LOCUS       NM_145899               1920 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens high mobility group AT-hook 1 (HMGA1), transcript
            variant 1, mRNA.
ACCESSION   NM_145899 NM_145900
VERSION     NM_145899.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1920)
  AUTHORS   Olan,I., Ando-Kuri,M., Parry,A.J., Handa,T., Schoenfelder,S.,
            Fraser,P., Ohkawa,Y., Kimura,H., Narita,M. and Narita,M.
  TITLE     HMGA1 orchestrates chromatin compartmentalization and sequesters
            genes into 3D networks coordinating senescence heterogeneity
  JOURNAL   Nat Commun 15 (1), 6891 (2024)
   PUBMED   39134516
  REMARK    GeneRIF: HMGA1 orchestrates chromatin compartmentalization and
            sequesters genes into 3D networks coordinating senescence
            heterogeneity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1920)
  AUTHORS   Li,K.J., Hong,Y., Yu,Y.Z., Xie,Z., Lv,D.J., Wang,C., Xie,T.,
            Chen,H., Chen,Z.S., Zeng,J. and Zhao,S.C.
  TITLE     NAT10 Promotes Prostate Cancer Growth and Metastasis by Acetylating
            mRNAs of HMGA1 and KRT8
  JOURNAL   Adv Sci (Weinh) 11 (32), e2310131 (2024)
   PUBMED   38922788
  REMARK    GeneRIF: NAT10 Promotes Prostate Cancer Growth and Metastasis by
            Acetylating mRNAs of HMGA1 and KRT8.
REFERENCE   3  (bases 1 to 1920)
  AUTHORS   Moura,D.S., Mondaza-Hernandez,J.L., Sanchez-Bustos,P.,
            Pena-Chilet,M., Cordero-Varela,J.A., Lopez-Alvarez,M.,
            Carrillo-Garcia,J., Martin-Ruiz,M., Romero-Gonzalez,P.,
            Renshaw-Calderon,M., Ramos,R., Marcilla,D., Alvarez-Alegret,R.,
            Agra-Pujol,C., Izquierdo,F., Ortega-Medina,L., Martin-Davila,F.,
            Hernandez-Leon,C.N., Romagosa,C., Salgado,M.A.V., Lavernia,J.,
            Bague,S., Mayodormo-Aranda,E., Alvarez,R., Valverde,C.,
            Martinez-Trufero,J., Castilla-Ramirez,C., Gutierrez,A., Dopazo,J.,
            Hindi,N., Garcia-Foncillas,J. and Martin-Broto,J.
  TITLE     HMGA1 regulates trabectedin sensitivity in advanced soft-tissue
            sarcoma (STS): A Spanish Group for Research on Sarcomas (GEIS)
            study
  JOURNAL   Cell Mol Life Sci 81 (1), 219 (2024)
   PUBMED   38758230
  REMARK    GeneRIF: HMGA1 regulates trabectedin sensitivity in advanced
            soft-tissue sarcoma (STS): A Spanish Group for Research on Sarcomas
            (GEIS) study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1920)
  AUTHORS   Wang,L., Zhang,J., Xia,M., Liu,C., Zu,X. and Zhong,J.
  TITLE     High Mobility Group A1 (HMGA1): Structure, Biological Function, and
            Therapeutic Potential
  JOURNAL   Int J Biol Sci 18 (11), 4414-4431 (2022)
   PUBMED   35864955
  REMARK    GeneRIF: High Mobility Group A1 (HMGA1): Structure, Biological
            Function, and Therapeutic Potential.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1920)
  AUTHORS   Sumter,T.F., Xian,L., Huso,T., Koo,M., Chang,Y.T., Almasri,T.N.,
            Chia,L., Inglis,C., Reid,D. and Resar,L.M.
  TITLE     The High Mobility Group A1 (HMGA1) Transcriptome in Cancer and
            Development
  JOURNAL   Curr Mol Med 16 (4), 353-393 (2016)
   PUBMED   26980699
  REMARK    Review article
REFERENCE   6  (bases 1 to 1920)
  AUTHORS   Friedmann,M., Holth,L.T., Zoghbi,H.Y. and Reeves,R.
  TITLE     Organization, inducible-expression and chromosome localization of
            the human HMG-I(Y) nonhistone protein gene
  JOURNAL   Nucleic Acids Res 21 (18), 4259-4267 (1993)
   PUBMED   8414980
REFERENCE   7  (bases 1 to 1920)
  AUTHORS   Nissen,M.S., Langan,T.A. and Reeves,R.
