LOCUS       NM_002126               5721 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens HLF transcription factor, PAR bZIP family member
            (HLF), transcript variant 1, mRNA.
ACCESSION   NM_002126
VERSION     NM_002126.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5721)
  AUTHORS   Zhou,H. and Wang,F.
  TITLE     Tensin 1 regulated by hepatic leukemia factor represses the
            progression of prostate cancer
  JOURNAL   Mutagenesis 38 (6), 295-304 (2023)
   PUBMED   37712764
  REMARK    GeneRIF: Tensin 1 regulated by hepatic leukemia factor represses
            the progression of prostate cancer.
REFERENCE   2  (bases 1 to 5721)
  AUTHORS   Han,T., Chen,T., Chen,L., Li,K., Xiang,D., Dou,L., Li,H. and Gu,Y.
  TITLE     HLF promotes ovarian cancer progression and chemoresistance via
            regulating Hippo signaling pathway
  JOURNAL   Cell Death Dis 14 (9), 606 (2023)
   PUBMED   37709768
  REMARK    GeneRIF: HLF promotes ovarian cancer progression and
            chemoresistance via regulating Hippo signaling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5721)
  AUTHORS   Xiang,D., Gu,M., Liu,J., Dong,W., Yang,Z., Wang,K., Fu,J. and
            Wang,H.
  TITLE     m6A RNA methylation-mediated upregulation of HLF promotes
            intrahepatic cholangiocarcinoma progression by regulating the
            FZD4/beta-catenin signaling pathway
  JOURNAL   Cancer Lett 560, 216144 (2023)
   PUBMED   36958694
  REMARK    GeneRIF: m6A RNA methylation-mediated upregulation of HLF promotes
            intrahepatic cholangiocarcinoma progression by regulating the
            FZD4/beta-catenin signaling pathway.
REFERENCE   4  (bases 1 to 5721)
  AUTHORS   Li,H., Yang,P., Wang,J., Zhang,J., Ma,Q., Jiang,Y., Wu,Y., Han,T.
            and Xiang,D.
  TITLE     HLF regulates ferroptosis, development and chemoresistance of
            triple-negative breast cancer by activating tumor cell-macrophage
            crosstalk
  JOURNAL   J Hematol Oncol 15 (1), 2 (2022)
   PUBMED   34991659
  REMARK    GeneRIF: HLF regulates ferroptosis, development and chemoresistance
            of triple-negative breast cancer by activating tumor
            cell-macrophage crosstalk.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5721)
  AUTHORS   Hu,P., Guo,J., Zhao,B., Zhang,Z., Zhu,J. and Liu,F.
  TITLE     CircCHD2/miR-200b-3p/HLF Axis Promotes Liver Cirrhosis
  JOURNAL   J Environ Pathol Toxicol Oncol 41 (4), 1-10 (2022)
   PUBMED   36374958
  REMARK    GeneRIF: CircCHD2/miR-200b-3p/HLF Axis Promotes Liver Cirrhosis.
REFERENCE   6  (bases 1 to 5721)
  AUTHORS   Falvey,E., Fleury-Olela,F. and Schibler,U.
  TITLE     The rat hepatic leukemia factor (HLF) gene encodes two
            transcriptional activators with distinct circadian rhythms, tissue
            distributions and target preferences
  JOURNAL   EMBO J 14 (17), 4307-4317 (1995)
   PUBMED   7556072
  REMARK    GeneRIF: The authors characterize variants of rat HLF, including
            use of two alternative promoters and a non-AUG translation
            initiation site that has not been confirmed in human.
REFERENCE   7  (bases 1 to 5721)
  AUTHORS   Hunger,S.P., Brown,R. and Cleary,M.L.
  TITLE     DNA-binding and transcriptional regulatory properties of hepatic
            leukemia factor (HLF) and the t(17;19) acute lymphoblastic leukemia
            chimera E2A-HLF
  JOURNAL   Mol Cell Biol 14 (9), 5986-5996 (1994)
   PUBMED   8065331
REFERENCE   8  (bases 1 to 5721)
  AUTHORS   Inaba,T., Shapiro,L.H., Funabiki,T., Sinclair,A.E., Jones,B.G.,
            Ashmun,R.A. and Look,A.T.
  TITLE     DNA-binding specificity and trans-activating potential of the
            leukemia-associated E2A-hepatic leukemia factor fusion protein
  JOURNAL   Mol Cell Biol 14 (5), 3403-3413 (1994)
   PUBMED   8164688
REFERENCE   9  (bases 1 to 5721)
  AUTHORS   Hunger,S.P., Ohyashiki,K., Toyama,K. and Cleary,M.L.
