LOCUS       NM_021958               2237 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens H2.0 like homeobox (HLX), mRNA.
ACCESSION   NM_021958
VERSION     NM_021958.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2237)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2237)
  AUTHORS   Nagel,S., Uphoff,C.C., Dirks,W.G., Pommerenke,C., Meyer,C. and
            Drexler,H.G.
  TITLE     Epstein-Barr virus (EBV) activates NKL homeobox gene HLX in DLBCL
  JOURNAL   PLoS One 14 (5), e0216898 (2019)
   PUBMED   31141539
  REMARK    GeneRIF: Epstein-Barr virus (EBV) activates NKL homeobox gene HLX
            in DLBCL.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2237)
  AUTHORS   Piragyte,I., Clapes,T., Polyzou,A., Klein Geltink,R.I.,
            Lefkopoulos,S., Yin,N., Cauchy,P., Curtis,J.D., Klaeyle,L.,
            Langa,X., Beckmann,C.C.A., Wlodarski,M.W., Muller,P., Van Essen,D.,
            Rambold,A., Kapp,F.G., Mione,M., Buescher,J.M., Pearce,E.L.,
            Polyzos,A. and Trompouki,E.
  TITLE     A metabolic interplay coordinated by HLX regulates myeloid
            differentiation and AML through partly overlapping pathways
  JOURNAL   Nat Commun 9 (1), 3090 (2018)
   PUBMED   30082823
  REMARK    GeneRIF: HLX has a role in coordinating metabolic interplay
            regulates myeloid differentiation both in zebrafish and human
            hematopoietic stem and progenitor cells and in acute myeloid
            leukemia through partly overlapping pathways
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2237)
  AUTHORS   Yuen,N., Brennecke,S.P., Umstad,M.P., Yong,H.E.J., Borg,A.J.,
            Rajaraman,G., Kalionis,B. and Murthi,P.
  TITLE     Expression of Homeobox Gene HLX and its Downstream Target Genes are
            Altered in Placentae From Discordant Twin Pregnancies
  JOURNAL   Twin Res Hum Genet 21 (1), 42-50 (2018)
   PUBMED   29212571
  REMARK    GeneRIF: An important association between HLX transcription factor
            expression and abnormal human placental development in discordant
            twin pregnancies.
REFERENCE   5  (bases 1 to 2237)
  AUTHORS   Farrell,S.A., Sodhi,S., Marshall,C.R., Guerin,A., Slavotinek,A.,
            Paton,T., Chong,K., Sirkin,W.L., Scherer,S.W., Berube-Simard,F.A.
            and Pilon,N.
  TITLE     HLX is a candidate gene for a pattern of anomalies associated with
            congenital diaphragmatic hernia, short bowel, and asplenia
  JOURNAL   Am J Med Genet A 173 (11), 3070-3074 (2017)
   PUBMED   28898547
  REMARK    GeneRIF: HLX is a homeobox transcription factor gene which is
            relatively conserved across species. Hlx homozygous null mice have
            a short bowel and reduced muscle cells in the diaphragm, closely
            resembling the anomalies in the two fetuses and we therefore
            suggest that the HLX mutation in this family could explain the
            fetal findings
REFERENCE   6  (bases 1 to 2237)
  AUTHORS   Najfeld,V., Menninger,J., Ballard,S.G., Deguchi,Y., Ward,D.C. and
            Kehrl,J.H.
  TITLE     Two diverged human homeobox genes involved in the differentiation
            of human hematopoietic progenitors map to chromosome 1, bands
            q41-42.1
  JOURNAL   Genes Chromosomes Cancer 5 (4), 343-347 (1992)
   PUBMED   1283323
REFERENCE   7  (bases 1 to 2237)
  AUTHORS   Deguchi,Y., Kirschenbaum,A. and Kehrl,J.H.
  TITLE     A diverged homeobox gene is involved in the proliferation and
            lineage commitment of human hematopoietic progenitors and highly
            expressed in acute myelogenous leukemia
  JOURNAL   Blood 79 (11), 2841-2848 (1992)
   PUBMED   1375114
REFERENCE   8  (bases 1 to 2237)
  AUTHORS   Deguchi,Y., Thevenin,C. and Kehrl,J.H.
