LOCUS       NM_002121               3991 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens major histocompatibility complex, class II, DP beta 1
            (HLA-DPB1), mRNA.
ACCESSION   NM_002121 XM_003119096 XM_003119097 XM_003119098 XM_003119099
            XM_003119100 XM_003119101 XR_113857
VERSION     NM_002121.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3991)
  AUTHORS   Senapati,S., Singh,H., Bk,T., Verma,N. and Kumar,U.
  TITLE     HLA sequencing identifies novel associations and suggests clinical
            relevance of DPB1*04:01 in ANCA-associated Granulomatosis with
            polyangiitis
  JOURNAL   Gene 896, 148024 (2024)
   PUBMED   38040271
  REMARK    GeneRIF: HLA sequencing identifies novel associations and suggests
            clinical relevance of DPB1*04:01 in ANCA-associated Granulomatosis
            with polyangiitis.
REFERENCE   2  (bases 1 to 3991)
  AUTHORS   Akgollu,E., Demirkazik,M. and Bilgin,R.
  TITLE     The effect of HLA-DP gene polymorphisms in Plasmodium Vivax-induced
            malaria susceptibility
  JOURNAL   Nucleosides Nucleotides Nucleic Acids 43 (6), 572-584 (2024)
   PUBMED   37980631
  REMARK    GeneRIF: The effect of HLA-DP gene polymorphisms in Plasmodium
            Vivax-induced malaria susceptibility.
REFERENCE   3  (bases 1 to 3991)
  AUTHORS   Cargou,M., Elsermans,V., Top,I., Wojciechowski,E. and Visentin,J.
  TITLE     Characterization of the novel HLA-DPB1*11:01:06 allele by
            sequencing-based typing
  JOURNAL   HLA 101 (3), 311-312 (2023)
   PUBMED   36411507
  REMARK    GeneRIF: Characterization of the novel HLA-DPB1*11:01:06 allele by
            sequencing-based typing.
REFERENCE   4  (bases 1 to 3991)
  AUTHORS   Cargou,M., Elsermans,V., Top,I., Ralazamahaleo,M. and Visentin,J.
  TITLE     Characterization of the novel HLA-DPB1*1348:01 allele by
            sequencing-based typing
  JOURNAL   HLA 101 (3), 313-314 (2023)
   PUBMED   36394166
  REMARK    GeneRIF: Characterization of the novel HLA-DPB1*1348:01 allele by
            sequencing-based typing.
REFERENCE   5  (bases 1 to 3991)
  AUTHORS   Roh,E.Y., Lim,S., Shin,S. and Yoon,J.H.
  TITLE     The novel HLA-DPB1 allele, HLA-DPB1*1344:01, first identified in
            Korean individuals by next-generation sequencing
  JOURNAL   HLA 101 (1), 96-97 (2023)
   PUBMED   36074540
  REMARK    GeneRIF: The novel HLA-DPB1 allele, HLA-DPB1*1344:01, first
            identified in Korean individuals by next-generation sequencing.
REFERENCE   6  (bases 1 to 3991)
  AUTHORS   Marsh,S.G. and Bodmer,J.G.
  TITLE     HLA class II nucleotide sequences, 1992
  JOURNAL   Tissue Antigens 40 (5), 229-243 (1992)
   PUBMED   1362295
  REMARK    Correction to:[Tissue Antigens. 1992 Apr;39(4):161-73. doi:
            10.1111/j.1399-0039.1992.tb01932.x.. PMID: 1529427]
REFERENCE   7  (bases 1 to 3991)
  AUTHORS   Eiermann,T.H., Uhl,S., Fakler,J. and Goldmann,S.F.
  TITLE     A novel HLA-DPB1 sequence, DPB1*2301
  JOURNAL   Tissue Antigens 40 (2), 108-110 (1992)
   PUBMED   1412416
REFERENCE   8  (bases 1 to 3991)
  AUTHORS   Mitsunaga,S., Kuwata,S., Tokunaga,K., Uchikawa,C., Takahashi,K.,
            Akaza,T., Mitomi,Y. and Juji,T.
  TITLE     Family study on HLA-DPB1 polymorphism: linkage analysis with
            HLA-DR/DQ and two 'new' alleles
  JOURNAL   Hum Immunol 34 (3), 203-211 (1992)
   PUBMED   1358867
REFERENCE   9  (bases 1 to 3991)
  AUTHORS   Korioth,F., Hartung,K., Deicher,H. and Frey,J.
  TITLE     A new HLA-DPB1 allele from a patient with systemic lupus
            erythematosus
  JOURNAL   Tissue Antigens 39 (4), 216-219 (1992)
   PUBMED   1529429
REFERENCE   10 (bases 1 to 3991)
  AUTHORS   de Koster,H.S., Kenter,M.J., D'Amaro,J., Luiten,R.M.,
            Schroeijers,W.E., Giphart,M.J. and Termijtelen,A.
