LOCUS       NM_019111               1235 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens major histocompatibility complex, class II, DR alpha
            (HLA-DRA), mRNA.
ACCESSION   NM_019111
VERSION     NM_019111.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1235)
  AUTHORS   Branciamore,S., Gogoshin,G., Rodin,A.S. and Myers,A.J.
  TITLE     Changes in expression of VGF, SPECC1L, HLA-DRA and RANBP3L act with
            APOE E4 to alter risk for late onset Alzheimer's disease
  JOURNAL   Sci Rep 14 (1), 14954 (2024)
   PUBMED   38942763
  REMARK    GeneRIF: Changes in expression of VGF, SPECC1L, HLA-DRA and RANBP3L
            act with APOE E4 to alter risk for late onset Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1235)
  AUTHORS   Hong,M., Jung,J., Jin,H.S. and Hwang,D.
  TITLE     Genetic polymorphism of HLA-DRA and alcohol consumption affect
            hepatitis development in the Korean population
  JOURNAL   Genes Genomics 44 (9), 1109-1116 (2022)
   PUBMED   35895219
  REMARK    GeneRIF: Genetic polymorphism of HLA-DRA and alcohol consumption
            affect hepatitis development in the Korean population.
REFERENCE   3  (bases 1 to 1235)
  AUTHORS   Mei,J., Jiang,G., Chen,Y., Xu,Y., Wan,Y., Chen,R., Liu,F., Mao,W.,
            Zheng,M. and Xu,J.
  TITLE     HLA class II molecule HLA-DRA identifies immuno-hot tumors and
            predicts the therapeutic response to anti-PD-1 immunotherapy in
            NSCLC
  JOURNAL   BMC Cancer 22 (1), 738 (2022)
   PUBMED   35794593
  REMARK    GeneRIF: HLA class II molecule HLA-DRA identifies immuno-hot tumors
            and predicts the therapeutic response to anti-PD-1 immunotherapy in
            NSCLC.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1235)
  AUTHORS   Liu,D. and Hofman,P.
  TITLE     Expression of NOTCH1, NOTCH4, HLA-DMA and HLA-DRA is
            synergistically associated with T cell exclusion, immune checkpoint
            blockade efficacy and recurrence risk in ER-negative breast cancer
  JOURNAL   Cell Oncol (Dordr) 45 (3), 463-477 (2022)
   PUBMED   35543859
  REMARK    GeneRIF: Expression of NOTCH1, NOTCH4, HLA-DMA and HLA-DRA is
            synergistically associated with T cell exclusion, immune checkpoint
            blockade efficacy and recurrence risk in ER-negative breast cancer.
REFERENCE   5  (bases 1 to 1235)
  AUTHORS   Luo,Y., Xue,Y., Tang,G., Lin,Q., Song,H., Liu,W., Yin,B., Huang,J.,
            Wei,W., Mao,L., Wang,F. and Sun,Z.
  TITLE     Combination of HLA-DR on Mycobacterium tuberculosis-Specific Cells
            and Tuberculosis Antigen/Phytohemagglutinin Ratio for
            Discriminating Active Tuberculosis From Latent Tuberculosis
            Infection
  JOURNAL   Front Immunol 12, 761209 (2021)
   PUBMED   34858413
  REMARK    GeneRIF: Combination of HLA-DR on Mycobacterium
            tuberculosis-Specific Cells and Tuberculosis
            Antigen/Phytohemagglutinin Ratio for Discriminating Active
            Tuberculosis From Latent Tuberculosis Infection.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1235)
  AUTHORS   Riberdy,J.M., Newcomb,J.R., Surman,M.J., Barbosa,J.A. and
            Cresswell,P.
  TITLE     HLA-DR molecules from an antigen-processing mutant cell line are
            associated with invariant chain peptides
  JOURNAL   Nature 360 (6403), 474-477 (1992)
   PUBMED   1448172
REFERENCE   7  (bases 1 to 1235)
  AUTHORS   Matsushima,G.K., Itoh-Lindstrom,Y. and Ting,J.P.
