LOCUS       NM_139048               4483 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens helicase like transcription factor (HLTF), transcript
            variant 2, mRNA.
ACCESSION   NM_139048
VERSION     NM_139048.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4483)
  AUTHORS   Bai,G., Endres,T., Kuhbacher,U., Mengoli,V., Greer,B.H.,
            Peacock,E.M., Newton,M.D., Stanage,T., Dello Stritto,M.R.,
            Lungu,R., Crossley,M.P., Sathirachinda,A., Cortez,D., Boulton,S.J.,
            Cejka,P., Eichman,B.F. and Cimprich,K.A.
  TITLE     HLTF resolves G4s and promotes G4-induced replication fork slowing
            to maintain genome stability
  JOURNAL   Mol Cell 84 (16), 3044-3060 (2024)
   PUBMED   39142279
  REMARK    GeneRIF: HLTF resolves G4s and promotes G4-induced replication fork
            slowing to maintain genome stability.
REFERENCE   2  (bases 1 to 4483)
  AUTHORS   Beauvois,A., Gazon,H., Chauhan,P.S., Jamakhani,M., Jacques,J.R.,
            Thiry,M., Dejardin,E., Valentin,E.D., Twizere,J.C.,
            Peloponese,J.M., Njock,M.S., Yasunaga,J.I., Matsuoka,M.,
            Hamaidia,M. and Willems,L.
  TITLE     The helicase-like transcription factor redirects the autophagic
            flux and restricts human T cell leukemia virus type 1 infection
  JOURNAL   Proc Natl Acad Sci U S A 120 (31), e2216127120 (2023)
   PUBMED   37487091
  REMARK    GeneRIF: The helicase-like transcription factor redirects the
            autophagic flux and restricts human T cell leukemia virus type 1
            infection.
REFERENCE   3  (bases 1 to 4483)
  AUTHORS   Helmer,R.A., Martinez-Zaguilan,R., Kaur,G., Smith,L.A., Dufour,J.M.
            and Chilton,B.S.
  TITLE     Helicase-like transcription factor-deletion from the tumor
            microenvironment in a cell line-derived xenograft model of
            colorectal cancer reprogrammed the human
            transcriptome-S-nitroso-proteome to promote inflammation and
            redirect metastasis
  JOURNAL   PLoS One 16 (5), e0251132 (2021)
   PUBMED   34010296
  REMARK    GeneRIF: Helicase-like transcription factor-deletion from the tumor
            microenvironment in a cell line-derived xenograft model of
            colorectal cancer reprogrammed the human
            transcriptome-S-nitroso-proteome to promote inflammation and
            redirect metastasis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4483)
  AUTHORS   Joseph,S.A., Taglialatela,A., Leuzzi,G., Huang,J.W.,
            Cuella-Martin,R. and Ciccia,A.
  TITLE     Time for remodeling: SNF2-family DNA translocases in replication
            fork metabolism and human disease
  JOURNAL   DNA Repair (Amst) 95, 102943 (2020)
   PUBMED   32971328
  REMARK    GeneRIF: Time for remodeling: SNF2-family DNA translocases in
            replication fork metabolism and human disease.
            Review article
REFERENCE   5  (bases 1 to 4483)
  AUTHORS   Gong,X., Kaushal,S., Ceccarelli,E., Bogdanova,N., Neville,C.,
            Nguyen,T., Clark,H., Khatib,Z.A., Valentine,M., Look,A.T. and
            Rosenthal,N.
  TITLE     Developmental regulation of Zbu1, a DNA-binding member of the
            SWI2/SNF2 family
  JOURNAL   Dev Biol 183 (2), 166-182 (1997)
   PUBMED   9126292
REFERENCE   6  (bases 1 to 4483)
  AUTHORS   Ding,H., Descheemaeker,K., Marynen,P., Nelles,L., Carvalho,T.,
            Carmo-Fonseca,M., Collen,D. and Belayew,A.
  TITLE     Characterization of a helicase-like transcription factor involved
            in the expression of the human plasminogen activator inhibitor-1
            gene
  JOURNAL   DNA Cell Biol 15 (6), 429-442 (1996)
   PUBMED   8672239
REFERENCE   7  (bases 1 to 4483)
  AUTHORS   Lin,Y., Sheridan,P.L., Jones,K.A. and Evans,G.A.
