcat tctgctgcca tcttagctgt
     1261 ggacaaaggg gggtcagctg gcatgagaat attttttttt tttaagtgcg gtagttttta
     1321 aactgtttgt ttttaaacaa actatagaac tcttcattgt cagcaaagca aagagtcact
     1381 gcatcaatga aagttcaaga acctcctgta cttaaacacg attcgcaacg ttctgttatt
     1441 ttttttgtat gtttagaatg ctgaaatgtt tttgaagtta aataaacagt attacatttt
     1501 taaaactctt ctctattata acagtcaatt tctgactcac agcagtgaac aaacccccac
     1561 tccattgtat ttggagactg gcctccctat aaatgtggta gcttctttta ttactcagtg
     1621 gccagctcac ttagggctga gatgaaggag agggctactt gaagctactg tgtgattttg
     1681 tttgtgtctg agtggcattc agatgaagtc tggaggagtt aggagaacga cataggcaag
     1741 gttcagcagc cttccaaggt ataggaaggt gggtgattag gactgaggct atctaggttt
     1801 aacttttgtc ccacctccac cccctatttt gtggggccaa atgcattgct aaacagcaat
     1861 ttcagagtgt atggtgtgtc aaaaattaag gccttattgt ttttctcttt cacccctacc
     1921 ccccgtgctc ctggcacata tcacattatt tgtggtgccc aacatttggg gtcttgagcc
     1981 tgctgctggt ctcctggatg ccagtgaggg tatgtgggat ggggtggtgg ggtaggggac
     2041 ggtatccttt ttttgctcct acttggaaac accaaacacc ccaaggaaga tgataggctc
     2101 catcttgggc cacctgagct atagggcagg ctaatggaat caaccatttc tgagcactaa
     2161 atgtatcatg aaaagttgaa tggcctgctc ataagtttag ctcattcact ggaaatgtag
     2221 attgatgttc aatgttaaac tggaaggagc ttggtttgtg tgtcagtggt tatattagtg
     2281 ggtagtgtaa cattttatcc aggttggggt gaggggagat ggccacagta gcaagtggtg
     2341 acactaaata ccattttgaa ggctgatgtg tatatacatc attactgtcc gtagcaatga
     2401 aggatacagt actgtgttgt gggtgagtgt tgctattgcc cagcattaat atttgggtgt
     2461 gtatgtttga ggctatgaaa cacgcaggag tgtttttgtg ctattaattt taagagaaag
     2521 cagctttttc ttaaaattca ctgttgagaa acttgcatgt ctggaggcgg tgtcctctcc
     2581 gccctgtcgg gtcctggatg agtacgagtt atggtcacgg tcacagcctg atctcttatg
     2641 tgttcatagc cattcgctct cccatcagaa ctgtttgtcc tgaatgtgtt cctctagttc
     2701 tagaaaatga ccactaattt aaaaaactcg gttgtgaggt ttgcccagag gcacttgttc
     2761 cagaatttcc cctcctgctt cagccatgtc cttgtcactt ggcattctaa gctaaagctt
     2821 tagcttccca attcgtgatg tgctaggcca agattcggga gctgttgcca gcctcgtcaa
     2881 atatggaaga gaaacaacct gcggtcaaaa gggagtgatt tgttaagtgg tgcgcgtcta
     2941 tctcataact agatgtacca accagggaag ggccaaggat ggaaaggggt aacttttgtg
     3001 cttccaaagt agctaagcag aagtggggga gcagtttagc cagatgatct ttgattaggc
     3061 aaacattgag ttttaaagag gctgtcaagt tgaggccact tggtccatta gctggggcag
     3121 caagatcact actcaacgtt ttcacactgt ggcaagattg ctcttctagt ggaataatgc
     3181 cctagtttct ctgagatgat gtaagtggca tgatgttacc taaggcttag gcttagcttg
     3241 atttctgggc ccactgtctg tgttcttaag atgccaacct gttgcttttt tttttttttt
     3301 cccccattta aaaggatagt acctactccc tctaaccacc tcaccccatt cttgaatgac
     3361 attttatcct tcggaaagaa caaggctgtg atgtagtgac tattgtctgt gtctcctgtg
     3421 tgtgtctgtt cttgtcacaa atgtatttgg ggacgttgga tgcattcatt ttctgtaata
     3481 aagtttctta atcactcttc ccaaaaa
//