  TITLE     Activation of the HLA-DRA gene in primary human T lymphocytes:
            novel usage of TATA and the X and Y promoter elements
  JOURNAL   Mol Cell Biol 12 (12), 5610-5619 (1992)
   PUBMED   1448091
  REMARK    Erratum:[Mol Cell Biol. 1993 Aug;13(8):5132. doi:
            10.1128/mcb.13.8.5132-.1993.. PMID: 8336739]
REFERENCE   8  (bases 1 to 1235)
  AUTHORS   Schaiff,W.T., Hruska,K.A. Jr., McCourt,D.W., Green,M. and
            Schwartz,B.D.
  TITLE     HLA-DR associates with specific stress proteins and is retained in
            the endoplasmic reticulum in invariant chain negative cells
  JOURNAL   J Exp Med 176 (3), 657-666 (1992)
   PUBMED   1512535
REFERENCE   9  (bases 1 to 1235)
  AUTHORS   Nong,Y., Kandil,O., Tobin,E.H., Rose,R.M. and Remold,H.G.
  TITLE     The HIV core protein p24 inhibits interferon-gamma-induced increase
            of HLA-DR and cytochrome b heavy chain mRNA levels in the human
            monocyte-like cell line THP1
  JOURNAL   Cell Immunol 132 (1), 10-16 (1991)
   PUBMED   1905983
REFERENCE   10 (bases 1 to 1235)
  AUTHORS   Koppelman,B. and Cresswell,P.
  TITLE     Rapid nonlysosomal degradation of assembled HLA class II
            glycoproteins incorporating a mutant DR alpha-chain
  JOURNAL   J Immunol 145 (8), 2730-2736 (1990)
   PUBMED   2212658
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM849755.1, BG548634.1,
            BC032350.1 and BC071659.1.
            
            On Nov 22, 2018 this sequence version replaced NM_019111.4.
            
            Summary: HLA-DRA is one of the HLA class II alpha chain paralogues.
            This class II molecule is a heterodimer consisting of an alpha and
            a beta chain, both anchored in the membrane. This molecule is
            expressed on the surface of various antigen presenting cells such
            as B lymphocytes, dendritic cells, and monocytes/macrophages, and
            plays a central role in the immune system and response by
            presenting peptides derived from extracellular proteins, in
            particular, pathogen-derived peptides to T cells. The alpha chain
            is approximately 33-35 kDa and its gene contains 5 exons. Exon 1
            encodes the leader peptide, exons 2 and 3 encode the two
            extracellular domains, and exon 4 encodes the transmembrane domain
            and the cytoplasmic tail. DRA does not have polymorphisms in the
            peptide binding part and acts as the sole alpha chain for DRB1,
            DRB3, DRB4 and DRB5. [provided by RefSeq, Aug 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.110441.1,
                                           SRR5189655.82949.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395388.7/ ENSP00000378786.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-417               BM849755.1         47-463
            418-957             BG548634.1         89-628
            958-1223            BC032350.1         934-1199
            1224-1235           BC071659.1         1208-1219
FEATURES             Location/Qualifiers
     source          1..1235
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.32"
     gene            1..1235
                     /gene="HLA-DRA"
                     /gene_synonym="HLA-DRA1"
                     /note="major histocompatibility complex, class II, DR
                     alpha"
                     /db_xref="GeneID:3122"
                     /db_xref="HGNC:HGNC:4947"
                     /db_xref="MIM:142860"
     exon            1..146
                     /gene="HLA-DRA"
