LOCUS       NM_001098479            1480 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens major histocompatibility complex, class I, F (HLA-F),
            transcript variant 1, mRNA.
ACCESSION   NM_001098479
VERSION     NM_001098479.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1480)
  AUTHORS   Han,N., Xia,W., Zhu,C., Zhang,X., Wang,F., Yin,Z. and Zeng,Q.
  TITLE     Association of human leukocyte antigen-G and -F with recurrent
            miscarriage and implantation failure: A systematic review and
            meta-analysis
  JOURNAL   Am J Reprod Immunol 90 (6), e13792 (2023)
   PUBMED   38009058
  REMARK    GeneRIF: Association of human leukocyte antigen-G and -F with
            recurrent miscarriage and implantation failure: A systematic review
            and meta-analysis.
            Review article
REFERENCE   2  (bases 1 to 1480)
  AUTHORS   Paganini,J., Faux,P., Beley,S., Picard,C., Chiaroni,J. and Di
            Cristofaro,J.
  TITLE     HLA-F transcriptional and protein differential expression according
            to its genetic polymorphisms
  JOURNAL   HLA 102 (5), 578-589 (2023)
   PUBMED   37166140
  REMARK    GeneRIF: HLA-F transcriptional and protein differential expression
            according to its genetic polymorphisms.
REFERENCE   3  (bases 1 to 1480)
  AUTHORS   Luo,F., Liu,F., Guo,Y., Xu,W., Li,Y., Yi,J., Fournier,T.,
            Degrelle,S., Zitouni,H., Hernandez,I., Liu,X., Huang,Y. and Yue,J.
  TITLE     Single-cell profiling reveals immune disturbances landscape and
            HLA-F-mediated immune tolerance at the maternal-fetal interface in
            preeclampsia
  JOURNAL   Front Immunol 14, 1234577 (2023)
   PUBMED   37854606
  REMARK    GeneRIF: Single-cell profiling reveals immune disturbances
            landscape and HLA-F-mediated immune tolerance at the maternal-fetal
            interface in preeclampsia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1480)
  AUTHORS   Bernit,E., Jean,E., Marlot,B., Laget,L., Izard,C., Dettori,I.,
            Beley,S., Gautier,I., Agouti,I., Frassati,C., Pedini,P., Picard,C.,
            Paganini,J., Chiaroni,J. and Di Cristofaro,J.
  TITLE     HLA-F and LILRB1 Genetic Polymorphisms Associated with
            Alloimmunisation in Sickle Cell Disease
  JOURNAL   Int J Mol Sci 24 (17), 13591 (2023)
   PUBMED   37686397
  REMARK    GeneRIF: HLA-F and LILRB1 Genetic Polymorphisms Associated with
            Alloimmunisation in Sickle Cell Disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1480)
  AUTHORS   Arnaiz-Villena,A., Suarez-Trujillo,F., Juarez,I.,
            Rodriguez-Sainz,C., Palacio-Gruber,J., Vaquero-Yuste,C.,
            Molina-Alejandre,M., Fernandez-Cruz,E. and Martin-Villa,J.M.
  TITLE     Evolution and molecular interactions of major histocompatibility
            complex (MHC)-G, -E and -F genes
  JOURNAL   Cell Mol Life Sci 79 (8), 464 (2022)
   PUBMED   35925520
  REMARK    GeneRIF: Evolution and molecular interactions of major
            histocompatibility complex (MHC)-G, -E and -F genes.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1480)
  AUTHORS   Howcroft,T.K., Palmer,L.A., Brown,J., Rellahan,B., Kashanchi,F.,
            Brady,J.N. and Singer,D.S.
  TITLE     HIV Tat represses transcription through Sp1-like elements in the
            basal promoter
  JOURNAL   Immunity 3 (1), 127-138 (1995)
   PUBMED   7621073
REFERENCE   7  (bases 1 to 1480)
  AUTHORS   Howcroft,T.K., Strebel,K., Martin,M.A. and Singer,D.S.
  TITLE     Repression of MHC class I gene promoter activity by two-exon Tat of
            HIV
  JOURNAL   Science 260 (5112), 1320-1322 (1993)
   PUBMED   8493575
REFERENCE   8  (bases 1 to 1480)
  AUTHORS   Gasparini,P., Borgato,L., Piperno,A., Girelli,D., Olivieri,O.,
            Gottardi,E., Roetto,A., Dianzani,I., Fargion,S., Schinaia,G. et al.
  TITLE     Linkage analysis of 6p21 polymorphic markers and the hereditary
            hemochromatosis: localization of the gene centromeric to HLA-F
  JOURNAL   Hum Mol Genet 2 (5), 571-576 (1993)
   PUBMED   8518796
REFERENCE   9  (bases 1 to 1480)
  AUTHORS   Geraghty,D.E., Wei,X.H., Orr,H.T. and Koller,B.H.
  TITLE     Human leukocyte antigen F (HLA-F). An expressed HLA gene composed
            of a class I coding sequence linked to a novel transcribed
            repetitive element
  JOURNAL   J Exp Med 171 (1), 1-18 (1990)
   PUBMED   1688605
REFERENCE   10 (bases 1 to 1480)
  AUTHORS   Lury,D., Epstein,H. and Holmes,N.
  TITLE     The human class I MHC gene HLA-F is expressed in lymphocytes
  JOURNAL   Int Immunol 2 (6), 531-537 (1990)
   PUBMED   1707659
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM798587.1, CT002787.1,
            CB528356.1, BC009260.2 and CD369507.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001098479.1.