  TITLE     Stable expression of HB24, a diverged human homeobox gene, in T
            lymphocytes induces genes involved in T cell activation and growth
  JOURNAL   J Biol Chem 267 (12), 8222-8229 (1992)
   PUBMED   1349016
REFERENCE   9  (bases 1 to 2237)
  AUTHORS   Deguchi,Y., Moroney,J.F., Wilson,G.L., Fox,C.H., Winter,H.S. and
            Kehrl,J.H.
  TITLE     Cloning of a human homeobox gene that resembles a diverged
            Drosophila homeobox gene and is expressed in activated lymphocytes
  JOURNAL   New Biol 3 (4), 353-363 (1991)
   PUBMED   1676597
REFERENCE   10 (bases 1 to 2237)
  AUTHORS   Allen,J.D., Lints,T., Jenkins,N.A., Copeland,N.G., Strasser,A.,
            Harvey,R.P. and Adams,J.M.
  TITLE     Novel murine homeo box gene on chromosome 1 expressed in specific
            hematopoietic lineages and during embryogenesis
  JOURNAL   Genes Dev 5 (4), 509-520 (1991)
   PUBMED   1672660
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA951303.1 and BC033808.1.
            
            On Nov 23, 2018 this sequence version replaced NM_021958.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK127923.1, BC007294.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366903.8/ ENSP00000355870.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               DA951303.1         43-242
            201-2237            BC033808.1         1-2037
FEATURES             Location/Qualifiers
     source          1..2237
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q41"
     gene            1..2237
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /note="H2.0 like homeobox"
                     /db_xref="GeneID:3142"
                     /db_xref="HGNC:HGNC:4978"
                     /db_xref="MIM:142995"
     exon            1..1007
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             416..1882
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /note="H2.0-like homeo box-1; H2.0-like homeobox 1;
                     homeobox protein HB24; homeobox protein HLX1"
                     /codon_start=1
                     /product="H2.0-like homeobox protein"
                     /protein_id="NP_068777.1"
                     /db_xref="CCDS:CCDS1527.1"
                     /db_xref="GeneID:3142"
                     /db_xref="HGNC:HGNC:4978"
                     /db_xref="MIM:142995"
                     /translation="MFAAGLAPFYASNFSLWSAAYCSSAGPGGCSFPLDPAAVKKPSF
                     CIADILHAGVGDLGAAPEGLAGASAAALTAHLGSVHPHASFQAAARSPLRPTPVVAPS
                     EVPAGFPQRLSPLSAAYHHHHPQQQQQQQQPQQQQPPPPPRAGALQPPASGTRVVPNP
                     HHSGSAPAPSSKDLKFGIDRILSAEFDPKVKEGNTLRDLTSLLTGGRPAGVHLSGLQP
                     SAGQFFASLDPINEASAILSPLNSNPRNSVQHQFQDTFPGPYAVLTKDTMPQTYKRKR
                     SWSRAVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWRHS
                     KEAQAQKDKDKEAGEKPSGGAPAADGEQDERSPSRSEGEAESESSDSESLDMAPSDTE
                     RTEGSERSLHQTTVIKAPVTGALITASSAGSGGSSGGGGNSFSFSSASSLSSSSTSAG
                     CASSLGGGGASELLPATQPTASSAPKSPEPAQGALGCL"
     exon            1008..1187
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1372
