LOCUS       NM_002119               3464 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens major histocompatibility complex, class II, DO alpha
            (HLA-DOA), mRNA.
ACCESSION   NM_002119 NM_015851
VERSION     NM_002119.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3464)
  AUTHORS   Okada,Y., Suzuki,A., Ikari,K., Terao,C., Kochi,Y., Ohmura,K.,
            Higasa,K., Akiyama,M., Ashikawa,K., Kanai,M., Hirata,J., Suita,N.,
            Teo,Y.Y., Xu,H., Bae,S.C., Takahashi,A., Momozawa,Y., Matsuda,K.,
            Momohara,S., Taniguchi,A., Yamada,R., Mimori,T., Kubo,M.,
            Brown,M.A., Raychaudhuri,S., Matsuda,F., Yamanaka,H., Kamatani,Y.
            and Yamamoto,K.
  TITLE     Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of
            Rheumatoid Arthritis
  JOURNAL   Am J Hum Genet 99 (2), 366-374 (2016)
   PUBMED   27486778
  REMARK    GeneRIF: Contribution of a Non-classical HLA Gene, HLA-DOA, to the
            Risk of Rheumatoid Arthritis
REFERENCE   2  (bases 1 to 3464)
  AUTHORS   Pirastu,N., Kooyman,M., Traglia,M., Robino,A., Willems,S.M.,
            Pistis,G., Amin,N., Sala,C., Karssen,L.C., van Duijn,C.M.,
            Toniolo,D. and Gasparini,P.
  TITLE     Genome-wide association analysis on five isolated populations
            identifies variants of the HLA-DOA gene associated with white wine
            liking
  JOURNAL   Eur J Hum Genet 23 (12), 1717-1722 (2015)
   PUBMED   25758996
  REMARK    GeneRIF: significant association was found between white wine
            liking and rs9276975:C>T polymorphism in the HLA-DOA gene.
REFERENCE   3  (bases 1 to 3464)
  AUTHORS   Jiang,W., Strohman,M.J., Somasundaram,S., Ayyangar,S., Hou,T.,
            Wang,N. and Mellins,E.D.
  TITLE     pH-susceptibility of HLA-DO tunes DO/DM ratios to regulate HLA-DM
            catalytic activity
  JOURNAL   Sci Rep 5, 17333 (2015)
   PUBMED   26610428
  REMARK    GeneRIF: pH-susceptibility of HLA-DO tunes DO/DM ratios to regulate
            HLA-DM catalytic activity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3464)
  AUTHORS   Huang,P., Zhang,Y., Lu,X., Xu,Y., Wang,J., Zhang,Y., Yu,R. and
            Su,J.
  TITLE     Association of polymorphisms in HLA antigen presentation-related
            genes with the outcomes of HCV infection
  JOURNAL   PLoS One 10 (4), e0123513 (2015)
   PUBMED   25874709
  REMARK    GeneRIF: TAP2, HLA-DOA, HLA-DOB, and tapasin loci are novel
            candidate regions for susceptibility to HCV infection and viral
            clearance in the Chinese population
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3464)
  AUTHORS   Kremer,A.N., van der Meijden,E.D., Honders,M.W., Pont,M.J.,
            Goeman,J.J., Falkenburg,J.H. and Griffioen,M.
  TITLE     Human leukocyte antigen-DO regulates surface presentation of human
            leukocyte antigen class II-restricted antigens on B cell
            malignancies
  JOURNAL   Biol Blood Marrow Transplant 20 (5), 742-747 (2014)
   PUBMED   24530695
  REMARK    GeneRIF: HLA-DO regulates surface presentation of human leukocyte
            antigen class II-restricted antigens on B cell malignancies.
REFERENCE   6  (bases 1 to 3464)
  AUTHORS   Rosen-Bronson,S. and Long,E.O.
  TITLE     An unusual form of alternative splicing in the HLA-DNA gene
  JOURNAL   Immunogenetics 33 (2), 124-131 (1991)
   PUBMED   1999352
REFERENCE   7  (bases 1 to 3464)
  AUTHORS   Young,J.A. and Trowsdale,J.
  TITLE     The HLA-DNA (DZA) gene is correctly expressed as a 1.1 kb mature
            mRNA transcript
  JOURNAL   Immunogenetics 31 (5-6), 386-388 (1990)
   PUBMED   2370084
REFERENCE   8  (bases 1 to 3464)
  AUTHORS   Jonsson,A.K. and Rask,L.
  TITLE     Human class II DNA and DOB genes display low sequence variability
  JOURNAL   Immunogenetics 29 (6), 411-413 (1989)
   PUBMED   2499532
REFERENCE   9  (bases 1 to 3464)
  AUTHORS   Trowsdale,J. and Kelly,A.
