LOCUS       NM_006120               1093 bp    mRNA    linear   PRI 29-NOV-2024
DEFINITION  Homo sapiens major histocompatibility complex, class II, DM alpha
            (HLA-DMA), mRNA.
ACCESSION   NM_006120
VERSION     NM_006120.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1093)
  AUTHORS   Huang,Y.J., He,J.K., Duan,X., Hou,R. and Shi,J.
  TITLE     Prognostic gene HLA-DMA associated with cell cycle and immune
            infiltrates in LUAD
  JOURNAL   Clin Respir J 17 (12), 1286-1300 (2023)
   PUBMED   37972401
  REMARK    GeneRIF: Prognostic gene HLA-DMA associated with cell cycle and
            immune infiltrates in LUAD.
REFERENCE   2  (bases 1 to 1093)
  AUTHORS   Liu,D. and Hofman,P.
  TITLE     Expression of NOTCH1, NOTCH4, HLA-DMA and HLA-DRA is
            synergistically associated with T cell exclusion, immune checkpoint
            blockade efficacy and recurrence risk in ER-negative breast cancer
  JOURNAL   Cell Oncol (Dordr) 45 (3), 463-477 (2022)
   PUBMED   35543859
  REMARK    GeneRIF: Expression of NOTCH1, NOTCH4, HLA-DMA and HLA-DRA is
            synergistically associated with T cell exclusion, immune checkpoint
            blockade efficacy and recurrence risk in ER-negative breast cancer.
REFERENCE   3  (bases 1 to 1093)
  AUTHORS   Meurer,T., Crivello,P., Metzing,M., Kester,M., Megger,D.A.,
            Chen,W., van Veelen,P.A., van Balen,P., Westendorf,A.M., Homa,G.,
            Layer,S.E., Turki,A.T., Griffioen,M., Horn,P.A., Sitek,B.,
            Beelen,D.W., Falkenburg,J.H.F., Arrieta-Bolanos,E. and
            Fleischhauer,K.
  TITLE     Permissive HLA-DPB1 mismatches in HCT depend on immunopeptidome
            divergence and editing by HLA-DM
  JOURNAL   Blood 137 (7), 923-928 (2021)
   PUBMED   33025005
  REMARK    GeneRIF: Permissive HLA-DPB1 mismatches in HCT depend on
            immunopeptidome divergence and editing by HLA-DM.
REFERENCE   4  (bases 1 to 1093)
  AUTHORS   Wang,J., Qi,X., Zhang,X., Yan,W. and You,C.
  TITLE     [Genetic polymorphisms of ARL15 and HLA-DMA are associated with
            rheumatoid arthritis in Han population from northwest China]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 33 (12), 1681-1685 (2017)
   PUBMED   29382430
  REMARK    GeneRIF: The ARL15 and HLA-DMA gene polymorphisms are associated
            with RA risk in Northwestern Han Chinese population.
REFERENCE   5  (bases 1 to 1093)
  AUTHORS   Jiang,W., Strohman,M.J., Somasundaram,S., Ayyangar,S., Hou,T.,
            Wang,N. and Mellins,E.D.
  TITLE     pH-susceptibility of HLA-DO tunes DO/DM ratios to regulate HLA-DM
            catalytic activity
  JOURNAL   Sci Rep 5, 17333 (2015)
   PUBMED   26610428
  REMARK    GeneRIF: pH-susceptibility of HLA-DO tunes DO/DM ratios to regulate
            HLA-DM catalytic activity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1093)
  AUTHORS   Denzin,L.K. and Cresswell,P.
  TITLE     HLA-DM induces CLIP dissociation from MHC class II alpha beta
            dimers and facilitates peptide loading
  JOURNAL   Cell 82 (1), 155-165 (1995)
   PUBMED   7606781
REFERENCE   7  (bases 1 to 1093)
  AUTHORS   Radley,E., Alderton,R.P., Kelly,A., Trowsdale,J. and Beck,S.
  TITLE     Genomic organization of HLA-DMA and HLA-DMB. Comparison of the gene
            organization of all six class II families in the human major
            histocompatibility complex
  JOURNAL   J Biol Chem 269 (29), 18834-18838 (1994)
   PUBMED   8034636
REFERENCE   8  (bases 1 to 1093)
  AUTHORS   Carrington,M. and Harding,A.
  TITLE     Sequence analysis of two novel HLA-DMA alleles
  JOURNAL   Immunogenetics 40 (2), 165 (1994)
   PUBMED   8026867
REFERENCE   9  (bases 1 to 1093)
  AUTHORS   Kelly,A., Powis,S.H., Glynne,R., Radley,E., Beck,S. and
            Trowsdale,J.
  TITLE     Second proteasome-related gene in the human MHC class II region
  JOURNAL   Nature 353 (6345), 667-668 (1991)
   PUBMED   1922385
REFERENCE   10 (bases 1 to 1093)
  AUTHORS   Kelly,A.P., Monaco,J.J., Cho,S.G. and Trowsdale,J.
