LOCUS       NM_002129               1441 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens high mobility group box 2 (HMGB2), transcript variant
            1, mRNA.
ACCESSION   NM_002129
VERSION     NM_002129.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1441)
  AUTHORS   Tian,H., Zhai,Y., Sun,S., Zhang,W. and Zhao,Z.
  TITLE     The transcription factor HMGB2 indirectly regulates APRIL
            expression and Gd-IgA1 production in patients with IgA nephropathy
  JOURNAL   Ren Fail 46 (1), 2338931 (2024)
   PUBMED   38622929
  REMARK    GeneRIF: The transcription factor HMGB2 indirectly regulates APRIL
            expression and Gd-IgA1 production in patients with IgA nephropathy.
REFERENCE   2  (bases 1 to 1441)
  AUTHORS   Fan,J., Gillespie,K.P., Mesaros,C. and Blair,I.A.
  TITLE     HMGB2-induced calreticulin translocation required for immunogenic
            cell death and ferroptosis of cancer cells are controlled by the
            nuclear exporter XPO1
  JOURNAL   Commun Biol 7 (1), 1234 (2024)
   PUBMED   39354146
  REMARK    GeneRIF: HMGB2-induced calreticulin translocation required for
            immunogenic cell death and ferroptosis of cancer cells are
            controlled by the nuclear exporter XPO1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1441)
  AUTHORS   Salamini-Montemurri,M., Vizoso-Vazquez,A., Barreiro-Alonso,A.,
            Lorenzo-Catoira,L., Rodriguez-Belmonte,E., Cerdan,M.E. and
            Lamas-Maceiras,M.
  TITLE     The Effect of HMGB1 and HMGB2 on Transcriptional Regulation Differs
            in Neuroendocrine and Adenocarcinoma Models of Prostate Cancer
  JOURNAL   Int J Mol Sci 25 (6), 3106 (2024)
   PUBMED   38542079
  REMARK    GeneRIF: The Effect of HMGB1 and HMGB2 on Transcriptional
            Regulation Differs in Neuroendocrine and Adenocarcinoma Models of
            Prostate Cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1441)
  AUTHORS   Xing,X. and Wang,H.
  TITLE     Correlation of serum HMGB1 and HMGB2 levels with clinical symptoms
            in allergic rhinitis children
  JOURNAL   Medicine (Baltimore) 102 (37), e34921 (2023)
   PUBMED   37713866
  REMARK    GeneRIF: Correlation of serum HMGB1 and HMGB2 levels with clinical
            symptoms in allergic rhinitis children.
REFERENCE   5  (bases 1 to 1441)
  AUTHORS   Starkova,T., Polyanichko,A., Tomilin,A.N. and Chikhirzhina,E.
  TITLE     Structure and Functions of HMGB2 Protein
  JOURNAL   Int J Mol Sci 24 (9), 8334 (2023)
   PUBMED   37176041
  REMARK    GeneRIF: Structure and Functions of HMGB2 Protein.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1441)
  AUTHORS   Alexandre,S., Li,W.W. and Lee,A.S.
  TITLE     A human HMG2 cDNA with a novel 3'-untranslated region
  JOURNAL   Nucleic Acids Res 20 (23), 6413 (1992)
   PUBMED   1475204
REFERENCE   7  (bases 1 to 1441)
  AUTHORS   Shirakawa,H. and Yoshida,M.
  TITLE     Structure of a gene coding for human HMG2 protein
  JOURNAL   J Biol Chem 267 (10), 6641-6645 (1992)
   PUBMED   1551873
REFERENCE   8  (bases 1 to 1441)
  AUTHORS   Majumdar,A., Brown,D., Kerby,S., Rudzinski,I., Polte,T.,
            Randhawa,Z. and Seidman,M.M.
  TITLE     Sequence of human HMG2 cDNA
  JOURNAL   Nucleic Acids Res 19 (23), 6643 (1991)
   PUBMED   1754403
REFERENCE   9  (bases 1 to 1441)
  AUTHORS   Bernues,J., Espel,E. and Querol,E.
  TITLE     Identification of the core-histone-binding domains of HMG1 and HMG2
  JOURNAL   Biochim Biophys Acta 866 (4), 242-251 (1986)
   PUBMED   3697355
REFERENCE   10 (bases 1 to 1441)
  AUTHORS   Chiou,W.L. and Niazi,S.
  TITLE     Pharmaceutical applications of solid dispersion systems:
            dissolution of griseofulvin-succinic acid eutectic mixture
  JOURNAL   J Pharm Sci 65 (8), 1212-1214 (1976)
   PUBMED   978439
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC097534.3, BM727941.1 and
            AA576809.1.
            
            On May 17, 2019 this sequence version replaced NM_002129.3.
            
            Summary: This gene encodes a member of the non-histone chromosomal
            high mobility group protein family. The proteins of this family are
            chromatin-associated and ubiquitously distributed in the nucleus of
            higher eukaryotic cells. In vitro studies have demonstrated that
            this protein is able to efficiently bend DNA and form DNA circles.