  TITLE     Hlf, a novel hepatic bZIP protein, shows altered DNA-binding
            properties following fusion to E2A in t(17;19) acute lymphoblastic
            leukemia
  JOURNAL   Genes Dev 6 (9), 1608-1620 (1992)
   PUBMED   1516826
REFERENCE   10 (bases 1 to 5721)
  AUTHORS   Inaba,T., Roberts,W.M., Shapiro,L.H., Jolly,K.W., Raimondi,S.C.,
            Smith,S.D. and Look,A.T.
  TITLE     Fusion of the leucine zipper gene HLF to the E2A gene in human
            acute B-lineage leukemia
  JOURNAL   Science 257 (5069), 531-534 (1992)
   PUBMED   1386162
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA104709.1, BC036093.1,
            M95585.1, AF035305.1, AA021027.1 and AC007638.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002126.4.
            
            Summary: This gene encodes a member of the proline and acidic-rich
            (PAR) protein family, a subset of the bZIP transcription factors.
            The encoded protein forms homodimers or heterodimers with other PAR
            family members and binds sequence-specific promoter elements to
            activate transcription. Chromosomal translocations fusing portions
            of this gene with the E2A gene cause a subset of childhood
            B-lineage acute lymphoid leukemias. Alternatively spliced
            transcript variants have been described, but their biological
            validity has not been determined. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.43262.1,
                                           SRR1660809.156869.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000226067.10/ ENSP00000226067.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               DA104709.1         1-131
            132-486             BC036093.1         82-436
            487-1631            BC036093.1         441-1585
            1632-4065           M95585.1           1429-3862
            4066-5343           AF035305.1         201-1478
            5344-5599           AA021027.1         9-264               c
            5600-5721           AC007638.8         78735-78856         c
FEATURES             Location/Qualifiers
     source          1..5721
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q22"
     gene            1..5721
                     /gene="HLF"
                     /note="HLF transcription factor, PAR bZIP family member"
                     /db_xref="GeneID:3131"
                     /db_xref="HGNC:HGNC:4977"
                     /db_xref="MIM:142385"
     exon            1..640
                     /gene="HLF"
                     /inference="alignment:Splign:2.1.0"
     CDS             526..1413
                     /gene="HLF"
                     /note="isoform 1 is encoded by transcript variant 1;
                     hepatic leukemia factor; HLF, PAR bZIP transcription
                     factor; E2A-HLF fusion transcript protein"
                     /codon_start=1
                     /product="hepatic leukemia factor isoform 1"
                     /protein_id="NP_002117.1"
                     /db_xref="CCDS:CCDS11585.1"
                     /db_xref="GeneID:3131"
                     /db_xref="HGNC:HGNC:4977"
                     /db_xref="MIM:142385"
                     /translation="MEKMSRPLPLNPTFIPPPYGVLRSLLENPLKLPLHHEDAFSKDK
                     DKEKKLDDESNSPTVPQSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSENGIPPSPS
                     QHDHSPHPPGLQPASSAAPSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNT
                     PSPIDPDTIQVPVGYEPDPADLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVF
                     IPDDLKDDKYWARRRKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRK
                     ELGKCKNILAKYEARHGPL"
     exon            641..976
                     /gene="HLF"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1197
                     /gene="HLF"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..5721