  TITLE     The human HLA class II alpha chain gene DZ alpha is distinct from
            genes in the DP, DQ and DR subregions
  JOURNAL   EMBO J 4 (9), 2231-2237 (1985)
   PUBMED   3000765
REFERENCE   10 (bases 1 to 3464)
  AUTHORS   Inoko,H., Ando,A., Kimura,M. and Tsuji,K.
  TITLE     Isolation and characterization of the cDNA clone and genomic clones
            of a new HLA class II antigen heavy chain, DO alpha
  JOURNAL   J Immunol 135 (3), 2156-2159 (1985)
   PUBMED   2991382
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from M31525.1 and AL645931.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002119.3.
            
            Summary: HLA-DOA belongs to the HLA class II alpha chain
            paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The
            heterodimer, HLA-DO, is found in lysosomes in B cells and regulates
            HLA-DM-mediated peptide loading on MHC class II molecules. In
            comparison with classical HLA class II molecules, this gene
            exhibits very little sequence variation, especially at the protein
            level. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.110203.1, BC013183.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000229829.7/ ENSP00000229829.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1085              M31525.1           22-1106
            1086-3464           AL645931.7         12118-14496         c
FEATURES             Location/Qualifiers
     source          1..3464
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.32"
     gene            1..3464
                     /gene="HLA-DOA"
                     /gene_synonym="HLA-DNA; HLA-DZA; HLADZ"
                     /note="major histocompatibility complex, class II, DO
                     alpha"
                     /db_xref="GeneID:3111"
                     /db_xref="HGNC:HGNC:4936"
                     /db_xref="MIM:142930"
     exon            1..137
                     /gene="HLA-DOA"
                     /gene_synonym="HLA-DNA; HLA-DZA; HLADZ"
                     /inference="alignment:Splign:2.1.0"
     exon            138..386
                     /gene="HLA-DOA"
                     /gene_synonym="HLA-DNA; HLA-DZA; HLADZ"
                     /inference="alignment:Splign:2.1.0"
     exon            387..668
                     /gene="HLA-DOA"
                     /gene_synonym="HLA-DNA; HLA-DZA; HLADZ"
                     /inference="alignment:Splign:2.1.0"
     exon            669..804
                     /gene="HLA-DOA"
                     /gene_synonym="HLA-DNA; HLA-DZA; HLADZ"
                     /inference="alignment:Splign:2.1.0"
     exon            805..3464
                     /gene="HLA-DOA"
                     /gene_synonym="HLA-DNA; HLA-DZA; HLADZ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3439..3444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HLA-DOA"
                     /gene_synonym="HLA-DNA; HLA-DZA; HLADZ"
                     /note="hexamer: ATTAAA"
     polyA_site      3464
                     /gene="HLA-DOA"
                     /gene_synonym="HLA-DNA; HLA-DZA; HLADZ"
                     /note="major polyA site"
ORIGIN      
        1 gttcctgtcc tcaccacacg gactgagact gatttgatta aagcaccaga gtgtaatggc
       61 cctcagagca gggctggtcc tggggttcca caccctgatg accctcctga gcccgcagga
      121 ggcaggggcc accaaggctg accacatggg ctcctacgga cccgccttct accagtctta
      181 cggcgcctcg ggccagttca cccatgaatt tgatgaggaa cagctgttct ctgtggacct
      241 gaagaaaagc gaggccgtgt ggcgtctgcc tgagtttggt gactttgccc gctttgaccc
      301 gcagggcggg ctggccggca tcgccgcaat caaagcccat ctggacatcc tggtggagcg
      361 ctccaaccgc agcagagcca tcaacgtgcc tccacgggtg accgtgctcc ccaagtctcg
      421 ggtggagctg ggccagccca acatcctcat ctgcatcgtg gacaacatct tcccccctgt