  TITLE     The HIP116 SNF2/SW12-related transcription factor gene (SNF2L3) is
            located on human chromosome 3q25.1-q26.1
  JOURNAL   Genomics 27 (2), 381-382 (1995)
   PUBMED   7558014
REFERENCE   8  (bases 1 to 4483)
  AUTHORS   Sheridan,P.L., Schorpp,M., Voz,M.L. and Jones,K.A.
  TITLE     Cloning of an SNF2/SWI2-related protein that binds specifically to
            the SPH motifs of the SV40 enhancer and to the HIV-1 promoter
  JOURNAL   J Biol Chem 270 (9), 4575-4587 (1995)
   PUBMED   7876228
REFERENCE   9  (bases 1 to 4483)
  AUTHORS   Descheemaeker,K.
  TITLE     On the regulation of the plasminogen activator inhibitor-1 gene
            expression
  JOURNAL   Verh K Acad Geneeskd Belg 55 (3), 225-264 (1993)
   PUBMED   8342330
REFERENCE   10 (bases 1 to 4483)
  AUTHORS   Osborn,M., Johnsson,N., Wehland,J. and Weber,K.
  TITLE     The submembranous location of p11 and its interaction with the p36
            substrate of pp60 src kinase in situ
  JOURNAL   Exp Cell Res 175 (1), 81-96 (1988)
   PUBMED   3126079
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC030976.1, L34673.1,
            AI971472.1 and AC021059.25.
            
            On May 31, 2019 this sequence version replaced NM_139048.2.
            
            Summary: This gene encodes a member of the SWI/SNF family. Members
            of this family have helicase and ATPase activities and are thought
            to regulate transcription of certain genes by altering the
            chromatin structure around those genes. The encoded protein
            contains a RING finger DNA binding motif. Two transcript variants
            encoding the same protein have been found for this gene. However,
            use of an alternative translation start site produces an isoform
            that is truncated at the N-terminus compared to the full-length
            protein. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 3' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L34673.1, SRR18074969.1069871.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               BC030976.1         22-325
            305-1105            L34673.1           285-1085
            1106-1343           AI971472.1         208-445             c
            1344-3438           L34673.1           1324-3418
            3439-4483           AC021059.25        61429-62473         c
FEATURES             Location/Qualifiers
     source          1..4483
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q24"
     gene            1..4483
                     /gene="HLTF"
                     /gene_synonym="HIP116; HIP116A; HLTF1; RNF80; SMARCA3;
                     SNF2L3; ZBU1"
                     /note="helicase like transcription factor"
                     /db_xref="GeneID:6596"
                     /db_xref="HGNC:HGNC:11099"
                     /db_xref="MIM:603257"
     exon            1..217
                     /gene="HLTF"
                     /gene_synonym="HIP116; HIP116A; HLTF1; RNF80; SMARCA3;
                     SNF2L3; ZBU1"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..3227
                     /gene="HLTF"
                     /gene_synonym="HIP116; HIP116A; HLTF1; RNF80; SMARCA3;
                     SNF2L3; ZBU1"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 2;
                     sucrose nonfermenting-like 3; DNA-binding
                     protein/plasminogen activator inhibitor-1 regulator;
