LOCUS       NM_001300790            1212 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens major histocompatibility complex, class II, DQ beta 2
            (HLA-DQB2), transcript variant 1, mRNA.
ACCESSION   NM_001300790
VERSION     NM_001300790.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1212)
  AUTHORS   Wang,X., Cao,X., Zhang,W., Zhang,L., Lu,L., Li,X., El-Ashram,S.,
            Wu,J. and Chen,C.
  TITLE     Association of human leukocyte antigens-DQB2/DPA1/DPB1 polymorphism
            and pulmonary tuberculosis in the Chinese Uygur population
  JOURNAL   Mol Genet Genomic Med 7 (3), e544 (2019)
   PUBMED   30600606
  REMARK    GeneRIF: The functional HLA-DQB2 rs7453920 G>A polymorphism may
            contribute to the genetic susceptibility to pulmonary tuberculosis
            in the Chinese Uygur population.
REFERENCE   2  (bases 1 to 1212)
  AUTHORS   Pereira,V.R.Z.B., Wolf,J.M., Stumm,G.Z., Boeira,T.R., Galvan,J.,
            Simon,D. and Lunge,V.R.
  TITLE     Lack of association between human leukocyte antigen polymorphisms
            rs9277535 and rs7453920 and chronic hepatitis B in a Brazilian
            population
  JOURNAL   Genet Mol Res 16 (2) (2017)
   PUBMED   28613373
  REMARK    GeneRIF: No statistically significant association was found between
            rs7453920 SNP and chronic hepatitis B.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1212)
  AUTHORS   Liu,X., Yang,B., Li,L., Cai,B., Liao,Y., Li,L., Wu,Z. and Wang,L.
  TITLE     Association of HLA-DP/DQ and STAT4 polymorphisms with ankylosing
            spondylitis in Southwest China
  JOURNAL   Int Immunopharmacol 39, 10-15 (2016)
   PUBMED   27394003
  REMARK    GeneRIF: this study shows that HLA-DQ gene polymorphisms are
            associated with ankylosing spondylitis in Southwest China
REFERENCE   4  (bases 1 to 1212)
  AUTHORS   Chang,S.W., Fann,C.S., Su,W.H., Wang,Y.C., Weng,C.C., Yu,C.J.,
            Hsu,C.L., Hsieh,A.R., Chien,R.N., Chu,C.M. and Tai,D.I.
  TITLE     A genome-wide association study on chronic HBV infection and its
            clinical progression in male Han-Taiwanese
  JOURNAL   PLoS One 9 (6), e99724 (2014)
   PUBMED   24940741
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1212)
  AUTHORS   Hu,Z., Liu,Y., Zhai,X., Dai,J., Jin,G., Wang,L., Zhu,L., Yang,Y.,
            Liu,J., Chu,M., Wen,J., Xie,K., Du,G., Wang,Q., Zhou,Y., Cao,M.,
            Liu,L., He,Y., Wang,Y., Zhou,G., Jia,W., Lu,J., Li,S., Liu,J.,
            Yang,H., Shi,Y., Zhou,W. and Shen,H.
  TITLE     New loci associated with chronic hepatitis B virus infection in Han
            Chinese
  JOURNAL   Nat Genet 45 (12), 1499-1503 (2013)
   PUBMED   24162738
REFERENCE   6  (bases 1 to 1212)
  AUTHORS   Beck,S., Abdulla,S., Alderton,R.P., Glynne,R.J., Gut,I.G.,
            Hosking,L.K., Jackson,A., Kelly,A., Newell,W.R., Sanseau,P.,
            Radley,E., Thorpe,K.L. and Trowsdale,J.
  TITLE     Evolutionary dynamics of non-coding sequences within the class II
            region of the human MHC
  JOURNAL   J Mol Biol 255 (1), 1-13 (1996)
   PUBMED   8568858
REFERENCE   7  (bases 1 to 1212)
  AUTHORS   Wang,Y., Lu,P., Zhou,K., Clay,T., Wood,N., Bradley,B. and
            Bidwell,J.