                     /gene="HLF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3498..3503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HLF"
                     /note="hexamer: ATTAAA"
     polyA_site      3523
                     /gene="HLF"
                     /note="major polyA site"
     regulatory      5575..5580
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HLF"
                     /note="hexamer: AATAAA"
     polyA_site      5599
                     /gene="HLF"
                     /note="major polyA site"
     regulatory      5692..5697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HLF"
                     /note="hexamer: AATAAA"
     polyA_site      5721
                     /gene="HLF"
ORIGIN      
        1 actcttgtca gggccgcggc acatgggcgg ccggatgcgc tgagcccggc gctgcggggc
       61 cgcggagcgc tggggagcag cggccgccgg cgcggggagg ggggtggggt gggacggcgc
      121 accgcctccg gtgctggcac taggggctgg ggtcggcgcg gtgtcttctg cccttctgca
      181 gccgtcgaca tttttttttc tttctttttt tcaattttga acattttgca aaacgagggg
      241 ttcgaggcag gtgagagcat cctgcacgtc gccggggagc ccgcgggcac ttggcgcgct
      301 ctcctgggac cgtctgcact ggaaacccga aagttttttt ttaatatata tttttatgca
      361 gatgtattta taaagatata agtaattttt ttcttccctt ttctccaccg ccttgagagc
      421 gagtactttt ggcaaaggac ggaggaaaag ctcagcaaca ttttaggggg cggttgtttc
      481 tttcttattt ctttttttaa ggggaaaaaa tttgagtgca tcgcgatgga gaaaatgtcc
      541 cgaccgctcc ccctgaatcc cacctttatc ccgcctccct acggcgtgct caggtccctg
      601 ctggagaacc cgctgaagct cccccttcac cacgaagacg catttagtaa agataaagac
      661 aaggaaaaga agctggatga tgagagtaac agcccgacgg tcccccagtc ggcattcctg
      721 gggcctacct tatgggacaa aacccttccc tatgacggag atactttcca gttggaatac
      781 atggacctgg aggagttttt gtcagaaaat ggcattcccc ccagcccatc tcagcatgac
      841 cacagccctc accctcctgg gctgcagcca gcttcctcgg ctgccccctc ggtcatggac
      901 ctcagcagcc gggcctctgc accccttcac cctggcatcc catctccgaa ctgtatgcag
      961 agccccatca gaccaggtca gctgttgcca gcaaaccgca atacaccaag tcccattgat
     1021 cctgacacca tccaggtccc agtgggttat gagccagacc cagcagatct tgccctttcc
     1081 agcatccctg gccaggaaat gtttgaccct cgcaaacgca agttctctga ggaagaactg
     1141 aagccacagc ccatgatcaa gaaagctcgc aaagtcttca tccctgatga cctgaaggat
     1201 gacaagtact gggcaaggcg cagaaagaac aacatggcag ccaagcgctc ccgcgacgcc
     1261 cggaggctga aagagaacca gatcgccatc cgggcctcgt tcctggagaa ggagaactcg
     1321 gccctccgcc aggaggtggc tgacttgagg aaggagctgg gcaaatgcaa gaacatactt
     1381 gccaagtatg aggccaggca cgggcccctg taggatggca tttttgcagg ctggctttgg
     1441 aatagatgga cagtttgttt cctgtctgat agcaccacac gcaaaccaac ctttctgaca
     1501 tcagcacttt accagaggca taaacacaac tgactcccat tttggtgtgc atctgtgtgt
     1561 gtgtgcgtgt atatgtgctt gtgctcatgt gtgtggtcag cggtatgtgc gtgtgcgtgt
     1621 tcctttgctc ttgccatttt aaggtagccc tctcatcgtc ttttagttcc aacaaagaaa
     1681 ggtgccatgt ctttactaga ctgaggagcc ctctcgcggg tctcccatcc cctccctcct
     1741 tcactcctgc ctcctcagct ttgcttcatg ttcgagctta cctactcttc caggactctc
     1801 tgcttggatt cactaaaaag ggccctggta aaatagtgga tctcagtttt taagagtaca
     1861 agctcttgtt tctgtttagt ccgtaagtta ccatgctaat gaggtgcaca caataactta
     1921 gcactactcc gcagctctag tcctttataa gttgctttcc tcttactttc agttttggtg
     1981 ataatcgtct tcaaattaaa gtgctgttta gatttattag atcccatatt tacttactgc
     2041 tatctactaa gtttcctttt aattctacca accccagata agtaagagta ctattaatag
     2101 aacacagagt gtgtttttgc actgtctgta cctaaagcaa taatcctatt gtacgctaga
     2161 gcatgctgcc tgagtattac tagtggacgt aggatatttt ccctacctaa gaatttcact
     2221 gtcttttaaa aaacaaaaag taaagtaatg catttgagca tggccagact attccctagg
     2281 acaaggaagc agagggaaat gggaggtcta aggatgaggg gttaatttat cagtacatga
     2341 gccaaaaact gcgtcttgga ttagcctttg acattgatgt gttcggtttt gttgttcccc
     2401 ttccctcaca ccctgcctcg cccccacttt tctagttaac tttttccata tccctcttga
     2461 cattcaaaac agttacttaa gattcagttt tcccactttt tggtaatata tatatttttg
     2521 tgaattatac tttgttgttt ttaaaaagaa aatcagttga ttaagttaat aagttgatgt