                     SNF2-like 3; RING finger protein 80; sucrose nonfermenting
                     protein 2-like 3; SWI/SNF-related matrix-associated
                     actin-dependent regulator of chromatin subfamily A member
                     3; RING-type E3 ubiquitin transferase HLTF; SWI/SNF
                     related, matrix associated, actin dependent regulator of
                     chromatin, subfamily a, member 3"
                     /codon_start=1
                     /product="helicase-like transcription factor isoform 1"
                     /protein_id="NP_620636.1"
                     /db_xref="CCDS:CCDS33875.1"
                     /db_xref="GeneID:6596"
                     /db_xref="HGNC:HGNC:11099"
                     /db_xref="MIM:603257"
                     /translation="MSWMFKRDPVWKYLQTVQYGVHGNFPRLSYPTFFPRFEFQDVIP
                     PDDFLTSDEEVDSVLFGSLRGHVVGLRYYTGVVNNNEMVALQRDPNNPYDKNAIKVNN
                     VNGNQVGHLKKELAGALAYIMDNKLAQIEGVVPFGANNAFTMPLHMTFWGKEENRKAV
                     SDQLKKHGFKLGPAPKTLGFNLESGWGSGRAGPSYSMPVHAAVQMTTEQLKTEFDKLF
                     EDLKEDDKTHEMEPAEAIETPLLPHQKQALAWMVSRENSKELPPFWEQRNDLYYNTIT
                     NFSEKDRPENVHGGILADDMGLGKTLTAIAVILTNFHDGRPLPIERVKKNLLKKEYNV
                     NDDSMKLGGNNTSEKADGLSKDASRCSEQPSISDIKEKSKFRMSELSSSRPKRRKTAV
                     QYIESSDSEEIETSELPQKMKGKLKNVQSETKGRAKAGSSKVIEDVAFACALTSSVPT
                     TKKKMLKKGACAVEGSKKTDVEERPRTTLIICPLSVLSNWIDQFGQHIKSDVHLNFYV
                     YYGPDRIREPALLSKQDIVLTTYNILTHDYGTKGDSPLHSIRWLRVILDEGHAIRNPN
                     AQQTKAVLDLESERRWVLTGTPIQNSLKDLWSLLSFLKLKPFIDREWWHRTIQRPVTM
                     GDEGGLRRLQSLIKNITLRRTKTSKIKGKPVLELPERKVFIQHITLSDEERKIYQSVK
                     NEGRATIGRYFNEGTVLAHYADVLGLLLRLRQICCHTYLLTNAVSSNGPSGNDTPEEL
                     RKKLIRKMKLILSSGSDEECAICLDSLTVPVITHCAHVFCKPCICQVIQNEQPHAKCP
                     LCRNDIHEDNLLECPPEELARDSEKKSDMEWTSSSKINALMHALTDLRKKNPNIKSLV
                     VSQFTTFLSLIEIPLKASGFVFTRLDGSMAQKKRVESIQCFQNTEAGSPTIMLLSLKA
                     GGVGLNLSAASRVFLMDPAWNPAAEDQCFDRCHRLGQKQEVIITKFIVKDSVEENMLK
                     IQNKKRELAAGAFGTKKPNADEMKQAKINEIRTLIDL"
     exon            218..425
                     /gene="HLTF"
                     /gene_synonym="HIP116; HIP116A; HLTF1; RNF80; SMARCA3;
                     SNF2L3; ZBU1"
                     /inference="alignment:Splign:2.1.0"
     exon            426..592
                     /gene="HLTF"
                     /gene_synonym="HIP116; HIP116A; HLTF1; RNF80; SMARCA3;
                     SNF2L3; ZBU1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..726
                     /gene="HLTF"
                     /gene_synonym="HIP116; HIP116A; HLTF1; RNF80; SMARCA3;
                     SNF2L3; ZBU1"
                     /inference="alignment:Splign:2.1.0"
     exon            727..824
                     /gene="HLTF"
                     /gene_synonym="HIP116; HIP116A; HLTF1; RNF80; SMARCA3;
                     SNF2L3; ZBU1"
                     /inference="alignment:Splign:2.1.0"
     exon            825..899
                     /gene="HLTF"
                     /gene_synonym="HIP116; HIP116A; HLTF1; RNF80; SMARCA3;
                     SNF2L3; ZBU1"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1091
                     /gene="HLTF"
