LOCUS       NM_006339               1585 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens high mobility group 20B (HMG20B), mRNA.
ACCESSION   NM_006339
VERSION     NM_006339.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1585)
  AUTHORS   Maiques-Diaz,A., Nicosia,L., Basma,N.J., Romero-Camarero,I.,
            Camera,F., Spencer,G.J., Amaral,F.M.R., Simeoni,F., Wingelhofer,B.,
            Williamson,A.J.K., Pierce,A., Whetton,A.D. and Somervaille,T.C.P.
  TITLE     HMG20B stabilizes association of LSD1 with GFI1 on chromatin to
            confer transcription repression and leukemia cell differentiation
            block
  JOURNAL   Oncogene 41 (44), 4841-4854 (2022)
   PUBMED   36171271
  REMARK    GeneRIF: HMG20B stabilizes association of LSD1 with GFI1 on
            chromatin to confer transcription repression and leukemia cell
            differentiation block.
REFERENCE   2  (bases 1 to 1585)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1585)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1585)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1585)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   6  (bases 1 to 1585)
  AUTHORS   Hakimi,M.A., Bochar,D.A., Chenoweth,J., Lane,W.S., Mandel,G. and
            Shiekhattar,R.
  TITLE     A core-BRAF35 complex containing histone deacetylase mediates
            repression of neuronal-specific genes
  JOURNAL   Proc Natl Acad Sci U S A 99 (11), 7420-7425 (2002)
   PUBMED   12032298
  REMARK    GeneRIF: complex containing histone deacetylase complex containing
            histone deacetylase mediates repression of neuronal-specific genes.
REFERENCE   7  (bases 1 to 1585)
  AUTHORS   Lee,Y.M., Shin,H., Choi,W., Ahn,S. and Kim,W.
  TITLE     Characterization of human SMARCE1r high-mobility-group protein
  JOURNAL   Biochim Biophys Acta 1574 (3), 269-276 (2002)
   PUBMED   11997092
  REMARK    GeneRIF: molecular cloning, nucleotide and amino acid sequencing
REFERENCE   8  (bases 1 to 1585)
  AUTHORS   Marmorstein,L.Y., Kinev,A.V., Chan,G.K., Bochar,D.A., Beniya,H.,
            Epstein,J.A., Yen,T.J. and Shiekhattar,R.
  TITLE     A human BRCA2 complex containing a structural DNA binding component
            influences cell cycle progression
  JOURNAL   Cell 104 (2), 247-257 (2001)
   PUBMED   11207365
REFERENCE   9  (bases 1 to 1585)
  AUTHORS   Sumoy,L., Carim,L., Escarceller,M., Nadal,M., Gratacos,M.,
            Pujana,M.A., Estivill,X. and Peral,B.
  TITLE     HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and
            constitute a distinct class of HMG-box genes with ubiquitous
            expression
  JOURNAL   Cytogenet Cell Genet 88 (1-2), 62-67 (2000)
   PUBMED   10773667
REFERENCE   10 (bases 1 to 1585)
  AUTHORS   Wattler,F., Wattler,S., Kelly,M., Skinner,H.B. and Nehls,M.