      481 gatcaatatc acctggctgc gcaacggcca aactgtcact gagggagtgg cccagaccag
      541 cttctattcc cagcctgacc atttgttccg caagttccac tacctgccct tcgtgccctc
      601 agccgaggac gtctatgact gccaggtgga gcactggggc ctggatgcgc cactcctcag
      661 gcattgggag ctccaggtgc ctattccacc accagatgcc atggagaccc tggtctgtgc
      721 cctgggcctg gccatcggcc tggtgggctt cctcgtgggc accgtcctca tcatcatggg
      781 cacatatgtg tccagtgtcc ccaggtaatg atccttctga gagaaatgac ttgtgggaga
      841 caccctgcag atcctcatgg gtttgtgaca gcccctgcgt gctcagtgcc ctttaagtgc
      901 atcccgctgt gctgactttg agtgggatca acatctgtcc tacgggtccc ctcttttttg
      961 gccccagtat tcatggcagg gtttgttgga cacctactag cttcccttcc cattcaacac
     1021 acacacacat tcttgctcta cccaaagctc tggctggcag cactaaatgc tttggtggtg
     1081 tttgcactgt gtcctttcca ggccttggcc agttcttcca ggggtgaggc atgtggtgct
     1141 ggggattggc agccatcctg gggcccacac aggtgtgtct tgctccattt ggcccattgt
     1201 gtgttacttt gtgaatgagc catttcacat ggacttcatg aaatttgcct cctgagttca
     1261 ggtttaccct gaaagggatg cagattatcc tgttcctcac gaccccctca gctaacaaca
     1321 gttctgaagg gtgctgggac aggacaggct catggggact ccactcctgc ctgggtttac
     1381 tctgtatgaa gaggccactg gtatcctgcc atgatgttat ctcctttttc tacttttccc
     1441 tagagtccca tgcatgataa agagaggccc aaggcttgga taaggtggcc acttccctca
     1501 gtggagtcag tcatgttagg taggaggtgg tagagtcggt ctgcgaggta tctcgtaaga
     1561 ggggaggtcc acctagacac actctaaata tgtggcctag aagattttgg tctacttttc
     1621 tgtgaacaga atttaaaaca tacaaagaga taaatcacca taccacatag tttatgtcag
     1681 gaccaaaatg agcaatacag attacggttt tcaaaccaga atgcacataa gaactgcttg
     1741 ggatcctttt aaaagtacag gcattggcct ggtgcagtgg ctcattcctg taatcccagc
     1801 actttgggag gccaagggga caggactgct tgaggccaag aggtggaaac catcttgggc
     1861 tacatagaga gaccccatct ctacaaagaa agatttaaaa attaaccagg catggtggct
     1921 cgcacctgta ttcccagcca ctggggaggc tgaggccgga ggagtgcttg agcccaggag
     1981 ttcaaggctg cagtgagcca agattgcgcc actgcactcc agcctaggtg acagagtgag
     2041 accctgtctc taaataaata aataaataaa atataaaaat aacagtcatc acccagacct
     2101 actgaattag aatctcggga gtgcaggggg cagcaacagg gaggctgtct tttctgagat
     2161 ggggtctcac tctgtcacca ggctggagtg ccatggcatg atctcagctc actgcaacct
     2221 ccacctcctg agttcaagcc attctcctgc ctcagcctcc tgagtagctg ggactacagg
     2281 tgtgcgccac tacactcagc taatttttgt attttaagta gagacggggt ttcatcatgt
     2341 tggccaggat ggcctccatc tcttgacctc gtgatccacc caccttccct cccaaagtac
     2401 tggaattaca ggcattagcc actgtgccca gccgaggctg tcatttttaa ccggctctgg
     2461 atgactctga tgcagccatc ctggaccttg gctgtggtct ggtaactgga acccagtgac
     2521 gtaatcaggt gccatcgggg gtcatgggaa agggggatcc ccaaggtctg aggtggacta
     2581 ggaaggcttt ctgaagaacc tgggtctgtt agggcatcag ccaatcaagg tacaagtaaa
     2641 tagaggcaaa atgagggttt gaactgtgag cagttggtcc tggaaaagaa agaaaccaag
     2701 agattatggg gactcaatgg gcttcttaag agagaataag ttgaaatcaa tgaccagaag
     2761 accctgatgg aagtggagga gaatcatctc aggcaaactt tttgtgtgcc agtaacagaa
     2821 accctctttg tgtgatcaca tgcaaagtat aggatatttg caatatagcc atggggagga
     2881 gtgcagggcc caagggtaga ttttagccag gcctcccagg aacagaactc ggatccgaaa
     2941 agcccagaga agctagagct gcccctccaa cactctcgga tccacatggt ctgtgttctc
     3001 tagacccccc tgcatgttag cggtgttctc tctctgtgga ctgactgtcc ttctcagtga
     3061 acatgtccac ccgacagctc ctgagtttat atcatctcaa ccctcacaac ccacagaggc
     3121 tgtgtctcct agtcacagct ttaaattact ggaaaaataa atgactggcc aaacttggag
     3181 caggtgtcca tcccagccct gtgtagttag agcaggaatc aagatctcaa cacaaatgtg
     3241 gctgccaagc actcagcccc ggggcgaggg gtcaagttct tctcagagaa agaggaataa
     3301 gttggttctc agaagacatc acaagatacg tgtgtaccca acaatctctg atctctgctg
     3361 atcttttgct tagacgttaa cttgatgcat cattggaaag gtgtttctct catctctgtc
     3421 ctaaggcttg ataaagtcat taaaattgtg ttcttttgac taaa
//
