LOCUS       NM_001135726            3711 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens homeobox containing 1 (HMBOX1), transcript variant 2,
            mRNA.
ACCESSION   NM_001135726
VERSION     NM_001135726.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3711)
  AUTHORS   Chen,X., Zha,G., Li,C. and Wang,K.
  TITLE     High expression of HMBOX1 promotes the progression of lung squamous
            cell carcinoma
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (5), 198-203 (2024)
   PUBMED   38814216
  REMARK    GeneRIF: High expression of HMBOX1 promotes the progression of lung
            squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3711)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3711)
  AUTHORS   Zhou,C., Wei,W., Ma,J., Yang,Y., Liang,L., Zhang,Y., Wang,Z.,
            Chen,X., Huang,L., Wang,W. and Wu,S.
  TITLE     Cancer-secreted exosomal miR-1468-5p promotes tumor immune escape
            via the immunosuppressive reprogramming of lymphatic vessels
  JOURNAL   Mol Ther 29 (4), 1512-1528 (2021)
   PUBMED   33388421
  REMARK    GeneRIF: Cancer-secreted exosomal miR-1468-5p promotes tumor immune
            escape via the immunosuppressive reprogramming of lymphatic
            vessels.
            Erratum:[Mol Ther. 2022 Feb 2;30(2):976-977. doi:
            10.1016/j.ymthe.2021.12.014.. PMID: 34982969]
REFERENCE   4  (bases 1 to 3711)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3711)
  AUTHORS   Dai,J., Wu,L., Zhang,C., Zheng,X., Tian,Z. and Zhang,J.
  TITLE     Recombinant expression of a novel human transcriptional repressor
            HMBOX1 and preparation of anti-HMBOX1 monoclonal antibody
  JOURNAL   Cell Mol Immunol 6 (4), 261-268 (2009)
   PUBMED   19728927
  REMARK    GeneRIF: decreased expression in hepatic carcinoma
REFERENCE   6  (bases 1 to 3711)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 3711)
  AUTHORS   Dejardin,J. and Kingston,R.E.
  TITLE     Purification of proteins associated with specific genomic Loci
  JOURNAL   Cell 136 (1), 175-186 (2009)
   PUBMED   19135898
REFERENCE   8  (bases 1 to 3711)
  AUTHORS   De Marco,A., Biancotto,C., Knezevich,A., Maiuri,P., Vardabasso,C.
            and Marcello,A.
  TITLE     Intragenic transcriptional cis-activation of the human
            immunodeficiency virus 1 does not result in allele-specific
            inhibition of the endogenous gene
  JOURNAL   Retrovirology 5, 98 (2008)
   PUBMED   18983639
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3711)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   10 (bases 1 to 3711)
  AUTHORS   Chen,S., Saiyin,H., Zeng,X., Xi,J., Liu,X., Li,X. and Yu,L.
  TITLE     Isolation and functional analysis of human HMBOX1, a homeobox
            containing protein with transcriptional repressor activity
  JOURNAL   Cytogenet Genome Res 114 (2), 131-136 (2006)
   PUBMED   16825764
  REMARK    GeneRIF: Hmbox1 is widely expressed in pancreas and the expression
            of this gene can also be detected in pallium, hippocampus and
            hypothalamus
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK290683.1, AC108449.5 and BQ019252.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001135726.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, and 3 all encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.793364.1,
                                           SRR3476690.513903.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000287701.15/ ENSP00000287701.10
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2052              AK290683.1         2-2053
            2053-3329           AC108449.5         53541-54817
            3330-3711           BQ019252.1         25-406              c
FEATURES             Location/Qualifiers
     source          1..3711
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.1-p12"
     gene            1..3711
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF; TAH1"
                     /note="homeobox containing 1"
                     /db_xref="GeneID:79618"
                     /db_xref="HGNC:HGNC:26137"
                     /db_xref="MIM:618610"