  TITLE     Cloning, chromosomal location, and expression analysis of murine
            Smarce1-related, a new member of the high-mobility 365 group gene
            family
  JOURNAL   Genomics 60 (2), 172-178 (1999)
   PUBMED   10486208
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005786.1, BI561304.1, BC003505.1 and AF072836.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006339.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.651764.1,
                                           SRR3476690.1084321.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333651.11/ ENSP00000328269.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC005786.1         38814-38814
            2-13                BI561304.1         14-25
            14-1577             BC003505.1         1-1564
            1578-1585           AF072836.1         1223-1230
FEATURES             Location/Qualifiers
     source          1..1585
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1585
                     /gene="HMG20B"
                     /gene_synonym="BRAF25; BRAF35; HMGX2; HMGXB2; PP7706;
                     pp8857; SMARCE1r; SOXL"
                     /note="high mobility group 20B"
                     /db_xref="GeneID:10362"
                     /db_xref="HGNC:HGNC:5002"
                     /db_xref="MIM:605535"
     exon            1..51
                     /gene="HMG20B"
                     /gene_synonym="BRAF25; BRAF35; HMGX2; HMGXB2; PP7706;
                     pp8857; SMARCE1r; SOXL"
                     /inference="alignment:Splign:2.1.0"
     exon            52..107
                     /gene="HMG20B"
                     /gene_synonym="BRAF25; BRAF35; HMGX2; HMGXB2; PP7706;
                     pp8857; SMARCE1r; SOXL"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1023
                     /gene="HMG20B"
                     /gene_synonym="BRAF25; BRAF35; HMGX2; HMGXB2; PP7706;
                     pp8857; SMARCE1r; SOXL"
                     /note="SWI/SNF-related matrix-associated actin-dependent
                     regulator of chromatin subfamily E, member 1-related; HMG
                     box domain containing 2; Sox-like transcriptional factor;
                     SMARCE1-related protein; BRCA2-associated factor 35; HMG
                     box-containing protein 20B; HMG domain-containing protein
                     2; HMG domain-containing protein HMGX2; structural
                     DNA-binding protein BRAF35"
                     /codon_start=1
                     /product="SWI/SNF-related matrix-associated
                     actin-dependent regulator of chromatin subfamily E member
                     1-related"
                     /protein_id="NP_006330.2"
                     /db_xref="CCDS:CCDS45919.1"
                     /db_xref="GeneID:10362"
                     /db_xref="HGNC:HGNC:5002"
                     /db_xref="MIM:605535"
                     /translation="MSHGPKQPGAAAAPAGGKAPGQHGGFVVTVKQERGEGPRAGEKG
                     SHEEEPVKKRGWPKGKKRKKILPNGPKAPVTGYVRFLNERREQIRTRHPDLPFPEITK
                     MLGAEWSKLQPTEKQRYLDEAEREKQQYMKELRAYQQSEAYKMCTEKIQEKKIKKEDS
                     SSGLMNTLLNGHKGGDCDGFSTFDVPIFTEEFLDQNKAREAELRRLRKMNVAFEEQNA
                     VLQRHTQSMSSARERLEQELALEERRTLALQQQLQAVRQALTASFASLPVPGTGETPT
                     LGTLDFYMARLHGAIERDPAQHEKLIVRIKEILAQVASEHL"
     exon            108..216
                     /gene="HMG20B"
                     /gene_synonym="BRAF25; BRAF35; HMGX2; HMGXB2; PP7706;
                     pp8857; SMARCE1r; SOXL"
                     /inference="alignment:Splign:2.1.0"
     exon            217..420
                     /gene="HMG20B"
                     /gene_synonym="BRAF25; BRAF35; HMGX2; HMGXB2; PP7706;
                     pp8857; SMARCE1r; SOXL"
                     /inference="alignment:Splign:2.1.0"