  TITLE     Positive correlation between oligonucleotide typing and T-cell
            recognition of HLA-DP molecules
  JOURNAL   Immunogenetics 34 (1), 12-22 (1991)
   PUBMED   1713190
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP213121.1, M28202.1 and
            AL645931.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002121.5.
            
            Summary: HLA-DPB belongs to the HLA class II beta chain paralogues.
            This class II molecule is a heterodimer consisting of an alpha
            (DPA) and a beta chain (DPB), both anchored in the membrane. It
            plays a central role in the immune system by presenting peptides
            derived from extracellular proteins. Class II molecules are
            expressed in antigen presenting cells (APC: B lymphocytes,
            dendritic cells, macrophages). The beta chain is approximately
            26-28 kDa and its gene contains 6 exons. Exon one encodes the
            leader peptide, exons 2 and 3 encode the two extracellular domains,
            exon 4 encodes the transmembrane domain and exon 5 encodes the
            cytoplasmic tail. Within the DP molecule both the alpha chain and
            the beta chain contain the polymorphisms specifying the peptide
            binding specificities, resulting in up to 4 different molecules.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.97053.1,
                                           SRR1163657.319583.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000418931.7/ ENSP00000408146.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                BP213121.1         65-140
            77-1065             M28202.1           1-989
            1066-3991           AL645931.7         94707-97632
FEATURES             Location/Qualifiers
     source          1..3991
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.32"
     gene            1..3991
                     /gene="HLA-DPB1"
                     /gene_synonym="DPB1; HLA-DP; HLA-DP1B; HLA-DPB"
                     /note="major histocompatibility complex, class II, DP beta
                     1"
                     /db_xref="GeneID:3115"
                     /db_xref="HGNC:HGNC:4940"
                     /db_xref="MIM:142858"
     exon            1..152
                     /gene="HLA-DPB1"
                     /gene_synonym="DPB1; HLA-DP; HLA-DP1B; HLA-DPB"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..829
                     /gene="HLA-DPB1"
                     /gene_synonym="DPB1; HLA-DP; HLA-DP1B; HLA-DPB"
                     /note="HLA-DP histocompatibility type, beta-1 subunit; HLA
                     class II histocompatibility antigen, DP beta 1 chain; MHC
                     HLA DPB1; MHC class II HLA-DP-beta-1; MHC class II antigen
                     DPB1; HLA class II histocompatibility antigen, DP(W4) beta
                     chain"
                     /codon_start=1
                     /product="HLA class II histocompatibility antigen, DP beta
                     1 chain precursor"
                     /protein_id="NP_002112.3"
                     /db_xref="CCDS:CCDS4765.1"
                     /db_xref="GeneID:3115"
                     /db_xref="HGNC:HGNC:4940"
                     /db_xref="MIM:142858"
                     /translation="MMVLQVSAAPRTVALTALLMVLLTSVVQGRATPENYLFQGRQEC
                     YAFNGTQRFLERYIYNREEFARFDSDVGEFRAVTELGRPAAEYWNSQKDILEEKRAVP
                     DRMCRHNYELGGPMTLQRRVQPRVNVSPSKKGPLQHHNLLVCHVTDFYPGSIQVRWFL
                     NGQEETAGVVSTNLIRNGDWTFQILVMLEMTPQQGDVYTCQVEHTSLDSPVTVEWKAQ
                     SDSARSKTLTGAGGFVLGLIICGVGIFMHRRSKKVQRGSA"
     exon            153..416
                     /gene="HLA-DPB1"
                     /gene_synonym="DPB1; HLA-DP; HLA-DP1B; HLA-DPB"
                     /inference="alignment:Splign:2.1.0"
     exon            417..698