  TITLE     Nucleotide sequencing of HLA-DQ gene second exons in Chinese
            homozygous cells
  JOURNAL   Eur J Immunogenet 19 (5), 287-293 (1992)
   PUBMED   1420115
REFERENCE   8  (bases 1 to 1212)
  AUTHORS   Berdoz,J., Tiercy,J.M., Rollini,P., Mach,B. and Gorski,J.
  TITLE     Remarkable sequence conservation of the HLA-DQB2 locus (DX beta)
            within the highly polymorphic DQ subregion of the human MHC
  JOURNAL   Immunogenetics 29 (4), 241-248 (1989)
   PUBMED   2564844
REFERENCE   9  (bases 1 to 1212)
  AUTHORS   Jonsson,A.K., Hyldig-Nielsen,J.J., Servenius,B., Larhammar,D.,
            Andersson,G., Jorgensen,F., Peterson,P.A. and Rask,L.
  TITLE     Class II genes of the human major histocompatibility complex.
            Comparisons of the DQ and DX alpha and beta genes
  JOURNAL   J Biol Chem 262 (18), 8767-8777 (1987)
   PUBMED   3036828
REFERENCE   10 (bases 1 to 1212)
  AUTHORS   Okada,K., Boss,J.M., Prentice,H., Spies,T., Mengler,R., Auffray,C.,
            Lillie,J., Grossberger,D. and Strominger,J.L.
  TITLE     Gene organization of DC and DX subregions of the human major
            histocompatibility complex
  JOURNAL   Proc Natl Acad Sci U S A 82 (10), 3410-3414 (1985)
   PUBMED   3858830
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL672104.4.
            
            On Nov 22, 2018 this sequence version replaced NM_001300790.1.
            
            Summary: HLA-DQB2 belongs to the family of HLA class II beta chain
            paralogs. Class II molecules are heterodimers consisting of an
            alpha (DQA) and a beta chain (DQB), both anchored in the membrane.
            They play a central role in the immune system by presenting
            peptides derived from extracellular proteins. Class II molecules
            are expressed in antigen presenting cells (APC: B lymphocytes,
            dendritic cells, macrophages). Polymorphisms in the alpha and beta
            chains specify the peptide binding specificity, and typing for
            these polymorphisms is routinely done for bone marrow
            transplantation. However this gene, HLA-DQB2, is not routinely
            typed, as it is not thought to have an effect on transplantation.
            There is conflicting evidence in the literature and public sequence
            databases for the protein-coding capacity of HLA-DQB2. Because
            there is evidence of transcription and an intact ORF, HLA-DQB2 is
            represented in Entrez Gene and in RefSeq as a protein-coding locus.
            [provided by RefSeq, Oct 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000437316.7/ ENSP00000396330.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               AL672104.4         27717-27875         c
            160-426             AL672104.4         26003-26269         c
            427-708             AL672104.4         23193-23474         c
            709-819             AL672104.4         22116-22226         c
            820-843             AL672104.4         21624-21647         c
            844-1212            AL672104.4         20441-20809         c
FEATURES             Location/Qualifiers
     source          1..1212
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.32"
     gene            1..1212
                     /gene="HLA-DQB2"
                     /gene_synonym="DQB2; HLA-DQB1; HLA-DXB"
                     /note="major histocompatibility complex, class II, DQ beta
                     2"
                     /db_xref="GeneID:3120"
                     /db_xref="HGNC:HGNC:4945"
                     /db_xref="MIM:615161"
     exon            1..159
                     /gene="HLA-DQB2"
                     /gene_synonym="DQB2; HLA-DQB1; HLA-DXB"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..857
                     /gene="HLA-DQB2"