     exon            421..541
                     /gene="HMG20B"
                     /gene_synonym="BRAF25; BRAF35; HMGX2; HMGXB2; PP7706;
                     pp8857; SMARCE1r; SOXL"
                     /inference="alignment:Splign:2.1.0"
     exon            542..588
                     /gene="HMG20B"
                     /gene_synonym="BRAF25; BRAF35; HMGX2; HMGXB2; PP7706;
                     pp8857; SMARCE1r; SOXL"
                     /inference="alignment:Splign:2.1.0"
     exon            589..661
                     /gene="HMG20B"
                     /gene_synonym="BRAF25; BRAF35; HMGX2; HMGXB2; PP7706;
                     pp8857; SMARCE1r; SOXL"
                     /inference="alignment:Splign:2.1.0"
     exon            662..877
                     /gene="HMG20B"
                     /gene_synonym="BRAF25; BRAF35; HMGX2; HMGXB2; PP7706;
                     pp8857; SMARCE1r; SOXL"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1010
                     /gene="HMG20B"
                     /gene_synonym="BRAF25; BRAF35; HMGX2; HMGXB2; PP7706;
                     pp8857; SMARCE1r; SOXL"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1585
                     /gene="HMG20B"
                     /gene_synonym="BRAF25; BRAF35; HMGX2; HMGXB2; PP7706;
                     pp8857; SMARCE1r; SOXL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1567..1572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HMG20B"
                     /gene_synonym="BRAF25; BRAF35; HMGX2; HMGXB2; PP7706;
                     pp8857; SMARCE1r; SOXL"
                     /note="hexamer: AGTAAA"
     polyA_site      1585
                     /gene="HMG20B"
                     /gene_synonym="BRAF25; BRAF35; HMGX2; HMGXB2; PP7706;
                     pp8857; SMARCE1r; SOXL"
                     /note="major polyA site"
ORIGIN      
        1 ggttggttgg agcgtcgcgc agtcgggagg tccgggaaag tttctttgga ggtccggccc
       61 ggagcggcca tgtcccacgg ccccaagcag cccggcgcgg ccgccgcgcc ggcgggcggc
      121 aaggctccgg gccagcatgg gggcttcgtg gtgactgtca agcaagagcg cggcgagggt
      181 ccacgcgcgg gcgagaaggg gtcccacgag gaggagccgg tgaagaaacg cggctggccc
      241 aagggcaaga agcggaagaa gattctgccg aatgggccca aggcaccggt cacgggctac
      301 gtgcgcttcc tgaacgagcg gcgcgagcag atccgcacgc gccacccgga tctgcccttt
      361 cccgagatca ccaagatgct gggcgccgag tggagcaagc tgcagccaac ggaaaagcag
      421 cggtacctgg atgaggccga gagagagaag cagcagtaca tgaaggagct gcgggcgtac
      481 cagcagtctg aagcctataa gatgtgcacg gagaagatcc aggagaagaa gatcaagaaa
      541 gaagactcga gctctgggct catgaacact ctcctgaatg gacacaaggg tggggactgc
      601 gatggcttct ccaccttcga tgttcccatc ttcactgaag agttcttgga ccaaaacaaa
      661 gcgcgtgagg cggagcttcg gcgcttgcgg aagatgaatg tggccttcga ggagcagaac
      721 gcggtactgc agaggcacac gcagagcatg agcagcgcgc gcgagcgtct ggagcaggag
      781 ctggcgctgg aggagcggag gacgctggcg ctgcagcagc agctccaggc cgtgcgccag
      841 gcgctcaccg ccagcttcgc ctcactgccg gtgccgggca cgggcgaaac gcccacgctg
      901 ggcactctgg acttctacat ggcccggctt cacggagcca tcgagcgcga ccccgcccag
      961 cacgagaagc tcatcgtccg catcaaggaa atcctggccc aggtcgccag cgagcacctg
     1021 tgaggagtgg gcgggcccac gatgcagagg agaagctgtg ggcgcggccc tgccacaccc
     1081 caccccgtgg acgagaggct gggggtccac cctttggggc ctggtcccat cctgcacctt
     1141 gggggctcca gcccccctaa aattaaattt ctgcagcatc cctttagctt tcaatctccc
     1201 cagccccctg aacccggaaa aagcactcgc tgcgcgatac acccagaaga acctcacagc
     1261 cgagggtgcc cctcctcgga ggacagccac gcgctacact ggctctccgg gccaccccca
     1321 ggacacaggg cagacgaaac ccacccccag cacacggcag gaccccccaa attactcact
     1381 acggggggct gtgccatagg ccacacagga agctgccttg tggggactta cctggggtgt
     1441 cccccgcatg cctgtacccc agatgggtgg gggccggctt tgcccatcct gctctcctcc
     1501 agccgaggga ccctggtggg ggtggctcct tctcactgct ggatccggac tttttaaata
     1561 aaaacaagta aaatttgtgt tttaa
//