                     /gene="HLA-DPB1"
                     /gene_synonym="DPB1; HLA-DP; HLA-DP1B; HLA-DPB"
                     /inference="alignment:Splign:2.1.0"
     exon            699..809
                     /gene="HLA-DPB1"
                     /gene_synonym="DPB1; HLA-DP; HLA-DP1B; HLA-DPB"
                     /inference="alignment:Splign:2.1.0"
     exon            810..833
                     /gene="HLA-DPB1"
                     /gene_synonym="DPB1; HLA-DP; HLA-DP1B; HLA-DPB"
                     /inference="alignment:Splign:2.1.0"
     exon            834..3991
                     /gene="HLA-DPB1"
                     /gene_synonym="DPB1; HLA-DP; HLA-DP1B; HLA-DPB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1049..1054
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HLA-DPB1"
                     /gene_synonym="DPB1; HLA-DP; HLA-DP1B; HLA-DPB"
                     /note="hexamer: AATAAT"
     polyA_site      1064
                     /gene="HLA-DPB1"
                     /gene_synonym="DPB1; HLA-DP; HLA-DP1B; HLA-DPB"
                     /note="major polyA site"
     polyA_site      1101
                     /gene="HLA-DPB1"
                     /gene_synonym="DPB1; HLA-DP; HLA-DP1B; HLA-DPB"
     polyA_site      1309
                     /gene="HLA-DPB1"
                     /gene_synonym="DPB1; HLA-DP; HLA-DP1B; HLA-DPB"
     regulatory      1671..1676
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HLA-DPB1"
                     /gene_synonym="DPB1; HLA-DP; HLA-DP1B; HLA-DPB"
                     /note="hexamer: AATACA"
     polyA_site      1695
                     /gene="HLA-DPB1"
                     /gene_synonym="DPB1; HLA-DP; HLA-DP1B; HLA-DPB"
     regulatory      2267..2272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HLA-DPB1"
                     /gene_synonym="DPB1; HLA-DP; HLA-DP1B; HLA-DPB"
                     /note="hexamer: TATAAA"
     polyA_site      2287
                     /gene="HLA-DPB1"
                     /gene_synonym="DPB1; HLA-DP; HLA-DP1B; HLA-DPB"
     regulatory      2563..2568
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HLA-DPB1"
                     /gene_synonym="DPB1; HLA-DP; HLA-DP1B; HLA-DPB"
                     /note="hexamer: ATTACA"
     polyA_site      2582
                     /gene="HLA-DPB1"
                     /gene_synonym="DPB1; HLA-DP; HLA-DP1B; HLA-DPB"
     regulatory      3970..3975
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HLA-DPB1"
                     /gene_synonym="DPB1; HLA-DP; HLA-DP1B; HLA-DPB"
                     /note="hexamer: AATAAA"
     polyA_site      3991
                     /gene="HLA-DPB1"
                     /gene_synonym="DPB1; HLA-DP; HLA-DP1B; HLA-DPB"
ORIGIN      
        1 ccttcttttc ctgactgcag ctcttttcat tttgccatcc ttttccagct ccatgatggt
       61 tctgcaggtt tctgcggccc cccggacagt ggctctgacg gcgttactga tggtgctgct
      121 cacatctgtg gtccagggca gggccactcc agagaattac cttttccagg gacggcagga
      181 atgctacgcg tttaatggga cacagcgctt cctggagaga tacatctaca accgggagga
      241 gttcgcgcgc ttcgacagcg acgtggggga gttccgggcg gtgacggagc tggggcggcc
      301 tgctgcggag tactggaaca gccagaagga catcctggag gagaagcggg cagtgccgga
      361 caggatgtgc agacacaact acgagctggg cgggcccatg accctgcagc gccgagtcca
      421 gcctagggtg aatgtttccc cctccaagaa ggggcccttg cagcaccaca acctgcttgt
      481 ctgccacgtg acggatttct acccaggcag cattcaagtc cgatggttcc tgaatggaca
      541 ggaggaaaca gctggggtcg tgtccaccaa cctgatccgt aatggagact ggaccttcca
      601 gatcctggtg atgctggaaa tgacccccca gcagggagat gtctacacct gccaagtgga
      661 gcacaccagc ctggatagtc ctgtcaccgt ggagtggaag gcacagtctg attctgcccg
      721 gagtaagaca ttgacgggag ctgggggctt cgtgctgggg ctcatcatct gtggagtggg
      781 catcttcatg cacaggagga gcaagaaagt tcaacgagga tctgcataaa cagggttcct
      841 gagctcactg aaaagactat tgtgccttag gaaaagcatt tgctgtgttt cgttagcatc