                     /gene_synonym="HIP116; HIP116A; HLTF1; RNF80; SMARCA3;
                     SNF2L3; ZBU1"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1187
                     /gene="HLTF"
                     /gene_synonym="HIP116; HIP116A; HLTF1; RNF80; SMARCA3;
                     SNF2L3; ZBU1"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1263
                     /gene="HLTF"
                     /gene_synonym="HIP116; HIP116A; HLTF1; RNF80; SMARCA3;
                     SNF2L3; ZBU1"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1357
                     /gene="HLTF"
                     /gene_synonym="HIP116; HIP116A; HLTF1; RNF80; SMARCA3;
                     SNF2L3; ZBU1"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1437
                     /gene="HLTF"
                     /gene_synonym="HIP116; HIP116A; HLTF1; RNF80; SMARCA3;
                     SNF2L3; ZBU1"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1482
                     /gene="HLTF"
                     /gene_synonym="HIP116; HIP116A; HLTF1; RNF80; SMARCA3;
                     SNF2L3; ZBU1"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1572
                     /gene="HLTF"
                     /gene_synonym="HIP116; HIP116A; HLTF1; RNF80; SMARCA3;
                     SNF2L3; ZBU1"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1670
                     /gene="HLTF"
                     /gene_synonym="HIP116; HIP116A; HLTF1; RNF80; SMARCA3;
                     SNF2L3; ZBU1"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1814
                     /gene="HLTF"
                     /gene_synonym="HIP116; HIP116A; HLTF1; RNF80; SMARCA3;
                     SNF2L3; ZBU1"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1953
                     /gene="HLTF"
                     /gene_synonym="HIP116; HIP116A; HLTF1; RNF80; SMARCA3;
                     SNF2L3; ZBU1"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2089
                     /gene="HLTF"
                     /gene_synonym="HIP116; HIP116A; HLTF1; RNF80; SMARCA3;
                     SNF2L3; ZBU1"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2269
                     /gene="HLTF"
                     /gene_synonym="HIP116; HIP116A; HLTF1; RNF80; SMARCA3;
                     SNF2L3; ZBU1"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2394
                     /gene="HLTF"
                     /gene_synonym="HIP116; HIP116A; HLTF1; RNF80; SMARCA3;
                     SNF2L3; ZBU1"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2573
                     /gene="HLTF"
                     /gene_synonym="HIP116; HIP116A; HLTF1; RNF80; SMARCA3;
                     SNF2L3; ZBU1"
                     /inference="alignment:Splign:2.1.0"
     exon            2574..2699
                     /gene="HLTF"
                     /gene_synonym="HIP116; HIP116A; HLTF1; RNF80; SMARCA3;
                     SNF2L3; ZBU1"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..2812
                     /gene="HLTF"
                     /gene_synonym="HIP116; HIP116A; HLTF1; RNF80; SMARCA3;
                     SNF2L3; ZBU1"
                     /inference="alignment:Splign:2.1.0"
     exon            2813..2993
                     /gene="HLTF"
                     /gene_synonym="HIP116; HIP116A; HLTF1; RNF80; SMARCA3;
                     SNF2L3; ZBU1"
                     /inference="alignment:Splign:2.1.0"