  TITLE     Phosphorylation by cdc2 kinase modulates DNA binding activity of
            high mobility group I nonhistone chromatin protein
  JOURNAL   J Biol Chem 266 (30), 19945-19952 (1991)
   PUBMED   1939057
REFERENCE   8  (bases 1 to 1920)
  AUTHORS   Reeves,R. and Nissen,M.S.
  TITLE     The A.T-DNA-binding domain of mammalian high mobility group I
            chromosomal proteins. A novel peptide motif for recognizing DNA
            structure
  JOURNAL   J Biol Chem 265 (15), 8573-8582 (1990)
   PUBMED   1692833
REFERENCE   9  (bases 1 to 1920)
  AUTHORS   Eckner,R. and Birnstiel,M.L.
  TITLE     Cloning of cDNAs coding for human HMG I and HMG Y proteins: both
            are capable of binding to the octamer sequence motif
  JOURNAL   Nucleic Acids Res 17 (15), 5947-5959 (1989)
   PUBMED   2505228
REFERENCE   10 (bases 1 to 1920)
  AUTHORS   Johnson,K.R., Lehn,D.A. and Reeves,R.
  TITLE     Alternative processing of mRNAs encoding mammalian chromosomal
            high-mobility-group proteins HMG-I and HMG-Y
  JOURNAL   Mol Cell Biol 9 (5), 2114-2123 (1989)
   PUBMED   2701943
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA049639.1, BC008832.2 and
            AL354740.29.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_145899.2.
            
            Summary: This gene encodes a chromatin-associated protein involved
            in the regulation of gene transcription, integration of
            retroviruses into chromosomes, and the metastatic progression of
            cancer cells. The encoded protein preferentially binds to the minor
            groove of AT-rich regions in double-stranded DNA. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. Pseudogenes of this gene have been identified on
            multiple chromosomes. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a, also called HMG-I).
            Variants 1, 3, 9, 10, 12, and 13 encode isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.731879.1, BC008832.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311487.9/ ENSP00000308227.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                DA049639.1         74-120
            48-654              BC008832.2         1-607
            655-1914            AL354740.29        112305-113564
            1915-1920           BC008832.2         1868-1873
FEATURES             Location/Qualifiers
     source          1..1920
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.31"
     gene            1..1920
                     /gene="HMGA1"
                     /gene_synonym="HMG-R; HMGA1A; HMGIY"
                     /note="high mobility group AT-hook 1"
                     /db_xref="GeneID:3159"
                     /db_xref="HGNC:HGNC:5010"
                     /db_xref="MIM:600701"
     exon            1..91
                     /gene="HMGA1"
                     /gene_synonym="HMG-R; HMGA1A; HMGIY"
                     /inference="alignment:Splign:2.1.0"
     exon            92..205
                     /gene="HMGA1"
                     /gene_synonym="HMG-R; HMGA1A; HMGIY"
                     /inference="alignment:Splign:2.1.0"
     exon            206..384
                     /gene="HMGA1"
                     /gene_synonym="HMG-R; HMGA1A; HMGIY"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..573
                     /gene="HMGA1"
                     /gene_synonym="HMG-R; HMGA1A; HMGIY"
                     /note="isoform a is encoded by transcript variant 1;
                     nonhistone chromosomal high-mobility group protein
                     HMG-I/HMG-Y; high mobility group protein HMG-I/HMG-Y; high
                     mobility group protein R; high mobility group protein A1"
                     /codon_start=1
                     /product="high mobility group protein HMG-I/HMG-Y isoform