            
            Summary: This gene belongs to the HLA class I heavy chain
            paralogues. It encodes a non-classical heavy chain that forms a
            heterodimer with a beta-2 microglobulin light chain, with the heavy
            chain anchored in the membrane. Unlike most other HLA heavy chains,
            this molecule is localized in the endoplasmic reticulum and Golgi
            apparatus, with a small amount present at the cell surface in some
            cell types. It contains a divergent peptide-binding groove, and is
            thought to bind a restricted subset of peptides for immune
            presentation. This gene exhibits few polymorphisms. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. These variants lack a coding exon found in transcripts
            from other HLA paralogues due to an altered splice acceptor site,
            resulting in a shorter cytoplasmic domain. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009260.2, SRR14243140.10901515.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259951.12/ ENSP00000259951.6
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                BM798587.1         96-187
            93-550              CT002787.1         106-563
            551-844             CB528356.1         358-651             c
            845-1086            BC009260.2         871-1112
            1087-1480           CD369507.1         18-411              c
FEATURES             Location/Qualifiers
     source          1..1480
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.1"
     gene            1..1480
                     /gene="HLA-F"
                     /gene_synonym="CDA12; HLA-5.4; HLA-CDA12; HLAF"
                     /note="major histocompatibility complex, class I, F"
                     /db_xref="GeneID:3134"
                     /db_xref="HGNC:HGNC:4963"
                     /db_xref="MIM:143110"
     exon            1..94
                     /gene="HLA-F"
                     /gene_synonym="CDA12; HLA-5.4; HLA-CDA12; HLAF"
                     /inference="alignment:Splign:2.1.0"
     exon            95..364
                     /gene="HLA-F"
                     /gene_synonym="CDA12; HLA-5.4; HLA-CDA12; HLAF"
                     /inference="alignment:Splign:2.1.0"
     exon            365..640
                     /gene="HLA-F"
                     /gene_synonym="CDA12; HLA-5.4; HLA-CDA12; HLAF"
                     /inference="alignment:Splign:2.1.0"
     exon            641..916
                     /gene="HLA-F"
                     /gene_synonym="CDA12; HLA-5.4; HLA-CDA12; HLAF"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1033
                     /gene="HLA-F"
                     /gene_synonym="CDA12; HLA-5.4; HLA-CDA12; HLAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1066
                     /gene="HLA-F"
                     /gene_synonym="CDA12; HLA-5.4; HLA-CDA12; HLAF"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1480
                     /gene="HLA-F"
                     /gene_synonym="CDA12; HLA-5.4; HLA-CDA12; HLAF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1459..1464
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HLA-F"
                     /gene_synonym="CDA12; HLA-5.4; HLA-CDA12; HLAF"
                     /note="hexamer: AATAAA"
     polyA_site      1480
                     /gene="HLA-F"
                     /gene_synonym="CDA12; HLA-5.4; HLA-CDA12; HLAF"
                     /note="major polyA site"
ORIGIN      
        1 atatttttcc cagacgcgga ggttggggtc atggcgcccc gaagcctcct cctgctgctc
       61 tcaggggccc tggccctgac cgatacttgg gcgggctccc actccttgag gtatttcagc
      121 accgctgtgt cgcggcccgg ccgcggggag ccccgctaca tcgccgtgga gtacgtagac
      181 gacacgcaat tcctgcggtt cgacagcgac gccgcgattc cgaggatgga gccgcgggag
      241 ccgtgggtgg agcaagaggg gccgcagtat tgggagtgga ccacagggta cgccaaggcc
      301 aacgcacaga ctgaccgagt ggccctgagg aacctgctcc gccgctacaa ccagagcgag
      361 gctgggtctc acaccctcca gggaatgaat ggctgcgaca tggggcccga cggacgcctc
      421 ctccgcgggt atcaccagca cgcgtacgac ggcaaggatt acatctccct gaacgaggac
      481 ctgcgctcct ggaccgcggc ggacaccgtg gctcagatca cccagcgctt ctatgaggca
      541 gaggaatatg cagaggagtt caggacctac ctggagggcg agtgcctgga gttgctccgc
      601 agatacttgg agaatgggaa ggagacgcta cagcgcgcag atcctccaaa ggcacacgtt
      661 gcccaccacc ccatctctga ccatgaggcc accctgaggt gctgggccct gggcttctac
      721 cctgcggaga tcacgctgac ctggcagcgg gatggggagg aacagaccca ggacacagag
      781 cttgtggaga ccaggcctgc aggggatgga accttccaga agtgggccgc tgtggtggtg
      841 cctcctggag aggaacagag atacacatgc catgtgcagc acgaggggct gccccagccc
      901 ctcatcctga gatgggagca gtctccccag cccaccatcc ccatcgtggg catcgttgct
      961 ggccttgttg tccttggagc tgtggtcact ggagctgtgg tcgctgctgt gatgtggagg
     1021 aagaagagct cagatagaaa cagagggagc tactctcagg ctgcagccta ctcagtggtc
     1081 agcggaaact tgatgataac atggtggtca agcttatttc tcctgggggt gctcttccaa
     1141 ggatatttgg gctgcctccg gagtcacagt gtcttgggcc gccggaaggt gggtgacatg
     1201 tggatcttgt tttttttgtg gctgtggaca tctttcaaca ctgccttctt ggccttgcaa
     1261 agccttcgct ttggcttcgg ctttaggagg ggcaggagct tccttcttcg ttcttggcac
     1321 catcttatga aaagggtcca gattaagatt tttgactgag tcattctaaa gtaagttgca
     1381 agacccatga tactagacca ctaaatactt catcacacac ctcctaagaa taagaaccaa
     1441 cattatcaca ccaaagaaaa taaataattc cataatatta
//
