LOCUS       NM_002118               1348 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens major histocompatibility complex, class II, DM beta
            (HLA-DMB), mRNA.
ACCESSION   NM_002118
VERSION     NM_002118.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1348)
  AUTHORS   Suarez-Trujillo,F., Juarez,I., Jose Recio-Hoyas,M., Rey,D.,
            Palacio-Gruber,J., Gil-Martin,R., Manuel Martin-Villa,J. and
            Arnaiz-Villena,A.
  TITLE     HLA-DMB alleles and haplotypes in Ecuador (Cuenca) Amerindians:
            Importance for HLA and disease studies
  JOURNAL   Hum Immunol 84 (4), 261-262 (2023)
   PUBMED   36870854
  REMARK    GeneRIF: HLA-DMB alleles and haplotypes in Ecuador (Cuenca)
            Amerindians: Importance for HLA and disease studies.
REFERENCE   2  (bases 1 to 1348)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1348)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 1348)
  AUTHORS   Yin,L., Maben,Z.J., Becerra,A. and Stern,L.J.
  TITLE     Evaluating the Role of HLA-DM in MHC Class II-Peptide Association
            Reactions
  JOURNAL   J Immunol 195 (2), 706-716 (2015)
   PUBMED   26062997
  REMARK    GeneRIF: This study provides novel insights into how HLA-DM
            efficiently catalyzes peptide loading during antigen presentation.
REFERENCE   5  (bases 1 to 1348)
  AUTHORS   Aissani,B., Boehme,A.K., Wiener,H.W., Shrestha,S., Jacobson,L.P.
            and Kaslow,R.A.
  TITLE     SNP screening of central MHC-identified HLA-DMB as a candidate
            susceptibility gene for HIV-related Kaposi's sarcoma
  JOURNAL   Genes Immun 15 (6), 424-429 (2014)
   PUBMED   25008864
  REMARK    GeneRIF: Data suggest that antigen processing by MHC class II
            HLA-DMB antigen is a target pathway in the pathogenesis of
            HIV-related Kaposi's sarcoma.
REFERENCE   6  (bases 1 to 1348)
  AUTHORS   Sherman,M.A., Weber,D.A. and Jensen,P.E.
  TITLE     DM enhances peptide binding to class II MHC by release of invariant
            chain-derived peptide
  JOURNAL   Immunity 3 (2), 197-205 (1995)
   PUBMED   7648393
REFERENCE   7  (bases 1 to 1348)
  AUTHORS   Denzin,L.K. and Cresswell,P.
  TITLE     HLA-DM induces CLIP dissociation from MHC class II alpha beta
            dimers and facilitates peptide loading
  JOURNAL   Cell 82 (1), 155-165 (1995)
   PUBMED   7606781
REFERENCE   8  (bases 1 to 1348)
  AUTHORS   Shaman,J., von Scheven,E., Morris,P., Chang,M.D. and Mellins,E.
  TITLE     Analysis of HLA-DMB mutants and -DMB genomic structure
  JOURNAL   Immunogenetics 41 (2-3), 117-124 (1995)
   PUBMED   7528727
REFERENCE   9  (bases 1 to 1348)
  AUTHORS   Radley,E., Alderton,R.P., Kelly,A., Trowsdale,J. and Beck,S.
  TITLE     Genomic organization of HLA-DMA and HLA-DMB. Comparison of the gene
            organization of all six class II families in the human major
            histocompatibility complex
  JOURNAL   J Biol Chem 269 (29), 18834-18838 (1994)
   PUBMED   8034636
REFERENCE   10 (bases 1 to 1348)
  AUTHORS   Kelly,A.P., Monaco,J.J., Cho,S.G. and Trowsdale,J.
  TITLE     A new human HLA class II-related locus, DM
  JOURNAL   Nature 353 (6344), 571-573 (1991)
   PUBMED   1922365
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U15085.1, EL948395.1 and
            CD742571.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002118.4.
            
            Summary: HLA-DMB belongs to the HLA class II beta chain paralogues.