                     a"
                     /protein_id="NP_665906.1"
                     /db_xref="CCDS:CCDS4789.1"
                     /db_xref="GeneID:3159"
                     /db_xref="HGNC:HGNC:5010"
                     /db_xref="MIM:600701"
                     /translation="MSESSSKSSQPLASKQEKDGTEKRGRGRPRKQPPVSPGTALVGS
                     QKEPSEVPTPKRPRGRPKGSKNKGAAKTRKTTTTPGRKPRGRPKKLEKEEEEGISQES
                     SEEEQ"
     exon            385..468
                     /gene="HMGA1"
                     /gene_synonym="HMG-R; HMGA1A; HMGIY"
                     /inference="alignment:Splign:2.1.0"
     exon            469..519
                     /gene="HMGA1"
                     /gene_synonym="HMG-R; HMGA1A; HMGIY"
                     /inference="alignment:Splign:2.1.0"
     exon            520..1920
                     /gene="HMGA1"
                     /gene_synonym="HMG-R; HMGA1A; HMGIY"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1896..1901
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HMGA1"
                     /gene_synonym="HMG-R; HMGA1A; HMGIY"
                     /note="hexamer: AATAAA"
     polyA_site      1920
                     /gene="HMGA1"
                     /gene_synonym="HMG-R; HMGA1A; HMGIY"
                     /note="major polyA site"
ORIGIN      
        1 ctttttaagc tcccctgagc cggtgctgcg ctcctctaat tgggactccg agccggggct
       61 atttctggcg ctggcgcggc tccaagaagg catccgcatt tgctaccagc ggcggccgcg
      121 gcggagccag gccggtcctc agcgcccagc accgccgctc ccggcaaccc ggagcgcgca
      181 ccgcaggccg gcggccgagc tcgcgcatcc cagccatcac tcttccacct gctccttaga
      241 gaagggaaga tgagtgagtc gagctcgaag tccagccagc ccttggcctc caagcaggaa
      301 aaggacggca ctgagaagcg gggccggggc aggccgcgca agcagcctcc ggtgagtccc
      361 gggacagcgc tggtagggag tcagaaggag cccagcgaag tgccaacacc taagagacct
      421 cggggccgac caaagggaag caaaaacaag ggtgctgcca agacccggaa aaccaccaca
      481 actccaggaa ggaaaccaag gggcagaccc aaaaaactgg agaaggagga agaggagggc
      541 atctcgcagg agtcctcgga ggaggagcag tgacccatgc gtgccgcctg ctcctcactg
      601 gaggagcagc ttccttctgg gactggacag ctttgctccg ctcccaccgc ccccacccct
      661 tccccaggcc caccatcacc accgcctctg gccgccaccc ccatcttcca cctgtgccct
      721 caccaccaca ctacacagca caccagccgc tgcagggctc ccatgggctg agtggggagc
      781 agttttcccc tggcctcagt tcccagctcc ccccgcccac ccacgcatac acacatgccc
      841 tcctggacaa ggctaacatc ccacttagcc gcaccctgca cctgctgcgt ccccactccc
      901 ttggtggtgg ggacattgct ctctgggctt ttggtttggg ggcgccctct ctgctccttc
      961 actgttccct ctggcttccc atagtggggc ctgggagggt tcccctggcc ttaaaagggg
     1021 cccaagcccc atctcatcct ggcacgccct actccactgc cctggcagca gcaggtgtgg
     1081 ccaatggagg ggggtgctgg cccccaggat tcccccagcc aaactgtctt tgtcaccacg
     1141 tggggctcac ttttcatcct tccccaactt ccctagtccc cgtactaggt tggacagccc
     1201 ccttcggtta caggaaggca ggaggggtga gtcccctact ccctcttcac tgtggccaca
     1261 gcccccttgc cctccgcctg ggatctgagt acatattgtg gtgatggaga tgcagtcact
     1321 tattgtccag gtgaggccca agagccctgt ggccgccacc tgaggtgggc tggggctgct
     1381 cccctaaccc tactttgctt ccgccactca gccatttccc cctcctcaga tggggcacca
     1441 ataacaagga gctcaccctg cccgctccca acccccctcc tgctcctccc tgccccccaa
     1501 ggttctggtt ccatttttcc tctgttcaca aactacctct ggacagttgt gttgtttttt
     1561 gttcaatgtt ccattcttcg acatccgtca ttgctgctgc taccagcgcc aaatgttcat
     1621 cctcattgcc tcctgttctg cccacgatcc cctcccccaa gatactcttt gtggggaaga
     1681 ggggctgggg catggcaggc tgggtgaccg actaccccag tcccagggaa ggtggggccc
     1741 tgcccctagg atgctgcagc agagtgagca agggggccca aatcgaccat aaagggtgta
     1801 ggggccacct cctccccctg ttctgttggg gaggggtagc catgatttgt cccagcctgg
     1861 ggctccctct ctggtttcct atttgcagtt acttgaataa aaaaaatatc cttttctgga
//
