LOCUS       NM_001384290            1319 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens major histocompatibility complex, class I, G (HLA-G),
            transcript variant 4, mRNA.
ACCESSION   NM_001384290
VERSION     NM_001384290.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1319)
  AUTHORS   Suarez-Trujillo,F., Juarez,I., Vaquero-Yuste,C.,
            Gutierrez-Calvo,A., Lopez-Garcia,A., Lasa,I., Gomez,R.,
            Martin-Villa,J.M. and Arnaiz-Villena,A.
  TITLE     The Immune Modulation HLA-G*01:01:01 Full Allele Is Associated with
            Gastric Adenocarcinoma Development
  JOURNAL   Int J Mol Sci 25 (19), 10645 (2024)
   PUBMED   39408976
  REMARK    GeneRIF: The Immune Modulation HLA-G*01:01:01 Full Allele Is
            Associated with Gastric Adenocarcinoma Development.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1319)
  AUTHORS   Lintao,R.C.V., Richardson,L.S., Kammala,A.K., Chapa,J.,
            Yunque-Yap,D.A., Khanipov,K., Golovko,G., Dalmacio,L.M.M. and
            Menon,R.
  TITLE     PGRMC2 and HLA-G regulate immune homeostasis in a
            microphysiological model of human maternal-fetal membrane interface
  JOURNAL   Commun Biol 7 (1), 1041 (2024)
   PUBMED   39179795
  REMARK    GeneRIF: PGRMC2 and HLA-G regulate immune homeostasis in a
            microphysiological model of human maternal-fetal membrane
            interface.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1319)
  AUTHORS   Wang,J., Chai,Q., Lei,Z., Wang,Y., He,J., Ge,P., Lu,Z., Qiang,L.,
            Zhao,D., Yu,S., Qiu,C., Zhong,Y., Li,B.X., Zhang,L., Pang,Y.,
            Gao,G.F. and Liu,C.H.
  TITLE     LILRB1-HLA-G axis defines a checkpoint driving natural killer cell
            exhaustion in tuberculosis
  JOURNAL   EMBO Mol Med 16 (8), 1755-1790 (2024)
   PUBMED   39030302
  REMARK    GeneRIF: LILRB1-HLA-G axis defines a checkpoint driving natural
            killer cell exhaustion in tuberculosis.
REFERENCE   4  (bases 1 to 1319)
  AUTHORS   Tsuneyoshi,N., Hosoya,T., Takeno,Y., Saitoh,K., Murai,H.,
            Amimoto,N., Tatsumi,R., Watanabe,S., Hasegawa,Y., Kikkawa,E.,
            Goto,K., Nishigaki,F., Tamura,K. and Kimura,H.
  TITLE     Hypoimmunogenic human iPSCs expressing HLA-G, PD-L1, and PD-L2
            evade innate and adaptive immunity
  JOURNAL   Stem Cell Res Ther 15 (1), 193 (2024)
   PUBMED   38956724
  REMARK    GeneRIF: Hypoimmunogenic human iPSCs expressing HLA-G, PD-L1, and
            PD-L2 evade innate and adaptive immunity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1319)
  AUTHORS   Bora,M., Singha,S., Madan,T., Deka,G., Hazarika,S.G. and Baruah,S.
  TITLE     HLA-G isoforms, HLA-C allotype and their expressions differ between
            early abortus and placenta in relation to spontaneous abortions
  JOURNAL   Placenta 149, 44-53 (2024)
   PUBMED   38492472
  REMARK    GeneRIF: HLA-G isoforms, HLA-C allotype and their expressions
            differ between early abortus and placenta in relation to
            spontaneous abortions.
REFERENCE   6  (bases 1 to 1319)
  AUTHORS   Houlihan,J.M., Biro,P.A., Fergar-Payne,A., Simpson,K.L. and
            Holmes,C.H.
  TITLE     Evidence for the expression of non-HLA-A,-B,-C class I genes in the
            human fetal liver
  JOURNAL   J Immunol 149 (2), 668-675 (1992)
   PUBMED   1624808
REFERENCE   7  (bases 1 to 1319)
  AUTHORS   Ishitani,A. and Geraghty,D.E.