            These studies suggest a role in facilitating cooperative
            interactions between cis-acting proteins by promoting DNA
            flexibility. This protein was also reported to be involved in the
            final ligation step in DNA end-joining processes of DNA
            double-strand breaks repair and V(D)J recombination. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.83467.1,
                                           SRR5189658.133062.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149004, SAMEA2150385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296503.10/ ENSP00000296503.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AC097534.3         80249-80335         c
            88-257              AC097534.3         79477-79646         c
            258-403             AC097534.3         79046-79191         c
            404-578             AC097534.3         78798-78972         c
            579-1109            AC097534.3         77685-78215         c
            1110-1182           BM727941.1         486-558
            1183-1441           AA576809.1         190-448
FEATURES             Location/Qualifiers
     source          1..1441
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q34.1"
     gene            1..1441
                     /gene="HMGB2"
                     /gene_synonym="HMG2"
                     /note="high mobility group box 2"
                     /db_xref="GeneID:3148"
                     /db_xref="HGNC:HGNC:5000"
                     /db_xref="MIM:163906"
     exon            1..87
                     /gene="HMGB2"
                     /gene_synonym="HMG2"
                     /inference="alignment:Splign:2.1.0"
     exon            88..257
                     /gene="HMGB2"
                     /gene_synonym="HMG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..737
                     /gene="HMGB2"
                     /gene_synonym="HMG2"
                     /note="high-mobility group (nonhistone chromosomal)
                     protein 2; HMG-2; high mobility group protein 2"
                     /codon_start=1
                     /product="high mobility group protein B2"
                     /protein_id="NP_002120.1"
                     /db_xref="CCDS:CCDS3816.1"
                     /db_xref="GeneID:3148"
                     /db_xref="HGNC:HGNC:5000"
                     /db_xref="MIM:163906"
                     /translation="MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKK
                     CSERWKTMSAKEKSKFEDMAKSDKARYDREMKNYVPPKGDKKGKKKDPNAPKRPPSAF
                     FLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIA
                     AYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEDEDEEEEDEDEE"
     exon            258..403
                     /gene="HMGB2"
                     /gene_synonym="HMG2"
                     /inference="alignment:Splign:2.1.0"
     exon            404..578
                     /gene="HMGB2"
                     /gene_synonym="HMG2"
                     /inference="alignment:Splign:2.1.0"
     exon            579..1441
                     /gene="HMGB2"
                     /gene_synonym="HMG2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1098..1103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HMGB2"
                     /gene_synonym="HMG2"
                     /note="hexamer: AATAAA"
     polyA_site      1116
                     /gene="HMGB2"
                     /gene_synonym="HMG2"
                     /note="major polyA site"
     polyA_site      1181
                     /gene="HMGB2"
                     /gene_synonym="HMG2"
     regulatory      1256..1261
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HMGB2"
                     /gene_synonym="HMG2"
                     /note="hexamer: ATTAAA"
     polyA_site      1267
                     /gene="HMGB2"
                     /gene_synonym="HMG2"
ORIGIN      
        1 aaaccagttc acgccggagc cccgtgaggg aagcgtctcc gttgggtccg gccgctctgc
       61 gggactctga ggaaaagctc gcaccaggtg gacgcggatc tgtcaacatg ggtaaaggag
      121 accccaacaa gccgcggggc aaaatgtcct cgtacgcctt cttcgtgcag acctgccggg
      181 aagagcacaa gaagaaacac ccggactctt ccgtcaattt cgcggaattc tccaagaagt
      241 gttcggagag atggaagacc atgtctgcaa aggagaagtc gaagtttgaa gatatggcaa
      301 aaagtgacaa agctcgctat gacagggaga tgaaaaatta cgttcctccc aaaggtgata
      361 agaaggggaa gaaaaaggac cccaatgctc ctaaaaggcc accatctgcc ttcttcctgt
      421 tttgctctga acatcgccca aagatcaaaa gtgaacaccc tggcctatcc attggggata
      481 ctgcaaagaa attgggtgaa atgtggtctg agcagtcagc caaagataaa caaccatatg
      541 aacagaaagc agctaagcta aaggagaaat atgaaaagga tattgctgca tatcgtgcca
      601 agggcaaaag tgaagcagga aagaagggcc ctggcaggcc aacaggctca aagaagaaga
      661 acgaaccaga agatgaggag gaggaggagg aagaagaaga tgaagatgag gaggaagagg
      721 atgaagatga agaataaatg gctatccttt aatgatgcgt gtggaatgtg tgtgtgtgct
      781 caggcaatta ttttgctaag aatgtgaatt caagtgcagc tcaatactag cttcagtata
      841 aaaactgtac agatttttgt atagctgata agattctctg tagagaaaat acttttaaaa
      901 aatgcaggtt gtagcttttt gatgggctac tcatacagtt agattttaca gcttctgatg
      961 ttgaatgttc ctaaatattt aatggttttt ttaatttctt gtgtatggta gcacagcaaa
     1021 cttgtaggaa ttagtatcaa tagtaaattt tgggtttttt aggatgttgc atttcgtttt
     1081 tttaaaaaaa attttgtaat aaaattatgt atattatttc tattgtcttt gtcttaatat
     1141 gctaagttaa ttttcacttt aaaaaagcca tttgaagacc agagctatgt tgattttttt
     1201 cggtatttct gcctagtagt tcttagacac agttgaccta gtaaaatgtt tgagaattaa
     1261 aaccaaacat gctcatattt gcaaaatgtt ctttaaaagt tacatgttga actcagtgaa
     1321 ctttataaga atttatgcag ttttacagaa cgttaagttt tgtacttgac gtttctgttt
     1381 attagctaaa ttgttcctca ggtgtgtgta tatatatata catatatata tatatatata
     1441 t
//
