LOCUS       NM_002120               1326 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens major histocompatibility complex, class II, DO beta
            (HLA-DOB), mRNA.
ACCESSION   NM_002120
VERSION     NM_002120.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1326)
  AUTHORS   Wang,B., Xiong,Y., Li,R. and Zhang,S.
  TITLE     Potential role of SNP rs2071475 in rheumatoid arthritis and
            inflammatory bowel disease in the East Asian population: a
            Mendelian randomization study
  JOURNAL   Inflammopharmacology 32 (1), 683-692 (2024)
   PUBMED   37855981
  REMARK    GeneRIF: Potential role of SNP rs2071475 in rheumatoid arthritis
            and inflammatory bowel disease in the East Asian population: a
            Mendelian randomization study.
REFERENCE   2  (bases 1 to 1326)
  AUTHORS   Castelli,E.C., de Castro,M.V., Naslavsky,M.S., Scliar,M.O.,
            Silva,N.S.B., Pereira,R.N., Ciriaco,V.A.O., Castro,C.F.B.,
            Mendes-Junior,C.T., Silveira,E.S., de Oliveira,I.M., Antonio,E.C.,
            Vieira,G.F., Meyer,D., Nunes,K., Matos,L.R.B., Silva,M.V.R.,
            Wang,J.Y.T., Esposito,J., Coria,V.R., Magawa,J.Y., Santos,K.S.,
            Cunha-Neto,E., Kalil,J., Bortolin,R.H., Hirata,M.H.,
            Dell'Aquila,L.P., Razuk-Filho,A., Batista-Junior,P.B.,
            Duarte-Neto,A.N., Dolhnikoff,M., Saldiva,P.H.N., Passos-Bueno,M.R.
            and Zatz,M.
  TITLE     MUC22, HLA-A, and HLA-DOB variants and COVID-19 in resilient
            super-agers from Brazil
  JOURNAL   Front Immunol 13, 975918 (2022)
   PUBMED   36389712
  REMARK    GeneRIF: MUC22, HLA-A, and HLA-DOB variants and COVID-19 in
            resilient super-agers from Brazil.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1326)
  AUTHORS   Denzin,L.K., Khan,A.A., Virdis,F., Wilks,J., Kane,M.,
            Beilinson,H.A., Dikiy,S., Case,L.K., Roopenian,D., Witkowski,M.,
            Chervonsky,A.V. and Golovkina,T.V.
  TITLE     Neutralizing Antibody Responses to Viral Infections Are Linked to
            the Non-classical MHC Class II Gene H2-Ob
  JOURNAL   Immunity 47 (2), 310-322 (2017)
   PUBMED   28813660
  REMARK    GeneRIF: results indicate that HLA-DOB is co-inherited with DQA2-B2
            genes and thus may contribute to HCV and HBV persistence
REFERENCE   4  (bases 1 to 1326)
  AUTHORS   Huang,P., Zhang,Y., Lu,X., Xu,Y., Wang,J., Zhang,Y., Yu,R. and
            Su,J.
  TITLE     Association of polymorphisms in HLA antigen presentation-related
            genes with the outcomes of HCV infection
  JOURNAL   PLoS One 10 (4), e0123513 (2015)
   PUBMED   25874709
  REMARK    GeneRIF: TAP2, HLA-DOA, HLA-DOB, and tapasin loci are novel
            candidate regions for susceptibility to HCV infection and viral
            clearance in the Chinese population
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1326)
  AUTHORS   Jahnke,M., Trowsdale,J. and Kelly,A.P.
  TITLE     Ubiquitination of HLA-DO by MARCH family E3 ligases
  JOURNAL   Eur J Immunol 43 (5), 1153-1161 (2013)
   PUBMED   23400868
  REMARK    GeneRIF: HLA-DO beta-chain antigens are ubiquitinated by MARCH
            family E3 ligases 1, 8, and 9.
REFERENCE   6  (bases 1 to 1326)
  AUTHORS   Glynne,R., Kerr,L.A., Mockridge,I., Beck,S., Kelly,A. and
            Trowsdale,J.
  TITLE     The major histocompatibility complex-encoded proteasome component
            LMP7: alternative first exons and post-translational processing
  JOURNAL   Eur J Immunol 23 (4), 860-866 (1993)
   PUBMED   8458375
REFERENCE   7  (bases 1 to 1326)
  AUTHORS   Beck,S., Kelly,A., Radley,E., Khurshid,F., Alderton,R.P. and
            Trowsdale,J.
  TITLE     DNA sequence analysis of 66 kb of the human MHC class II region
            encoding a cluster of genes for antigen processing
  JOURNAL   J Mol Biol 228 (2), 433-441 (1992)
   PUBMED   1453454
REFERENCE   8  (bases 1 to 1326)
  AUTHORS   Jonsson,A.K. and Rask,L.
  TITLE     Human class II DNA and DOB genes display low sequence variability
  JOURNAL   Immunogenetics 29 (6), 411-413 (1989)
   PUBMED   2499532
REFERENCE   9  (bases 1 to 1326)
  AUTHORS   Servenius,B., Rask,L. and Peterson,P.A.
  TITLE     Class II genes of the human major histocompatibility complex. The
            DO beta gene is a divergent member of the class II beta gene family
  JOURNAL   J Biol Chem 262 (18), 8759-8766 (1987)
   PUBMED   3036827
REFERENCE   10 (bases 1 to 1326)
  AUTHORS   Tonnelle,C., DeMars,R. and Long,E.O.