  TITLE     Alternative splicing of HLA-G transcripts yields proteins with
            primary structures resembling both class I and class II antigens
  JOURNAL   Proc Natl Acad Sci U S A 89 (9), 3947-3951 (1992)
   PUBMED   1570318
REFERENCE   8  (bases 1 to 1319)
  AUTHORS   Pook,M.A., Woodcock,V., Tassabehji,M., Campbell,R.D., Summers,C.W.,
            Taylor,M. and Strachan,T.
  TITLE     Characterization of an expressible nonclassical class I HLA gene
  JOURNAL   Hum Immunol 32 (2), 102-109 (1991)
   PUBMED   1744000
REFERENCE   9  (bases 1 to 1319)
  AUTHORS   Sanders,S.K., Giblin,P.A. and Kavathas,P.
  TITLE     Cell-cell adhesion mediated by CD8 and human histocompatibility
            leukocyte antigen G, a nonclassical major histocompatibility
            complex class 1 molecule on cytotrophoblasts
  JOURNAL   J Exp Med 174 (3), 737-740 (1991)
   PUBMED   1908512
REFERENCE   10 (bases 1 to 1319)
  AUTHORS   Zemmour,J. and Parham,P.
  TITLE     HLA class I nucleotide sequences, 1991
  JOURNAL   Hum Immunol 31 (3), 195-206 (1991)
   PUBMED   1890021
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL645929.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: HLA-G belongs to the HLA class I heavy chain paralogues.
            This class I molecule is a heterodimer consisting of a heavy chain
            and a light chain (beta-2 microglobulin). The heavy chain is
            anchored in the membrane. HLA-G is expressed on fetal derived
            placental cells. The heavy chain is approximately 45 kDa and its
            gene contains 8 exons. Exon one encodes the leader peptide, exons 2
            and 3 encode the alpha1 and alpha2 domain, which both bind the
            peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the
            transmembrane region, and exon 6 encodes the cytoplasmic tail.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X17273.1, M32800.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360323.11/ ENSP00000353472.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                AL645929.4         3169-3261
            94-363              AL645929.4         3391-3660
            364-639             AL645929.4         3887-4162
            640-915             AL645929.4         4762-5037
            916-1032            AL645929.4         5160-5276
            1033-1065           AL645929.4         5722-5754
            1066-1319           AL645929.4         6112-6365
FEATURES             Location/Qualifiers
     source          1..1319
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..1319
                     /gene="HLA-G"
                     /gene_synonym="MHC-G"
                     /note="major histocompatibility complex, class I, G"
                     /db_xref="GeneID:3135"
                     /db_xref="HGNC:HGNC:4964"
                     /db_xref="MIM:142871"
     exon            1..93
                     /gene="HLA-G"
                     /gene_synonym="MHC-G"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1037
                     /gene="HLA-G"
                     /gene_synonym="MHC-G"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 4; HLA-G histocompatibility antigen, class I, G;
                     HLA class I histocompatibility antigen, alpha chain G; b2
                     microglobulin; MHC class I antigen G; HLA G antigen;
                     mutant MHC class I antigen; MHC class Ib antigen; mutant
                     MHC class Ib antigen; MHC class I protein"
                     /codon_start=1
                     /product="HLA class I histocompatibility antigen, alpha