                     /gene_synonym="DQB2; HLA-DQB1; HLA-DXB"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; MHC class II antigen DQB2; HLA class II
                     histocompatibility antigen, DX beta chain; HLA class II
                     histocompatibility antigen, DQ beta 2 chain; DV19.1 (major
                     histocompatibility complex, class II, DQ beta 2
                     (HLA-DXB))"
                     /codon_start=1
                     /product="HLA class II histocompatibility antigen, DQ beta
                     2 chain isoform 1 precursor"
                     /protein_id="NP_001287719.1"
                     /db_xref="CCDS:CCDS78128.1"
                     /db_xref="GeneID:3120"
                     /db_xref="HGNC:HGNC:4945"
                     /db_xref="MIM:615161"
                     /translation="MALQIPGGFWAAAVTVMLVMLSTPVAEARDFPKDFLVQFKGMCY
                     FTNGTERVRGVARYIYNREEYGRFDSDVGEFQAVTELGRSIEDWNNYKDFLEQERAAV
                     DKVCRHNYEAELRTTLQRQVEPTVTISPSRTEALNHHNLLVCSVTDFYPAQIKVRWFR
                     NDQEETAGVVSTSLIRNGDWTFQILVMLEITPQRGDIYTCQVEHPSLQSPITVEWRAQ
                     SESAQSKMLSGIGGFVLGLIFLGLGLIIRHRGQKGPRGPPPAGLLH"
     exon            160..426
                     /gene="HLA-DQB2"
                     /gene_synonym="DQB2; HLA-DQB1; HLA-DXB"
                     /inference="alignment:Splign:2.1.0"
     exon            427..708
                     /gene="HLA-DQB2"
                     /gene_synonym="DQB2; HLA-DQB1; HLA-DXB"
                     /inference="alignment:Splign:2.1.0"
     exon            709..819
                     /gene="HLA-DQB2"
                     /gene_synonym="DQB2; HLA-DQB1; HLA-DXB"
                     /inference="alignment:Splign:2.1.0"
     exon            820..843
                     /gene="HLA-DQB2"
                     /gene_synonym="DQB2; HLA-DQB1; HLA-DXB"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1212
                     /gene="HLA-DQB2"
                     /gene_synonym="DQB2; HLA-DQB1; HLA-DXB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1192..1197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HLA-DQB2"
                     /gene_synonym="DQB2; HLA-DQB1; HLA-DXB"
                     /note="hexamer: ATTAAA"
     polyA_site      1212
                     /gene="HLA-DQB2"
                     /gene_synonym="DQB2; HLA-DQB1; HLA-DXB"
                     /note="major polyA site"
ORIGIN      
        1 attaggtttg agctgtgttg actaccactg ctttttcctt ggtctcactt acgtcttgga
       61 agatggctct gcagatccct ggaggctttt gggcagcagc tgtgaccgtg atgctggtga
      121 tgctgagcac cccagtggct gaggccagag actttcccaa ggatttcttg gtccagttta
      181 agggcatgtg ctacttcacc aacgggacag agcgcgtgcg cggtgtggcc agatacatct
      241 ataaccgcga ggagtacggg cgcttcgaca gcgacgttgg ggagttccag gcggtgaccg
      301 agctggggcg gagcatcgag gactggaaca actataagga cttcttggag caggagcggg
      361 ccgcggtgga caaggtgtgc agacacaact acgaggcgga gctgcgcacg accttgcagc
      421 ggcaagtgga gcccacagtg accatctccc catccaggac agaggccctc aaccaccaca
      481 acctgctggt ctgctcggtg acagatttct atccagccca gatcaaagtc cggtggtttc
      541 ggaatgacca ggaggagaca gccggtgttg tgtccacctc cctcattagg aatggtgact
      601 ggaccttcca gattctggtg atgctggaaa taactcccca gcgtggagac atctacacct
      661 gccaagtgga gcaccccagc ctccagagcc ccatcaccgt ggagtggcgg gctcagtctg
      721 aatctgccca gagcaagatg ctgagtggca ttggaggctt cgtgctgggg ctgatcttcc
      781 tcgggctggg ccttatcatc cgtcacaggg gtcagaaagg acctcgaggg cctccaccag
      841 caggactcct gcactgactc ctgaggactt ttgtctggga ttggtcatca ctcttctgta
      901 atgcccacct gcccctgccc agaattccta gctgcctgtg tcaccctgtc ccactgaggt
      961 cagagtccta cagtggctca tgcagccaca ggtcaccttc tgtgatcccc atcccaaggc
     1021 actggtggtg actctgcttc ctgcactgac ccagagcctc tgcctgtgca ctgcaagctg
     1081 tgtctactca ggccccaagg ggcatctctg tttccattct ccccccacag acctgtcaag
     1141 agaagcatga caaacaaaat catttacctg actttagtgc tttttcccat aattaaacct
     1201 gattctgagt ta
//
