LOCUS       NM_001304504            3805 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens high mobility group 20A (HMG20A), transcript variant
            2, mRNA.
ACCESSION   NM_001304504 XM_005254123
VERSION     NM_001304504.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3805)
  AUTHORS   Na,L., Meijie,Z., Wenjing,Z., Bing,Z., Yanhao,D., Shanshan,L. and
            Yongle,Q.
  TITLE     HMG20A was identified as a key enhancer driver associated with DNA
            damage repair in oral squamous cell carcinomas
  JOURNAL   BMC Oral Health 22 (1), 473 (2022)
   PUBMED   36335317
  REMARK    GeneRIF: HMG20A was identified as a key enhancer driver associated
            with DNA damage repair in oral squamous cell carcinomas.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3805)
  AUTHORS   Gomez-Marin,E., Posavec-Marjanovic,M., Zarzuela,L.,
            Basurto-Cayuela,L., Guerrero-Martinez,J.A., Arribas,G., Yerbes,R.,
            Ceballos-Chavez,M., Rodriguez-Paredes,M., Tome,M., Duran,R.V.,
            Buschbeck,M. and Reyes,J.C.
  TITLE     The high mobility group protein HMG20A cooperates with the histone
            reader PHF14 to modulate TGFbeta and Hippo pathways
  JOURNAL   Nucleic Acids Res 50 (17), 9838-9857 (2022)
   PUBMED   36124662
  REMARK    GeneRIF: The high mobility group protein HMG20A cooperates with the
            histone reader PHF14 to modulate TGFbeta and Hippo pathways.
REFERENCE   3  (bases 1 to 3805)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3805)
  AUTHORS   Yamamoto,M., Kondo,R., Hozumi,H., Doi,S., Denda,M., Magari,M.,
            Kanayama,N., Hatano,N., Morishita,R. and Tokumitsu,H.
  TITLE     Identification and Biochemical Characterization of High Mobility
            Group Protein 20A as a Novel Ca2+/S100A6 Target
  JOURNAL   Biomolecules 11 (4), 510 (2021)
   PUBMED   33808200
  REMARK    GeneRIF: Identification and Biochemical Characterization of High
            Mobility Group Protein 20A as a Novel Ca(2+)/S100A6 Target.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3805)
  AUTHORS   Huang,T., Wang,L., Bai,M., Zheng,J., Yuan,D., He,Y., Wang,Y.,
            Jin,T. and Cui,W.
  TITLE     Influence of IGF2BP2, HMG20A, and HNF1B genetic polymorphisms on
            the susceptibility to Type 2 diabetes mellitus in Chinese Han
            population
  JOURNAL   Biosci Rep 40 (5) (2020)
   PUBMED   32329795
  REMARK    GeneRIF: Influence of IGF2BP2, HMG20A, and HNF1B genetic
            polymorphisms on the susceptibility to Type 2 diabetes mellitus in
            Chinese Han population.
REFERENCE   6  (bases 1 to 3805)
  AUTHORS   Bantscheff,M., Hopf,C., Savitski,M.M., Dittmann,A., Grandi,P.,
            Michon,A.M., Schlegl,J., Abraham,Y., Becher,I., Bergamini,G.,
            Boesche,M., Delling,M., Dumpelfeld,B., Eberhard,D., Huthmacher,C.,
            Mathieson,T., Poeckel,D., Reader,V., Strunk,K., Sweetman,G.,
            Kruse,U., Neubauer,G., Ramsden,N.G. and Drewes,G.
  TITLE     Chemoproteomics profiling of HDAC inhibitors reveals selective
            targeting of HDAC complexes
  JOURNAL   Nat Biotechnol 29 (3), 255-265 (2011)
   PUBMED   21258344
REFERENCE   7  (bases 1 to 3805)
  AUTHORS   Nicolas,E., Poitelon,Y., Chouery,E., Salem,N., Levy,N.,
            Megarbane,A. and Delague,V.
  TITLE     CAMOS, a nonprogressive, autosomal recessive, congenital cerebellar
            ataxia, is caused by a mutant zinc-finger protein, ZNF592
  JOURNAL   Eur J Hum Genet 18 (10), 1107-1113 (2010)
   PUBMED   20531441
REFERENCE   8  (bases 1 to 3805)
  AUTHORS   Artegiani,B., Labbaye,C., Sferra,A., Quaranta,M.T., Torreri,P.,
            Macchia,G., Ceccarini,M., Petrucci,T.C. and Macioce,P.