     exon            1..284
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF; TAH1"
                     /inference="alignment:Splign:2.1.0"
     exon            285..364
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF; TAH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             342..1604
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF; TAH1"
                     /note="isoform 1 is encoded by transcript variant 2;
                     homeobox-containing protein 1; homeobox telomere-binding
                     protein 1; homeobox-containing protein PBHNF;
                     telomere-associated homeobox-containing protein 1"
                     /codon_start=1
                     /product="homeobox-containing protein 1 isoform 1"
                     /protein_id="NP_001129198.1"
                     /db_xref="CCDS:CCDS6071.1"
                     /db_xref="GeneID:79618"
                     /db_xref="HGNC:HGNC:26137"
                     /db_xref="MIM:618610"
                     /translation="MLSSFPVVLLETMSHYTDEPRFTIEQIDLLQRLRRTGMTKHEIL
                     HALETLDRLDQEHSDKFGRRSSYGGSSYGNSTNNVPASSSTATASTQTQHSGMSPSPS
                     NSYDTSPQPCTTNQNGRENNERLSTSNGKMSPTRYHANSMGQRSYSFEASEEDLDVDD
                     KVEELMRRDSSVIKEEIKAFLANRRISQAVVAQVTGISQSRISHWLLQQGSDLSEQKK
                     RAFYRWYQLEKTNPGATLSMRPAPIPIEDPEWRQTPPPVSATSGTFRLRRGSRFTWRK
                     ECLAVMESYFNENQYPDEAKREEIANACNAVIQKPGKKLSDLERVTSLKVYNWFANRR
                     KEIKRRANIEAAILESHGIDVQSPGGHSNSDDVDGNDYSEQDDSTSHSDHQDPISLAV
                     EMAAVNHTILALARQGANEIKTEALDDD"
     exon            365..841
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF; TAH1"
                     /inference="alignment:Splign:2.1.0"
     exon            842..927
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF; TAH1"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1038
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF; TAH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1192
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF; TAH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1275
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF; TAH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1371
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF; TAH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1466
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF; TAH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..3711
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF; TAH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2316..2321
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF; TAH1"
                     /note="hexamer: ATTAAA"
     regulatory      2322..2327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF; TAH1"
                     /note="hexamer: AACAAA"
     polyA_site      2335
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF; TAH1"
     polyA_site      2341
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF; TAH1"
                     /note="major polyA site"
     regulatory      3146..3151
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF; TAH1"
                     /note="hexamer: ATTAAA"
     polyA_site      3169
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF; TAH1"
     regulatory      3685..3690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF; TAH1"
                     /note="hexamer: AATATA"
     polyA_site      3711
                     /gene="HMBOX1"
                     /gene_synonym="HNF1LA; HOT1; PBHNF; TAH1"
ORIGIN      
        1 gttgatatca atatggcggt tgtcagccag acaaagacag tcagtctgat gtgattgaga
       61 caagggaggt ttttcagggg gagactggga gataggggcc tcccctcccc cttctcctct
      121 tcctgcgccg gcctcaaccc ctccccagtc ccctcccgac gggcgcccca cgcggaagac
      181 acccctcccc ctcccgcctt ccctcctccc tatctcagcc cttcgtactg ggacgttggg
      241 gagggggctg tgccgggcgg agagaactca gcgaggattc tgagaatggt agataacgca
      301 gatcatctct ggaaaggata ttgatccgcc tcatgtaaag tatgcttagt tcctttccag
      361 tggttttgct ggaaaccatg tctcattata cagatgaacc cagatttacc atagagcaga