     exon            2994..3074
                     /gene="HLTF"
                     /gene_synonym="HIP116; HIP116A; HLTF1; RNF80; SMARCA3;
                     SNF2L3; ZBU1"
                     /inference="alignment:Splign:2.1.0"
     exon            3075..3246
                     /gene="HLTF"
                     /gene_synonym="HIP116; HIP116A; HLTF1; RNF80; SMARCA3;
                     SNF2L3; ZBU1"
                     /inference="alignment:Splign:2.1.0"
     exon            3247..4483
                     /gene="HLTF"
                     /gene_synonym="HIP116; HIP116A; HLTF1; RNF80; SMARCA3;
                     SNF2L3; ZBU1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4465..4470
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HLTF"
                     /gene_synonym="HIP116; HIP116A; HLTF1; RNF80; SMARCA3;
                     SNF2L3; ZBU1"
                     /note="hexamer: AATAAA"
     polyA_site      4483
                     /gene="HLTF"
                     /gene_synonym="HIP116; HIP116A; HLTF1; RNF80; SMARCA3;
                     SNF2L3; ZBU1"
                     /note="major polyA site"
ORIGIN      
        1 agattgttgc agaaggagac ggcgtcgacg tctgactgga ctcgcggcga cttacctttc
       61 agtcgtgcgc tcctgatccg gcgctcggaa tttgtccccg gcttcagggc tgcggggcct
      121 ggaaggaggc gtatcgaggc ggctcgaaaa cgatccaggg gagccgaggc gctcctcttg
      181 tcatcccact cagcgccatg tcctggatgt tcaagaggga tccagtttgg aagtacttgc
      241 agactgtcca gtatggagtt catggaaatt ttccacgcct ctcatatcca actttctttc
      301 cacgttttga attccaagat gttatccctc cagatgactt tctaactagt gatgaagaag
      361 tagattccgt tttatttgga agtttgagag gtcatgtggt tggactacgc tattacacgg
      421 gagtagttaa taataatgaa atggttgcat tacaacgaga tcctaataac ccttatgata
      481 agaatgcaat taaagtaaac aatgtgaatg gaaatcaagt tggccattta aagaaagagc
      541 ttgcaggtgc tttggcctat atcatggaca acaaattggc acaaattgaa ggggtagttc
      601 cttttggtgc aaacaatgct tttaccatgc ctctgcatat gactttttgg ggaaaagaag
      661 aaaatagaaa agcggtttca gatcagttga agaaacatgg atttaaattg ggtcctgcac
      721 caaaaacttt aggattcaat ttggaaagtg gttggggctc tggaagagct ggaccaagct
      781 atagtatgcc agtgcatgct gcagtacaga tgacaactga acagcttaaa acagaatttg
      841 acaaattgtt tgaagattta aaagaagatg ataaaaccca tgaaatggaa ccagctgagg
      901 ctattgaaac accactgctt ccacatcaaa aacaagctct agcttggatg gtgtcacggg
      961 aaaatagcaa agaacttcca ccattctggg aacagcgaaa tgacttatac tataacacaa
     1021 taacaaattt ttctgagaag gaccgaccag aaaatgtcca tggaggaatt ttagctgatg
     1081 atatgggttt gggtaaaact cttacggcca ttgcagtaat ccttaccaac ttccatgatg
     1141 gcagacctct tcctattgaa agagttaaaa agaatctact gaagaaggaa tataatgtta
     1201 acgatgactc tatgaaactt ggaggaaaca ataccagtga aaaggcagat ggactaagca
     1261 aagacgcatc tagatgtagt gaacaaccca gtatttcaga tatcaaggag aagagtaagt
     1321 ttcgcatgtc agaattgtct agctcccgcc ccaaaagaag aaaaactgct gtccagtaca
     1381 tagaaagcag tgattcagag gaaattgaaa caagtgaatt gccgcagaaa atgaaaggca
     1441 aactgaaaaa tgtacagtct gaaactaaag gcagggcgaa agcaggatct tctaaggtta
     1501 tagaagatgt ggcatttgca tgtgcattaa cttcatctgt tcctacaaca aaaaagaaaa
     1561 tgttgaaaaa gggagcttgt gcagtggagg ggtcaaagaa aactgatgtt gaggagagac
     1621 caagaacaac actgatcatc tgtccgcttt ctgtgttaag caactggatt gaccagtttg
     1681 gacaacatat aaaatcagat gtacacttga atttttatgt ttattatggt cctgatcgta
     1741 ttagagaacc ggccttactt tcaaaacagg atattgtttt gactacgtat aatattttaa