  TITLE     DO beta: a new beta chain gene in HLA-D with a distinct regulation
            of expression
  JOURNAL   EMBO J 4 (11), 2839-2847 (1985)
   PUBMED   2998758
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM152694.1, BC006097.1 and
            BQ010608.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002120.3.
            
            Summary: HLA-DOB belongs to the HLA class II beta chain paralogues.
            This class II molecule is a heterodimer consisting of an alpha
            (DOA) and a beta chain (DOB), both anchored in the membrane. It is
            located in intracellular vesicles. DO suppresses peptide loading of
            MHC class II molecules by inhibiting HLA-DM. Class II molecules are
            expressed in antigen presenting cells (APC: B lymphocytes,
            dendritic cells, macrophages). The beta chain is approximately
            26-28 kDa and its gene contains 6 exons. Exon one encodes the
            leader peptide, exons 2 and 3 encode the two extracellular domains,
            exon 4 encodes the transmembrane domain and exon 5 encodes the
            cytoplasmic tail. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006097.1, SRR1163657.226391.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000438763.7/ ENSP00000390020.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               BM152694.1         48-193
            147-1276            BC006097.1         154-1283
            1277-1326           BQ010608.1         17-66               c
FEATURES             Location/Qualifiers
     source          1..1326
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.32"
     gene            1..1326
                     /gene="HLA-DOB"
                     /gene_synonym="DOB; HLA_DOB"
                     /note="major histocompatibility complex, class II, DO
                     beta"
                     /db_xref="GeneID:3112"
                     /db_xref="HGNC:HGNC:4937"
                     /db_xref="MIM:600629"
     exon            1..142
                     /gene="HLA-DOB"
                     /gene_synonym="DOB; HLA_DOB"
                     /inference="alignment:Splign:2.1.0"
     exon            143..412
                     /gene="HLA-DOB"
                     /gene_synonym="DOB; HLA_DOB"
                     /inference="alignment:Splign:2.1.0"
     exon            413..694
                     /gene="HLA-DOB"
                     /gene_synonym="DOB; HLA_DOB"
                     /inference="alignment:Splign:2.1.0"
     exon            695..805
                     /gene="HLA-DOB"
                     /gene_synonym="DOB; HLA_DOB"
                     /inference="alignment:Splign:2.1.0"
     exon            806..837
                     /gene="HLA-DOB"
                     /gene_synonym="DOB; HLA_DOB"
                     /inference="alignment:Splign:2.1.0"
     exon            838..1326
                     /gene="HLA-DOB"
                     /gene_synonym="DOB; HLA_DOB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1301..1306
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HLA-DOB"
                     /gene_synonym="DOB; HLA_DOB"
                     /note="hexamer: AATAAA"
     polyA_site      1326
                     /gene="HLA-DOB"
                     /gene_synonym="DOB; HLA_DOB"
                     /note="major polyA site"
ORIGIN      
        1 attctgaaga ggctgacgat tttactatct catttttttc ctttctccag aatgggttct
       61 gggtgggtcc cctgggtggt ggctctgcta gtgaatctga cccgactgga ttcctccatg
      121 actcaaggca cagactctcc agaagatttt gtgattcagg caaaggctga ctgttacttc
      181 accaacggga cagaaaaggt gcagtttgtg gtcagattca tctttaactt ggaggagtat
      241 gtacgtttcg acagtgatgt ggggatgttt gtggcattga ccaagctggg gcagccagat
      301 gctgagcagt ggaacagccg gctggatctc ttggagagga gcagacaggc cgtggatggg
      361 gtctgtagac acaactacag gctgggcgca cccttcactg tggggagaaa agtgcaacca
      421 gaggtgacag tgtacccaga gaggacccca ctcctgcacc agcataatct gctgcactgc
      481 tctgtgacag gcttctatcc aggggatatc aagatcaagt ggttcctgaa tgggcaggag
      541 gagagagctg gggtcatgtc cactggccct atcaggaatg gagactggac ctttcagact
      601 gtggtgatgc tagaaatgac tcctgaactt ggacatgtct acacctgcct tgtcgatcac
      661 tccagcctgc tgagccctgt ttctgtggag tggagagctc agtctgaata ttcttggaga
      721 aagatgctga gtggcattgc agccttccta cttgggctaa tcttccttct ggtgggaatc
      781 gtcatccagc taagggctca gaaaggatat gtgaggacgc agatgtctgg taatgaggtc
      841 tcaagagctg ttctgctccc tcagtcatgc taaggtcctc actgaagctt ctctctctgg
      901 agcctgaagt agtgatgagt agtctgggcc ctgggtgagg taaaggacat tcatgaggtc
      961 aatgttctgg gaataactct cttccctgat ccttggagga gcccgaactg attctggagc
     1021 tctgtgttct gagatcatgc atctcccacc catctgccct tctcccttct acgtgtacat
     1081 cattaatccc cattgccaag ggcattgtcc agaaactccc ctgagacctt actccttcca
     1141 gccccaaatc atttactttt ctgtggtcca gccctactcc tataagtcat gatctccaaa
     1201 gctttctgtc ttccaactgc agtctccaca gtcttcagaa gacaaatgct caggtagtca
     1261 ctgtttcctt ttcactgttt ttaaaaacct tttattgtca aataaaatgg agatacaaaa
     1321 aatgta
//