  TITLE     The interaction with HMG20a/b proteins suggests a potential role
            for beta-dystrobrevin in neuronal differentiation
  JOURNAL   J Biol Chem 285 (32), 24740-24750 (2010)
   PUBMED   20530487
  REMARK    GeneRIF: beta-dystrobrevin interacts with the HMG20 proteins iBRAF
            and BRAF35
REFERENCE   9  (bases 1 to 3805)
  AUTHORS   Ravasi,T., Suzuki,H., Cannistraci,C.V., Katayama,S., Bajic,V.B.,
            Tan,K., Akalin,A., Schmeier,S., Kanamori-Katayama,M., Bertin,N.,
            Carninci,P., Daub,C.O., Forrest,A.R., Gough,J., Grimmond,S.,
            Han,J.H., Hashimoto,T., Hide,W., Hofmann,O., Kamburov,A., Kaur,M.,
            Kawaji,H., Kubosaki,A., Lassmann,T., van Nimwegen,E.,
            MacPherson,C.R., Ogawa,C., Radovanovic,A., Schwartz,A.,
            Teasdale,R.D., Tegner,J., Lenhard,B., Teichmann,S.A., Arakawa,T.,
            Ninomiya,N., Murakami,K., Tagami,M., Fukuda,S., Imamura,K., Kai,C.,
            Ishihara,R., Kitazume,Y., Kawai,J., Hume,D.A., Ideker,T. and
            Hayashizaki,Y.
  TITLE     An atlas of combinatorial transcriptional regulation in mouse and
            man
  JOURNAL   Cell 140 (5), 744-752 (2010)
   PUBMED   20211142
  REMARK    Erratum:[Cell. 2010 Apr 16;141(2):369. Kamburov, Atanas [added];
            Kaur, Mandeep [added]; MacPherson, Cameron Ross [added];
            Radovanovic, Aleksandar [added]; Schwartz, Ariel [added]]
REFERENCE   10 (bases 1 to 3805)
  AUTHORS   Sumoy,L., Carim,L., Escarceller,M., Nadal,M., Gratacos,M.,
            Pujana,M.A., Estivill,X. and Peral,B.
  TITLE     HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and
            constitute a distinct class of HMG-box genes with ubiquitous
            expression
  JOURNAL   Cytogenet Cell Genet 88 (1-2), 62-67 (2000)
   PUBMED   10773667
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK001601.1, AK096546.1 and AA233289.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001304504.1.
            
            Transcript Variant: This variant (2) lacks an exon in the 5' UTR
            compared to variant 1. Variants 1 and 2 encode the same isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK001601.1, SRR1660807.132029.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336216.9/ ENSP00000336856.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2584              AK001601.1         1-2584
            2585-2585           AK096546.1         1530-1530
            2586-3803           AK001601.1         2586-3803
            3804-3805           AA233289.1         19-20               c
FEATURES             Location/Qualifiers
     source          1..3805
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.3"
     gene            1..3805
                     /gene="HMG20A"
                     /gene_synonym="HMGX1; HMGXB1"
                     /note="high mobility group 20A"
                     /db_xref="GeneID:10363"
                     /db_xref="HGNC:HGNC:5001"
                     /db_xref="MIM:605534"
     exon            1..117
                     /gene="HMG20A"
                     /gene_synonym="HMGX1; HMGXB1"
                     /inference="alignment:Splign:2.1.0"
     exon            118..210
                     /gene="HMG20A"
                     /gene_synonym="HMGX1; HMGXB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1165
                     /gene="HMG20A"
                     /gene_synonym="HMGX1; HMGXB1"
                     /note="isoform a is encoded by transcript variant 2; HMG
                     box domain containing 1; high mobility group protein 20A;
                     HMG box-containing protein 20A; HMG domain-containing