            This class II molecule is a heterodimer consisting of an alpha
            (DMA) and a beta (DMB) chain, both anchored in the membrane. It is
            located in intracellular vesicles. DM plays a central role in the
            peptide loading of MHC class II molecules by helping to release the
            CLIP (class II-associated invariant chain peptide) molecule from
            the peptide binding site. Class II molecules are expressed in
            antigen presenting cells (APC: B lymphocytes, dendritic cells,
            macrophages). The beta chain is approximately 26-28 kDa and its
            gene contains 6 exons. Exon one encodes the leader peptide, exons 2
            and 3 encode the two extracellular domains, exon 4 encodes the
            transmembrane domain and exon 5 encodes the cytoplasmic tail.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U15085.1, AY645722.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2145313
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000418107.3/ ENSP00000398890.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-810               U15085.1           13-822
            811-1099            EL948395.1         286-574
            1100-1348           CD742571.1         23-271              c
FEATURES             Location/Qualifiers
     source          1..1348
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.32"
     gene            1..1348
                     /gene="HLA-DMB"
                     /gene_synonym="D6S221E; RING7"
                     /note="major histocompatibility complex, class II, DM
                     beta"
                     /db_xref="GeneID:3109"
                     /db_xref="HGNC:HGNC:4935"
                     /db_xref="MIM:142856"
     exon            1..276
                     /gene="HLA-DMB"
                     /gene_synonym="D6S221E; RING7"
                     /inference="alignment:Splign:2.1.0"
     exon            277..558
                     /gene="HLA-DMB"
                     /gene_synonym="D6S221E; RING7"
                     /inference="alignment:Splign:2.1.0"
     exon            559..843
                     /gene="HLA-DMB"
                     /gene_synonym="D6S221E; RING7"
                     /inference="alignment:Splign:2.1.0"
     exon            844..960
                     /gene="HLA-DMB"
                     /gene_synonym="D6S221E; RING7"
                     /inference="alignment:Splign:2.1.0"
     exon            961..996
                     /gene="HLA-DMB"
                     /gene_synonym="D6S221E; RING7"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1348
                     /gene="HLA-DMB"
                     /gene_synonym="D6S221E; RING7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1331..1336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HLA-DMB"
                     /gene_synonym="D6S221E; RING7"
                     /note="hexamer: AATAAA"
     polyA_site      1348
                     /gene="HLA-DMB"
                     /gene_synonym="D6S221E; RING7"
                     /note="major polyA site"
ORIGIN      
        1 actggactcc cgtgagctgg aaggaacaga tttaatatct aggggctggg tatccccaca
       61 tcactcattt ggggggtcaa gggacccggg caatatagta ttctgctcag tgtctggaga
      121 tcatctaccc aggctggggc ttctgggaca ggcgaggacc cacggaccct ggaagagctg
      181 gtccagggga ctgaactccc ggcatcttta cagagcagag catgatcaca ttcctgccgc
      241 tgctgctggg gctcagcctg ggctgcacag gagcaggtgg cttcgtggcc catgtggaaa
      301 gcacctgtct gttggatgat gctgggactc caaaggattt cacatactgc atctccttca
      361 acaaggatct gctgacctgc tgggatccag aggagaataa gatggcccct tgcgaatttg
      421 gggtgctgaa tagcttggcg aatgtcctct cacagcacct caaccaaaaa gacaccctga
      481 tgcagcgctt gcgcaatggg cttcagaatt gtgccacaca cacccagccc ttctggggat
      541 cactgaccaa caggacacgg ccaccatctg tgcaagtagc caaaaccact ccttttaaca
      601 cgagggagcc tgtgatgctg gcctgctatg tgtggggctt ctatccagca gaagtgacta
      661 tcacgtggag gaagaacggg aagcttgtca tgcctcacag cagtgcgcac aagactgccc
      721 agcccaatgg agactggaca taccagaccc tctcccattt agccttaacc ccctcttacg
      781 gggacactta cacctgtgtg gtagagcaca ctggggctcc tgagcccatc cttcgggact
      841 ggacacctgg gctgtccccc atgcagaccc tgaaggtttc tgtgtctgca gtgactctgg
      901 gcctgggcct catcatcttc tctcttggtg tgatcagctg gcggagagct ggccactcta
      961 gttacactcc tcttcctggg tccaattatt cagaaggatg gcacatttcc tagaggcaga
     1021 atcctacaac ttccactcca agtgagaagg agattcaaac tcaatgatgc taccatgcct
     1081 ctccaacatc ttcaaccccc tgacattatc ttggatccta tggtttctcc atccaattct
     1141 ttgaatttcc cagtctcccc tatgtaaaac ttagcaactt gggggacctc attcctggga
     1201 ctatgctgta accaaattat tgtccaaggc tatatttctg ggatgaatat aatctgagga
     1261 agggagttaa agaccctcct ggggctctca gtgtgccata gaggacagca actggtgatt
     1321 gtttcagaga aataaacttt ggtggaaa
//