  TITLE     A new human HLA class II-related locus, DM
  JOURNAL   Nature 353 (6344), 571-573 (1991)
   PUBMED   1922365
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AU100342.1, BC011447.1 and
            AA649861.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_006120.3.
            
            Summary: HLA-DMA belongs to the HLA class II alpha chain
            paralogues. This class II molecule is a heterodimer consisting of
            an alpha (DMA) and a beta chain (DMB), both anchored in the
            membrane. It is located in intracellular vesicles. DM plays a
            central role in the peptide loading of MHC class II molecules by
            helping to release the CLIP molecule from the peptide binding site.
            Class II molecules are expressed in antigen presenting cells (APC:
            B lymphocytes, dendritic cells, macrophages). The alpha chain is
            approximately 33-35 kDa and its gene contains 5 exons. Exon one
            encodes the leader peptide, exons 2 and 3 encode the two
            extracellular domains, exon 4 encodes the transmembrane domain and
            the cytoplasmic tail. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.121619.1,
                                           SRR5189655.179218.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374843.9/ ENSP00000363976.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AU100342.1         26-31
            7-947               BC011447.1         5-945
            948-1091            BC011447.1         949-1092
            1092-1093           AA649861.1         5-6                 c
FEATURES             Location/Qualifiers
     source          1..1093
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.32"
     gene            1..1093
                     /gene="HLA-DMA"
                     /gene_synonym="D6S222E; DMA; HLADM; RING6"
                     /note="major histocompatibility complex, class II, DM
                     alpha"
                     /db_xref="GeneID:3108"
                     /db_xref="HGNC:HGNC:4934"
                     /db_xref="MIM:142855"
     exon            1..149
                     /gene="HLA-DMA"
                     /gene_synonym="D6S222E; DMA; HLADM; RING6"
                     /inference="alignment:Splign:2.1.0"
     exon            150..434
                     /gene="HLA-DMA"
                     /gene_synonym="D6S222E; DMA; HLADM; RING6"
                     /inference="alignment:Splign:2.1.0"
     exon            435..713
                     /gene="HLA-DMA"
                     /gene_synonym="D6S222E; DMA; HLADM; RING6"
                     /inference="alignment:Splign:2.1.0"
     exon            714..842
                     /gene="HLA-DMA"
                     /gene_synonym="D6S222E; DMA; HLADM; RING6"
                     /inference="alignment:Splign:2.1.0"
     exon            843..1093
                     /gene="HLA-DMA"
                     /gene_synonym="D6S222E; DMA; HLADM; RING6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1075..1080
                     /regulatory_class="polyA_signal_sequence"
                     /gene="HLA-DMA"
                     /gene_synonym="D6S222E; DMA; HLADM; RING6"
                     /note="hexamer: AATAAA"
     polyA_site      1093
                     /gene="HLA-DMA"
                     /gene_synonym="D6S222E; DMA; HLADM; RING6"
                     /note="major polyA site"
ORIGIN      
        1 ggagttgggg aagctgggtt ggctgggttg gtagctccta cctactgtgt ggcaagaagg
       61 tatgggtcat gaacagaacc aaggagctgc gctgctacag atgttaccac ttctgtggct
      121 gctaccccac tcctgggccg tccctgaagc tcctactcca atgtggccag atgacctgca
      181 aaaccacaca ttcctgcaca cagtgtactg ccaggatggg agtcccagtg tgggactctc
      241 tgaggcctac gacgaggacc agcttttctt cttcgacttt tcccagaaca ctcgggtgcc
      301 tcgcctgccc gaatttgctg actgggctca ggaacaggga gatgctcctg ccattttatt
      361 tgacaaagag ttctgcgagt ggatgatcca gcaaataggg ccaaaacttg atgggaaaat
      421 cccggtgtcc agagggtttc ctatcgctga agtgttcacg ctgaagcccc tggagtttgg
      481 caagcccaac actttggtct gttttgtcag taatctcttc ccacccatgc tgacagtgaa
      541 ctggcagcat cattccgtcc ctgtggaagg atttgggcct acttttgtct cagctgtcga
      601 tggactcagc ttccaggcct tttcttactt aaacttcaca ccagaacctt ctgacatttt
      661 ctcctgcatt gtgactcacg aaattgaccg ctacacagca attgcctatt gggtaccccg
      721 gaacgcactg ccctcagatc tgctggagaa tgtgctgtgt ggcgtggcct ttggcctggg
      781 tgtgctgggc atcatcgtgg gcattgttct catcatctac ttccggaagc cttgctcagg
      841 tgactgattc ttccagacca gagtttgatg ccagcagctt cggccatcca aacagaggat
      901 gctcagattt ctcacatcct gcccaggatc tcctcttagg gtagaagtct ctgggacatc
      961 cctggggtgt gtgtgtagat ttcccacctg gggactctgc tgtccctggg cttgcatccc
     1021 agggatccca gagtggcctg cctatcacaa ccacatccct tccccccaca aggcaataaa
     1081 tctcatttct tta
//