                     protein 1; HMG domain-containing protein HMGX1"
                     /codon_start=1
                     /product="high mobility group protein 20A isoform a"
                     /protein_id="NP_001291433.1"
                     /db_xref="CCDS:CCDS10295.1"
                     /db_xref="GeneID:10363"
                     /db_xref="HGNC:HGNC:5001"
                     /db_xref="MIM:605534"
                     /translation="MENLMTSSTLPPLFADEDGSKESNDLATTGLNHPEVPYSSGATS
                     STNNPEFVEDLSQGQLLQSESSNAAEGNEQRHEDEQRSKRGGWSKGRKRKKPLRDSNA
                     PKSPLTGYVRFMNERREQLRAKRPEVPFPEITRMLGNEWSKLPPEEKQRYLDEADRDK
                     ERYMKELEQYQKTEAYKVFSRKTQDRQKGKSHRQDAARQATHDHEKETEVKERSVFDI
                     PIFTEEFLNHSKAREAELRQLRKSNMEFEERNAALQKHVESMRTAVEKLEVDVIQERS
                     RNTVLQQHLETLRQVLTSSFASMPLPGSGETPTVDTIDSYMNRLHSIILANPQDNENF
                     IATVREVVNRLDR"
     exon            211..358
                     /gene="HMG20A"
                     /gene_synonym="HMGX1; HMGXB1"
                     /inference="alignment:Splign:2.1.0"
     exon            359..571
                     /gene="HMG20A"
                     /gene_synonym="HMGX1; HMGXB1"
                     /inference="alignment:Splign:2.1.0"
     exon            572..704
                     /gene="HMG20A"
                     /gene_synonym="HMGX1; HMGXB1"
                     /inference="alignment:Splign:2.1.0"
     exon            705..736
                     /gene="HMG20A"
                     /gene_synonym="HMGX1; HMGXB1"
                     /inference="alignment:Splign:2.1.0"
     exon            737..812
                     /gene="HMG20A"
                     /gene_synonym="HMGX1; HMGXB1"
                     /inference="alignment:Splign:2.1.0"
     exon            813..1028
                     /gene="HMG20A"
                     /gene_synonym="HMGX1; HMGXB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1171
                     /gene="HMG20A"
                     /gene_synonym="HMGX1; HMGXB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..3805
                     /gene="HMG20A"
                     /gene_synonym="HMGX1; HMGXB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3784..3789
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HMG20A"
                     /gene_synonym="HMGX1; HMGXB1"
                     /note="hexamer: ATTAAA"
     polyA_site      3805
                     /gene="HMG20A"
                     /gene_synonym="HMGX1; HMGXB1"
                     /note="major polyA site"
ORIGIN      
        1 agctgtgaga cgacgagtgc gtgaagtgaa ggcgattgag aggggctgag ggaattgtcc
       61 tctgtggaag ggactttctt ttggccctag gccccttcct gcccctgtcg tcagcagaga
      121 gatggaaaac ttgatgacta gctccaccct accgcccctt tttgcagatg aagacggttc
      181 caaggagagt aatgatctgg ctaccactgg gttaaatcac ccagaggttc catacagtag
      241 tggcgccaca tcatccacca acaatccaga atttgtggag gatctctctc aaggtcagtt
      301 gcttcagagt gagtcttcaa atgcagcaga aggcaatgaa cagaggcatg aagatgagca
      361 acgaagtaaa cgaggaggtt ggtccaaagg aagaaagagg aagaaacctc ttcgagacag
      421 caatgcaccc aaatcccccc ttacaggata tgttcggttc atgaatgagc gtcgagaaca
      481 acttcgagca aagagaccag aagtcccatt tccagaaatc acaaggatgt taggcaatga
      541 atggagtaaa ctgcctcctg aggaaaaaca gcgctacctt gatgaagcag acagagataa
      601 ggagcgttac atgaaggaac tggaacagta tcagaaaaca gaggcctaca aggtcttcag
      661 taggaaaacc caggaccgtc agaaaggcaa atctcatagg caagatgcag cccggcaggc
      721 cactcatgat catgagaaag aaacagaggt aaaggaacgg tctgtttttg acatccctat
      781 atttacagag gaattcttga accatagcaa agctcgggaa gcagagctcc gccagcttcg
      841 caaatccaac atggagtttg aggagaggaa tgcagccctg caaaagcacg tggagagcat