     2581 tttctaaggc cctttttcct agtggtgtca tttttgaatg cctcataaat taatgattct
     2641 gaagcttatg tttcttattc tctgtttgct tttgaacgta tgtgctctta taaagtggac
     2701 ttctgaaaaa tgaatgtaaa agacactggt gtatctcaga aggggatggt gttgtcacaa
     2761 actgtggtta atccaatcaa tttaaatgtt tactatagac caaaaggaga gattattaaa
     2821 tcgtttaatg tttatacaga gtaattatag gaagttcttt tttgtacagt atttttcaga
     2881 tataaatact gacaatgtat tttggaagac atatattata tatagaaaag aggagaggaa
     2941 aactattcca tgttttaaaa ttatatagca aagatatata ttcaccaatg ttgtacagag
     3001 aagaagtgct tgggggtttt tgaagtcttt aatattttaa gccctatcac tgacacatca
     3061 gcatgttttc tgctttaaat taaaatttta tgacagtatc gaggcttgtg atgacgaatc
     3121 ctgctctaaa atacacaagg agctttcttg tttcttatta ggcctcagaa agaagtcagt
     3181 taacgtcacc caaaagcaca aaatggattt tagtcaaata tttattggat gatacagtgt
     3241 tttttaggaa aagcatctgc cacaaaaatg ttcacttcga aattctgagt tcctggaatg
     3301 gcacgttgct gccagtgccc cagacagttc ttttctaccc tgcgggcccg cacgttttat
     3361 gaggttgata tcggtgctat gtgtttggtt tataatttga tagatgtttg actttaaaga
     3421 tgattgttct tttgtttcat taagttgtaa aatgtcaaga aattctgctg ttacgacaaa
     3481 gaaacatttt acgctagatt aaaatatcct ttcatcaatg ggattttcta gtttcctgcc
     3541 ttcagagtat ctaatccttt aatgatctgg tggtctcctc gtcaatccat cagcaatgct
     3601 tctctcatag tgtcatagac ttgggaaacc caaccagtag gatatttcta caaggtgttc
     3661 attttgtcac aagctgtaga taacagcaag agatgggggt gtattggaat tgcaatacat
     3721 tgttcaggtg aataataaaa tcaaaaactt ttgcaatctt aagcagagat aaataaaaga
     3781 tagcaatatg agacacaggt ggacgtagag ttggcctttt tacaggcaaa gaggcgaatt
     3841 gtagaattgt tagatggcaa tagtcattaa aaacatagaa aaatgatgtc tttaagtgga
     3901 gaattgtgga aggattgtaa catggaccat ccaaatttat ggccgtatca aatggtagct
     3961 gaaaaaacta tatttgagca ctggtctctc ttggaattag atgtttatat caaatgagca
     4021 tctcaaatgt tttctgcaga aaaaaataaa aagattctaa taaaatgtat tctcttgtgt
     4081 gccaggagag gtttcagaaa cctacctcgt cttacaaatt taaacacttt ggagtctgta
     4141 caggtgcctt atatgtaggt cattgtcacg atacacacac acgaacactc cctctggact
     4201 ggctgcctct ccatccaggg cagttaacta gcaaacaagg cagatctgct tcatggagcg
     4261 ggaggccatg gcttgactct gagtgatttg ggtcaaccgg agtcagacgc atgtctgcac
     4321 gctgcagcta ttatgagagt ccctttgtca tttttcacct tttcatccta agcatctttc
     4381 agagattaat tatttggcca ttaacaatga atccaaatca tatcatactg acatcatcta
     4441 gacatgattt ggaaggaaca gcttaggacc tcctgatgag gtcacattgt tgtttctttt
     4501 aactagactt ggcaaagaaa ggcaaaaatt gaccagccta tctttctgct ggtgctgcct
     4561 taaggaggta gtttgttgag gggagggctg tagatcatta cttctttctc ttcaggaagt
     4621 ggccactttg aaccattcaa ataccacatt aggcaagact gtgataggcc ttttgtcttc
     4681 aaatacaaca ggcctccact gacccatccc tcaaagcaga aggacccttt gaggagagta
     4741 cagatgggat tccacagtgg ggtgggtgga atggaaacct gtactagacc acccagaggt
     4801 tccttctaac ccactggttt ggtggggaac tcacagtaat tccaaatgta caatcagatg
     4861 tctagggtct gttttcggaa gaagcaagaa ttatcagtgg caccctcccc actgccccca
     4921 gtgtaaaaca atagacattc tgtgaaatgc aaagctattc tttggttttt ctagtagttt
     4981 atctcatttt accctattct tcctttaagg aaaactcaat ctttatcaca gtcaattaga
     5041 gcgatcccaa ggcatgggac caggcctgct tgcctatgtg tgatggcaat tggagatctg
     5101 gatttagcac tggggtctca gcaccctgca ggtgtctgag actaagtgat ctgccctcca
     5161 ggtggcgatc accttctgct cctaggtacc cccactggca aggccaaggt ctcctccacg
     5221 ttttttctgc aattaataat gtcatttaaa aaatgagcaa agccttatcc gaatcggata
     5281 tagcaactaa agtcaataca ttttgcagga ggctaagtgt aagagtgtgt gtgtgtgtgt
     5341 gtgcgtgcat gtgtgtgtgt gtgtatgtgt gtgaataagt cgacataaag tctttaattt
     5401 tgagcacctt accaaacata acaataatcc attatccttt tggcaacacc acaaagatcg
     5461 catctgttaa acaggtacaa gttgacatga ggttagttta attgtacacc atgatattgg
     5521 tggtatttat gctgttaagt ccaaaccttt atctgtctgt tattcttaat gttgaataaa
     5581 ctttgaattt tttcctttct ttcatgtatt tttattaaca gttggctagc aatggtattc
     5641 tgttcccacc tcggtagcaa agagaccatt tgtagagatt attacctaga taataaaatg
     5701 ataatactat ataattagta a
//