      421 tagatctgct tcagcgactt cggcgtactg gaatgactaa acatgaaatt ctccatgcct
      481 tggaaacttt ggaccgtctt gatcaagagc atagtgacaa gtttggaaga aggtccagct
      541 atggaggaag ttcatatggg aatagtacta acaatgtccc agcatcttcc tctacagcta
      601 cagcttccac acagacgcag cattcgggaa tgtccccgtc acctagcaac agttatgata
      661 cttccccaca gccttgcact accaatcaaa atgggaggga gaataatgag cgattatcta
      721 catccaatgg aaagatgtca ccaactcgct accatgcaaa cagcatgggt cagaggtcat
      781 acagttttga agcctcagaa gaggacctag atgtagatga taaagtggaa gaattaatga
      841 ggagggacag cagtgtgata aaagaggaaa tcaaagcctt tcttgccaat cggaggattt
      901 cccaagcagt tgttgcacag gtaacaggta tcagtcagag ccggatctct cattggctgt
      961 tgcagcaggg atcagacctg agtgaacaga agaaaagagc attttaccga tggtatcaac
     1021 ttgagaagac aaaccctggc gctacactaa gtatgagacc agcccccatt ccaatagagg
     1081 accctgaatg gagacaaacg cctcccccag tctctgccac atctggtact ttccgactgc
     1141 gacgagggag tcgatttacc tggagaaagg agtgcctggc tgttatggaa agttacttca
     1201 atgagaatca atacccagat gaagcaaaga gggaagaaat tgcaaacgct tgcaatgcag
     1261 ttatacagaa gccaggcaaa aagctgtcag atctggaaag agttacctcc ctgaaagtat
     1321 ataattggtt tgctaacaga aggaaggaga tcaagaggag agccaatatt gaagcagcaa
     1381 tcctggagag tcatgggata gatgtgcaga gtccaggagg ccactcaaac agtgatgatg
     1441 tcgacgggaa tgactactct gagcaggatg acagtacgag ccatagtgac caccaagacc
     1501 ccatctcatt agctgtggaa atggcagcag tcaaccacac tatcttggca ttggcccgac
     1561 aaggagccaa cgaaatcaag acagaggccc tggatgatga ctgatcaggg aggttaaaca
     1621 tgacaagtta acttagttta gacgtagcac cttagcagac tttcctcggt ccttaacatg
     1681 tgttcttaca gtataacttg cagtttcttg tatgtcaggt agctgttagg gtcttgttct
     1741 gtgaagatgg catggtgccc tcagcctttg catatactct ctcagtatta actcccagta
     1801 aataataacc aaccaaccaa ccaaacttcc ctctcccagc ccccgaggct agaaaatctt
     1861 gctgctccgt cttagcattc caagaaagtg cttccaggta tttagatagc cctcagttct
     1921 caaatattag actacgtgta aaatcttggg tacctttaga ttcttgtaac actagtctgt
     1981 actccctttt ccttccccaa gactgatagg atgcaagctg aggtcgtggc acaggaatga
     2041 cagacaccat ttggggagta tccacagagt caaaggaaca ctagaatccc cacctcagcg
     2101 tgaggataat tgatttccag ctgcaataag ccgtgcctca ttatagccac actgtggcta
     2161 gattatactt ctttgggtgc tgtgctaaga atgtcaatgg aaaaagccga tctcagattt
     2221 tgtttgaagt taacatgcct gacacagaca tcctttcctc tcacaagctg tgtgacttag
     2281 tagataaaat actgccttct gcctttggga ccatgattaa aaacaaagac aaaaaccaaa
     2341 agtcattaaa aaaaaaaaaa aaaaaaaccc agcttgagag cattggaaaa aaaaaatatg
     2401 agctgaatgt ctaatggatg ctaagtccag ttttcagaac cactgtacat tccacggcac
     2461 agttagcagt gcctgcctgg aaaagttttg gaggtcatcg tggaagttgc tttgcctcct
     2521 gtcagtgtcc cctttccctg ctaccaaaaa agtctttcaa ggatggagct aaggtcaaaa
     2581 atgagtgaaa aaacttgcag tgtttgtatc cattaaacgg aagccccctc actctgagag
     2641 gtcactagag gacttcatag tggggttgtg ctgcttatca cagatgcaga cacttgccca
     2701 gataggagca gagaaaagca ggggacgttt cctactcaca ttgtggctgt atgagaacac
     2761 gatgggactg ctttgctgtt ctctttactc tgtccttgga gaggtgtgaa aagctgtatt
     2821 gctacaggca atttatttaa taattggaag ccatattgat aatggatgtg gtaatatttg
     2881 taaagtttaa tctactttaa gcggcagtaa ctaatggaat ttttttcctt gatcacatat
     2941 gtagcacttt tgttactttt taaagatatt tatatttgat aaatcttttt ttcattttga
     3001 gaactcaaaa taccaaacag tgaacttgca ttctaaagtc accctgtgat caccttgtca
     3061 tctagtagca aaatgatgaa ctattcatgc atcaaagaaa attacatctg ctggccttgt
     3121 atgaaaatga tctcttggca tcccgattaa atgacacact gtcactgtgg gtaagaggaa
     3181 agagccttca atgtagcagc acagggtgcg cctgaaagag gcacaactgc tgtggatttt
     3241 ctgcctcgct ccatctctcc tatgtataat gaagccttgt ttaaaggggc atgtggggct
     3301 ggatgttaag cacggcttct ttttgtccgt tacctgaaaa caatttctaa gataaaagga
     3361 aggtgccatt tccttacctc ttcacccatc ctcctccacc aaatgtattc aacttaaaac
     3421 tgtgagagag agagactgaa tgaccttcct cagttttccc tttctcattc aggagatact
     3481 gaatatccgc cagtttgtag ttggtttcct tccacttaag gcacacgctg actgcatcat
     3541 ttccttatct gttaatcctg cttatgtgag tgtgaggaaa gtctttgaga gggcatgaaa
     3601 gtgccacctt atatatgtct gtgactttaa agagctatat gcagggcctg gtcccacttt
     3661 tgtccatgga tttcaggggg aaaaaatata tgtacttttt tcagcttcca a
//