      901 gcgcacagca gtggagaagc tggaggtgga tgtgatccag gagcggagcc gcaacacagt
      961 cttacagcag cacctggaga ccctgcggca ggtgctgacc agcagctttg ccagcatgcc
     1021 cttgcctgga agtggagaga cacctacagt ggacaccatt gactcatata tgaacagact
     1081 gcacagtatt attttagcta atccccaaga caatgaaaac ttcatagcta cagttcgaga
     1141 agttgtgaac agactcgatc gttagggaat ggtcttagaa ctccaagatg ttccataagt
     1201 gtttttactt gtgaggaatg agaagccatc catggaaatt tgaactgagt gggggcagag
     1261 aaagagtgca gatccctttg cttgtgaaag aattatcagt gagtgaaagg ccatcacccc
     1321 aggaagccaa atgagggagc agcaacatgt atatgagctt cctatggaat tgtccttatg
     1381 tgaagctttg aaggtgtaca gccactctcc cgggtcttca ggttcctacc atttccattt
     1441 ctgttaaagt ggatctgcat atcttcagct tactaggtga cccggatgct gacatctgct
     1501 gctgcagaaa ggaagacttt tcattgtaat ttcgcttaga cccttttatc agtggagctc
     1561 cagttttctt acctagctgt cactttttta aatgcctctg ggggttattt ttgctttcct
     1621 tggcccccac caatttatac atctccattt tctgacctct ggactaactg gttgctcagc
     1681 aaggttctga aggagagttt cttgcattgg acaggcccag tcttctccca tcattgccct
     1741 gctgtgactc caaagaaagg agcttcttgc tgacagtgcc ctgtggagca aggctgtgtt
     1801 tcctacccca cacggtgctc agtgggtgcc agccctcagt gtggctttgt gattgctgcc
     1861 ctaaaggaga atgctctttc cttcctcact ggtactgcct gctgttttct aagcattgct
     1921 cctgcacaga catggagtcc cagccccagc aaggctcttc tgttcccatc tgttgacaat
     1981 gtcttgtgga gcatttttgc tgaggaaaag gtcacttgta aacagaggag aaagggaaag
     2041 agtacaaagc cctaagttta ttgtaagtga aaactgaggg aattcctgtc ttctttagga
     2101 gtaatgattc atagatctag ataggtggaa atatcattca aaatagtcac ttgagctcac
     2161 aaaaaaagca aggaagaatt ctcatgtcct ttgtcttcct tctgtagcca ttaactgctg
     2221 aatccatgtg aggaagacag gcttcccttc cttccccctc cttagtgatt ttttctttaa
     2281 cagcataagt aaagaggact ttctggttca tttttgtttg ttttgttttg ttttgttttg
     2341 tttacagatg aggtcttcct gtgttgccca ggctggagtg cggtggctat tcacagatgc
     2401 tatcatagca cactacagcc tacaactctt gggctcaagc atcacgccta gcagtttctg
     2461 gttcctttaa cagcaaaagg aaagagaggt tctgattctt acctcagggt tttttggttg
     2521 ttcattgttt ttgtttttgt ttttgttttg acactgcaga gcacaaggct aaaggttaca
     2581 gctgagatct ttggaaccaa aggcagagca agcagagccc gttgtctggg ccccacacca
     2641 ctgcaggcag gtggatagaa gtgcggcccc tctcatagta tgcccataag tcagggcata
     2701 gggcagaact acctgtcatg ttgctacacc atcctgtctt ctcagcatct ccttgcctgt
     2761 tttctttatt agtccaaagg aaaacaacag caacaaaatc tgtttttaaa atgtcttata
     2821 tgaacatata tcaaatatcc atgcgctgaa acccacatac catcacttgg caatttttta
     2881 gaataagacc ccattattat ctattgctat aaacctagcc agttctcttg ctcttctgta
     2941 ttttcctatt tccctgccat catctgctat ttctgccact tctcttagac tccttgtctg
     3001 caaagcccaa gctagaactc actgtctatg gcagaaggac atccagagcc cattctggag
     3061 ttttgttttt tccttctgcc agatgctttg tgtcctgtct tccttcctcc tcatatttct
     3121 gtttctcatt tgtgttcagt tttgtgcagc attgctagca ctgcttttgt gaccagaaaa
     3181 ggccataaca tggtccagga tcatcattct tctgactcta gatgggacac ttgacagtga
     3241 cttgaaacat ttgcatattc aggaatgcat gagatttcaa gagagcctac agtatgaaat
     3301 cattttcaca aaataagcag cttgcttctg aaatgctgtc tttcccagta gctactcacc
     3361 tgcctctggt ggctgggatt cagatgccac aaaactgtca gtatctatag accaggtctg
     3421 tgccacctcc tctctcctct gtgctcagtg aggaggcagt aaatgaagtt acaggctagc
     3481 acaataccta actcatgttt cccagtacac ctgtagatat tactgtactt ttatgttctc
     3541 aagaaataag ttgttgccta ttcagtgtta cagatttctt tgtttctttt taattaaaat
     3601 acaagaagca gctgaggaaa gggagacaag gtattttatt tctgactgat tttagaaaaa
     3661 acttgtgtac atgtgtttgg aactgttgaa atgccaagtt ttctgtataa gtgtttttgt
     3721 aattaaactt tcagattttc tttgtttttt aagaagttga tgtgcttgtt tgacatttgt
     3781 ctcattaaaa cttttctacg ttgaa
//