                     /gene_synonym="HLA-DRA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..829
                     /gene="HLA-DRA"
                     /gene_synonym="HLA-DRA1"
                     /note="HLA class II histocompatibility antigen, DR alpha
                     chain; histocompatibility antigen HLA-DR alpha; MHC class
                     II antigen DRA"
                     /codon_start=1
                     /product="HLA class II histocompatibility antigen, DR
                     alpha chain precursor"
                     /protein_id="NP_061984.2"
                     /db_xref="CCDS:CCDS4750.1"
                     /db_xref="GeneID:3122"
                     /db_xref="HGNC:HGNC:4947"
                     /db_xref="MIM:142860"
                     /translation="MAISGVPVLGFFIIAVLMSAQESWAIKEEHVIIQAEFYLNPDQS
                     GEFMFDFDGDEIFHVDMAKKETVWRLEEFGRFASFEAQGALANIAVDKANLEIMTKRS
                     NYTPITNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWLRNGKPVTTGVSET
                     VFLPREDHLFRKFHYLPFLPSTEDVYDCRVEHWGLDEPLLKHWEFDAPSPLPETTENV
                     VCALGLTVGLVGIIIGTIFIIKGLRKSNAAERRGPL"
     exon            147..392
                     /gene="HLA-DRA"
                     /gene_synonym="HLA-DRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            393..674
                     /gene="HLA-DRA"
                     /gene_synonym="HLA-DRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            675..840
                     /gene="HLA-DRA"
                     /gene_synonym="HLA-DRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1235
                     /gene="HLA-DRA"
                     /gene_synonym="HLA-DRA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1206..1211
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HLA-DRA"
                     /gene_synonym="HLA-DRA1"
                     /note="hexamer: AATAAA"
     polyA_site      1235
                     /gene="HLA-DRA"
                     /gene_synonym="HLA-DRA1"
                     /note="major polyA site"
ORIGIN      
        1 attcttgtct gttctgcctc actcccgagc tctactgact cccaacagag cgcccaagaa
       61 gaaaatggcc ataagtggag tccctgtgct aggatttttc atcatagctg tgctgatgag
      121 cgctcaggaa tcatgggcta tcaaagaaga acatgtgatc atccaggccg agttctatct
      181 gaatcctgac caatcaggcg agtttatgtt tgactttgat ggtgatgaga ttttccatgt
      241 ggatatggca aagaaggaga cggtctggcg gcttgaagaa tttggacgat ttgccagctt
      301 tgaggctcaa ggtgcattgg ccaacatagc tgtggacaaa gccaacctgg aaatcatgac
      361 aaagcgctcc aactatactc cgatcaccaa tgtacctcca gaggtaactg tgctcacaaa
      421 cagccctgtg gaactgagag agcccaacgt cctcatctgt ttcatagaca agttcacccc
      481 accagtggtc aatgtcacgt ggcttcgaaa tggaaaacct gtcaccacag gagtgtcaga
      541 gacagtcttc ctgcccaggg aagaccacct tttccgcaag ttccactatc tccccttcct
      601 gccctcaact gaggacgttt acgactgcag ggtggagcac tggggcttgg atgagcctct
      661 tctcaagcac tgggagtttg atgctccaag ccctctccca gagactacag agaacgtggt
      721 gtgtgccctg ggcctgactg tgggtctggt gggcatcatt attgggacca tcttcatcat
      781 caagggattg cgcaaaagca atgcagcaga acgcaggggg cctctgtaag gcacatggag
      841 gtgatggtgt ttcttagaga gaagatcact gaagaaactt ctgctttaat ggctttacaa
      901 agctggcaat attacaatcc ttgacctcag tgaaagcagt catcttcagc attttccagc
      961 cctatagcca ccccaagtgt ggatatgcct cttcgattgc tccgtactct aacatctagc
     1021 tggcttccct gtctattgcc ttttcctgta tctattttcc tctatttcct atcattttat
     1081 tatcaccatg caatgcctct ggaataaaac atacaggagt ctgtctctgc tatggaatgc
     1141 cccatggggc atctcttgtg tacttattgt ttaaggtttc ctcaaactgt gatttttctg
     1201 aacacaataa actattttga tgatcttggg tggaa
//