      901 tggctccagg acagaccttc aacttccaaa ttggatactg ctgccaagaa gttgctctga
      961 agtcagtttc tatcattctg ctctttgatt caaagcactg tttctctcac tgggcctcca
     1021 accatgttcc cttcttctta gcaccacaaa taatcaaaac ccaacatgac tgtttgtttt
     1081 cctttaaaaa tatgcaccaa atcatctctc atcacttttc tctgagggtt ttagtagaca
     1141 gtaggagtta ataaagaagt tcattttggt ttaaacatag gaaagaagag aaccatgaaa
     1201 atggggatat gttaactatt gtataatggg gcctgttaca catgacactc ttctgaattg
     1261 actgtatttc agtgagctgc ccccaaatca agtttagtgc cctcatccat ttatgtctca
     1321 gaccactatt cttaactatt caatggtgag cagactgcaa atctgcctga taggacccat
     1381 attcccacag cactaattca acatatacct tactgagagc atgttttatc attaccatta
     1441 agaagttaaa tgaacatcag aatttaaaat cataaatata atctaataca ctttaaccat
     1501 tttctttgtg tgccatcaca aatactcctt aaccaaatac ggcttggact tttgaatgca
     1561 tccaatagac gtcatttgtc gtctaagtct gcattcatcc accagcctag gcctcctgtc
     1621 ttaattttca tacagacaga aatgactccc cactggggaa agagcaaagc aatacatgta
     1681 gcactctttt tcaaacactg gtcttttttt ttttcttaac aatccaacat tgttatgtgt
     1741 tttgcgtctc atattgacac cttttggtca aggtagagga catgtttgtt gtaagctttc
     1801 tttttcgtgt agaggatgga ttcttcactc ctgatacaca caatcagtgc acagcagctc
     1861 tcttatacat ccagttgatg ccttcagtct ccctggcttc ttacaagcat cttctgggcc
     1921 ttgtgtgtcc ctgggcacct gtccctggtc aattcccgaa agctactgtg ctcctcttgc
     1981 ccatctcccc ttgcaaataa tatcttccat cgggggaccg gcttcctcca atttcaggag
     2041 aggtggggct gaaggcacag acttgggcgt cactggcaca gatataagta aatacagctg
     2101 gagtctgcag agaggctgga ctgagtcagg gagtcaggaa agagaagcca cacacaagga
     2161 caaccaatca tgtttctcat aatcttctta acctagggaa taggacacaa tcattttttc
     2221 tttttaaaac atctttatcc ctgatcagcc tcatttcctc aaaaactata aaggaaaatg
     2281 ctgctgactt gtttttgcgt agtaatttca gctgtcacat aataagctaa ggaagacagt
     2341 atatagtaaa taaggaccct ttatctgtct tattttccct tttggcttca caggaaactt
     2401 gtgagaaacc tatgcagcat aaaattaata tgatttcaat ccagggattc aacgatggaa
     2461 ggaggtcatg agaatagcag aaagtcttca aatcgagatc attatgaaat cctcagaccc
     2521 agagcacata aatcctaccc tcagagtcac tgagcagtta acattacaaa ttacaaacca
     2581 tatccagtca gagtcattct ctttcctgct tgtctcctgt actcatgtta caggttaggg
     2641 cagtaccccg agtggagtga acaatctctg gactaacact tgtcaggatc agaagctgag
     2701 gtatctgcac ccacattaca ggaacaggat atgtgctcct agggaactga gggtgtcagg
     2761 agatgaggaa tgtccctgga gtcacagaaa gaaggtatca gatgtgtctc actctgacat
     2821 atgcaggtgt ttatgaaact ctgggatttc taaggaagga tgcagtgcag agacaggtcc
     2881 cagaggagac aagagctgag agaccatcca aactgggacc accttgtcac tagacttcaa
     2941 attttcaata ttgatagagt gttttctaag agtcaggccc tttgctgagt gctatgtgca
     3001 gcaggatcaa aggcagccag gaggtagagg agtcttgagg tacatcagtc attggagttg
     3061 aagagcagag attcaaagga aagttggaac tggagcttta aaggagatgt gaagtgggtg
     3121 actcaacctc tgactcagaa aaattgatac ctgcagaaga aaaaacccgg cgggcttagg
     3181 actcccagct gagtgttgta tcctccatcc ctttccacct ggtcccttca ttttctaccc
     3241 ctcacagttc cctaacgaga aggtggtcca cccaacagac aacactgcct cagatggtta
     3301 tcaaggggta ccctaagaag aaatcatctc accctctctt tgtccccatt tgtcaagtag
     3361 cagtgaggcc gagccagggg atggtgaaag tggaaggagg tgggagttgg gcatcgggtg
     3421 tgaagatgct cttgaaaggg gttttaataa ccacttgcta ccaggccagt gaacacttac
     3481 catagttgat gccttttgag catgttgcat tgtaaactgt ccctgaaatt actgtgcact
     3541 tggcttatgg gatgaaacat cctcctagtt cttttgtctc tcagcttctc tgaagtctca
     3601 ttgagcacct tctcttcaat ttcttttaca cagtaagaat aggatcagct gtgctaaact
     3661 aacaaatacc cagatatcca ggtttggctc atgttacacg tccaaagtaa gtcatgcagg
     3721 aagctctgct catcatcgta ctcaggaagt caggctgaca gtctttctcc tgcacatctg
     3781 ctcccagaac ctccccagca gaatgaaggg aacctaagaa tttattcact ggcttttaat
     3841 gatccctcct agaaagaaca cacttctcgc atttcatttt ccaatgtaaa tcatatggct
     3901 gcaactaact tcaaataagt gggaatactt gaaggtggaa aacatttaag aagtacacac
     3961 taaataaata ataaaatact tctacaagag a
//