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..2237
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2211..2216
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /note="hexamer: AATAAA"
     polyA_site      2237
                     /gene="HLX"
                     /gene_synonym="HB24; HLX1"
                     /note="major polyA site"
ORIGIN      
        1 attacttttc ccccccccta actaacggac tattattgtt gttgttttaa atttagctct
       61 tagggcttag ctatttgggt tttcttgcgg tgtccggctc ccgtctccct ggctcccccg
      121 cccgccctgc ggccccagcg cccctcgctc tcatccagcc cgcgaggagt gcgggcgccg
      181 cgccgccttt aaagcgaggc cagggagcga ggcggtgacc ggccgagatc cggccctcgc
      241 ctcctccctc ggtggcgcta gggctcccgg cctctcttcc tcagtgcggg cggagaagcg
      301 aaagcggatc gtcctcggct gccgccgcct tctccgggac tcgcgcgccc ctccccgcgc
      361 gcccacccac ccagtccggc tggactgcgg cagccgcgcg gctcaccccg gcaggatgtt
      421 cgcagccggg ctggctccct tctacgcctc caacttcagc ctctggtcgg ccgcttactg
      481 ctcctcggcc ggcccaggcg gctgctcctt ccccttggac cccgccgccg tcaaaaagcc
      541 ctccttctgc atcgcagaca ttctgcacgc cggcgtgggg gatctggggg cggccccgga
      601 gggcctggca ggggcctcgg ccgccgccct caccgcgcac ttgggctcgg ttcacccgca
      661 cgcctctttc caagcggcgg ccagatcccc gcttcgaccc accccagtgg tggcgccctc
      721 cgaagtcccg gctggcttcc cgcagcggct gtctccgctc tcagccgcct accaccacca
      781 tcacccgcaa caacaacagc agcagcaaca gccgcagcag caacagcctc cgcctccgcc
      841 ccgggctggc gccctgcagc ccccggcctc ggggacgcga gtggttccga acccccacca
      901 cagtggctct gccccggccc cctccagcaa agacctcaaa tttggaattg accgcatttt
      961 atctgcagaa tttgacccaa aagtcaaaga aggcaacacg ctgagagatc tcacttccct
     1021 gctaaccggt gggcggcccg ccggggtgca cctctcaggc ctgcagccct cggccggcca
     1081 gttcttcgca tctctagatc ccattaacga ggcttctgca atcctgagtc ccttaaactc
     1141 gaacccaaga aattcagttc agcatcagtt ccaagacacg tttccaggtc cctatgctgt
     1201 gctcacgaag gacaccatgc cgcagacgta caaaaggaag cgttcatggt cgcgcgctgt
     1261 gttctccaac ctgcagagga aaggcctgga gaaaaggttt gagattcaga agtacgtgac
     1321 caagccggac cgaaagcagc tggcggcgat gctgggcctc acggacgcac aggtgaaggt
     1381 gtggttccag aaccggcgga tgaagtggcg gcactccaag gaggcccagg cccaaaagga
     1441 caaggacaag gaggctggcg agaagccatc aggtggagcc ccggctgcgg atggcgagca
     1501 ggacgagagg agccccagcc gttctgaagg cgaggctgag agcgagagca gcgactccga
     1561 gtccctggac atggccccca gcgacacgga gcggactgag gggagtgagc gttctctgca
     1621 ccaaacaaca gttattaagg ccccggtcac tggcgccctc attaccgcca gcagtgctgg
     1681 gagtggtggg agcagcggcg gcggcggcaa tagtttcagc ttcagcagcg ccagcagtct
     1741 tagtagcagc agcaccagtg cgggttgcgc cagcagcctt ggcggcggcg gcgcctcgga
     1801 gcttctccct gcaacacagc ccacagccag cagcgctccc aaaagccccg agccagccca
     1861 aggcgcgctt ggctgcttat agactgtact agggcggagg ggatccgggc cttgcgtgca
     1921 gcctcccaac catgggctgg gttttgtgct tactgtatgt tggcgacttg gtagggcagg
     1981 agacgcagcg tggagcctac ctcccgacat tcacgcttcg ccccacgctg ctccgactgg
     2041 ctgcagcgga cactgcccaa agcagagggg agtctcagtg tcctgctagc cagccgaaca
     2101 cttctctccg gaagcaggct ggttcgactg tgaggtgttt gactaaactg tttctctgac
     2161 tcgccccaga ggtcgtggct caaaggcact taggacgcct taaatttgta aataaaatgt
     2221 ttactacggt ttgtaaa
//