                     chain G isoform 2 precursor"
                     /protein_id="NP_001371219.1"
                     /db_xref="CCDS:CCDS4668.1"
                     /db_xref="GeneID:3135"
                     /db_xref="HGNC:HGNC:4964"
                     /db_xref="MIM:142871"
                     /translation="MVVMAPRTLFLLLSGALTLTETWAGSHSMRYFSAAVSRPGRGEP
                     RFIAMGYVDDTQFVRFDSDSACPRMEPRAPWVEQEGPEYWEEETRNTKAHAQTDRMNL
                     QTLRGYYNQSEASSHTLQWMIGCDLGSDGRLLRGYEQYAYDGKDYLALNEDLRSWTAA
                     DTAAQISKRKCEAANVAEQRRAYLEGTCVEWLHRYLENGKEMLQRADPPKTHVTHHPV
                     FDYEATLRCWALGFYPAEIILTWQRDGEDQTQDVELVETRPAGDGTFQKWAAVVVPSG
                     EEQRYTCHVQHEGLPEPLMLRWKQSSLPTIPIMGIVAGLVVLAAVVTGAAVAAVLWRK
                     KSSD"
     exon            94..363
                     /gene="HLA-G"
                     /gene_synonym="MHC-G"
                     /inference="alignment:Splign:2.1.0"
     exon            364..639
                     /gene="HLA-G"
                     /gene_synonym="MHC-G"
                     /inference="alignment:Splign:2.1.0"
     exon            640..915
                     /gene="HLA-G"
                     /gene_synonym="MHC-G"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1032
                     /gene="HLA-G"
                     /gene_synonym="MHC-G"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1065
                     /gene="HLA-G"
                     /gene_synonym="MHC-G"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1319
                     /gene="HLA-G"
                     /gene_synonym="MHC-G"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1295..1300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HLA-G"
                     /gene_synonym="MHC-G"
                     /note="hexamer: ATTAAA"
     polyA_site      1319
                     /gene="HLA-G"
                     /gene_synonym="MHC-G"
                     /note="major polyA site"
ORIGIN      
        1 attctcccca gacgccaagg atggtggtca tggcgccccg aaccctcttc ctgctgctct
       61 cgggggccct gaccctgacc gagacctggg cgggctccca ctccatgagg tatttcagcg
      121 ccgccgtgtc ccggcccggc cgcggggagc cccgcttcat cgccatgggc tacgtggacg
      181 acacgcagtt cgtgcggttc gacagcgact cggcgtgtcc gaggatggag ccgcgggcgc
      241 cgtgggtgga gcaggagggg ccggagtatt gggaagagga gacacggaac accaaggccc
      301 acgcacagac tgacagaatg aacctgcaga ccctgcgcgg ctactacaac cagagcgagg
      361 ccagttctca caccctccag tggatgattg gctgcgacct ggggtccgac ggacgcctcc
      421 tccgcgggta tgaacagtat gcctacgatg gcaaggatta cctcgccctg aacgaggacc
      481 tgcgctcctg gaccgcagcg gacactgcgg ctcagatctc caagcgcaag tgtgaggcgg
      541 ccaatgtggc tgaacaaagg agagcctacc tggagggcac gtgcgtggag tggctccaca
      601 gatacctgga gaacgggaag gagatgctgc agcgcgcgga cccccccaag acacacgtga
      661 cccaccaccc tgtctttgac tatgaggcca ccctgaggtg ctgggccctg ggcttctacc
      721 ctgcggagat catactgacc tggcagcggg atggggagga ccagacccag gacgtggagc
      781 tcgtggagac caggcctgca ggggatggaa ccttccagaa gtgggcagct gtggtggtgc
      841 cttctggaga ggagcagaga tacacgtgcc atgtgcagca tgaggggctg ccggagcccc
      901 tcatgctgag atggaagcag tcttccctgc ccaccatccc catcatgggt atcgttgctg
      961 gcctggttgt ccttgcagct gtagtcactg gagctgcggt cgctgctgtg ctgtggagaa
     1021 agaagagctc agattgaaaa ggagggagct actctcaggc tgcaatgtga aacagctgcc
     1081 ctgtgtggga ctgagtggca agtccctttg tgacttcaag aaccctgact cctctttgtg
     1141 cagagaccag cccacccctg tgcccaccat gaccctcttc ctcatgctga actgcattcc
     1201 ttccccaatc acctttcctg ttccagaaaa ggggctggga tgtctccgtc tctgtctcaa
     1261 atttgtggtc cactgagcta taacttactt ctgtattaaa attagaatct gagtataaa
//