     1801 ctcatgacta tggaactaaa ggagatagtc cattacatag cataaggtgg ctaagagtga
     1861 tcctggatga aggacatgcc atacgaaatc caaatgctca gcagacaaaa gctgtacttg
     1921 acttagaatc agaaagaaga tgggttttga caggtactcc aatccagaat tctttaaagg
     1981 acttgtggtc tcttctttcc tttttaaaac ttaaaccatt tattgataga gaatggtggc
     2041 atagaacaat acagcgtcct gtcacaatgg gagatgaagg aggacttagg cgtttacagt
     2101 ccctaattaa aaatattaca cttagaagaa caaagacaag caaaattaaa ggaaaacctg
     2161 ttttggagtt accagaacgt aaagtattta ttcagcacat tacactttca gatgaagaga
     2221 gaaagattta tcagtctgtg aaaaatgaag gcagagccac tattggaagg tattttaatg
     2281 aagggactgt cctggcacat tatgcagatg tcctgggtct tttgcttaga ctgcggcaaa
     2341 tttgttgcca tacttacctt cttacaaatg cagtgtcttc caatggcccc tcaggaaatg
     2401 atacacctga agaactgaga aagaagttaa taaggaagat gaagttaatt ctgagctcag
     2461 gttcagatga ggaatgtgca atttgcctgg attctttaac agttcctgtg ataacacatt
     2521 gtgcacatgt attttgtaaa ccctgtattt gccaagtcat tcagaatgag cagccacatg
     2581 ctaaatgccc tttatgcaga aatgatatac atgaagataa tttattagaa tgtcctccag
     2641 aagaattagc acgtgacagt gagaaaaagt ctgatatgga atggacatcc agttcaaaga
     2701 ttaatgcgct aatgcacgca ttgactgact taagaaagaa gaatcccaac ataaaaagtt
     2761 tggttgtttc tcagtttaca acattcctgt ctttaataga aataccactt aaagcctctg
     2821 gatttgtgtt tactcgtttg gatggttcca tggcccaaaa gaaaagagtt gaatcaattc
     2881 agtgttttca aaacactgaa gcaggatctc caactataat gcttctgtcc ttaaaagcag
     2941 gtggagttgg tttgaatctg tctgcagctt ctcgagtgtt tttaatggat ccagcctgga
     3001 atcctgctgc tgaagatcag tgctttgaca gatgccatag acttggtcag aagcaagaag
     3061 ttatcatcac aaaattcatt gtaaaggact ctgttgaaga aaatatgctg aaaatacaaa
     3121 acaaaaagag agaacttgca gcaggagcct ttggaactaa aaaaccaaat gctgacgaaa
     3181 tgaaacaagc caaaattaat gaaatcagaa cattaattga cttataattt gtgggatttt
     3241 agtaagaaga ctactatatg tgagaggcgt gatatctgga tggaagttgg gctggatgat
     3301 ctccaaagtc gtttcaactc ttaaagacat cttaatcctg aatgtaaaca attgttatgt
     3361 gtttagaatc agaatttgat tttgaacttg agtaattcat ccttacagct atctgtagaa
     3421 ttagtcatct tttttctttt cttttttttt tacttttttg ttaataagca aacttatttg
     3481 ctgcagaatt tgggttgact cctgagcata tttaaaacaa agaagctaga aatttagcag
     3541 tcagattagg taggtggttt tatttcaaag ggaaacttta atccaaagaa agattaatta
     3601 ctctaacaaa caagagaagc ttcatgtttg atgatacaga tttaagaata cctgagactt
     3661 aagagtgttg gaagtcattt gatagaaaga tgagatcgga gacaatgttg tgttataggg
     3721 cacacattga aggtatatgc caaatctctc accagataag tccttttctc cctgtgccgt
     3781 tttcttgctc aaagggaaca gtgaattagc cagctagaat cttcctggtc cctttttgag
     3841 gcagtagcag gtaaggaaag ggctgatttt catcaaaacc aagacctttc tgcagggatg
     3901 atagtggaat aataatgtgg gattagcccg ctagcattag gagcagttgg gaagttacct
     3961 ggtagatcaa gcattacaca caaaaaatca agttgatcag agtatgggtt ctccatatag
     4021 caatacttca gtgagattaa gtataaacag tttttggcaa aaaacaacac agtctactct
     4081 ttctgcttac aaagacaaag ccttacaaac tcactatgaa ggtaaaggga ggacagcttg
     4141 cttctttgcc cagacattta caaagttgtt tttaaaacac actcataagt aagtttggca
     4201 agttgtttaa aaaatgtctc tttgttttgt acagttctgt tagatgttgt tatattttaa
     4261 aagtttaatt taaaaaattt aatttgtcct tcctaagaag gataaatata taaaaaagcc
     4321 actggaatga aaacttccta tatgctatgc tgttgtctta ttattatata gaaaaataac
     4381 tttagaaaaa tattgaagac attgtattac cacttgtgat tcaaacaatt ttgtggttaa
     4441 aactggattt taaatttaaa aatcaataaa aatttcaaat gtt
//
